Rimonabant (Hydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0970736
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0928993
FAM13A family with sequence similarity 13, member A 0.0922666
HELZ helicase with zinc finger 0.0544927
SDC4 syndecan 4 0.0530571
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0498247
VEGFA vascular endothelial growth factor A 0.0474285
TPM3 tropomyosin 3 0.0470982
TRIO trio Rho guanine nucleotide exchange factor 0.0470171
FNDC3B fibronectin type III domain containing 3B 0.0468052
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0462497
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0427809
MYH9 myosin, heavy chain 9, non-muscle 0.0404815
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0404578
INSIG2 insulin induced gene 2 0.0402
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0398405
ATP13A3 ATPase type 13A3 0.0390331
ANLN anillin, actin binding protein 0.0388115
OGA O-GlcNAcase 0.0379246
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0374557
SETD5 SET domain containing 5 0.0368209
UBA6 ubiquitin-like modifier activating enzyme 6 0.0364532
DSCAM Down syndrome cell adhesion molecule 0.0364338
NAV2 neuron navigator 2 0.035917
PRELID2 PRELI domain containing 2 0.0359063
SET SET nuclear proto-oncogene 0.0357869
ZNF395 zinc finger protein 395 0.035237
DGKD diacylglycerol kinase, delta 130kDa 0.034815
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0338709
SDK1 sidekick cell adhesion molecule 1 0.0335269
SMAD3 SMAD family member 3 0.0333267
HILPDA hypoxia inducible lipid droplet-associated 0.0332875
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0325928
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0317969
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0316289
COPA coatomer protein complex, subunit alpha 0.0312647
YEATS2 YEATS domain containing 2 0.0311781
PCBP2 poly(rC) binding protein 2 0.0304649
FNIP1 folliculin interacting protein 1 0.0303009
COL6A3 collagen, type VI, alpha 3 0.0302125
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0297195
TRA2A transformer 2 alpha homolog (Drosophila) 0.0296738
CD109 CD109 molecule 0.0293439
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0289515
MAP2K1 mitogen-activated protein kinase kinase 1 0.0286756
USP3 ubiquitin specific peptidase 3 0.0284205
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0282725
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0280618
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0279732
FXR1 fragile X mental retardation, autosomal homolog 1 0.027523
FAM219A family with sequence similarity 219, member A 0.0275015
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0273063
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0272383
NFE2L1 nuclear factor, erythroid 2-like 1 0.0266311
CENPF centromere protein F, 350/400kDa 0.0265335
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0260461
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0259298
NUP58 nucleoporin 58 0.0255115
PICALM phosphatidylinositol binding clathrin assembly protein 0.0252118
ASPH aspartate beta-hydroxylase 0.0251512
CDK19 cyclin-dependent kinase 19 0.0251007
KMT2E lysine (K)-specific methyltransferase 2E 0.0249109
MXI1 MAX interactor 1, dimerization protein 0.024675
MSN moesin 0.0245757
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0245455
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0245
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0244231
COL5A1 collagen, type V, alpha 1 0.0242415
ARRDC3 arrestin domain containing 3 0.024206
SFPQ splicing factor proline/glutamine-rich 0.0238934
TNIP1 TNFAIP3 interacting protein 1 0.0238413
ZNF292 zinc finger protein 292 0.0237625
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.023118
CCNL1 cyclin L1 0.023102
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0227395
ANKRD11 ankyrin repeat domain 11 0.0226824
RRM2 ribonucleotide reductase M2 0.0226206
JARID2 jumonji, AT rich interactive domain 2 0.0224188
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0224036
SMC4 structural maintenance of chromosomes 4 0.0221701
RNF145 ring finger protein 145 0.0221526
SEC23A Sec23 homolog A (S. cerevisiae) 0.0221223
POM121 POM121 transmembrane nucleoporin 0.0221142
APP amyloid beta (A4) precursor protein 0.02206
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0219166
SPAG9 sperm associated antigen 9 0.0217301
MEF2A myocyte enhancer factor 2A 0.0215476
CHD1L chromodomain helicase DNA binding protein 1-like 0.0214369
KCMF1 potassium channel modulatory factor 1 0.0213658
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0210577
XPO1 exportin 1 0.0208454
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0205462
KDM6A lysine (K)-specific demethylase 6A 0.0204466
SNX13 sorting nexin 13 0.0204347
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.02029
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0202194
ZNF160 zinc finger protein 160 0.0202126
SEPTIN7 septin 7 0.0199271
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0199095
EIF4B eukaryotic translation initiation factor 4B 0.0198973

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.312801
FTL ferritin, light polypeptide -0.246945
TMSB10 thymosin beta 10 -0.169345
MT2A metallothionein 2A -0.151516
VIM vimentin -0.115678
IGFBP3 insulin-like growth factor binding protein 3 -0.0983905
NALF1 NALCN channel auxiliary factor 1 -0.0900818
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0847376
FN1 fibronectin 1 -0.0706935
RPLP1 ribosomal protein, large, P1 -0.0591647
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0586941
EGR1 early growth response 1 -0.0545512
RPL35A ribosomal protein L35a -0.0534246
LOX lysyl oxidase -0.0530246
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0527587
MT1X metallothionein 1X -0.0511676
RPS6 ribosomal protein S6 -0.0467628
RPS19 ribosomal protein S19 -0.0465622
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0408528
EXT1 exostosin glycosyltransferase 1 -0.0406343
LOC112694756 uncharaterized LOC112694756 -0.0404571
RPL32 ribosomal protein L32 -0.0400347
EIF1 eukaryotic translation initiation factor 1 -0.0375495
RPL34 ribosomal protein L34 -0.0369826
CD44 CD44 molecule (Indian blood group) -0.0353725
NDRG1 N-myc downstream regulated 1 -0.0347135
RPL28 ribosomal protein L28 -0.0338896
HLA-B major histocompatibility complex, class I, B -0.0338759
SCFD2 sec1 family domain containing 2 -0.0328327
MAP1B microtubule-associated protein 1B -0.0325337
RPLP2 ribosomal protein, large, P2 -0.0324134
GARS1 glycyl-tRNA synthetase 1 -0.0322962
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0319014
RPS13 ribosomal protein S13 -0.031389
PDIA3 protein disulfide isomerase family A, member 3 -0.0307281
RACK1 receptor for activated C kinase 1 -0.0302
RPS24 ribosomal protein S24 -0.0296841
TPT1 tumor protein, translationally-controlled 1 -0.0296261
TXNRD1 thioredoxin reductase 1 -0.0287778
RPS23 ribosomal protein S23 -0.0287091
TUBB tubulin, beta class I -0.0285708
RPLP0 ribosomal protein, large, P0 -0.028416
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0280299
RPL12 ribosomal protein L12 -0.0273971
TNNC1 troponin C type 1 (slow) -0.0273807
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0273107
VDAC1 voltage-dependent anion channel 1 -0.0271685
TENM3 teneurin transmembrane protein 3 -0.0269647
LMAN1 lectin, mannose-binding, 1 -0.0266547
PHF14 PHD finger protein 14 -0.0257701
IGF2 insulin-like growth factor 2 -0.0251969
OSMR oncostatin M receptor -0.0247252
INHBA inhibin, beta A -0.0242129
RPS8 ribosomal protein S8 -0.0240943
RPS5 ribosomal protein S5 -0.0239429
TPM4 tropomyosin 4 -0.023808
RPL23 ribosomal protein L23 -0.0235805
PRSS23 protease, serine, 23 -0.0235382
HDLBP high density lipoprotein binding protein -0.0234863
RPL31 ribosomal protein L31 -0.0232845
GNAS GNAS complex locus -0.023223
RPS29 ribosomal protein S29 -0.0228831
RRBP1 ribosome binding protein 1 -0.0228798
FTH1 ferritin, heavy polypeptide 1 -0.0224433
TTC3 tetratricopeptide repeat domain 3 -0.0221502
CCND1 cyclin D1 -0.0219181
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0216901
TXNIP thioredoxin interacting protein -0.0216268
PTCHD4 patched domain containing 4 -0.0215628
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0215602
FKBP10 FK506 binding protein 10, 65 kDa -0.0214929
CAVIN1 caveolae associated protein 1 -0.021408
TGFBI transforming growth factor, beta-induced, 68kDa -0.0210249
ZBTB20 zinc finger and BTB domain containing 20 -0.0207268
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0206579
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0200962
ARF1 ADP-ribosylation factor 1 -0.0198858
CREB5 cAMP responsive element binding protein 5 -0.0197398
PXDN peroxidasin -0.0194544
NAV3 neuron navigator 3 -0.0194421
SLC38A1 solute carrier family 38, member 1 -0.0194242
RPL36 ribosomal protein L36 -0.0193988
TPI1 triosephosphate isomerase 1 -0.0188064
B2M beta-2-microglobulin -0.018588
RPS11 ribosomal protein S11 -0.0185833
GOLGB1 golgin B1 -0.0185564
LYPD6B LY6/PLAUR domain containing 6B -0.0185086
TMEM263 transmembrane protein 263 -0.0184469
FBXL17 F-box and leucine-rich repeat protein 17 -0.0183973
RPL38 ribosomal protein L38 -0.0183387
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0181771
NF1 neurofibromin 1 -0.0181082
RPL27A ribosomal protein L27a -0.0180678
JAZF1 JAZF zinc finger 1 -0.0180389
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0179807
SLC38A2 solute carrier family 38, member 2 -0.0179711
EHBP1 EH domain binding protein 1 -0.0174308
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0172658
PNRC1 proline-rich nuclear receptor coactivator 1 -0.017189
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0171363