Rimonabant (Hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.158443
GPC3 glypican 3 0.12131
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.10776
TPT1 tumor protein, translationally-controlled 1 0.103901
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0895025
APOA2 apolipoprotein A-II 0.0761007
RPL11 ribosomal protein L11 0.0751433
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0728196
RPL37A ribosomal protein L37a 0.0673856
VEGFA vascular endothelial growth factor A 0.0665344
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0655327
RPS27A ribosomal protein S27a 0.0648022
PTMA prothymosin, alpha 0.0645738
RPS12 ribosomal protein S12 0.0645016
TM4SF1 transmembrane 4 L six family member 1 0.0606061
SLC38A2 solute carrier family 38, member 2 0.0605964
KDM3A lysine (K)-specific demethylase 3A 0.0568508
RPS8 ribosomal protein S8 0.0550398
RPS6 ribosomal protein S6 0.0540146
TIMP1 TIMP metallopeptidase inhibitor 1 0.0524246
APOE apolipoprotein E 0.0494015
RPS24 ribosomal protein S24 0.0488063
RPS3 ribosomal protein S3 0.0482432
DDIT4 DNA-damage-inducible transcript 4 0.0469631
RPL12 ribosomal protein L12 0.0466387
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0450296
AKAP12 A kinase (PRKA) anchor protein 12 0.0446199
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0437364
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0437348
RPLP1 ribosomal protein, large, P1 0.0435707
UBC ubiquitin C 0.0435331
AHNAK AHNAK nucleoprotein 0.0434608
FMNL2 formin-like 2 0.0413884
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0408341
FBF1 Fas (TNFRSF6) binding factor 1 0.0405525
FTL ferritin, light polypeptide 0.0401272
TRIM26 tripartite motif containing 26 0.0382423
RPL5 ribosomal protein L5 0.0378126
RACK1 receptor for activated C kinase 1 0.0376098
SRRM1 serine/arginine repetitive matrix 1 0.0369219
AFDN afadin, adherens junction formation factor 0.0366565
CAMTA1 calmodulin binding transcription activator 1 0.0354022
RPL4 ribosomal protein L4 0.0352426
TRIO trio Rho guanine nucleotide exchange factor 0.0351765
LDHA lactate dehydrogenase A 0.0351396
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.034954
KRT18 keratin 18, type I 0.0348394
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.034821
RPL31 ribosomal protein L31 0.034795
TMSB10 thymosin beta 10 0.0343837
RPS17 ribosomal protein S17 0.0341468
RPS23 ribosomal protein S23 0.0340752
NAMPT nicotinamide phosphoribosyltransferase 0.0336165
RPS29 ribosomal protein S29 0.0335843
B2M beta-2-microglobulin 0.0332218
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0331204
PRRC2C proline-rich coiled-coil 2C 0.0328978
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.032667
CALR calreticulin 0.0326033
OGA O-GlcNAcase 0.0322328
RPS11 ribosomal protein S11 0.0321237
SDC4 syndecan 4 0.0313373
MACF1 microtubule-actin crosslinking factor 1 0.031316
AMBP alpha-1-microglobulin/bikunin precursor 0.0311927
PGK1 phosphoglycerate kinase 1 0.0305
APOA1 apolipoprotein A-I 0.0303851
INSIG2 insulin induced gene 2 0.0298502
RPL19 ribosomal protein L19 0.0292038
ERRFI1 ERBB receptor feedback inhibitor 1 0.0288234
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0283177
RPL23 ribosomal protein L23 0.0282171
RPS13 ribosomal protein S13 0.0281172
WSB1 WD repeat and SOCS box containing 1 0.0277186
RPS19 ribosomal protein S19 0.0276799
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0274579
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0274379
CSDE1 cold shock domain containing E1, RNA-binding 0.0274099
RPL9 ribosomal protein L9 0.0272717
RPS5 ribosomal protein S5 0.0272322
PDIA6 protein disulfide isomerase family A, member 6 0.0270387
ELL2 elongation factor, RNA polymerase II, 2 0.026512
NPEPPS aminopeptidase puromycin sensitive 0.026341
ENO1 enolase 1, (alpha) 0.0260776
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0259873
PTPRF protein tyrosine phosphatase, receptor type, F 0.0257611
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0255383
RPS25 ribosomal protein S25 0.0255236
FAM107B family with sequence similarity 107, member B 0.0254788
HELZ helicase with zinc finger 0.0253982
YBX1 Y box binding protein 1 0.0253572
SRRM2 serine/arginine repetitive matrix 2 0.0253347
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0252827
CANX calnexin 0.0252422
S100A10 S100 calcium binding protein A10 0.0251079
RPL7 ribosomal protein L7 0.0247273
GPX4 glutathione peroxidase 4 0.0245318
EIF4A1 eukaryotic translation initiation factor 4A1 0.0244933
RPS10 ribosomal protein S10 0.0241778
FRMD5 FERM domain containing 5 0.024049
RPL14 ribosomal protein L14 0.023923

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.484424
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.301683
FN1 fibronectin 1 -0.190723
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.135843
APOB apolipoprotein B -0.0807456
C3 complement component 3 -0.0661565
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0531988
EGR1 early growth response 1 -0.0511683
LRMDA leucine rich melanocyte differentiation associated -0.0462801
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0448463
GPC6 glypican 6 -0.0413004
ZBTB20 zinc finger and BTB domain containing 20 -0.040549
CRLS1 cardiolipin synthase 1 -0.0396812
FNDC3B fibronectin type III domain containing 3B -0.0388551
JMJD1C jumonji domain containing 1C -0.0378547
VCL vinculin -0.0370099
SOX5 SRY (sex determining region Y)-box 5 -0.0354935
LOC112694756 uncharaterized LOC112694756 -0.0339382
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0337854
NRIP1 nuclear receptor interacting protein 1 -0.0334242
OSMR oncostatin M receptor -0.0327183
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.0298341
RNF213 ring finger protein 213 -0.0297589
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0295959
EML4 echinoderm microtubule associated protein like 4 -0.0294473
GSE1 Gse1 coiled-coil protein -0.0291597
DLC1 DLC1 Rho GTPase activating protein -0.029026
MRTFA myocardin related transcription factor A -0.0286519
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0280745
ATXN1 ataxin 1 -0.027897
DSPP dentin sialophosphoprotein -0.0275883
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0269597
FTH1 ferritin, heavy polypeptide 1 -0.0265765
TAS2R14 taste receptor, type 2, member 14 -0.0260333
TBK1 TANK-binding kinase 1 -0.0249945
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0240038
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0237128
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0236377
SESTD1 SEC14 and spectrin domains 1 -0.0235093
FILIP1L filamin A interacting protein 1-like -0.0234549
AHR aryl hydrocarbon receptor -0.0229843
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0228102
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0226459
FAM135A family with sequence similarity 135, member A -0.0225499
NPAS2 neuronal PAS domain protein 2 -0.0217578
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.020866
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0204665
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0203503
AGFG1 ArfGAP with FG repeats 1 -0.020257
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0202026
PTCHD4 patched domain containing 4 -0.0200995
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0200639
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0199934
FRK fyn-related Src family tyrosine kinase -0.0199182
PEG3 paternally expressed 3 -0.0198038
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0196554
SVIL supervillin -0.019649
RELL1 RELT-like 1 -0.0196444
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.019586
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.01938
STAU2 staufen double-stranded RNA binding protein 2 -0.0193159
MAML2 mastermind-like 2 (Drosophila) -0.0193081
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0192584
JAG1 jagged 1 -0.0191722
EPAS1 endothelial PAS domain protein 1 -0.0190248
FOXP1 forkhead box P1 -0.0188786
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0183441
TMEM87A transmembrane protein 87A -0.0183412
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0181945
ARL15 ADP-ribosylation factor-like 15 -0.0179338
MBTD1 mbt domain containing 1 -0.0178806
FOXO1 forkhead box O1 -0.0176685
TRIM24 tripartite motif containing 24 -0.0175579
ZFR zinc finger RNA binding protein -0.0175498
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0172396
WNK1 WNK lysine deficient protein kinase 1 -0.0171789
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0169077
KDM4C lysine (K)-specific demethylase 4C -0.0168691
TMEM123 transmembrane protein 123 -0.0167565
PTPRM protein tyrosine phosphatase, receptor type, M -0.016753
DOCK4 dedicator of cytokinesis 4 -0.0167101
UTRN utrophin -0.016704
IL6ST interleukin 6 signal transducer -0.0166716
CCDC146 coiled-coil domain containing 146 -0.0165931
HMGA1 high mobility group AT-hook 1 -0.0164866
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0164647
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.016461
POTEF POTE ankyrin domain family, member F -0.0164274
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0164141
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0163437
YAP1 Yes-associated protein 1 -0.0162055
KIF21A kinesin family member 21A -0.015896
ARHGAP9 Rho GTPase activating protein 9 -0.0158312
NABP1 nucleic acid binding protein 1 -0.0158238
ATE1 arginyltransferase 1 -0.0156174
DOK6 docking protein 6 -0.0155269
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0154767
MED13L mediator complex subunit 13-like -0.015431
SETD2 SET domain containing 2 -0.0152642
ZBTB44 zinc finger and BTB domain containing 44 -0.0150051