Rimonabant (Hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.141693
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.102941
TMSB4X thymosin beta 4, X-linked 0.0944822
MYH9 myosin, heavy chain 9, non-muscle 0.0907672
MT2A metallothionein 2A 0.0871095
AHNAK AHNAK nucleoprotein 0.0812695
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0737206
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0703441
B2M beta-2-microglobulin 0.066538
SET SET nuclear proto-oncogene 0.0659427
TPT1 tumor protein, translationally-controlled 1 0.0600499
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0591676
APP amyloid beta (A4) precursor protein 0.0569512
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0567982
LAMB3 laminin, beta 3 0.0533254
ENO1 enolase 1, (alpha) 0.0528647
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0494765
KRT7 keratin 7, type II 0.0466051
RPS8 ribosomal protein S8 0.0465904
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0457058
RNF145 ring finger protein 145 0.0453035
RPS27A ribosomal protein S27a 0.0436923
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.042449
RPL7A ribosomal protein L7a 0.0416835
TPM3 tropomyosin 3 0.0413542
MACF1 microtubule-actin crosslinking factor 1 0.0412604
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0411574
TNIP1 TNFAIP3 interacting protein 1 0.0411133
ASPH aspartate beta-hydroxylase 0.0410333
BHLHE40 basic helix-loop-helix family, member e40 0.0397291
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0394591
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0394298
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0387922
RPS3 ribosomal protein S3 0.0385949
CALR calreticulin 0.0379386
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0377092
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0375602
SDC4 syndecan 4 0.037021
FNDC3B fibronectin type III domain containing 3B 0.0368392
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0367437
ANKRD10 ankyrin repeat domain 10 0.0361883
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0360816
ANLN anillin, actin binding protein 0.0359907
DDIT4 DNA-damage-inducible transcript 4 0.0359092
UPP1 uridine phosphorylase 1 0.0358428
RPL23 ribosomal protein L23 0.0355192
ZNF292 zinc finger protein 292 0.0354805
CSDE1 cold shock domain containing E1, RNA-binding 0.0354021
SRRM2 serine/arginine repetitive matrix 2 0.035214
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.035149
MKI67 marker of proliferation Ki-67 0.034871
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0343885
WAC WW domain containing adaptor with coiled-coil 0.0334661
ANXA1 annexin A1 0.0334249
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0331441
OGA O-GlcNAcase 0.0328707
UGCG UDP-glucose ceramide glucosyltransferase 0.0326392
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0324729
INSIG2 insulin induced gene 2 0.0323859
RPS12 ribosomal protein S12 0.032314
RPL4 ribosomal protein L4 0.0320039
TRA2A transformer 2 alpha homolog (Drosophila) 0.0314711
KDM3A lysine (K)-specific demethylase 3A 0.0313961
RPS6 ribosomal protein S6 0.0311961
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0309659
ANXA2 annexin A2 0.030864
PGK1 phosphoglycerate kinase 1 0.0305136
NCKAP1 NCK-associated protein 1 0.0304389
AXL AXL receptor tyrosine kinase 0.0303693
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0302918
HDGF hepatoma-derived growth factor 0.0302273
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0298771
KRT18 keratin 18, type I 0.0297819
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0297572
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0297511
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0296513
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0296459
RPL3 ribosomal protein L3 0.0295403
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0294617
HSPA8 heat shock 70kDa protein 8 0.0293529
HELZ helicase with zinc finger 0.0292104
RPL19 ribosomal protein L19 0.0290922
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0287008
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0286331
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0286241
FXR1 fragile X mental retardation, autosomal homolog 1 0.0285148
ADAM9 ADAM metallopeptidase domain 9 0.0281041
FTL ferritin, light polypeptide 0.0279415
RPL37A ribosomal protein L37a 0.0277557
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0276164
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0275208
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0273606
PDIA6 protein disulfide isomerase family A, member 6 0.0267778
RHOA ras homolog family member A 0.0266795
KMT2E lysine (K)-specific methyltransferase 2E 0.0265631
RAD23B RAD23 homolog B (S. cerevisiae) 0.026537
RPL14 ribosomal protein L14 0.026517
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0263869
RPLP2 ribosomal protein, large, P2 0.0261355
RPL7 ribosomal protein L7 0.026024

decreased expression

Symbol Name Standardized Value
ZBTB20 zinc finger and BTB domain containing 20 -0.0678558
WWC1 WW and C2 domain containing 1 -0.0543704
EGR1 early growth response 1 -0.0495673
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0435056
MBD5 methyl-CpG binding domain protein 5 -0.0390548
LOC112694756 uncharaterized LOC112694756 -0.035187
ZSWIM6 zinc finger, SWIM-type containing 6 -0.033179
ALCAM activated leukocyte cell adhesion molecule -0.0328944
CCDC138 coiled-coil domain containing 138 -0.0321493
ZNF644 zinc finger protein 644 -0.0320324
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0317647
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0316997
FTH1 ferritin, heavy polypeptide 1 -0.0316251
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0314644
TAS2R14 taste receptor, type 2, member 14 -0.0310558
NF1 neurofibromin 1 -0.0310062
CREB5 cAMP responsive element binding protein 5 -0.0298246
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0291939
GOLGB1 golgin B1 -0.0269692
MON2 MON2 homolog (S. cerevisiae) -0.0268397
IARS1 isoleucyl-tRNA synthetase 1 -0.0266251
HMGA1 high mobility group AT-hook 1 -0.0261685
TJP1 tight junction protein 1 -0.0239814
ATXN1 ataxin 1 -0.0238919
FNIP1 folliculin interacting protein 1 -0.0235982
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.023565
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0233986
ITGB8 integrin, beta 8 -0.0233311
JMJD1C jumonji domain containing 1C -0.0230069
RANBP17 RAN binding protein 17 -0.022808
AHI1 Abelson helper integration site 1 -0.0226528
SCAPER S-phase cyclin A-associated protein in the ER -0.0226499
GPHN gephyrin -0.0226332
PATJ PATJ crumbs cell polarity complex component -0.0225255
RPL35A ribosomal protein L35a -0.0221982
BPTF bromodomain PHD finger transcription factor -0.0219126
SCLT1 sodium channel and clathrin linker 1 -0.0216145
PTPRK protein tyrosine phosphatase, receptor type, K -0.021605
SCFD1 sec1 family domain containing 1 -0.0215966
RAB7A RAB7A, member RAS oncogene family -0.0213158
ERBIN erbb2 interacting protein -0.0213031
AGO3 argonaute RISC catalytic component 3 -0.0212455
NFX1 nuclear transcription factor, X-box binding 1 -0.020684
BIRC6 baculoviral IAP repeat containing 6 -0.0204226
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0202588
AEBP2 AE binding protein 2 -0.0201615
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0201536
INTS6 integrator complex subunit 6 -0.0200929
PKP4 plakophilin 4 -0.0200841
TOR1AIP2 torsin A interacting protein 2 -0.0200664
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0198323
HMGA2 high mobility group AT-hook 2 -0.0196023
CCND1 cyclin D1 -0.0194029
AFF4 AF4/FMR2 family, member 4 -0.0193578
ANKRD17 ankyrin repeat domain 17 -0.0191907
EXT1 exostosin glycosyltransferase 1 -0.0191484
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0189496
COMMD10 COMM domain containing 10 -0.01886
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0187503
CDK13 cyclin-dependent kinase 13 -0.0187279
RTN3 reticulon 3 -0.0183718
AKAP9 A kinase (PRKA) anchor protein 9 -0.0183497
DNAH14 dynein, axonemal, heavy chain 14 -0.0182019
PCNX4 pecanex 4 -0.0181007
ARF1 ADP-ribosylation factor 1 -0.0176713
TGFA transforming growth factor, alpha -0.0175534
BBS9 Bardet-Biedl syndrome 9 -0.0175244
LCORL ligand dependent nuclear receptor corepressor-like -0.0174532
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0173031
PHKB phosphorylase kinase, beta -0.0170748
BICD1 bicaudal D homolog 1 (Drosophila) -0.0170339
TAOK1 TAO kinase 1 -0.0169806
ATF6 activating transcription factor 6 -0.0167507
TCF12 transcription factor 12 -0.0166412
MBNL1 muscleblind-like splicing regulator 1 -0.0164608
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.016416
TTC3 tetratricopeptide repeat domain 3 -0.0163408
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.016294
TNRC6C trinucleotide repeat containing 6C -0.0162089
GOSR1 golgi SNAP receptor complex member 1 -0.01601
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -0.0159863
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0159819
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0158541
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0158489
BICC1 BicC family RNA binding protein 1 -0.0157969
NBEA neurobeachin -0.0156184
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0155894
VCL vinculin -0.0155607
MYO1E myosin IE -0.0154239
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0152598
CCNH cyclin H -0.0152044
TBC1D22A TBC1 domain family, member 22A -0.0151653
UBAP2 ubiquitin associated protein 2 -0.0151534
MAPK8 mitogen-activated protein kinase 8 -0.0150809
MMS22L MMS22-like, DNA repair protein -0.0148711
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0148055
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0147313
STAU2 staufen double-stranded RNA binding protein 2 -0.0147004
CSNK1A1 casein kinase 1, alpha 1 -0.0145327
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -0.0145259