Rimonabant (Hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0371524
AHNAK AHNAK nucleoprotein 0.0332912
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0306911
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0294213
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0275886
ZNF841 zinc finger protein 841 0.026849
KRT8 keratin 8, type II 0.02327
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0223719
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0216431
ANKRD10 ankyrin repeat domain 10 0.021177
SMAD3 SMAD family member 3 0.0207456
NAMPT nicotinamide phosphoribosyltransferase 0.0206325
KRT18 keratin 18, type I 0.0202223
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0199275
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0197112
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0194575
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0188665
SLC12A8 solute carrier family 12, member 8 0.0188065
HMGB2 high mobility group box 2 0.0186771
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0168459
ZNF432 zinc finger protein 432 0.0167824
COL7A1 collagen, type VII, alpha 1 0.0167302
ARGLU1 arginine and glutamate rich 1 0.0164522
NEK7 NIMA-related kinase 7 0.0156111
LRMDA leucine rich melanocyte differentiation associated 0.0153796
ATP13A3 ATPase type 13A3 0.0151179
H1-4 H1.4 linker histone, cluster member 0.0151067
NCKAP1 NCK-associated protein 1 0.0150031
ANO6 anoctamin 6 0.0148073
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0141922
WWOX WW domain containing oxidoreductase 0.0140331
TMSB4X thymosin beta 4, X-linked 0.0139303
RPL4 ribosomal protein L4 0.0136904
BASP1 brain abundant, membrane attached signal protein 1 0.0135076
VGLL3 vestigial-like family member 3 0.0134092
HEG1 heart development protein with EGF-like domains 1 0.0133499
SET SET nuclear proto-oncogene 0.0133229
OSMR oncostatin M receptor 0.0129979
ANKRD11 ankyrin repeat domain 11 0.012605
HSPA8 heat shock 70kDa protein 8 0.0123334
TNIP1 TNFAIP3 interacting protein 1 0.0120252
PPME1 protein phosphatase methylesterase 1 0.0119664
FHIT fragile histidine triad 0.0117428
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0112643
THBS1 thrombospondin 1 0.0110184
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0110165
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0108945
BCL2L1 BCL2-like 1 0.0108557
BHLHE40 basic helix-loop-helix family, member e40 0.0105843
ELL2 elongation factor, RNA polymerase II, 2 0.00992326
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00963807
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0096232
BCAR3 breast cancer anti-estrogen resistance 3 0.0095757
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.00945377
AGFG1 ArfGAP with FG repeats 1 0.0094155
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00935703
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.00927744
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0092758
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00925214
CKAP5 cytoskeleton associated protein 5 0.00925145
FAR1 fatty acyl CoA reductase 1 0.00913982
NASP nuclear autoantigenic sperm protein (histone-binding) 0.00909778
ITGAV integrin, alpha V 0.00901717
OGA O-GlcNAcase 0.00901138
MKI67 marker of proliferation Ki-67 0.00891813
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00883402
SERINC1 serine incorporator 1 0.00868501
PDLIM5 PDZ and LIM domain 5 0.00867663
COL4A2 collagen, type IV, alpha 2 0.00863499
ATAD2 ATPase family, AAA domain containing 2 0.00861982
PNN pinin, desmosome associated protein 0.00854281
ASPH aspartate beta-hydroxylase 0.00851147
WDR33 WD repeat domain 33 0.00850004
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.00848547
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00843767
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00835864
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.00832995
SPACA6 sperm acrosome associated 6 0.00827471
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.00826717
MTAP methylthioadenosine phosphorylase 0.00825851
SMG7 SMG7 nonsense mediated mRNA decay factor 0.00816761
SENP5 SUMO1/sentrin specific peptidase 5 0.00814836
GLS2 glutaminase 2 (liver, mitochondrial) 0.00810326
SP3 Sp3 transcription factor 0.00809126
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 0.0080789
MAPK8 mitogen-activated protein kinase 8 0.00802744
MB21D2 Mab-21 domain containing 2 0.00798729
ANLN anillin, actin binding protein 0.00770265
PICALM phosphatidylinositol binding clathrin assembly protein 0.00768336
RPL14 ribosomal protein L14 0.00767882
ZFC3H1 zinc finger, C3H1-type containing 0.00758517
CNOT12 CCR4-NOT transcription complex subunit 12 0.00752885
RRM2 ribonucleotide reductase M2 0.00746885
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.00744636
MATR3 matrin 3 0.00742054
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00741296
DIAPH1 diaphanous-related formin 1 0.00739967
TRIM44 tripartite motif containing 44 0.00739913
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.00739159
CAPRIN1 cell cycle associated protein 1 0.00732731

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.220868
FN1 fibronectin 1 -0.176469
NDRG1 N-myc downstream regulated 1 -0.175011
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.148143
NALF1 NALCN channel auxiliary factor 1 -0.128088
ABI3BP ABI family, member 3 (NESH) binding protein -0.0939042
FTH1 ferritin, heavy polypeptide 1 -0.0904154
FTL ferritin, light polypeptide -0.0887071
DLG1 discs, large homolog 1 (Drosophila) -0.0776027
HLA-B major histocompatibility complex, class I, B -0.0656464
F3 coagulation factor III (thromboplastin, tissue factor) -0.0653373
MT2A metallothionein 2A -0.0627707
PHACTR1 phosphatase and actin regulator 1 -0.0613499
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0603053
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0595815
GLIS3 GLIS family zinc finger 3 -0.0540844
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0489259
PDIA3 protein disulfide isomerase family A, member 3 -0.0479543
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0469273
PLIN2 perilipin 2 -0.0468208
POTEF POTE ankyrin domain family, member F -0.0465255
VIM vimentin -0.0443484
ADM adrenomedullin -0.0417449
AKAP12 A kinase (PRKA) anchor protein 12 -0.0408667
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0403568
RAI14 retinoic acid induced 14 -0.0389998
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0385931
LOX lysyl oxidase -0.0378605
UGCG UDP-glucose ceramide glucosyltransferase -0.0370244
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0365586
MMP12 matrix metallopeptidase 12 -0.0356969
TRIO trio Rho guanine nucleotide exchange factor -0.035471
TMSB10 thymosin beta 10 -0.0339837
RPL35A ribosomal protein L35a -0.0329211
DEK DEK proto-oncogene -0.0329178
CTSD cathepsin D -0.0312865
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0312476
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0312344
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0310304
SLIT2 slit homolog 2 (Drosophila) -0.0304583
VDAC1 voltage-dependent anion channel 1 -0.0304525
IGFBP5 insulin-like growth factor binding protein 5 -0.0285435
MAP4 microtubule-associated protein 4 -0.0285309
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0278184
PFN1 profilin 1 -0.0278145
PGK1 phosphoglycerate kinase 1 -0.0267703
ENO2 enolase 2 (gamma, neuronal) -0.0261504
RAB7A RAB7A, member RAS oncogene family -0.0261234
BTG1 B-cell translocation gene 1, anti-proliferative -0.0256785
CCBE1 collagen and calcium binding EGF domains 1 -0.0252807
SOD2 superoxide dismutase 2, mitochondrial -0.0252714
PKM pyruvate kinase, muscle -0.0248379
LMAN1 lectin, mannose-binding, 1 -0.024598
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0245815
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0241845
RPS6 ribosomal protein S6 -0.0237954
LOC112694756 uncharaterized LOC112694756 -0.0234776
MAP1B microtubule-associated protein 1B -0.0231814
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0227594
EGR1 early growth response 1 -0.0225563
HILPDA hypoxia inducible lipid droplet-associated -0.0217687
IARS1 isoleucyl-tRNA synthetase 1 -0.0215596
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0214328
GOLGA4 golgin A4 -0.0213777
TPM4 tropomyosin 4 -0.0211618
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.020926
LDHA lactate dehydrogenase A -0.0208945
PLCB4 phospholipase C, beta 4 -0.0207891
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0207
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0205912
CANX calnexin -0.0203122
S100A6 S100 calcium binding protein A6 -0.0202834
ACTG1 actin gamma 1 -0.0201028
PTBP3 polypyrimidine tract binding protein 3 -0.019857
KPNB1 karyopherin (importin) beta 1 -0.0198239
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0196663
FOSL1 FOS-like antigen 1 -0.0195937
KMT2C lysine (K)-specific methyltransferase 2C -0.0191863
PTPRF protein tyrosine phosphatase, receptor type, F -0.0188585
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0188191
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0187903
COPB1 coatomer protein complex, subunit beta 1 -0.0185603
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0185173
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0180425
AFF4 AF4/FMR2 family, member 4 -0.0179919
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0179559
VEGFC vascular endothelial growth factor C -0.0178782
HMGA1 high mobility group AT-hook 1 -0.0176418
CCDC80 coiled-coil domain containing 80 -0.0176114
KDM2A lysine (K)-specific demethylase 2A -0.0175978
ANXA1 annexin A1 -0.0174548
ANXA2 annexin A2 -0.0173867
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0173566
DTNA dystrobrevin, alpha -0.0168567
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0168517
FAM162A family with sequence similarity 162, member A -0.0167804
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.016764
EGFR epidermal growth factor receptor -0.0167123
TGFB2 transforming growth factor, beta 2 -0.0166323
GNAS GNAS complex locus -0.0166223