Rimonabant (Hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.0926935
AKAP12 A kinase (PRKA) anchor protein 12 0.0834618
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.069954
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0647896
TPT1 tumor protein, translationally-controlled 1 0.0552481
GLS2 glutaminase 2 (liver, mitochondrial) 0.0504445
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0496056
AHNAK AHNAK nucleoprotein 0.0490132
ACTG1 actin gamma 1 0.0488238
KRT8 keratin 8, type II 0.047606
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0446465
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0437909
TRA2A transformer 2 alpha homolog (Drosophila) 0.0437491
ITGA6 integrin, alpha 6 0.0416783
CAB39 calcium binding protein 39 0.0412988
SDC4 syndecan 4 0.0407963
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0407546
MYH9 myosin, heavy chain 9, non-muscle 0.0401546
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0398379
EPCAM epithelial cell adhesion molecule 0.0393146
ASPH aspartate beta-hydroxylase 0.0385452
SLMAP sarcolemma associated protein 0.0383214
TOP1 topoisomerase (DNA) I 0.0380964
ANKRD10 ankyrin repeat domain 10 0.037908
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0377828
ITPRID2 ITPR interacting domain containing 2 0.0377322
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0376737
EPS8 epidermal growth factor receptor pathway substrate 8 0.0373344
MYO6 myosin VI 0.036697
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0359362
DSCAM Down syndrome cell adhesion molecule 0.0356193
ARHGAP26 Rho GTPase activating protein 26 0.0342102
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0339857
PARD3 par-3 family cell polarity regulator 0.0326495
PTK2 protein tyrosine kinase 2 0.0323567
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0321174
AFDN afadin, adherens junction formation factor 0.0313402
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0309364
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0307918
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0306558
RTN4 reticulon 4 0.0298826
NCKAP1 NCK-associated protein 1 0.0298236
PUM2 pumilio RNA-binding family member 2 0.0297906
SMAD3 SMAD family member 3 0.0295947
LAMC2 laminin, gamma 2 0.0295699
ZEB1 zinc finger E-box binding homeobox 1 0.0293496
AKAP13 A kinase (PRKA) anchor protein 13 0.0290621
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0288351
DST dystonin 0.0287391
FOXO3 forkhead box O3 0.0286393
ADAM9 ADAM metallopeptidase domain 9 0.0284296
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0283035
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0279182
VCL vinculin 0.0274868
BCAR3 breast cancer anti-estrogen resistance 3 0.026441
ARGLU1 arginine and glutamate rich 1 0.0264337
NRIP1 nuclear receptor interacting protein 1 0.0264254
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0264114
ANXA11 annexin A11 0.0263933
PTMA prothymosin, alpha 0.0262942
PLAUR plasminogen activator, urokinase receptor 0.0262313
RBM25 RNA binding motif protein 25 0.0261952
CUL3 cullin 3 0.0261386
PPARG peroxisome proliferator-activated receptor gamma 0.025672
RPS12 ribosomal protein S12 0.0256587
OGA O-GlcNAcase 0.0256453
CD46 CD46 molecule, complement regulatory protein 0.0254978
OSBPL3 oxysterol binding protein-like 3 0.0252145
RPL37A ribosomal protein L37a 0.0248858
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0245728
NCOA3 nuclear receptor coactivator 3 0.0242807
CTNND1 catenin (cadherin-associated protein), delta 1 0.0240457
SET SET nuclear proto-oncogene 0.0239044
LMTK2 lemur tyrosine kinase 2 0.0238226
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0237967
NAP1L1 nucleosome assembly protein 1-like 1 0.023687
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0234041
SLTM SAFB-like, transcription modulator 0.0233807
NEK7 NIMA-related kinase 7 0.0230868
CELF1 CUGBP, Elav-like family member 1 0.0230161
CYRIB CYFIP related Rac1 interactor B 0.0230134
ATP13A3 ATPase type 13A3 0.0229293
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0228595
EFNA5 ephrin-A5 0.0226688
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0226481
TMC7 transmembrane channel-like 7 0.0222701
ADAM17 ADAM metallopeptidase domain 17 0.022196
NPAS2 neuronal PAS domain protein 2 0.0221884
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0217962
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0215632
PLEC plectin 0.0215389
TMSB4X thymosin beta 4, X-linked 0.0214482
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0211111
TNIP1 TNFAIP3 interacting protein 1 0.0210868
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0210407
PSME4 proteasome (prosome, macropain) activator subunit 4 0.020993
RPL9 ribosomal protein L9 0.0209335
RHEB Ras homolog enriched in brain 0.0207785
RPS3 ribosomal protein S3 0.0207687
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0207682

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.253722
NDRG1 N-myc downstream regulated 1 -0.246841
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.235218
MUC17 mucin 17, cell surface associated -0.147709
FTH1 ferritin, heavy polypeptide 1 -0.143198
LOC112694756 uncharaterized LOC112694756 -0.122748
TMSB10 thymosin beta 10 -0.110863
HMGA1 high mobility group AT-hook 1 -0.104018
EGR1 early growth response 1 -0.0902133
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0854538
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0839214
EGFR epidermal growth factor receptor -0.0781614
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0758826
TXNRD1 thioredoxin reductase 1 -0.0732096
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0728793
ERRFI1 ERBB receptor feedback inhibitor 1 -0.069527
TXNIP thioredoxin interacting protein -0.068848
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0684289
POTEF POTE ankyrin domain family, member F -0.0674912
VIM vimentin -0.0643879
TSC22D2 TSC22 domain family, member 2 -0.0625485
S100A10 S100 calcium binding protein A10 -0.0618387
RIOK3 RIO kinase 3 -0.0614371
SACK1A scaffolding CK1 anchoring protein A -0.0608866
FAM107B family with sequence similarity 107, member B -0.0589963
ANXA2 annexin A2 -0.0578226
EZR ezrin -0.056754
LDHA lactate dehydrogenase A -0.0551133
SPAG9 sperm associated antigen 9 -0.0550501
LMO7 LIM domain 7 -0.053098
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0508986
MXD1 MAX dimerization protein 1 -0.0506556
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0494954
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0482866
AKAP9 A kinase (PRKA) anchor protein 9 -0.0474839
SEC31A SEC31 homolog A (S. cerevisiae) -0.0473082
ARF4 ADP-ribosylation factor 4 -0.0440562
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0438363
MORF4L2 mortality factor 4 like 2 -0.0436524
COPB1 coatomer protein complex, subunit beta 1 -0.0405111
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0404766
S100A11 S100 calcium binding protein A11 -0.0400805
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0400795
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0398229
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0394724
EXT1 exostosin glycosyltransferase 1 -0.0393706
RAB2A RAB2A, member RAS oncogene family -0.0384573
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0383382
SP100 SP100 nuclear antigen -0.0381882
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0378542
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0375125
BLZF1 basic leucine zipper nuclear factor 1 -0.0373317
ARF1 ADP-ribosylation factor 1 -0.0372652
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0369545
ENO1 enolase 1, (alpha) -0.0369042
CALU calumenin -0.0366444
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0365917
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0365389
FSCN1 fascin actin-bundling protein 1 -0.0344336
RRBP1 ribosome binding protein 1 -0.0339466
PMM2 phosphomannomutase 2 -0.0337702
SEC24A SEC24 family member A -0.0334981
DSG2 desmoglein 2 -0.0333035
PGK1 phosphoglycerate kinase 1 -0.0329255
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0329029
SGMS2 sphingomyelin synthase 2 -0.0328512
VDAC1 voltage-dependent anion channel 1 -0.0327819
UBC ubiquitin C -0.0327392
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0324858
AFF4 AF4/FMR2 family, member 4 -0.0323117
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0323004
RNASEH2A ribonuclease H2, subunit A -0.0321699
PKM pyruvate kinase, muscle -0.0318684
GOLGA4 golgin A4 -0.0312637
FBXO11 F-box protein 11 -0.0311333
HDLBP high density lipoprotein binding protein -0.0311054
GOLGB1 golgin B1 -0.0309644
BHLHE40 basic helix-loop-helix family, member e40 -0.0307185
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0300957
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0298173
GCC2 GRIP and coiled-coil domain containing 2 -0.0296718
KRT19 keratin 19, type I -0.0291832
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0285287
TRRAP transformation/transcription domain-associated protein -0.0283921
TMEM263 transmembrane protein 263 -0.0282964
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0281642
ESYT2 extended synaptotagmin-like protein 2 -0.0281212
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0280422
NCEH1 neutral cholesterol ester hydrolase 1 -0.0280416
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0279823
CSTB cystatin B (stefin B) -0.0279751
OXSR1 oxidative stress responsive 1 -0.027759
SRP54 signal recognition particle 54kDa -0.0270095
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0269107
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0266506
TPI1 triosephosphate isomerase 1 -0.026631
FTL ferritin, light polypeptide -0.0263994
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -0.0263381
LY6E lymphocyte antigen 6 complex, locus E -0.0262954
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0261055