Rimonabant (Hydrochloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A 0.0742113
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0718094
NUP58 nucleoporin 58 0.0641462
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0614225
YBX3 Y box binding protein 3 0.0600767
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.052738
NAMPT nicotinamide phosphoribosyltransferase 0.0502458
ZNF292 zinc finger protein 292 0.0492301
RAD21 RAD21 homolog (S. pombe) 0.0480077
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0480062
SPAG9 sperm associated antigen 9 0.0475491
RBM39 RNA binding motif protein 39 0.0442887
ADAM9 ADAM metallopeptidase domain 9 0.0439375
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0408817
UGCG UDP-glucose ceramide glucosyltransferase 0.0403103
AHNAK AHNAK nucleoprotein 0.0401005
NCKAP1 NCK-associated protein 1 0.0391973
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0388039
MCTP1 multiple C2 domains, transmembrane 1 0.038656
OGA O-GlcNAcase 0.0378941
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0377321
ATP13A3 ATPase type 13A3 0.0374519
MARCHF6 membrane associated ring-CH-type finger 6 0.0357668
WDR45B WD repeat domain 45B 0.0350531
RTN4 reticulon 4 0.034918
WDR43 WD repeat domain 43 0.0348051
APP amyloid beta (A4) precursor protein 0.034379
PNISR PNN-interacting serine/arginine-rich protein 0.0343391
TXNRD1 thioredoxin reductase 1 0.0333193
RLF rearranged L-myc fusion 0.033289
ELL2 elongation factor, RNA polymerase II, 2 0.0327207
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0320082
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0318608
QKI QKI, KH domain containing, RNA binding 0.0317956
CD109 CD109 molecule 0.0308362
HELZ helicase with zinc finger 0.0308307
WAC WW domain containing adaptor with coiled-coil 0.030545
TSC22D2 TSC22 domain family, member 2 0.0303917
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0287179
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0282891
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0282805
PUM1 pumilio RNA-binding family member 1 0.0281727
ZMYM2 zinc finger, MYM-type 2 0.0281191
PICALM phosphatidylinositol binding clathrin assembly protein 0.0280436
NEK7 NIMA-related kinase 7 0.0280025
RNF145 ring finger protein 145 0.0279251
VCL vinculin 0.0277664
STRN3 striatin, calmodulin binding protein 3 0.027171
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0268834
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0267692
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0265627
ZFC3H1 zinc finger, C3H1-type containing 0.0264137
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0263552
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0260514
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.025979
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0259325
ZFAND3 zinc finger, AN1-type domain 3 0.0257816
SMAD3 SMAD family member 3 0.0255086
ECT2 epithelial cell transforming 2 0.0255073
MED13L mediator complex subunit 13-like 0.0251761
RAB8B RAB8B, member RAS oncogene family 0.0250335
ABI1 abl-interactor 1 0.0243395
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0240198
CHD1 chromodomain helicase DNA binding protein 1 0.0239945
CDC73 cell division cycle 73 0.0239668
MYH9 myosin, heavy chain 9, non-muscle 0.0237578
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0236501
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0236194
USP3 ubiquitin specific peptidase 3 0.0235948
PAWR PRKC, apoptosis, WT1, regulator 0.0232491
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0232487
PHIP pleckstrin homology domain interacting protein 0.0231969
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0228041
SEPTIN7 septin 7 0.0224738
EIF4A1 eukaryotic translation initiation factor 4A1 0.0223641
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0223581
PUM2 pumilio RNA-binding family member 2 0.0223309
TRA2A transformer 2 alpha homolog (Drosophila) 0.0223301
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0223219
SPRED1 sprouty-related, EVH1 domain containing 1 0.0222104
RB1CC1 RB1-inducible coiled-coil 1 0.022172
ARGLU1 arginine and glutamate rich 1 0.0221608
CUL3 cullin 3 0.0219432
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0217808
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0217749
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0216915
FUBP1 far upstream element (FUSE) binding protein 1 0.0216435
TFG TRK-fused gene 0.0213785
WSB1 WD repeat and SOCS box containing 1 0.0211552
BRWD3 bromodomain and WD repeat domain containing 3 0.0210948
DST dystonin 0.02109
NUP153 nucleoporin 153kDa 0.0208619
KMT2E lysine (K)-specific methyltransferase 2E 0.020804
CSDE1 cold shock domain containing E1, RNA-binding 0.0205848
RAB1A RAB1A, member RAS oncogene family 0.0205703
MYO6 myosin VI 0.020459
CASC3 cancer susceptibility candidate 3 0.0204384
GLS2 glutaminase 2 (liver, mitochondrial) 0.020372
YTHDC1 YTH domain containing 1 0.0201288
MTF2 metal response element binding transcription factor 2 0.0199885

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.236359
EFNA5 ephrin-A5 -0.118724
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.116436
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.108584
TMSB10 thymosin beta 10 -0.107665
PHACTR1 phosphatase and actin regulator 1 -0.104725
PRKG1 protein kinase, cGMP-dependent, type I -0.103456
SAMD3 sterile alpha motif domain containing 3 -0.094707
RPS6 ribosomal protein S6 -0.0935646
LSAMP limbic system-associated membrane protein -0.0916549
EXT1 exostosin glycosyltransferase 1 -0.0903809
DTNA dystrobrevin, alpha -0.0832062
CDH13 cadherin 13 -0.0814424
AKAP12 A kinase (PRKA) anchor protein 12 -0.0796319
EGR1 early growth response 1 -0.0726522
KIAA1217 KIAA1217 -0.0710188
PTPRG protein tyrosine phosphatase, receptor type, G -0.0680306
RPL35A ribosomal protein L35a -0.0661907
NALF1 NALCN channel auxiliary factor 1 -0.0659163
NAV1 neuron navigator 1 -0.0625846
SDCCAG8 serologically defined colon cancer antigen 8 -0.0603473
ASPH aspartate beta-hydroxylase -0.0592365
HMGA2 high mobility group AT-hook 2 -0.0588994
KIAA1549L KIAA1549-like -0.0572988
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0545722
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.052935
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0512295
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.050043
PBX3 pre-B-cell leukemia homeobox 3 -0.0497317
RPL31 ribosomal protein L31 -0.0476704
NDRG1 N-myc downstream regulated 1 -0.0464385
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0461486
NTM neurotrimin -0.0458372
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.04548
GPC6 glypican 6 -0.0445505
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0443623
RPLP1 ribosomal protein, large, P1 -0.0431944
PTPRD protein tyrosine phosphatase, receptor type, D -0.0431443
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0420224
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0399541
TPT1 tumor protein, translationally-controlled 1 -0.0394137
ZNF804A zinc finger protein 804A -0.0390017
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0384481
INTS6 integrator complex subunit 6 -0.0382987
HDAC9 histone deacetylase 9 -0.0379479
MYO10 myosin X -0.0361023
RPL37A ribosomal protein L37a -0.0354413
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0353549
CDK6 cyclin-dependent kinase 6 -0.0347786
RPS25 ribosomal protein S25 -0.0347437
HMGA1 high mobility group AT-hook 1 -0.0344581
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0334736
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0332476
ADAM32 ADAM metallopeptidase domain 32 -0.0310535
DOCK4 dedicator of cytokinesis 4 -0.0309683
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0305223
RPS19 ribosomal protein S19 -0.030487
RPS13 ribosomal protein S13 -0.0304764
RPL23 ribosomal protein L23 -0.0303835
RPS8 ribosomal protein S8 -0.0294389
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0293534
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0293288
C2CD2 C2 calcium-dependent domain containing 2 -0.0283204
RAD51B RAD51 paralog B -0.0278911
EGFR epidermal growth factor receptor -0.0278047
PRKCE protein kinase C, epsilon -0.0277324
DGKI diacylglycerol kinase, iota -0.0270551
MACF1 microtubule-actin crosslinking factor 1 -0.026713
PTPRK protein tyrosine phosphatase, receptor type, K -0.0263407
CUX1 cut-like homeobox 1 -0.0262567
RPLP0 ribosomal protein, large, P0 -0.0261831
NABP1 nucleic acid binding protein 1 -0.0260099
RPS29 ribosomal protein S29 -0.0252498
RPS20 ribosomal protein S20 -0.0247356
PTCHD4 patched domain containing 4 -0.0247145
BPTF bromodomain PHD finger transcription factor -0.0246358
RPS23 ribosomal protein S23 -0.0244883
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.024298
RPL9 ribosomal protein L9 -0.0242818
RAB7A RAB7A, member RAS oncogene family -0.0241894
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0241091
POTEF POTE ankyrin domain family, member F -0.0240796
KDM4C lysine (K)-specific demethylase 4C -0.0239496
AEBP2 AE binding protein 2 -0.0236744
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0231584
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0227615
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0227397
CDK14 cyclin-dependent kinase 14 -0.0224067
AGO2 argonaute RISC catalytic component 2 -0.0223179
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0222696
FOXP1 forkhead box P1 -0.0220132
DIAPH2 diaphanous-related formin 2 -0.0220112
PTK2 protein tyrosine kinase 2 -0.0213641
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0213389
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.021282
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0210849
DSCAM Down syndrome cell adhesion molecule -0.0208452
USP34 ubiquitin specific peptidase 34 -0.0207837
ANTXR2 anthrax toxin receptor 2 -0.02065
ZBTB20 zinc finger and BTB domain containing 20 -0.0204303