Rimonabant (Hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.141224
FAM13A family with sequence similarity 13, member A 0.115147
AKAP12 A kinase (PRKA) anchor protein 12 0.0822686
FN1 fibronectin 1 0.0751365
VEGFA vascular endothelial growth factor A 0.070798
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0704327
KDM3A lysine (K)-specific demethylase 3A 0.0677177
CDH13 cadherin 13 0.0636061
BHLHE40 basic helix-loop-helix family, member e40 0.0622287
PTMA prothymosin, alpha 0.0606943
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.057508
UBA6 ubiquitin-like modifier activating enzyme 6 0.0550195
PCBP2 poly(rC) binding protein 2 0.0511073
ESYT2 extended synaptotagmin-like protein 2 0.0506242
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0503047
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0498711
SDK1 sidekick cell adhesion molecule 1 0.0497222
USP3 ubiquitin specific peptidase 3 0.0489922
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0488875
PIAS2 protein inhibitor of activated STAT, 2 0.0469554
MTSS1 metastasis suppressor 1 0.0467734
MEF2A myocyte enhancer factor 2A 0.0440723
WAC WW domain containing adaptor with coiled-coil 0.0429301
NGLY1 N-glycanase 1 0.0428366
GRB10 growth factor receptor-bound protein 10 0.0425019
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0418514
ATP13A3 ATPase type 13A3 0.0413952
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0410832
KTN1 kinectin 1 (kinesin receptor) 0.0407181
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.040208
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0399383
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0396473
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0396218
RNF145 ring finger protein 145 0.0391801
HELZ helicase with zinc finger 0.038999
TNIP1 TNFAIP3 interacting protein 1 0.0382964
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0374108
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0373622
FMNL2 formin-like 2 0.0369955
RIOK3 RIO kinase 3 0.0365742
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0361519
RICTOR RPTOR independent companion of MTOR, complex 2 0.0357875
TMSB4X thymosin beta 4, X-linked 0.0356788
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0354755
PTK2 protein tyrosine kinase 2 0.0346293
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0344748
NAP1L1 nucleosome assembly protein 1-like 1 0.0341765
DLG1 discs, large homolog 1 (Drosophila) 0.0339848
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0336824
ENO1 enolase 1, (alpha) 0.0328538
OTUD7B OTU deubiquitinase 7B 0.0324498
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0321597
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0321306
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0316517
CALR calreticulin 0.0314859
CCNY cyclin Y 0.031232
NAMPT nicotinamide phosphoribosyltransferase 0.0311726
KMT2C lysine (K)-specific methyltransferase 2C 0.0309408
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0303868
INSIG2 insulin induced gene 2 0.0303825
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0300444
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0297761
CHD1L chromodomain helicase DNA binding protein 1-like 0.0293906
PSD3 pleckstrin and Sec7 domain containing 3 0.0289232
OGA O-GlcNAcase 0.0288982
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0287884
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0287328
RPL3 ribosomal protein L3 0.0286231
MACF1 microtubule-actin crosslinking factor 1 0.0280935
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0280377
ANKRD11 ankyrin repeat domain 11 0.0280197
DTNA dystrobrevin, alpha 0.0278181
RAB8B RAB8B, member RAS oncogene family 0.0276203
COL7A1 collagen, type VII, alpha 1 0.0274725
PICALM phosphatidylinositol binding clathrin assembly protein 0.0273802
PGK1 phosphoglycerate kinase 1 0.027271
RAI1 retinoic acid induced 1 0.0272115
TRIO trio Rho guanine nucleotide exchange factor 0.0265963
ZFAND3 zinc finger, AN1-type domain 3 0.0265401
MYH9 myosin, heavy chain 9, non-muscle 0.0263786
NPEPPS aminopeptidase puromycin sensitive 0.0262798
JARID2 jumonji, AT rich interactive domain 2 0.0261642
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0260398
EEF2 eukaryotic translation elongation factor 2 0.0257263
KCMF1 potassium channel modulatory factor 1 0.0257196
PRELID2 PRELI domain containing 2 0.0257163
CTNNBL1 catenin, beta like 1 0.0257072
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.025608
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0255326
LRRC8C leucine rich repeat containing 8 family, member C 0.0253944
OXR1 oxidation resistance 1 0.025278
TFPI2 tissue factor pathway inhibitor 2 0.0250486
AMPD3 adenosine monophosphate deaminase 3 0.0246499
MARCHF6 membrane associated ring-CH-type finger 6 0.0245719
TIMP1 TIMP metallopeptidase inhibitor 1 0.0245664
PDIA6 protein disulfide isomerase family A, member 6 0.0241592
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0241311
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0239419
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0236642
SLMAP sarcolemma associated protein 0.0236473

decreased expression

Symbol Name Standardized Value
CD44 CD44 molecule (Indian blood group) -0.222277
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157647
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.139336
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.126224
FNDC3B fibronectin type III domain containing 3B -0.117817
OSMR oncostatin M receptor -0.111621
NCOA7 nuclear receptor coactivator 7 -0.0959075
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0930886
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0929319
LOX lysyl oxidase -0.0790859
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0747744
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0747309
GLCCI1 glucocorticoid induced 1 -0.0717082
TNNC1 troponin C type 1 (slow) -0.0646211
KYNU kynureninase -0.063898
EGR1 early growth response 1 -0.0615635
NTN4 netrin 4 -0.0594399
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0565894
EGFR epidermal growth factor receptor -0.0557031
RAD51B RAD51 paralog B -0.0526336
SEC31A SEC31 homolog A (S. cerevisiae) -0.0519857
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0512852
NPC1 Niemann-Pick disease, type C1 -0.0503461
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0500912
RBM39 RNA binding motif protein 39 -0.0495399
VMP1 vacuole membrane protein 1 -0.0488361
ANKRD28 ankyrin repeat domain 28 -0.0488287
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0485245
BPTF bromodomain PHD finger transcription factor -0.0483147
VCL vinculin -0.047199
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0453718
IL1R1 interleukin 1 receptor, type I -0.0453268
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0453219
AKAP9 A kinase (PRKA) anchor protein 9 -0.0448237
ZBTB20 zinc finger and BTB domain containing 20 -0.0443933
KSR1 kinase suppressor of ras 1 -0.0440479
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0434549
EFNA5 ephrin-A5 -0.0427209
BLZF1 basic leucine zipper nuclear factor 1 -0.0426819
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.041658
EXT1 exostosin glycosyltransferase 1 -0.0411448
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0407465
ANKRD17 ankyrin repeat domain 17 -0.0399512
SYAP1 synapse associated protein 1 -0.0393103
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0387793
PDE4D phosphodiesterase 4D, cAMP-specific -0.0387786
ZC3H12C zinc finger CCCH-type containing 12C -0.0379245
MON2 MON2 homolog (S. cerevisiae) -0.0378404
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0376504
GPATCH2L G patch domain containing 2-like -0.0375678
RNF24 ring finger protein 24 -0.0362997
HEG1 heart development protein with EGF-like domains 1 -0.0355941
EHBP1 EH domain binding protein 1 -0.0355399
HM13 histocompatibility (minor) 13 -0.0348937
ZBTB38 zinc finger and BTB domain containing 38 -0.0346686
GLIPR1 GLI pathogenesis-related 1 -0.0341967
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0341768
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0338187
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0330163
FRMD4A FERM domain containing 4A -0.0328644
ARF4 ADP-ribosylation factor 4 -0.0322181
TGM2 transglutaminase 2 -0.0311817
CALU calumenin -0.0303136
MORF4L2 mortality factor 4 like 2 -0.0302022
YME1L1 YME1-like 1 ATPase -0.0301404
TMEM263 transmembrane protein 263 -0.0298867
RAP1B RAP1B, member of RAS oncogene family -0.0295681
DOCK4 dedicator of cytokinesis 4 -0.0295584
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0294957
NABP1 nucleic acid binding protein 1 -0.0292441
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0292247
KLF6 Kruppel-like factor 6 -0.0273973
MT2A metallothionein 2A -0.0271743
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0270724
KIAA1328 KIAA1328 -0.0267349
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0266408
LMAN1 lectin, mannose-binding, 1 -0.0264896
RAB5A RAB5A, member RAS oncogene family -0.0258821
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0258039
SEC24D SEC24 family member D -0.0256507
ARHGAP5 Rho GTPase activating protein 5 -0.0255001
IGFBP3 insulin-like growth factor binding protein 3 -0.0252796
HDLBP high density lipoprotein binding protein -0.0252427
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0252321
RAB1A RAB1A, member RAS oncogene family -0.0250676
MEIS1 Meis homeobox 1 -0.0250208
PRKCSH protein kinase C substrate 80K-H -0.0248312
SCFD1 sec1 family domain containing 1 -0.0241449
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.023939
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0238143
GOLGA4 golgin A4 -0.0236961
AADAC arylacetamide deacetylase -0.0236111
COPB1 coatomer protein complex, subunit beta 1 -0.0235829
MYO1E myosin IE -0.0235807
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0234263
RAB7A RAB7A, member RAS oncogene family -0.0232802
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0228997
GOLGA3 golgin A3 -0.0228467
GOLGB1 golgin B1 -0.0226778
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0226618