Rimonabant (Hydrochloride)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.27463
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.125871
EREG epiregulin 0.118176
PTMA prothymosin, alpha 0.107207
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0874084
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0838377
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0739147
RNF145 ring finger protein 145 0.0718352
EEF2 eukaryotic translation elongation factor 2 0.0712936
VEGFA vascular endothelial growth factor A 0.0684973
FAM13A family with sequence similarity 13, member A 0.0684743
GOLGA4 golgin A4 0.0660942
KDM3A lysine (K)-specific demethylase 3A 0.064312
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0600224
EPCAM epithelial cell adhesion molecule 0.0580823
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0566031
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0565867
RBM39 RNA binding motif protein 39 0.055731
EIF1 eukaryotic translation initiation factor 1 0.0549259
FTH1 ferritin, heavy polypeptide 1 0.0511432
OGA O-GlcNAcase 0.0510615
KRT18 keratin 18, type I 0.0498017
WAC WW domain containing adaptor with coiled-coil 0.0493002
CALR calreticulin 0.0478221
ANKRD11 ankyrin repeat domain 11 0.0459942
GARS1 glycyl-tRNA synthetase 1 0.0458832
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0456945
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0417475
ZFAND3 zinc finger, AN1-type domain 3 0.0414668
RNF43 ring finger protein 43 0.0414353
LDHA lactate dehydrogenase A 0.0411328
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0408008
KIF5B kinesin family member 5B 0.0403593
KMT2E lysine (K)-specific methyltransferase 2E 0.0400469
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0397816
MATR3 matrin 3 0.0387946
DDIT4 DNA-damage-inducible transcript 4 0.0381485
COPA coatomer protein complex, subunit alpha 0.0376746
RAB1A RAB1A, member RAS oncogene family 0.0374932
MED13L mediator complex subunit 13-like 0.0372104
RPS3 ribosomal protein S3 0.037106
TXNIP thioredoxin interacting protein 0.0370654
TMSB4X thymosin beta 4, X-linked 0.0370405
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0368113
GDF15 growth differentiation factor 15 0.036361
UBC ubiquitin C 0.0355044
RPL4 ribosomal protein L4 0.0354716
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0350601
PGK1 phosphoglycerate kinase 1 0.0340966
ZFC3H1 zinc finger, C3H1-type containing 0.0338624
YTHDC1 YTH domain containing 1 0.0338454
KLF5 Kruppel-like factor 5 (intestinal) 0.033684
RPLP0 ribosomal protein, large, P0 0.033635
ATF4 activating transcription factor 4 0.0330578
TFG TRK-fused gene 0.0325147
MARCHF6 membrane associated ring-CH-type finger 6 0.0324464
WDR45B WD repeat domain 45B 0.0324026
RPL3 ribosomal protein L3 0.0322989
DSCAM Down syndrome cell adhesion molecule 0.0322464
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0316322
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0314749
BHLHE40 basic helix-loop-helix family, member e40 0.0313735
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0307366
PNISR PNN-interacting serine/arginine-rich protein 0.0306138
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0301262
S100P S100 calcium binding protein P 0.0300416
NCKAP1 NCK-associated protein 1 0.0299925
RPL12 ribosomal protein L12 0.0298819
CANX calnexin 0.0298379
TM9SF3 transmembrane 9 superfamily member 3 0.0296601
TRA2A transformer 2 alpha homolog (Drosophila) 0.0294188
DERA deoxyribose-phosphate aldolase (putative) 0.0291346
PDIA6 protein disulfide isomerase family A, member 6 0.0290974
SRRM2 serine/arginine repetitive matrix 2 0.0288358
NAMPT nicotinamide phosphoribosyltransferase 0.0287545
RPL26 ribosomal protein L26 0.0286353
HELZ helicase with zinc finger 0.0285507
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0284659
YME1L1 YME1-like 1 ATPase 0.0283756
MBNL2 muscleblind-like splicing regulator 2 0.0279968
NUP58 nucleoporin 58 0.0279343
H1-0 H1.0 linker histone 0.027483
NEK7 NIMA-related kinase 7 0.0273323
RLF rearranged L-myc fusion 0.0273168
PRRC2C proline-rich coiled-coil 2C 0.0272014
RPL7 ribosomal protein L7 0.0270856
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0270855
RPL13A ribosomal protein L13a 0.0270431
ANXA2 annexin A2 0.0268895
YBX1 Y box binding protein 1 0.0264605
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0264506
FUBP1 far upstream element (FUSE) binding protein 1 0.0263847
SRRM1 serine/arginine repetitive matrix 1 0.0263835
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0261795
CSDE1 cold shock domain containing E1, RNA-binding 0.0261251
USP3 ubiquitin specific peptidase 3 0.0257553
TCEA1 transcription elongation factor A (SII), 1 0.0255868
MON2 MON2 homolog (S. cerevisiae) 0.0255301
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0254242
RAD21 RAD21 homolog (S. pombe) 0.0253793

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.212258
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.147751
NALF1 NALCN channel auxiliary factor 1 -0.115098
MYO1E myosin IE -0.110876
GMDS GDP-mannose 4,6-dehydratase -0.101701
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0920363
ALCAM activated leukocyte cell adhesion molecule -0.0850538
ANTXR2 anthrax toxin receptor 2 -0.0813333
PTPRK protein tyrosine phosphatase, receptor type, K -0.080761
GREB1L growth regulation by estrogen in breast cancer-like -0.0793784
VCL vinculin -0.0792779
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0678094
CEMIP cell migration inducing protein, hyaluronan binding -0.0652678
FLNB filamin B, beta -0.0629861
PDE4D phosphodiesterase 4D, cAMP-specific -0.0598583
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0597677
PSD3 pleckstrin and Sec7 domain containing 3 -0.0592227
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0582715
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0580759
RNF217 ring finger protein 217 -0.0577234
FHIT fragile histidine triad -0.0576485
ACTG1 actin gamma 1 -0.0563376
MAML3 mastermind-like 3 (Drosophila) -0.0552204
CCSER1 coiled-coil serine-rich protein 1 -0.0535206
LAMA4 laminin, alpha 4 -0.0530002
PDLIM5 PDZ and LIM domain 5 -0.0523712
EGFR epidermal growth factor receptor -0.051756
SLC35F3 solute carrier family 35, member F3 -0.0504621
SMYD3 SET and MYND domain containing 3 -0.0500508
EXT1 exostosin glycosyltransferase 1 -0.0499848
RAD51B RAD51 paralog B -0.0496633
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0493154
SAMD5 sterile alpha motif domain containing 5 -0.0486538
ITGA6 integrin, alpha 6 -0.047973
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0454863
ONECUT3 one cut homeobox 3 -0.0453463
ASPH aspartate beta-hydroxylase -0.0442313
LPP LIM domain containing preferred translocation partner in lipoma -0.0434683
SVIL supervillin -0.0425487
PATJ PATJ crumbs cell polarity complex component -0.0414217
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0411831
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0408903
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0401083
ZBTB20 zinc finger and BTB domain containing 20 -0.0396957
PARD3B par-3 family cell polarity regulator beta -0.0381066
CADPS Ca++-dependent secretion activator -0.037742
SH3D19 SH3 domain containing 19 -0.0361404
DIAPH2 diaphanous-related formin 2 -0.0359063
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0353227
FOXP1 forkhead box P1 -0.0351912
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0343591
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0338743
MBNL1 muscleblind-like splicing regulator 1 -0.0337224
PTPRB protein tyrosine phosphatase, receptor type, B -0.0336829
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0334525
PARD3 par-3 family cell polarity regulator -0.0321136
AKAP13 A kinase (PRKA) anchor protein 13 -0.0318966
ACTN4 actinin, alpha 4 -0.0317678
POTEF POTE ankyrin domain family, member F -0.0314815
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0314713
CUX1 cut-like homeobox 1 -0.0313108
BACE2 beta-site APP-cleaving enzyme 2 -0.0311197
TMSB10 thymosin beta 10 -0.0307771
KDM4C lysine (K)-specific demethylase 4C -0.0306335
FAT1 FAT atypical cadherin 1 -0.0303908
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0301646
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0301332
LMO7 LIM domain 7 -0.0301245
DENND1A DENN/MADD domain containing 1A -0.0300913
MECOM MDS1 and EVI1 complex locus -0.0299093
LSAMP limbic system-associated membrane protein -0.029607
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0295959
MUC17 mucin 17, cell surface associated -0.0293445
TRAPPC9 trafficking protein particle complex 9 -0.029281
FRMD5 FERM domain containing 5 -0.028853
RIN2 Ras and Rab interactor 2 -0.0287723
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.028567
CCDC91 coiled-coil domain containing 91 -0.0285285
EHBP1 EH domain binding protein 1 -0.0282762
CALB1 calbindin 1, 28kDa -0.0280236
GLS2 glutaminase 2 (liver, mitochondrial) -0.0277817
SOX4 SRY (sex determining region Y)-box 4 -0.0276041
MYH14 myosin, heavy chain 14, non-muscle -0.0274381
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0271124
NPAS2 neuronal PAS domain protein 2 -0.0269976
LOC102724023 ES1 protein homolog, mitochondrial -0.0268052
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0266382
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0265004
LIMCH1 LIM and calponin homology domains 1 -0.0263884
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0262875
CMIP c-Maf inducing protein -0.0261547
CNKSR3 CNKSR family member 3 -0.0258351
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0257173
RABGAP1L RAB GTPase activating protein 1-like -0.0256676
FBXO11 F-box protein 11 -0.0255298
ABR active BCR-related -0.0254955
IGF1R insulin-like growth factor 1 receptor -0.0251646
MPRIP myosin phosphatase Rho interacting protein -0.025153
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0251399
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0250863