Rimonabant (Hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.121539
PTMA prothymosin, alpha 0.0982608
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0877387
HELZ helicase with zinc finger 0.0663203
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0656588
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0654331
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0631396
DSCAM Down syndrome cell adhesion molecule 0.0602543
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0577313
OGA O-GlcNAcase 0.0564953
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.051901
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0515331
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0507598
HMGB2 high mobility group box 2 0.0505439
ENAH enabled homolog (Drosophila) 0.0500392
PRRC2C proline-rich coiled-coil 2C 0.0494397
AHNAK AHNAK nucleoprotein 0.0486013
SET SET nuclear proto-oncogene 0.0457447
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0457229
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0439533
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0435765
NAP1L1 nucleosome assembly protein 1-like 1 0.0432421
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0428778
SPAG9 sperm associated antigen 9 0.0420855
MYH9 myosin, heavy chain 9, non-muscle 0.0414326
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0413791
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0408494
RNF145 ring finger protein 145 0.0404097
RPL4 ribosomal protein L4 0.0390756
TRIO trio Rho guanine nucleotide exchange factor 0.0387535
WAC WW domain containing adaptor with coiled-coil 0.0386737
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0383986
CSDE1 cold shock domain containing E1, RNA-binding 0.0383597
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0379647
FAM13A family with sequence similarity 13, member A 0.0373626
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.037231
APP amyloid beta (A4) precursor protein 0.0369354
PCBP2 poly(rC) binding protein 2 0.036864
KDM3A lysine (K)-specific demethylase 3A 0.0366216
SMAD3 SMAD family member 3 0.0358813
VEGFA vascular endothelial growth factor A 0.0345614
ZFAND3 zinc finger, AN1-type domain 3 0.0343934
PTK2 protein tyrosine kinase 2 0.0337767
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0335521
SEPTIN9 septin 9 0.0330508
CCNY cyclin Y 0.0327805
TPR translocated promoter region, nuclear basket protein 0.0324963
RPL37A ribosomal protein L37a 0.0323326
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0322216
XPO1 exportin 1 0.0321078
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0317736
COPA coatomer protein complex, subunit alpha 0.0302046
CKAP5 cytoskeleton associated protein 5 0.0298791
EIF4B eukaryotic translation initiation factor 4B 0.0298671
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0296922
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.029546
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0289452
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0286593
SOS1 son of sevenless homolog 1 (Drosophila) 0.0284508
CASC3 cancer susceptibility candidate 3 0.0282047
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0281897
HSPA8 heat shock 70kDa protein 8 0.0280465
TENT2 terminal nucleotidyltransferase 2 0.0276403
DST dystonin 0.027471
ARRDC3 arrestin domain containing 3 0.0273996
NCKAP1 NCK-associated protein 1 0.0272098
PICALM phosphatidylinositol binding clathrin assembly protein 0.02715
COL3A1 collagen, type III, alpha 1 0.0271032
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0270908
FXR1 fragile X mental retardation, autosomal homolog 1 0.0270505
SBF2 SET binding factor 2 0.0268503
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0267711
MSI2 musashi RNA-binding protein 2 0.0266399
ANXA2 annexin A2 0.0266085
TCERG1 transcription elongation regulator 1 0.0263545
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0262692
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0262083
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0261448
TOP1 topoisomerase (DNA) I 0.0259047
NAMPT nicotinamide phosphoribosyltransferase 0.0255976
MATR3 matrin 3 0.0254799
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0254625
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0254485
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0252387
ELP2 elongator acetyltransferase complex subunit 2 0.0251113
USP3 ubiquitin specific peptidase 3 0.0248733
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0248646
ZNF292 zinc finger protein 292 0.0243554
ZMYM2 zinc finger, MYM-type 2 0.0241709
PKM pyruvate kinase, muscle 0.0240839
FNDC3B fibronectin type III domain containing 3B 0.0239908
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.023961
ADAM9 ADAM metallopeptidase domain 9 0.0238823
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0237748
RPS12 ribosomal protein S12 0.0236518
ANKRD11 ankyrin repeat domain 11 0.023627
YEATS2 YEATS domain containing 2 0.0236167
TNRC6A trinucleotide repeat containing 6A 0.0232817
MORF4L1 mortality factor 4 like 1 0.0232813
SRPK2 SRSF protein kinase 2 0.0232038

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.613397
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190117
VCL vinculin -0.130476
FMN1 formin 1 -0.123183
SYT1 synaptotagmin I -0.0730095
EGR1 early growth response 1 -0.0584649
TLE4 transducin-like enhancer of split 4 -0.0533164
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0524387
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0481188
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.047117
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0424903
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0420703
FTH1 ferritin, heavy polypeptide 1 -0.0411249
GLCCI1 glucocorticoid induced 1 -0.0401634
TPST1 tyrosylprotein sulfotransferase 1 -0.0397687
AKAP12 A kinase (PRKA) anchor protein 12 -0.0395935
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0393658
SIK2 salt-inducible kinase 2 -0.0384344
RAB7A RAB7A, member RAS oncogene family -0.0360266
RPL35A ribosomal protein L35a -0.0339408
BPTF bromodomain PHD finger transcription factor -0.0337708
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0334223
FNDC3A fibronectin type III domain containing 3A -0.0327836
LOC112694756 uncharaterized LOC112694756 -0.0327112
NDRG1 N-myc downstream regulated 1 -0.0318326
FRMD4A FERM domain containing 4A -0.0312865
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0307702
FKBP10 FK506 binding protein 10, 65 kDa -0.030634
ZNF804A zinc finger protein 804A -0.0306231
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0295876
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.029157
RARA retinoic acid receptor, alpha -0.0287125
MBD5 methyl-CpG binding domain protein 5 -0.0281266
MYO1E myosin IE -0.0279001
PTPRK protein tyrosine phosphatase, receptor type, K -0.0275387
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0272784
THSD4 thrombospondin, type I, domain containing 4 -0.0272757
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.027045
ARF1 ADP-ribosylation factor 1 -0.0269686
PDIA3 protein disulfide isomerase family A, member 3 -0.0269157
ZBTB20 zinc finger and BTB domain containing 20 -0.02689
SP100 SP100 nuclear antigen -0.0264476
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0262599
TIMP3 TIMP metallopeptidase inhibitor 3 -0.026001
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0259273
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0257078
EIF1 eukaryotic translation initiation factor 1 -0.0253581
TMSB10 thymosin beta 10 -0.0251859
COL4A5 collagen, type IV, alpha 5 -0.0249477
SLITRK6 SLIT and NTRK-like family, member 6 -0.0249264
CHD9 chromodomain helicase DNA binding protein 9 -0.0247463
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0244615
NRG1 neuregulin 1 -0.0238119
BCAS3 breast carcinoma amplified sequence 3 -0.0234586
SLIT2 slit homolog 2 (Drosophila) -0.0233217
PTPRD protein tyrosine phosphatase, receptor type, D -0.0231037
STC1 stanniocalcin 1 -0.0230658
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0226754
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0225524
STK38L serine/threonine kinase 38 like -0.02234
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.022066
TAS2R14 taste receptor, type 2, member 14 -0.0219855
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0219151
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0217847
RIGI RNA sensor RIG-I -0.0217542
TOB1 transducer of ERBB2, 1 -0.0210131
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0206338
EXT1 exostosin glycosyltransferase 1 -0.0205734
GREM2 gremlin 2, DAN family BMP antagonist -0.0205638
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0205405
PDE10A phosphodiesterase 10A -0.0204601
NPAS2 neuronal PAS domain protein 2 -0.0203207
VIM vimentin -0.0202602
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0202245
ARHGAP24 Rho GTPase activating protein 24 -0.01999
NCOA7 nuclear receptor coactivator 7 -0.0199592
FERMT2 fermitin family member 2 -0.0198609
BICD1 bicaudal D homolog 1 (Drosophila) -0.0197277
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -0.0196571
HDX highly divergent homeobox -0.0193908
LIMA1 LIM domain and actin binding 1 -0.0192708
IGFBP3 insulin-like growth factor binding protein 3 -0.0192191
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0192093
FTL ferritin, light polypeptide -0.0189829
RPL28 ribosomal protein L28 -0.0188748
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0185536
IFI16 interferon, gamma-inducible protein 16 -0.0185397
PCDH10 protocadherin 10 -0.0184587
TRIB2 tribbles pseudokinase 2 -0.018448
CEP350 centrosomal protein 350kDa -0.0181776
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0179647
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0179474
TPM1 tropomyosin 1 (alpha) -0.0178285
SLC38A2 solute carrier family 38, member 2 -0.01726
MED13 mediator complex subunit 13 -0.0171082
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0170923
BLZF1 basic leucine zipper nuclear factor 1 -0.0170307
NALF1 NALCN channel auxiliary factor 1 -0.0170229
GNAS GNAS complex locus -0.016838
STXBP5 syntaxin binding protein 5 (tomosyn) -0.016736