Rimonabant (Hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.112148
MYH9 myosin, heavy chain 9, non-muscle 0.080382
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0641237
OGA O-GlcNAcase 0.0612673
ITCH itchy E3 ubiquitin protein ligase 0.0546473
ANLN anillin, actin binding protein 0.0536429
TNIP1 TNFAIP3 interacting protein 1 0.0461025
RNF145 ring finger protein 145 0.0453274
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0452802
KRT17 keratin 17, type I 0.0448523
KDM6A lysine (K)-specific demethylase 6A 0.0439492
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0428857
TMSB4X thymosin beta 4, X-linked 0.0416418
ARRDC3 arrestin domain containing 3 0.0413844
HDGF hepatoma-derived growth factor 0.041179
TRIO trio Rho guanine nucleotide exchange factor 0.0410602
MSN moesin 0.0409963
SUCO SUN domain containing ossification factor 0.0404094
SRRM1 serine/arginine repetitive matrix 1 0.0398666
KDM3A lysine (K)-specific demethylase 3A 0.0381289
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0374784
BHLHE40 basic helix-loop-helix family, member e40 0.0360392
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.03526
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0345227
RPS12 ribosomal protein S12 0.0333649
GOLGA4 golgin A4 0.0332381
KTN1 kinectin 1 (kinesin receptor) 0.03313
TPM3 tropomyosin 3 0.0323006
MEF2A myocyte enhancer factor 2A 0.0321316
INSIG2 insulin induced gene 2 0.0319583
SET SET nuclear proto-oncogene 0.0318888
RPL3 ribosomal protein L3 0.0318499
PCBP2 poly(rC) binding protein 2 0.0317285
EHBP1L1 EH domain binding protein 1-like 1 0.0311767
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit 0.030249
ZNF292 zinc finger protein 292 0.0301788
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0300621
VEGFA vascular endothelial growth factor A 0.0300472
PRRC2C proline-rich coiled-coil 2C 0.0300013
DIDO1 death inducer-obliterator 1 0.0298342
RPL7A ribosomal protein L7a 0.0293343
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0290341
ARGLU1 arginine and glutamate rich 1 0.0289042
ATP13A3 ATPase type 13A3 0.0284866
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0284519
CAPRIN2 caprin family member 2 0.0281022
UBA6 ubiquitin-like modifier activating enzyme 6 0.0278787
RPS3 ribosomal protein S3 0.0278715
UBA2 ubiquitin-like modifier activating enzyme 2 0.0277114
ANKRD11 ankyrin repeat domain 11 0.0267243
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0265796
HELZ helicase with zinc finger 0.0265012
MYO10 myosin X 0.0264346
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0260757
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0256251
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0252429
SRRM2 serine/arginine repetitive matrix 2 0.0249167
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0248035
TGM2 transglutaminase 2 0.0247253
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.024554
NAV2 neuron navigator 2 0.0243864
FOXO3 forkhead box O3 0.0239168
RPL4 ribosomal protein L4 0.0238876
SLMAP sarcolemma associated protein 0.0238644
NUP58 nucleoporin 58 0.0238029
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0235617
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0235231
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0235225
CALR calreticulin 0.0234051
NAP1L1 nucleosome assembly protein 1-like 1 0.0230846
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.0230738
ZMYM2 zinc finger, MYM-type 2 0.0230471
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0226911
ESYT2 extended synaptotagmin-like protein 2 0.0224367
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0223469
FAM13A family with sequence similarity 13, member A 0.0223243
RBM26 RNA binding motif protein 26 0.0220888
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0219678
CEP250 centrosomal protein 250kDa 0.0219567
XPO1 exportin 1 0.0218992
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0218777
ADAM17 ADAM metallopeptidase domain 17 0.0218576
LNPEP leucyl/cystinyl aminopeptidase 0.0218461
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0217015
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0215996
UBC ubiquitin C 0.021594
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0215577
RPL5 ribosomal protein L5 0.0215533
ECPAS Ecm29 proteasome adaptor and scaffold 0.0214973
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0211598
RPL23 ribosomal protein L23 0.0211334
GATA6 GATA binding protein 6 0.0210933
SQLE squalene epoxidase 0.0210509
PDIA6 protein disulfide isomerase family A, member 6 0.021029
RPL21 ribosomal protein L21 0.0210102
TOP1 topoisomerase (DNA) I 0.0207758
COPA coatomer protein complex, subunit alpha 0.0203748
TM9SF2 transmembrane 9 superfamily member 2 0.0203062
PPME1 protein phosphatase methylesterase 1 0.0202705
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0201602

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.388233
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.175351
NDRG1 N-myc downstream regulated 1 -0.125696
TIMP3 TIMP metallopeptidase inhibitor 3 -0.115247
CD44 CD44 molecule (Indian blood group) -0.115043
LMO7 LIM domain 7 -0.100708
LOC112694756 uncharaterized LOC112694756 -0.092267
MTSS1 metastasis suppressor 1 -0.0859115
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0820867
DPYD dihydropyrimidine dehydrogenase -0.0797374
OSMR oncostatin M receptor -0.0775724
PDE4D phosphodiesterase 4D, cAMP-specific -0.0768278
IGF2 insulin-like growth factor 2 -0.0744462
CAV1 caveolin 1, caveolae protein, 22kDa -0.0686852
FOXO1 forkhead box O1 -0.0680397
PDLIM5 PDZ and LIM domain 5 -0.064481
RIGI RNA sensor RIG-I -0.06164
FTH1 ferritin, heavy polypeptide 1 -0.0607232
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0603008
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0586479
PALLD palladin, cytoskeletal associated protein -0.0582153
SAMD9 sterile alpha motif domain containing 9 -0.0547746
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0540342
SLC35F3 solute carrier family 35, member F3 -0.0522994
MECOM MDS1 and EVI1 complex locus -0.0505514
ALCAM activated leukocyte cell adhesion molecule -0.0499792
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0470994
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0463286
AOPEP aminopeptidase O (putative) -0.04562
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0455524
EGR1 early growth response 1 -0.0435479
JMJD1C jumonji domain containing 1C -0.0432433
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0420588
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0418542
PODXL podocalyxin-like -0.0410422
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0407928
HSPG2 heparan sulfate proteoglycan 2 -0.0404993
VCL vinculin -0.0388893
GNAS GNAS complex locus -0.0388891
ARF1 ADP-ribosylation factor 1 -0.0388795
MBNL1 muscleblind-like splicing regulator 1 -0.0385869
IFITM1 interferon induced transmembrane protein 1 -0.0380955
RASAL2 RAS protein activator like 2 -0.0380478
HM13 histocompatibility (minor) 13 -0.0379517
BMAL2 basic helix-loop-helix ARNT like 2 -0.0378211
FN1 fibronectin 1 -0.0368775
FOXP1 forkhead box P1 -0.0365712
ZNFX1 zinc finger, NFX1-type containing 1 -0.0363645
CDK6 cyclin-dependent kinase 6 -0.0358397
RABGAP1L RAB GTPase activating protein 1-like -0.0355177
TMSB10 thymosin beta 10 -0.0352296
RRBP1 ribosome binding protein 1 -0.0333981
MORF4L2 mortality factor 4 like 2 -0.0329396
ACTN4 actinin, alpha 4 -0.0328717
PLS3 plastin 3 -0.032743
RIN2 Ras and Rab interactor 2 -0.032611
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0323376
PRSS23 protease, serine, 23 -0.0321224
NRIP1 nuclear receptor interacting protein 1 -0.0319612
HLA-B major histocompatibility complex, class I, B -0.0319021
NEK7 NIMA-related kinase 7 -0.0317691
EMP1 epithelial membrane protein 1 -0.0316348
EXT1 exostosin glycosyltransferase 1 -0.0314216
SDCBP syndecan binding protein (syntenin) -0.0308192
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0307774
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.030638
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.030466
DGKH diacylglycerol kinase, eta -0.0299264
EFNA5 ephrin-A5 -0.0298147
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0296615
CNTNAP3 contactin associated protein-like 3 -0.0295611
RPL35A ribosomal protein L35a -0.0291597
LDHA lactate dehydrogenase A -0.0291319
MTAP methylthioadenosine phosphorylase -0.0289008
IFI16 interferon, gamma-inducible protein 16 -0.0281963
STC1 stanniocalcin 1 -0.0281718
WARS1 tryptophanyl-tRNA synthetase 1 -0.0281272
RAB7A RAB7A, member RAS oncogene family -0.0280083
FSCN1 fascin actin-bundling protein 1 -0.0275634
THBD thrombomodulin -0.0269309
IL6ST interleukin 6 signal transducer -0.0269249
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.026559
FNDC3A fibronectin type III domain containing 3A -0.0265131
EGFR epidermal growth factor receptor -0.0263736
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0263323
SULF2 sulfatase 2 -0.0262942
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0261941
NRCAM neuronal cell adhesion molecule -0.0258265
TXNIP thioredoxin interacting protein -0.0256697
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0251669
PDIA3 protein disulfide isomerase family A, member 3 -0.0251472
FBXO11 F-box protein 11 -0.0251135
ABI3BP ABI family, member 3 (NESH) binding protein -0.0250681
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0249487
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0246531
HLA-E major histocompatibility complex, class I, E -0.0246143
SMYD3 SET and MYND domain containing 3 -0.0245538
PSD3 pleckstrin and Sec7 domain containing 3 -0.024426
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0243864
DUSP4 dual specificity phosphatase 4 -0.0240394