Rimonabant (Hydrochloride)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 0.134367
ZMYM2 zinc finger, MYM-type 2 0.0864189
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0723655
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0719989
ZMYND8 zinc finger, MYND-type containing 8 0.0687419
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0595369
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0588744
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0588327
PHF3 PHD finger protein 3 0.0573524
N4BP2L2 NEDD4 binding protein 2-like 2 0.0567616
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0560019
ARHGAP26 Rho GTPase activating protein 26 0.0554037
IFNGR1 interferon gamma receptor 1 0.0550109
EPSTI1 epithelial stromal interaction 1 (breast) 0.0533932
SORBS1 sorbin and SH3 domain containing 1 0.0528779
ARGLU1 arginine and glutamate rich 1 0.0519159
RNF43 ring finger protein 43 0.0480546
AHNAK AHNAK nucleoprotein 0.0474212
PRELID2 PRELI domain containing 2 0.0471644
CTNND1 catenin (cadherin-associated protein), delta 1 0.0441144
LPP LIM domain containing preferred translocation partner in lipoma 0.042964
MYH9 myosin, heavy chain 9, non-muscle 0.0427128
RUNX1 runt-related transcription factor 1 0.0427011
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0425046
PTBP3 polypyrimidine tract binding protein 3 0.0421858
RAD51B RAD51 paralog B 0.0418052
OARD1 O-acyl-ADP-ribose deacylase 1 0.04142
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0411367
UBAC2 UBA domain containing 2 0.0396283
MCTP2 multiple C2 domains, transmembrane 2 0.0390893
BICRAL BICRA like chromatin remodeling complex associated protein 0.0387238
RNF149 ring finger protein 149 0.0379932
RBM26 RNA binding motif protein 26 0.0379121
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0378324
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0377666
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.037266
IGF1R insulin-like growth factor 1 receptor 0.0359592
FNDC3B fibronectin type III domain containing 3B 0.0357429
NRIP1 nuclear receptor interacting protein 1 0.0356109
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0352112
KLF5 Kruppel-like factor 5 (intestinal) 0.0348686
OGA O-GlcNAcase 0.0348602
MSI2 musashi RNA-binding protein 2 0.0347772
CD46 CD46 molecule, complement regulatory protein 0.0346309
DIAPH3 diaphanous-related formin 3 0.0343182
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0343047
TM9SF2 transmembrane 9 superfamily member 2 0.0339851
FNIP1 folliculin interacting protein 1 0.0335283
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0333609
SPRED1 sprouty-related, EVH1 domain containing 1 0.0329944
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.032868
SMC5 structural maintenance of chromosomes 5 0.0326914
ARHGAP32 Rho GTPase activating protein 32 0.0325298
FNDC3A fibronectin type III domain containing 3A 0.0324651
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0324621
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0316438
ASPH aspartate beta-hydroxylase 0.0309822
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0309199
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0303407
ZBTB20 zinc finger and BTB domain containing 20 0.0302332
NF1 neurofibromin 1 0.0301325
MED13 mediator complex subunit 13 0.0301276
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0295857
PRKCA protein kinase C, alpha 0.0295088
CD2AP CD2-associated protein 0.0292956
AOPEP aminopeptidase O (putative) 0.0292558
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0290872
GRK3 G protein-coupled receptor kinase 3 0.0289815
ZDHHC20 zinc finger, DHHC-type containing 20 0.0289328
PTGR1 prostaglandin reductase 1 0.0288629
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0286193
ZC3H13 zinc finger CCCH-type containing 13 0.0280532
FAT1 FAT atypical cadherin 1 0.0277247
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0275633
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0271879
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0271716
BRCA2 breast cancer 2, early onset 0.0269446
TNRC6B trinucleotide repeat containing 6B 0.0268124
ZNF148 zinc finger protein 148 0.0267889
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0267666
EHF ets homologous factor 0.0266225
TENT2 terminal nucleotidyltransferase 2 0.0265592
ADAM10 ADAM metallopeptidase domain 10 0.0262365
PTEN phosphatase and tensin homolog 0.0259076
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0258067
CANX calnexin 0.0257456
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0257012
MLPH melanophilin 0.025678
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0253412
TUBGCP3 tubulin, gamma complex associated protein 3 0.0252615
PDS5B PDS5 cohesin associated factor B 0.0251425
XRN1 5'-3' exoribonuclease 1 0.0250473
TBC1D22A TBC1 domain family, member 22A 0.0248526
SBF2 SET binding factor 2 0.0247006
KIF16B kinesin family member 16B 0.0246677
EXOC4 exocyst complex component 4 0.0246664
ANKRD10 ankyrin repeat domain 10 0.0246218
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0244929
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0244647
WDR26 WD repeat domain 26 0.02398

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.217221
LMO7 LIM domain 7 -0.189236
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.141417
B2M beta-2-microglobulin -0.137408
EZR ezrin -0.123085
ANXA2 annexin A2 -0.116822
RAB7A RAB7A, member RAS oncogene family -0.108885
FOS FBJ murine osteosarcoma viral oncogene homolog -0.107023
MYO1E myosin IE -0.094482
LOC102724023 ES1 protein homolog, mitochondrial -0.0928
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0891304
FTH1 ferritin, heavy polypeptide 1 -0.0864116
INTS6 integrator complex subunit 6 -0.0852354
IRF1 interferon regulatory factor 1 -0.0747149
MACC1 metastasis associated in colon cancer 1 -0.0739361
AREG amphiregulin -0.0714905
FTL ferritin, light polypeptide -0.0703344
LCN2 lipocalin 2 -0.0671984
JUN jun proto-oncogene -0.0661468
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0649479
SQSTM1 sequestosome 1 -0.0633352
NDRG1 N-myc downstream regulated 1 -0.0622634
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0595486
MORF4L2 mortality factor 4 like 2 -0.0583506
GCLC glutamate-cysteine ligase, catalytic subunit -0.0570745
TJP1 tight junction protein 1 -0.0570579
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0555272
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0553604
PERP PERP, TP53 apoptosis effector -0.0535569
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0507981
RPL35A ribosomal protein L35a -0.0486185
PDIA3 protein disulfide isomerase family A, member 3 -0.0485182
LOC112694756 uncharaterized LOC112694756 -0.0484877
ITPKC inositol-trisphosphate 3-kinase C -0.0471896
TMSB10 thymosin beta 10 -0.0465548
CCNL1 cyclin L1 -0.0462284
BLZF1 basic leucine zipper nuclear factor 1 -0.0453709
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0451782
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0449075
MCL1 myeloid cell leukemia 1 -0.0446335
EFNB2 ephrin-B2 -0.0446074
PKM pyruvate kinase, muscle -0.0445613
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0445146
C6ORF132 chromosome 6 open reading frame 132 -0.0439999
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0437091
MT2A metallothionein 2A -0.0435185
HM13 histocompatibility (minor) 13 -0.0434138
RIGI RNA sensor RIG-I -0.0426212
HLA-B major histocompatibility complex, class I, B -0.041812
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0403671
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0399225
DDIT3 DNA-damage-inducible transcript 3 -0.0396145
UGDH UDP-glucose 6-dehydrogenase -0.0388877
IFI6 interferon, alpha-inducible protein 6 -0.0379795
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0377131
PHACTR4 phosphatase and actin regulator 4 -0.0376041
ACTG1 actin gamma 1 -0.0364956
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0364434
HLA-A major histocompatibility complex, class I, A -0.0354824
EIF1 eukaryotic translation initiation factor 1 -0.0353169
VCL vinculin -0.0347002
ARF4 ADP-ribosylation factor 4 -0.0345598
MX2 MX dynamin-like GTPase 2 -0.0345589
CLDN4 claudin 4 -0.0341685
DUSP10 dual specificity phosphatase 10 -0.0337572
UBAP2 ubiquitin associated protein 2 -0.0334355
IER2 immediate early response 2 -0.0325192
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0322924
IGFBP3 insulin-like growth factor binding protein 3 -0.0317979
MAGT1 magnesium transporter 1 -0.0317235
MCTP1 multiple C2 domains, transmembrane 1 -0.0314374
SPAG9 sperm associated antigen 9 -0.0309287
TRIB1 tribbles pseudokinase 1 -0.0306726
SEC31A SEC31 homolog A (S. cerevisiae) -0.030631
SP100 SP100 nuclear antigen -0.0306013
ANXA1 annexin A1 -0.0302705
S100P S100 calcium binding protein P -0.0300055
IFI27 interferon, alpha-inducible protein 27 -0.0298663
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0298476
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0298227
RNF213 ring finger protein 213 -0.0296874
NAMPT nicotinamide phosphoribosyltransferase -0.0291538
SLC38A2 solute carrier family 38, member 2 -0.0290292
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0289977
HLA-E major histocompatibility complex, class I, E -0.0288504
ADIPOR2 adiponectin receptor 2 -0.027693
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0276458
SEC24A SEC24 family member A -0.0275367
FOSL1 FOS-like antigen 1 -0.0274944
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0273508
UBAP1 ubiquitin associated protein 1 -0.0268733
UBC ubiquitin C -0.0267226
SPDYA speedy/RINGO cell cycle regulator family member A -0.0264822
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0261949
S100A10 S100 calcium binding protein A10 -0.0261928
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0261905
PLSCR1 phospholipid scramblase 1 -0.0261819
SLC38A1 solute carrier family 38, member 1 -0.0260492
UFM1 ubiquitin-fold modifier 1 -0.0259316
AGR2 anterior gradient 2 -0.0258926