Rimonabant (Hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANKRD10 ankyrin repeat domain 10 0.0774607
TOP1 topoisomerase (DNA) I 0.0734426
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0593044
PTMA prothymosin, alpha 0.0586396
RNF145 ring finger protein 145 0.0524256
FAM13A family with sequence similarity 13, member A 0.0489021
NAMPT nicotinamide phosphoribosyltransferase 0.0442931
OGA O-GlcNAcase 0.0435262
GRAMD1B GRAM domain containing 1B 0.0427691
PDE4D phosphodiesterase 4D, cAMP-specific 0.0421116
LAMB3 laminin, beta 3 0.0418884
PTPRM protein tyrosine phosphatase, receptor type, M 0.0406474
ARRDC3 arrestin domain containing 3 0.0403897
SMAD3 SMAD family member 3 0.0397169
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0385132
PGK1 phosphoglycerate kinase 1 0.0382136
UVRAG UV radiation resistance associated 0.036797
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0367347
ADAM17 ADAM metallopeptidase domain 17 0.0354729
HELZ helicase with zinc finger 0.0344011
RPL4 ribosomal protein L4 0.0341196
ATP13A3 ATPase type 13A3 0.0338612
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0332132
WDR45B WD repeat domain 45B 0.0322678
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0321376
TPT1 tumor protein, translationally-controlled 1 0.0309133
FNDC3B fibronectin type III domain containing 3B 0.0304561
PUM2 pumilio RNA-binding family member 2 0.0297951
RICTOR RPTOR independent companion of MTOR, complex 2 0.0296606
MYH9 myosin, heavy chain 9, non-muscle 0.0296009
NPAS2 neuronal PAS domain protein 2 0.029498
SDC4 syndecan 4 0.0287435
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0281165
USP9X ubiquitin specific peptidase 9, X-linked 0.0277201
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0275815
ARL8B ADP-ribosylation factor-like 8B 0.0275235
PDE8A phosphodiesterase 8A 0.0272353
CEMIP cell migration inducing protein, hyaluronan binding 0.0267141
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0264143
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0263405
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0261852
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0258712
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0255644
ARGLU1 arginine and glutamate rich 1 0.0252983
GSK3B glycogen synthase kinase 3 beta 0.0250775
SEC61G Sec61 gamma subunit 0.0248567
TMEM165 transmembrane protein 165 0.0247858
NGLY1 N-glycanase 1 0.0245754
PLEC plectin 0.0245326
KDM6A lysine (K)-specific demethylase 6A 0.0243966
NCKAP1 NCK-associated protein 1 0.024355
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0242678
CD163L1 CD163 molecule-like 1 0.0242437
RPS3 ribosomal protein S3 0.0240612
SLMAP sarcolemma associated protein 0.0240498
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0236799
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0235342
CAMTA1 calmodulin binding transcription activator 1 0.0234435
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0234188
AHNAK AHNAK nucleoprotein 0.0233695
WAC WW domain containing adaptor with coiled-coil 0.0232783
BHLHE40 basic helix-loop-helix family, member e40 0.0228718
ZFC3H1 zinc finger, C3H1-type containing 0.0227124
PCBP2 poly(rC) binding protein 2 0.0226369
RPS12 ribosomal protein S12 0.0221127
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0217172
KCMF1 potassium channel modulatory factor 1 0.0215575
RPL37A ribosomal protein L37a 0.021356
USP3 ubiquitin specific peptidase 3 0.0213243
ATG14 autophagy related 14 0.0213102
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0211359
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.0210616
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0210545
UBA6 ubiquitin-like modifier activating enzyme 6 0.0208093
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0207189
UBE2O ubiquitin-conjugating enzyme E2O 0.0206931
NUP58 nucleoporin 58 0.0204479
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0203023
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0201683
NDE1 nudE neurodevelopment protein 1 0.0198907
RPS4X ribosomal protein S4, X-linked 0.0197684
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0196497
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0196244
GLS2 glutaminase 2 (liver, mitochondrial) 0.0193813
RUNX1 runt-related transcription factor 1 0.0192512
TFG TRK-fused gene 0.0191424
WTAP Wilms tumor 1 associated protein 0.0187849
RNF24 ring finger protein 24 0.0187456
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0186911
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0185236
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.0183378
CASC3 cancer susceptibility candidate 3 0.0180523
RNMT RNA (guanine-7-) methyltransferase 0.018024
NPTN neuroplastin 0.0179119
TENT2 terminal nucleotidyltransferase 2 0.0178849
TPD52 tumor protein D52 0.0178623
RPS8 ribosomal protein S8 0.0175782
RAB27B RAB27B, member RAS oncogene family 0.0174392
SQSTM1 sequestosome 1 0.0172882
BCAR3 breast cancer anti-estrogen resistance 3 0.0171536

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.237642
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.171541
EGFR epidermal growth factor receptor -0.167921
NDRG1 N-myc downstream regulated 1 -0.107723
TXNRD1 thioredoxin reductase 1 -0.0900331
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0744612
EGR1 early growth response 1 -0.0740737
FTH1 ferritin, heavy polypeptide 1 -0.0682782
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0524573
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0523393
GOLGB1 golgin B1 -0.046677
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0463894
CAV1 caveolin 1, caveolae protein, 22kDa -0.0457504
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0457237
PKM pyruvate kinase, muscle -0.0426853
LOC112694756 uncharaterized LOC112694756 -0.0411812
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0408849
PDIA3 protein disulfide isomerase family A, member 3 -0.0408416
PATJ PATJ crumbs cell polarity complex component -0.0405414
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0400585
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0391893
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0380974
BLZF1 basic leucine zipper nuclear factor 1 -0.0378407
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0374614
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0373582
JMJD1C jumonji domain containing 1C -0.0359536
CES1 carboxylesterase 1 -0.0359527
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0320769
TES testin LIM domain protein -0.0303172
CAV2 caveolin 2 -0.0295706
NABP1 nucleic acid binding protein 1 -0.0289442
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0283889
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0280618
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0277505
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0270694
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0270561
AKAP9 A kinase (PRKA) anchor protein 9 -0.0270551
HDLBP high density lipoprotein binding protein -0.0259357
IGFBP3 insulin-like growth factor binding protein 3 -0.0256006
ZBTB20 zinc finger and BTB domain containing 20 -0.025231
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0247439
MYO1E myosin IE -0.0242744
EFNA5 ephrin-A5 -0.0241826
OSMR oncostatin M receptor -0.024121
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0238758
MCL1 myeloid cell leukemia 1 -0.0238148
CANX calnexin -0.0233243
RPS2 ribosomal protein S2 -0.0231373
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0222187
SLTM SAFB-like, transcription modulator -0.0216511
AGR2 anterior gradient 2 -0.0216491
FOXP1 forkhead box P1 -0.0212452
GOLGA4 golgin A4 -0.0211061
ARCN1 archain 1 -0.0210604
MACC1 metastasis associated in colon cancer 1 -0.0208374
CST3 cystatin C -0.0208317
MAML3 mastermind-like 3 (Drosophila) -0.0207474
CCND1 cyclin D1 -0.0206633
MORF4L2 mortality factor 4 like 2 -0.0205643
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0205558
MGAT4C MGAT4 family, member C -0.0203995
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0201719
LAMC2 laminin, gamma 2 -0.0200496
HMGA1 high mobility group AT-hook 1 -0.0200198
USP53 ubiquitin specific peptidase 53 -0.0198811
SLC38A2 solute carrier family 38, member 2 -0.0198575
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0197037
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0195731
LPP LIM domain containing preferred translocation partner in lipoma -0.0193396
CCNK cyclin K -0.0191735
STC1 stanniocalcin 1 -0.0191281
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.019039
P4HB prolyl 4-hydroxylase, beta polypeptide -0.019034
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0188453
TMSB10 thymosin beta 10 -0.0188199
BRD2 bromodomain containing 2 -0.0186589
NBEAL1 neurobeachin-like 1 -0.0185066
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0183045
CEP350 centrosomal protein 350kDa -0.018136
EXT1 exostosin glycosyltransferase 1 -0.0178633
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0177241
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.01766
LRP12 low density lipoprotein receptor-related protein 12 -0.0176131
SEC24D SEC24 family member D -0.0175003
INTS6 integrator complex subunit 6 -0.0174759
EMP1 epithelial membrane protein 1 -0.0173623
RIN2 Ras and Rab interactor 2 -0.0172463
MYO9A myosin IXA -0.0172152
NSUN6 NOP2/Sun domain family, member 6 -0.0171811
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0170857
HM13 histocompatibility (minor) 13 -0.0170249
BPTF bromodomain PHD finger transcription factor -0.0169471
SYAP1 synapse associated protein 1 -0.0166617
VMP1 vacuole membrane protein 1 -0.0165826
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -0.0163181
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0162909
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0161234
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0161169
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0160182
MT2A metallothionein 2A -0.0159372