Rimonabant (Hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
OGA O-GlcNAcase 0.0831738
PTK2 protein tyrosine kinase 2 0.0738859
KRT8 keratin 8, type II 0.0731473
CTNND1 catenin (cadherin-associated protein), delta 1 0.0682593
PICALM phosphatidylinositol binding clathrin assembly protein 0.0623702
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0623412
ZMYM2 zinc finger, MYM-type 2 0.0582305
RAD21 RAD21 homolog (S. pombe) 0.0572108
KDM6A lysine (K)-specific demethylase 6A 0.0557288
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0545941
DSCAM Down syndrome cell adhesion molecule 0.0528288
ATAD2 ATPase family, AAA domain containing 2 0.0509786
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0509057
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0502992
ACTN4 actinin, alpha 4 0.0491941
AHNAK AHNAK nucleoprotein 0.0488927
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0476034
TXNRD1 thioredoxin reductase 1 0.0473215
ANKRD10 ankyrin repeat domain 10 0.0466945
SMAD3 SMAD family member 3 0.0465328
BIRC6 baculoviral IAP repeat containing 6 0.0460409
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0449936
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0448165
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0437782
NF1 neurofibromin 1 0.0435136
ANKRD11 ankyrin repeat domain 11 0.0424994
COG5 component of oligomeric golgi complex 5 0.0422174
MYH9 myosin, heavy chain 9, non-muscle 0.0421446
ADAM17 ADAM metallopeptidase domain 17 0.041584
ZFAND3 zinc finger, AN1-type domain 3 0.0413094
FNIP1 folliculin interacting protein 1 0.0412401
USP3 ubiquitin specific peptidase 3 0.0411622
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.040172
TPM3 tropomyosin 3 0.0398141
FAM91A1 family with sequence similarity 91, member A1 0.0396597
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0389573
VMP1 vacuole membrane protein 1 0.0386545
KMT2C lysine (K)-specific methyltransferase 2C 0.0385721
PUM2 pumilio RNA-binding family member 2 0.038429
AFDN afadin, adherens junction formation factor 0.0384162
ATXN1 ataxin 1 0.0381771
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0381598
SBF2 SET binding factor 2 0.0370651
CNOT12 CCR4-NOT transcription complex subunit 12 0.0363769
NCKAP1 NCK-associated protein 1 0.0361794
ARGLU1 arginine and glutamate rich 1 0.0353897
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0352045
RBM39 RNA binding motif protein 39 0.0350381
STK24 serine/threonine kinase 24 0.0345535
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0340691
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0339399
UBA2 ubiquitin-like modifier activating enzyme 2 0.0337197
DIAPH3 diaphanous-related formin 3 0.0335429
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.033321
HELZ helicase with zinc finger 0.0329532
SUCO SUN domain containing ossification factor 0.0329169
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0321182
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0316405
TOP1 topoisomerase (DNA) I 0.0316095
GSK3B glycogen synthase kinase 3 beta 0.0314238
USP9X ubiquitin specific peptidase 9, X-linked 0.031163
RICTOR RPTOR independent companion of MTOR, complex 2 0.0310204
PDS5B PDS5 cohesin associated factor B 0.0310148
ITCH itchy E3 ubiquitin protein ligase 0.0305716
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0305669
DIDO1 death inducer-obliterator 1 0.0299952
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.029949
UBA6 ubiquitin-like modifier activating enzyme 6 0.0299392
TRA2A transformer 2 alpha homolog (Drosophila) 0.0297548
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0295492
CCNL1 cyclin L1 0.0293646
MBNL2 muscleblind-like splicing regulator 2 0.0290917
CKAP5 cytoskeleton associated protein 5 0.0290091
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0288788
SPRED1 sprouty-related, EVH1 domain containing 1 0.0286176
XPO1 exportin 1 0.0286008
AKAP13 A kinase (PRKA) anchor protein 13 0.0283998
SND1 staphylococcal nuclease and tudor domain containing 1 0.0283834
PSPC1 paraspeckle component 1 0.0282857
YTHDC1 YTH domain containing 1 0.0281892
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0281511
RPL4 ribosomal protein L4 0.0281238
RBM26 RNA binding motif protein 26 0.0281088
ZNF292 zinc finger protein 292 0.0280761
MARCHF6 membrane associated ring-CH-type finger 6 0.0280676
CSNK1A1 casein kinase 1, alpha 1 0.0277799
JMJD1C jumonji domain containing 1C 0.027761
MSN moesin 0.02772
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0277181
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0275518
BCL2L1 BCL2-like 1 0.0274111
EIF4B eukaryotic translation initiation factor 4B 0.0274009
NBAS neuroblastoma amplified sequence 0.0273439
VEGFA vascular endothelial growth factor A 0.0273063
ANLN anillin, actin binding protein 0.0272786
ARHGAP12 Rho GTPase activating protein 12 0.0272144
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0267375
WAC WW domain containing adaptor with coiled-coil 0.0267284
KDM3A lysine (K)-specific demethylase 3A 0.0264149
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0264026

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.25249
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.198577
FTH1 ferritin, heavy polypeptide 1 -0.19763
NDRG1 N-myc downstream regulated 1 -0.178748
TPT1 tumor protein, translationally-controlled 1 -0.13891
RPLP1 ribosomal protein, large, P1 -0.117312
KRT20 keratin 20, type I -0.115626
LOC102724023 ES1 protein homolog, mitochondrial -0.108057
TMSB10 thymosin beta 10 -0.105536
EGR1 early growth response 1 -0.105078
RPS6 ribosomal protein S6 -0.0982455
MYH14 myosin, heavy chain 14, non-muscle -0.0958582
LOC112694756 uncharaterized LOC112694756 -0.0810361
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0802693
RPS19 ribosomal protein S19 -0.0799735
RPL35A ribosomal protein L35a -0.076075
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.066325
RPLP0 ribosomal protein, large, P0 -0.0656477
TJP1 tight junction protein 1 -0.0612812
FRY furry homolog (Drosophila) -0.0578931
JUN jun proto-oncogene -0.0567162
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0566882
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0565055
RPS8 ribosomal protein S8 -0.0564715
TRIB1 tribbles pseudokinase 1 -0.0555852
ITPKC inositol-trisphosphate 3-kinase C -0.0548719
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0507174
RPL34 ribosomal protein L34 -0.0498917
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0495963
EZR ezrin -0.0490303
RPL31 ribosomal protein L31 -0.0468983
KRT19 keratin 19, type I -0.0467776
LYZ lysozyme -0.0462695
PKM pyruvate kinase, muscle -0.0450157
RPS5 ribosomal protein S5 -0.0446738
RPL23 ribosomal protein L23 -0.0430797
LDHA lactate dehydrogenase A -0.0429325
RPS16 ribosomal protein S16 -0.041214
GNAS GNAS complex locus -0.0403012
RPL12 ribosomal protein L12 -0.0402683
HMGA1 high mobility group AT-hook 1 -0.0396153
RPS13 ribosomal protein S13 -0.039371
EIF1 eukaryotic translation initiation factor 1 -0.0388556
S100A10 S100 calcium binding protein A10 -0.0384994
RPL27A ribosomal protein L27a -0.0379899
RPS24 ribosomal protein S24 -0.0373784
RPL11 ribosomal protein L11 -0.0373524
B2M beta-2-microglobulin -0.0373024
RNF213 ring finger protein 213 -0.037174
RPLP2 ribosomal protein, large, P2 -0.0370629
RPS11 ribosomal protein S11 -0.0360029
CLDN4 claudin 4 -0.0358608
LMO7 LIM domain 7 -0.0355185
POF1B premature ovarian failure, 1B -0.0352888
AGR2 anterior gradient 2 -0.0351868
ASTN2 astrotactin 2 -0.0351358
RACK1 receptor for activated C kinase 1 -0.0349597
RPL28 ribosomal protein L28 -0.0346614
S100A6 S100 calcium binding protein A6 -0.0345738
PGK1 phosphoglycerate kinase 1 -0.0341764
RPS23 ribosomal protein S23 -0.0340937
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0323664
RPS14 ribosomal protein S14 -0.0316159
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0311685
MYO1E myosin IE -0.0311113
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0303022
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0299074
AREG amphiregulin -0.02959
RPS21 ribosomal protein S21 -0.0295872
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0295
MUC13 mucin 13, cell surface associated -0.0292553
EEF2 eukaryotic translation elongation factor 2 -0.0289169
SOX4 SRY (sex determining region Y)-box 4 -0.0289082
TPI1 triosephosphate isomerase 1 -0.0289037
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0284799
RAB7A RAB7A, member RAS oncogene family -0.0276428
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0276247
LAMA4 laminin, alpha 4 -0.0275087
GSN gelsolin -0.0273569
RPS3 ribosomal protein S3 -0.0272974
RPL8 ribosomal protein L8 -0.0272488
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0270473
PPARD peroxisome proliferator-activated receptor delta -0.0269555
ACTG1 actin gamma 1 -0.0267614
RND3 Rho family GTPase 3 -0.0265628
RRBP1 ribosome binding protein 1 -0.0264943
TMEM123 transmembrane protein 123 -0.0263457
EMP1 epithelial membrane protein 1 -0.0260099
RPS25 ribosomal protein S25 -0.0259757
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0258082
FBXO32 F-box protein 32 -0.0257867
RPL9 ribosomal protein L9 -0.0255053
MMP7 matrix metallopeptidase 7 -0.025329
RPL19 ribosomal protein L19 -0.0252351
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0251991
SLC45A4 solute carrier family 45, member 4 -0.0251393
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0251214
ENO1 enolase 1, (alpha) -0.0250021
RPS27 ribosomal protein S27 -0.0249599
FHL2 four and a half LIM domains 2 -0.0249452