Rimonabant (Hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0835834
PARD3 par-3 family cell polarity regulator 0.0588153
TPM3 tropomyosin 3 0.0545218
ACTG1 actin gamma 1 0.0447727
SDC4 syndecan 4 0.0403049
FMNL2 formin-like 2 0.0387922
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0386107
DOCK4 dedicator of cytokinesis 4 0.0381214
CCNL1 cyclin L1 0.037852
WDR43 WD repeat domain 43 0.0370324
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0348382
PTK2 protein tyrosine kinase 2 0.0347465
USP3 ubiquitin specific peptidase 3 0.0311128
APP amyloid beta (A4) precursor protein 0.0310356
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0310355
DENND4A DENN/MADD domain containing 4A 0.0296556
ANKRD11 ankyrin repeat domain 11 0.0288857
MACF1 microtubule-actin crosslinking factor 1 0.0281327
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0273004
PCBP2 poly(rC) binding protein 2 0.0272342
LPP LIM domain containing preferred translocation partner in lipoma 0.0272187
FNDC3B fibronectin type III domain containing 3B 0.0266709
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0258497
ELL2 elongation factor, RNA polymerase II, 2 0.0256978
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0256879
ZFAND3 zinc finger, AN1-type domain 3 0.0249224
FAM168A family with sequence similarity 168, member A 0.024693
UGCG UDP-glucose ceramide glucosyltransferase 0.023887
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0231078
ADAM9 ADAM metallopeptidase domain 9 0.023058
MTMR3 myotubularin related protein 3 0.023028
IGFBP3 insulin-like growth factor binding protein 3 0.0222289
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0218283
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0215534
ERBIN erbb2 interacting protein 0.0214374
PAWR PRKC, apoptosis, WT1, regulator 0.0210405
COPA coatomer protein complex, subunit alpha 0.0209688
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0207582
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0207514
CYTH1 cytohesin 1 0.0203165
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0202554
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0199247
ADAM17 ADAM metallopeptidase domain 17 0.0199121
NUP58 nucleoporin 58 0.0198824
FXR1 fragile X mental retardation, autosomal homolog 1 0.0197845
SAMD4A sterile alpha motif domain containing 4A 0.0195573
RBM39 RNA binding motif protein 39 0.0194905
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0194811
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0193201
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0191469
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0190588
THBS1 thrombospondin 1 0.0188235
SMOC1 SPARC related modular calcium binding 1 0.0186881
FNBP1L formin binding protein 1-like 0.0186703
TPD52 tumor protein D52 0.0184579
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0184426
IST1 increased sodium tolerance 1 homolog (yeast) 0.0184063
WAC WW domain containing adaptor with coiled-coil 0.0183382
GLS2 glutaminase 2 (liver, mitochondrial) 0.018257
SPAG9 sperm associated antigen 9 0.0180565
PTPRJ protein tyrosine phosphatase, receptor type, J 0.018001
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0177608
TRIO trio Rho guanine nucleotide exchange factor 0.0177282
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0177238
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0176765
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0175991
TFG TRK-fused gene 0.0175782
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0174344
CDC73 cell division cycle 73 0.0173936
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0171212
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0170521
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0170176
PLS3 plastin 3 0.0169019
ECT2 epithelial cell transforming 2 0.0168373
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0166793
KMT2E lysine (K)-specific methyltransferase 2E 0.0165997
RBM33 RNA binding motif protein 33 0.0165996
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0163882
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0162469
PDLIM5 PDZ and LIM domain 5 0.0161828
PUM1 pumilio RNA-binding family member 1 0.0160733
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0159791
ELOVL5 ELOVL fatty acid elongase 5 0.0158769
PUM2 pumilio RNA-binding family member 2 0.0158223
TRA2A transformer 2 alpha homolog (Drosophila) 0.0157206
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.015685
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0154514
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0154383
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0153656
PYGL phosphorylase, glycogen, liver 0.0153519
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0152681
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0152589
KTN1 kinectin 1 (kinesin receptor) 0.0152283
MRTFA myocardin related transcription factor A 0.0151834
MSN moesin 0.0150409
MORF4L1 mortality factor 4 like 1 0.0148194
JAK1 Janus kinase 1 0.014545
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0145255
THSD4 thrombospondin, type I, domain containing 4 0.0145007
RRM2 ribonucleotide reductase M2 0.0145007

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.416832
TMSB10 thymosin beta 10 -0.305823
FTL ferritin, light polypeptide -0.286721
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.212863
VIM vimentin -0.200694
RPL23 ribosomal protein L23 -0.102345
RPLP1 ribosomal protein, large, P1 -0.101617
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0998234
TM4SF1 transmembrane 4 L six family member 1 -0.0897148
FTH1 ferritin, heavy polypeptide 1 -0.0859871
EIF1 eukaryotic translation initiation factor 1 -0.0830624
RPS27A ribosomal protein S27a -0.0758262
RPL19 ribosomal protein L19 -0.0725466
RPS19 ribosomal protein S19 -0.062871
RPL31 ribosomal protein L31 -0.060006
IER3 immediate early response 3 -0.0595403
RPS29 ribosomal protein S29 -0.0586881
PTMA prothymosin, alpha -0.0561609
RPS21 ribosomal protein S21 -0.0552722
RPS8 ribosomal protein S8 -0.0538343
RPL36 ribosomal protein L36 -0.0535217
TPT1 tumor protein, translationally-controlled 1 -0.0522594
TXNRD1 thioredoxin reductase 1 -0.0492208
TFPI2 tissue factor pathway inhibitor 2 -0.0479904
RPS23 ribosomal protein S23 -0.0471707
RPL37A ribosomal protein L37a -0.0436258
EEF2 eukaryotic translation elongation factor 2 -0.0433058
RPL12 ribosomal protein L12 -0.0409002
RPL8 ribosomal protein L8 -0.0407466
AKAP12 A kinase (PRKA) anchor protein 12 -0.0402763
RACK1 receptor for activated C kinase 1 -0.038968
RPL35A ribosomal protein L35a -0.0388445
RPS5 ribosomal protein S5 -0.0379916
UBC ubiquitin C -0.037896
RPLP0 ribosomal protein, large, P0 -0.0373684
RPS16 ribosomal protein S16 -0.0368006
GRAMD1B GRAM domain containing 1B -0.0366723
RPL11 ribosomal protein L11 -0.0365294
ATP5F1E ATP synthase F1 subunit epsilon -0.0357014
RPL28 ribosomal protein L28 -0.0352756
RPL32 ribosomal protein L32 -0.0350057
PFN1 profilin 1 -0.0349579
RPS24 ribosomal protein S24 -0.0344112
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0336413
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0331639
S100A10 S100 calcium binding protein A10 -0.0329327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0328674
RPS27 ribosomal protein S27 -0.0326089
RPS17 ribosomal protein S17 -0.0324916
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.031669
RPS6 ribosomal protein S6 -0.0316329
RPLP2 ribosomal protein, large, P2 -0.0312416
PM20D1 peptidase M20 domain containing 1 -0.0311731
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0309825
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.03098
SLC38A1 solute carrier family 38, member 1 -0.0309489
RPL37 ribosomal protein L37 -0.0306718
RPS25 ribosomal protein S25 -0.0305627
SERF2 small EDRK-rich factor 2 -0.0304003
PDE4D phosphodiesterase 4D, cAMP-specific -0.0299819
RPL9 ribosomal protein L9 -0.0299646
RPS3 ribosomal protein S3 -0.0299613
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0297686
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0294758
S100A6 S100 calcium binding protein A6 -0.0294031
RPL7 ribosomal protein L7 -0.029401
NNMT nicotinamide N-methyltransferase -0.0289234
SLC38A2 solute carrier family 38, member 2 -0.0289041
RPS15 ribosomal protein S15 -0.0287657
TIMP1 TIMP metallopeptidase inhibitor 1 -0.028581
RPL36AL ribosomal protein L36a-like -0.0284631
RPS12 ribosomal protein S12 -0.0281888
S100A11 S100 calcium binding protein A11 -0.0273162
C15ORF48 chromosome 15 open reading frame 48 -0.0268721
PKM pyruvate kinase, muscle -0.0265889
RPS11 ribosomal protein S11 -0.0264116
ENO1 enolase 1, (alpha) -0.0264108
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0262932
RPL18 ribosomal protein L18 -0.0262671
UBB ubiquitin B -0.0257771
RPL30 ribosomal protein L30 -0.0254495
RPS20 ribosomal protein S20 -0.0253836
AREG amphiregulin -0.025369
RPL34 ribosomal protein L34 -0.0251378
RPS13 ribosomal protein S13 -0.0249197
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0249085
HMGB1 high mobility group box 1 -0.0248852
RPL10A ribosomal protein L10a -0.024437
FGB fibrinogen beta chain -0.0241217
TPI1 triosephosphate isomerase 1 -0.02401
S100A9 S100 calcium binding protein A9 -0.023901
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0238787
GABARAPL2 GABA(A) receptor-associated protein-like 2 -0.0232676
RPL26 ribosomal protein L26 -0.0229871
RPS14 ribosomal protein S14 -0.0229248
LMNA lamin A/C -0.0228105
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0227597
EIF4A1 eukaryotic translation initiation factor 4A1 -0.022258
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0219905
LOC102724023 ES1 protein homolog, mitochondrial -0.0216116