Rimonabant (Hydrochloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.315114
ERRFI1 ERBB receptor feedback inhibitor 1 0.111078
PTMA prothymosin, alpha 0.108455
TMSB10 thymosin beta 10 0.0935487
VEGFA vascular endothelial growth factor A 0.0882743
MT2A metallothionein 2A 0.0834201
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0820055
FAM13A family with sequence similarity 13, member A 0.0817637
BHLHE40 basic helix-loop-helix family, member e40 0.0766524
TPT1 tumor protein, translationally-controlled 1 0.0623794
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.054332
RPS6 ribosomal protein S6 0.0513566
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.049275
NGLY1 N-glycanase 1 0.0486313
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0484195
KDM3A lysine (K)-specific demethylase 3A 0.0454611
FTL ferritin, light polypeptide 0.0451854
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0448898
EIF1 eukaryotic translation initiation factor 1 0.0447249
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0438039
INHBA inhibin, beta A 0.0431219
RPL12 ribosomal protein L12 0.0426096
OGA O-GlcNAcase 0.0423276
UBC ubiquitin C 0.0408618
DTNA dystrobrevin, alpha 0.0393413
RNF24 ring finger protein 24 0.0379338
RPL23 ribosomal protein L23 0.0366752
ADM adrenomedullin 0.0362687
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0361076
ELL2 elongation factor, RNA polymerase II, 2 0.0360694
RNF145 ring finger protein 145 0.0348084
TM4SF1 transmembrane 4 L six family member 1 0.0342692
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0341016
DDIT4 DNA-damage-inducible transcript 4 0.0339186
TRIO trio Rho guanine nucleotide exchange factor 0.0329451
RPS27A ribosomal protein S27a 0.032589
JARID2 jumonji, AT rich interactive domain 2 0.0324627
RACK1 receptor for activated C kinase 1 0.0320173
ZMYND8 zinc finger, MYND-type containing 8 0.031432
WSB1 WD repeat and SOCS box containing 1 0.0312561
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0305164
INSIG2 insulin induced gene 2 0.0300523
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0297017
AMPD3 adenosine monophosphate deaminase 3 0.0296574
STC1 stanniocalcin 1 0.0295598
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0292449
IRS2 insulin receptor substrate 2 0.0289776
CALR calreticulin 0.0288224
RUNX1 runt-related transcription factor 1 0.028657
RPLP1 ribosomal protein, large, P1 0.0285857
RPL37 ribosomal protein L37 0.0283921
IER3 immediate early response 3 0.0283894
PGK1 phosphoglycerate kinase 1 0.0280308
KDM7A lysine (K)-specific demethylase 7A 0.0276336
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.027336
CDCP1 CUB domain containing protein 1 0.0273342
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0272481
CD109 CD109 molecule 0.0271173
TNIP1 TNFAIP3 interacting protein 1 0.0271057
RPS12 ribosomal protein S12 0.0270841
RPL7A ribosomal protein L7a 0.0267263
RPS3 ribosomal protein S3 0.0265054
RPL31 ribosomal protein L31 0.0263537
TIMP1 TIMP metallopeptidase inhibitor 1 0.0263519
PRRC2C proline-rich coiled-coil 2C 0.0261961
HSPA8 heat shock 70kDa protein 8 0.0261233
RPL32 ribosomal protein L32 0.0259543
RPS8 ribosomal protein S8 0.0258761
ZFC3H1 zinc finger, C3H1-type containing 0.0258549
RPL37A ribosomal protein L37a 0.0257535
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0257028
EEF2 eukaryotic translation elongation factor 2 0.0256977
RPL4 ribosomal protein L4 0.0255834
S100A10 S100 calcium binding protein A10 0.0254328
AKAP12 A kinase (PRKA) anchor protein 12 0.0253938
RPL7 ribosomal protein L7 0.0253504
ESYT2 extended synaptotagmin-like protein 2 0.0252895
RICTOR RPTOR independent companion of MTOR, complex 2 0.0248788
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0248587
PDIA6 protein disulfide isomerase family A, member 6 0.024786
RPS17 ribosomal protein S17 0.0245675
RPS19 ribosomal protein S19 0.0242758
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0242622
RPS24 ribosomal protein S24 0.0239636
RPLP0 ribosomal protein, large, P0 0.0237499
RPL8 ribosomal protein L8 0.0234656
ZNF148 zinc finger protein 148 0.0232654
WDR45B WD repeat domain 45B 0.0229294
RPL11 ribosomal protein L11 0.0226462
TMSB4X thymosin beta 4, X-linked 0.0225952
PNRC1 proline-rich nuclear receptor coactivator 1 0.0225729
MARCHF6 membrane associated ring-CH-type finger 6 0.0224957
FAM162A family with sequence similarity 162, member A 0.0223707
RPL3 ribosomal protein L3 0.022218
CXCL8 chemokine (C-X-C motif) ligand 8 0.0221695
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0219935
TNS1 tensin 1 0.0219473
RNMT RNA (guanine-7-) methyltransferase 0.0211657
MXI1 MAX interactor 1, dimerization protein 0.020939
UBA2 ubiquitin-like modifier activating enzyme 2 0.0209271

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.243548
FN1 fibronectin 1 -0.185424
ACTG1 actin gamma 1 -0.128275
EGR1 early growth response 1 -0.0965617
VCL vinculin -0.0941496
NDRG1 N-myc downstream regulated 1 -0.0733232
FNDC3B fibronectin type III domain containing 3B -0.0728218
COL5A1 collagen, type V, alpha 1 -0.0670459
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0655604
COL6A3 collagen, type VI, alpha 3 -0.0621866
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0611277
GLIS3 GLIS family zinc finger 3 -0.0585744
TGFBI transforming growth factor, beta-induced, 68kDa -0.0572413
CLIC4 chloride intracellular channel 4 -0.0565898
NAV1 neuron navigator 1 -0.0554975
HMGA2 high mobility group AT-hook 2 -0.0527813
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0522293
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0519932
LOC112694756 uncharaterized LOC112694756 -0.0508471
CDH13 cadherin 13 -0.0508176
TAS2R14 taste receptor, type 2, member 14 -0.0495734
LOX lysyl oxidase -0.0466527
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0449686
ACTN1 actinin, alpha 1 -0.0432531
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0428654
IGFBP3 insulin-like growth factor binding protein 3 -0.0425822
ASPH aspartate beta-hydroxylase -0.0409718
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.040209
AHNAK AHNAK nucleoprotein -0.0400707
IGF2 insulin-like growth factor 2 -0.0399979
VMP1 vacuole membrane protein 1 -0.0396409
NALF1 NALCN channel auxiliary factor 1 -0.0395726
DIAPH2 diaphanous-related formin 2 -0.0394803
EXT1 exostosin glycosyltransferase 1 -0.0374045
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0360715
NABP1 nucleic acid binding protein 1 -0.0359852
COL6A2 collagen, type VI, alpha 2 -0.0350767
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.034662
RAB7A RAB7A, member RAS oncogene family -0.0340213
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0338859
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0329358
MSN moesin -0.0326998
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0326707
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0324138
SMYD3 SET and MYND domain containing 3 -0.0317231
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0307658
EGFR epidermal growth factor receptor -0.03037
BICD1 bicaudal D homolog 1 (Drosophila) -0.0299546
SETX senataxin -0.0290791
COL6A1 collagen, type VI, alpha 1 -0.0287321
LPP LIM domain containing preferred translocation partner in lipoma -0.0287253
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0284505
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0281857
AGO3 argonaute RISC catalytic component 3 -0.027845
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0278279
MCL1 myeloid cell leukemia 1 -0.0277207
ATXN1 ataxin 1 -0.0274415
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0270335
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0265833
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0262747
RAD51B RAD51 paralog B -0.0261893
SMC4 structural maintenance of chromosomes 4 -0.0261363
WNK1 WNK lysine deficient protein kinase 1 -0.0261153
SEC24D SEC24 family member D -0.0258728
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0256653
CLTC clathrin, heavy chain (Hc) -0.0256199
CENPF centromere protein F, 350/400kDa -0.0255989
SYAP1 synapse associated protein 1 -0.0253999
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0253775
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0253749
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0253519
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0250837
PRELID2 PRELI domain containing 2 -0.0247653
FMN1 formin 1 -0.0243586
ZBTB20 zinc finger and BTB domain containing 20 -0.0240871
RTN4 reticulon 4 -0.0240665
RCOR1 REST corepressor 1 -0.0237699
JMJD1C jumonji domain containing 1C -0.0234649
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0231166
AGRN agrin -0.0230798
FER fer (fps/fes related) tyrosine kinase -0.0230251
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.02293
TNNC1 troponin C type 1 (slow) -0.0228302
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.022509
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0224975
TUBB6 tubulin, beta 6 class V -0.0221612
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0221424
SFPQ splicing factor proline/glutamine-rich -0.0221363
ZNF207 zinc finger protein 207 -0.0221033
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0219226
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0219025
TGFB1 transforming growth factor, beta 1 -0.021622
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.021486
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0214003
ANXA5 annexin A5 -0.0213645
ACTN4 actinin, alpha 4 -0.0213598
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0211379
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0211343
MBD5 methyl-CpG binding domain protein 5 -0.0210577
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0207615