Rimonabant (Hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.128867
PTMA prothymosin, alpha 0.117516
AKAP12 A kinase (PRKA) anchor protein 12 0.102675
MYH9 myosin, heavy chain 9, non-muscle 0.097287
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0964331
FAM13A family with sequence similarity 13, member A 0.0854845
TNIP1 TNFAIP3 interacting protein 1 0.0836452
NAMPT nicotinamide phosphoribosyltransferase 0.0833011
APOL1 apolipoprotein L, 1 0.0740479
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0716693
TMSB4X thymosin beta 4, X-linked 0.0678057
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0676852
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0657288
MAML2 mastermind-like 2 (Drosophila) 0.061344
ANKRD11 ankyrin repeat domain 11 0.0611253
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.060305
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0602216
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0581874
APLP2 amyloid beta (A4) precursor-like protein 2 0.0578134
WSB1 WD repeat and SOCS box containing 1 0.0571194
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0553917
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0552366
SMAD3 SMAD family member 3 0.0525467
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0515146
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0506862
BHLHE40 basic helix-loop-helix family, member e40 0.0501102
CP ceruloplasmin (ferroxidase) 0.048831
CCNY cyclin Y 0.0485822
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0485412
NUP58 nucleoporin 58 0.0471814
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0469841
CALR calreticulin 0.0449618
DDIT4 DNA-damage-inducible transcript 4 0.0447132
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0438188
TGM2 transglutaminase 2 0.0427712
ARHGAP26 Rho GTPase activating protein 26 0.0427042
PKM pyruvate kinase, muscle 0.0416295
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0405851
UBC ubiquitin C 0.0403775
FOSL1 FOS-like antigen 1 0.0390417
ADAM9 ADAM metallopeptidase domain 9 0.0383524
ENO1 enolase 1, (alpha) 0.0376781
INSIG2 insulin induced gene 2 0.0372501
HELZ helicase with zinc finger 0.0369005
MATR3 matrin 3 0.0360669
GRB10 growth factor receptor-bound protein 10 0.0360349
HDGF hepatoma-derived growth factor 0.0356001
ZMYND8 zinc finger, MYND-type containing 8 0.0355012
BIRC3 baculoviral IAP repeat containing 3 0.0354
MCL1 myeloid cell leukemia 1 0.0348872
MACF1 microtubule-actin crosslinking factor 1 0.0348535
CTNND1 catenin (cadherin-associated protein), delta 1 0.0345535
SRRM2 serine/arginine repetitive matrix 2 0.0342378
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0339444
TPM3 tropomyosin 3 0.0335879
ASPH aspartate beta-hydroxylase 0.0334109
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0329141
RPL3 ribosomal protein L3 0.0318714
MKI67 marker of proliferation Ki-67 0.0317277
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0313605
FLNB filamin B, beta 0.0312712
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.030942
CASC3 cancer susceptibility candidate 3 0.0309353
PDIA6 protein disulfide isomerase family A, member 6 0.030737
ZFP36L1 ZFP36 ring finger protein-like 1 0.0306051
KRT18 keratin 18, type I 0.0302751
USP3 ubiquitin specific peptidase 3 0.0299582
AHNAK AHNAK nucleoprotein 0.0297805
PGK1 phosphoglycerate kinase 1 0.0295514
ARRDC3 arrestin domain containing 3 0.02953
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0295206
HSPA8 heat shock 70kDa protein 8 0.0292824
FNDC3B fibronectin type III domain containing 3B 0.0286258
LPP LIM domain containing preferred translocation partner in lipoma 0.0285785
ITGA6 integrin, alpha 6 0.0280968
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0279641
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0275658
ZMIZ1 zinc finger, MIZ-type containing 1 0.0274203
ATP13A3 ATPase type 13A3 0.0273065
KTN1 kinectin 1 (kinesin receptor) 0.0272838
UBA6 ubiquitin-like modifier activating enzyme 6 0.027187
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0269127
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0266587
PLAT plasminogen activator, tissue 0.0264591
HPCAL1 hippocalcin-like 1 0.0263734
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0258956
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0258685
RAD23B RAD23 homolog B (S. cerevisiae) 0.0258622
PCBP2 poly(rC) binding protein 2 0.0257936
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.025667
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0254482
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0253255
AFAP1 actin filament associated protein 1 0.0250159
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0248347
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0247548
ELL2 elongation factor, RNA polymerase II, 2 0.0245937
OGA O-GlcNAcase 0.0242628
FXR1 fragile X mental retardation, autosomal homolog 1 0.0242304
EZR ezrin 0.02407
PROSER2 proline and serine rich 2 0.0239657

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254442
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.119894
LOC112694756 uncharaterized LOC112694756 -0.101447
ACTG1 actin gamma 1 -0.0947861
TMSB10 thymosin beta 10 -0.0873164
EIF1 eukaryotic translation initiation factor 1 -0.0850245
RPL35A ribosomal protein L35a -0.0757931
RAB7A RAB7A, member RAS oncogene family -0.0735112
ARHGAP5 Rho GTPase activating protein 5 -0.0673531
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0672623
MYO1E myosin IE -0.0662105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0652378
SPAG9 sperm associated antigen 9 -0.0641756
MT1X metallothionein 1X -0.0630138
MT2A metallothionein 2A -0.057232
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0557546
HLA-B major histocompatibility complex, class I, B -0.0541829
HMGA1 high mobility group AT-hook 1 -0.0527295
UGDH UDP-glucose 6-dehydrogenase -0.0490403
BLZF1 basic leucine zipper nuclear factor 1 -0.0478378
AFF4 AF4/FMR2 family, member 4 -0.047217
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0471835
FTH1 ferritin, heavy polypeptide 1 -0.0455962
TTC3 tetratricopeptide repeat domain 3 -0.0448059
TJP1 tight junction protein 1 -0.0438848
GOLGB1 golgin B1 -0.0435756
CD2AP CD2-associated protein -0.0434541
BICC1 BicC family RNA binding protein 1 -0.0428691
AKAP9 A kinase (PRKA) anchor protein 9 -0.0427969
LMO7 LIM domain 7 -0.0422524
RPLP1 ribosomal protein, large, P1 -0.0420529
SEC31A SEC31 homolog A (S. cerevisiae) -0.0419418
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0408907
RTN4 reticulon 4 -0.0399988
GNAS GNAS complex locus -0.0393668
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0392686
VMP1 vacuole membrane protein 1 -0.039093
KRT19 keratin 19, type I -0.0387524
NABP1 nucleic acid binding protein 1 -0.037278
MORF4L2 mortality factor 4 like 2 -0.0372468
SP100 SP100 nuclear antigen -0.0365909
KLF6 Kruppel-like factor 6 -0.0364114
FTL ferritin, light polypeptide -0.0360548
PHF3 PHD finger protein 3 -0.0359143
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0359136
NDRG1 N-myc downstream regulated 1 -0.0358515
RPL34 ribosomal protein L34 -0.035324
SGMS2 sphingomyelin synthase 2 -0.0336835
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0334402
UBE2H ubiquitin-conjugating enzyme E2H -0.0332881
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0331765
ALCAM activated leukocyte cell adhesion molecule -0.0326912
SLC38A1 solute carrier family 38, member 1 -0.0323387
FNIP1 folliculin interacting protein 1 -0.0320466
NPEPPS aminopeptidase puromycin sensitive -0.031836
EMP1 epithelial membrane protein 1 -0.0318008
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0317961
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.031558
SYNRG synergin, gamma -0.0314008
RAB1A RAB1A, member RAS oncogene family -0.0313614
RB1CC1 RB1-inducible coiled-coil 1 -0.031231
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0309415
ERBIN erbb2 interacting protein -0.0308391
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0306607
LOC102724023 ES1 protein homolog, mitochondrial -0.030432
SQSTM1 sequestosome 1 -0.0301423
GCC2 GRIP and coiled-coil domain containing 2 -0.0299499
EGR1 early growth response 1 -0.029754
RBM47 RNA binding motif protein 47 -0.0296587
PATJ PATJ crumbs cell polarity complex component -0.029456
RPL19 ribosomal protein L19 -0.0293355
FBXO11 F-box protein 11 -0.0290276
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0290254
MUC4 mucin 4, cell surface associated -0.0289877
LASP1 LIM and SH3 protein 1 -0.028753
MON2 MON2 homolog (S. cerevisiae) -0.0287009
ARF1 ADP-ribosylation factor 1 -0.0285524
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0285398
CLTC clathrin, heavy chain (Hc) -0.0282314
HLA-C major histocompatibility complex, class I, C -0.0279876
RPS24 ribosomal protein S24 -0.0275598
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0275388
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0275271
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0272273
MACC1 metastasis associated in colon cancer 1 -0.0271036
NIPBL Nipped-B homolog (Drosophila) -0.0270434
FAM3C family with sequence similarity 3, member C -0.0269572
CDK12 cyclin-dependent kinase 12 -0.0262622
TACSTD2 tumor-associated calcium signal transducer 2 -0.026183
RAP2B RAP2B, member of RAS oncogene family -0.0258553
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0256417
FBXL20 F-box and leucine-rich repeat protein 20 -0.0254465
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0252292
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0251741
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0251327
RRBP1 ribosome binding protein 1 -0.0250389
HDLBP high density lipoprotein binding protein -0.0249535
ANXA2 annexin A2 -0.0249364
ANKRD17 ankyrin repeat domain 17 -0.0248227
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0246938