Rimonabant (Hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.118872
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.109908
AHNAK AHNAK nucleoprotein 0.10118
PRELID2 PRELI domain containing 2 0.0881988
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0816092
CTNND1 catenin (cadherin-associated protein), delta 1 0.0673862
MYH9 myosin, heavy chain 9, non-muscle 0.0642409
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.058128
KDM4C lysine (K)-specific demethylase 4C 0.0546113
RAD51B RAD51 paralog B 0.0530058
RERE arginine-glutamic acid dipeptide (RE) repeats 0.049699
N4BP2L2 NEDD4 binding protein 2-like 2 0.0479967
ZNF292 zinc finger protein 292 0.0458408
SMYD3 SET and MYND domain containing 3 0.0457148
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0416072
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0410654
ZNF638 zinc finger protein 638 0.0399271
KIAA1217 KIAA1217 0.0387124
SEC31A SEC31 homolog A (S. cerevisiae) 0.0380645
OGA O-GlcNAcase 0.036851
SDC4 syndecan 4 0.0365892
TBC1D22A TBC1 domain family, member 22A 0.0362568
CSNK1A1 casein kinase 1, alpha 1 0.0360427
ANKRD11 ankyrin repeat domain 11 0.0358377
VCL vinculin 0.0350968
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0344748
EIF4B eukaryotic translation initiation factor 4B 0.0339426
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0339312
WDR26 WD repeat domain 26 0.0336173
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.033585
ZFAND3 zinc finger, AN1-type domain 3 0.0326795
RPL4 ribosomal protein L4 0.0324913
ANKRD36 ankyrin repeat domain 36 0.0318156
EP300 E1A binding protein p300 0.0316532
SMC5 structural maintenance of chromosomes 5 0.0313752
YEATS2 YEATS domain containing 2 0.0308247
CCNG2 cyclin G2 0.0300061
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0299768
TXNRD1 thioredoxin reductase 1 0.0298679
PDE4D phosphodiesterase 4D, cAMP-specific 0.0297071
GIGYF2 GRB10 interacting GYF protein 2 0.0294311
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0288783
VMP1 vacuole membrane protein 1 0.0288301
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0287987
MCL1 myeloid cell leukemia 1 0.0287918
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0287367
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0285508
TMF1 TATA element modulatory factor 1 0.0283548
SAMD4A sterile alpha motif domain containing 4A 0.027851
YME1L1 YME1-like 1 ATPase 0.027313
PATJ PATJ crumbs cell polarity complex component 0.0270876
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0270544
CALU calumenin 0.0265873
RB1CC1 RB1-inducible coiled-coil 1 0.0264776
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0260605
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0257727
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0256658
TRIP12 thyroid hormone receptor interactor 12 0.0256365
WDR33 WD repeat domain 33 0.0254681
RBM26 RNA binding motif protein 26 0.0253813
PNISR PNN-interacting serine/arginine-rich protein 0.0250641
SFPQ splicing factor proline/glutamine-rich 0.0248228
KRT8 keratin 8, type II 0.024726
GALK2 galactokinase 2 0.024197
PLAUR plasminogen activator, urokinase receptor 0.0241642
ATXN1 ataxin 1 0.0241303
BTBD9 BTB (POZ) domain containing 9 0.023965
METTL15 methyltransferase like 15 0.0238734
CSDE1 cold shock domain containing E1, RNA-binding 0.0237927
CDK19 cyclin-dependent kinase 19 0.0236348
PMM2 phosphomannomutase 2 0.0235786
NEBL nebulette 0.023501
WWC2 WW and C2 domain containing 2 0.0233996
MED13L mediator complex subunit 13-like 0.0233626
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0233495
CELF1 CUGBP, Elav-like family member 1 0.0231962
ANKRD12 ankyrin repeat domain 12 0.0231876
JMJD1C jumonji domain containing 1C 0.0231707
AFDN afadin, adherens junction formation factor 0.0230044
XRN1 5'-3' exoribonuclease 1 0.0229763
AEBP2 AE binding protein 2 0.0229674
SRSF4 serine/arginine-rich splicing factor 4 0.022881
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0228266
RRM2 ribonucleotide reductase M2 0.0225315
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0222776
MON2 MON2 homolog (S. cerevisiae) 0.022238
CEP112 centrosomal protein 112kDa 0.0222152
ESRP1 epithelial splicing regulatory protein 1 0.0222018
MAP2K1 mitogen-activated protein kinase kinase 1 0.0220819
CEP95 centrosomal protein 95kDa 0.0219797
MYO1D myosin ID 0.0219573
CEP192 centrosomal protein 192kDa 0.0218804
MBD5 methyl-CpG binding domain protein 5 0.021789
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.021719
RAB1A RAB1A, member RAS oncogene family 0.0216095
ZFC3H1 zinc finger, C3H1-type containing 0.0215919
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0215563
NBAS neuroblastoma amplified sequence 0.0215496
UTRN utrophin 0.0214927
HDAC8 histone deacetylase 8 0.0213955

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.376317
PTMA prothymosin, alpha -0.211094
NDRG1 N-myc downstream regulated 1 -0.206296
P4HB prolyl 4-hydroxylase, beta polypeptide -0.166198
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.149924
LOC112694756 uncharaterized LOC112694756 -0.125292
TMSB10 thymosin beta 10 -0.119996
ENO1 enolase 1, (alpha) -0.104412
RPL35A ribosomal protein L35a -0.0715973
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0651507
FTL ferritin, light polypeptide -0.0625267
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0610798
FTH1 ferritin, heavy polypeptide 1 -0.0598095
RPS6 ribosomal protein S6 -0.0583346
RPLP0 ribosomal protein, large, P0 -0.0577949
EEF2 eukaryotic translation elongation factor 2 -0.0575563
RPS8 ribosomal protein S8 -0.0564341
HMGA1 high mobility group AT-hook 1 -0.054909
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0543291
TPT1 tumor protein, translationally-controlled 1 -0.0530953
EGR1 early growth response 1 -0.0512443
TUBA1B tubulin, alpha 1b -0.0480131
RAB7A RAB7A, member RAS oncogene family -0.0464392
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0457241
KPNB1 karyopherin (importin) beta 1 -0.0447616
KRT19 keratin 19, type I -0.0442398
LMAN1 lectin, mannose-binding, 1 -0.0437035
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0431981
PDIA3 protein disulfide isomerase family A, member 3 -0.041919
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0416661
S100A9 S100 calcium binding protein A9 -0.0412158
MT2A metallothionein 2A -0.0396289
TPI1 triosephosphate isomerase 1 -0.0384156
PKM pyruvate kinase, muscle -0.0382253
ACTG1 actin gamma 1 -0.0381978
HILPDA hypoxia inducible lipid droplet-associated -0.0379363
LDHA lactate dehydrogenase A -0.036352
FAT1 FAT atypical cadherin 1 -0.0356496
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0337942
RPLP1 ribosomal protein, large, P1 -0.0335604
YBX1 Y box binding protein 1 -0.0331289
BRD2 bromodomain containing 2 -0.0330918
MORF4L2 mortality factor 4 like 2 -0.0328336
PFN1 profilin 1 -0.0315105
RPL11 ribosomal protein L11 -0.0308187
TXNIP thioredoxin interacting protein -0.0305916
ESYT2 extended synaptotagmin-like protein 2 -0.0305734
WDR45B WD repeat domain 45B -0.0303188
DLG1 discs, large homolog 1 (Drosophila) -0.0295717
RPL8 ribosomal protein L8 -0.0295139
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.029488
TUBB tubulin, beta class I -0.029328
RPS14 ribosomal protein S14 -0.0292764
POTEF POTE ankyrin domain family, member F -0.0287216
RPS2 ribosomal protein S2 -0.0283066
RPL34 ribosomal protein L34 -0.0280362
S100A6 S100 calcium binding protein A6 -0.0275572
GNAS GNAS complex locus -0.0274024
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0272387
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0267722
RACK1 receptor for activated C kinase 1 -0.0267017
LMNA lamin A/C -0.0261233
RPS13 ribosomal protein S13 -0.0261119
CCND1 cyclin D1 -0.0260332
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0260269
ARF1 ADP-ribosylation factor 1 -0.0258367
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0256721
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0256333
RPS5 ribosomal protein S5 -0.0255955
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0252562
IFITM3 interferon induced transmembrane protein 3 -0.0250271
FAM162A family with sequence similarity 162, member A -0.0248677
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0242339
PA2G4 proliferation-associated 2G4, 38kDa -0.0240627
TUBB4B tubulin, beta 4B class IVb -0.0237086
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0230657
RPS19 ribosomal protein S19 -0.0230452
NCOR1 nuclear receptor corepressor 1 -0.0230281
IARS1 isoleucyl-tRNA synthetase 1 -0.0229031
RPS24 ribosomal protein S24 -0.022847
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0224683
VDAC1 voltage-dependent anion channel 1 -0.0216741
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0212981
CLDN7 claudin 7 -0.0209962
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0209814
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0205371
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0202212
PRDX2 peroxiredoxin 2 -0.0200277
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0199648
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0198913
CADPS Ca++-dependent secretion activator -0.0197572
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0196357
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0196296
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0193639
GOLGA4 golgin A4 -0.0192038
HLA-A major histocompatibility complex, class I, A -0.0191169
ANKRD37 ankyrin repeat domain 37 -0.0190814
TAPBP TAP binding protein (tapasin) -0.019034
SERBP1 SERPINE1 mRNA binding protein 1 -0.0189634
BZW2 basic leucine zipper and W2 domains 2 -0.0189546