Rimonabant (Hydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.133991
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.117435
TRIO trio Rho guanine nucleotide exchange factor 0.0686053
ASPH aspartate beta-hydroxylase 0.0683633
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0634206
TM4SF1 transmembrane 4 L six family member 1 0.060279
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0579314
PTMA prothymosin, alpha 0.0567609
OGA O-GlcNAcase 0.0559049
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0510035
AGFG1 ArfGAP with FG repeats 1 0.0489949
TPT1 tumor protein, translationally-controlled 1 0.0489238
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0451687
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0451623
KDM3A lysine (K)-specific demethylase 3A 0.044857
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0447263
EFNA5 ephrin-A5 0.0431603
NAP1L1 nucleosome assembly protein 1-like 1 0.0426319
GDA guanine deaminase 0.0417302
PGK1 phosphoglycerate kinase 1 0.0410806
RPL4 ribosomal protein L4 0.0407923
NEK7 NIMA-related kinase 7 0.0397955
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0388325
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0360564
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.035855
SPAG9 sperm associated antigen 9 0.0353507
ZEB2 zinc finger E-box binding homeobox 2 0.035041
PCBP3 poly(rC) binding protein 3 0.0339363
TMSB4X thymosin beta 4, X-linked 0.03316
CANX calnexin 0.0329898
ELL2 elongation factor, RNA polymerase II, 2 0.0325344
ATP13A3 ATPase type 13A3 0.0314209
TNIP1 TNFAIP3 interacting protein 1 0.0314164
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0307694
RBM39 RNA binding motif protein 39 0.0302113
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0292417
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0287213
FAM13A family with sequence similarity 13, member A 0.0286994
TXNRD1 thioredoxin reductase 1 0.0285956
TNPO1 transportin 1 0.0285161
MARCHF6 membrane associated ring-CH-type finger 6 0.027953
PTGR1 prostaglandin reductase 1 0.0277848
USP9X ubiquitin specific peptidase 9, X-linked 0.0273909
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0270252
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0269451
ZFC3H1 zinc finger, C3H1-type containing 0.0267567
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0261359
AHNAK AHNAK nucleoprotein 0.0261075
BRWD3 bromodomain and WD repeat domain containing 3 0.026047
COL5A2 collagen, type V, alpha 2 0.0251563
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0250509
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0250193
SAMD4A sterile alpha motif domain containing 4A 0.024918
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0247325
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0243177
AOPEP aminopeptidase O (putative) 0.0242736
OSMR oncostatin M receptor 0.023732
NCKAP1 NCK-associated protein 1 0.0233575
AFG2A AFG2 AAA ATPase homolog A 0.0231842
HSPA8 heat shock 70kDa protein 8 0.0231645
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0225318
ITPRID2 ITPR interacting domain containing 2 0.0225037
RNF145 ring finger protein 145 0.0224291
NBAS neuroblastoma amplified sequence 0.0224194
UBC ubiquitin C 0.0223899
ESYT2 extended synaptotagmin-like protein 2 0.0221489
CTSL cathepsin L 0.0220677
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0220411
MATR3 matrin 3 0.0219879
APP amyloid beta (A4) precursor protein 0.0219825
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0219093
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0217796
RAI1 retinoic acid induced 1 0.0216947
MXI1 MAX interactor 1, dimerization protein 0.0216002
CXCL5 chemokine (C-X-C motif) ligand 5 0.0215856
USP3 ubiquitin specific peptidase 3 0.0212896
RPL14 ribosomal protein L14 0.0212859
NGLY1 N-glycanase 1 0.0212437
ENAH enabled homolog (Drosophila) 0.0211555
UBAP2L ubiquitin associated protein 2-like 0.0211405
RLIM ring finger protein, LIM domain interacting 0.0210666
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.02106
PRRC2C proline-rich coiled-coil 2C 0.0207954
TM9SF3 transmembrane 9 superfamily member 3 0.0207062
BCAR3 breast cancer anti-estrogen resistance 3 0.0206607
BMERB1 bMERB domain containing 1 0.0205052
ERRFI1 ERBB receptor feedback inhibitor 1 0.0204582
SEPTIN10 septin 10 0.0203738
ZMYND8 zinc finger, MYND-type containing 8 0.0202237
CUL4B cullin 4B 0.0200359
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0200204
NIPBL Nipped-B homolog (Drosophila) 0.0199586
WAC WW domain containing adaptor with coiled-coil 0.0199548
NRCAM neuronal cell adhesion molecule 0.0197955
BZW1 basic leucine zipper and W2 domains 1 0.0197029
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0195689
WDR43 WD repeat domain 43 0.019527
MKI67 marker of proliferation Ki-67 0.0194938
TPD52 tumor protein D52 0.0194825
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0193767

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.233659
PDE4D phosphodiesterase 4D, cAMP-specific -0.162583
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.122222
FN1 fibronectin 1 -0.0885635
VCL vinculin -0.0733728
RPS6 ribosomal protein S6 -0.0680564
COL8A1 collagen, type VIII, alpha 1 -0.067686
DST dystonin -0.0674369
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0668132
MT2A metallothionein 2A -0.0664302
RPL35A ribosomal protein L35a -0.0642671
TMSB10 thymosin beta 10 -0.0636484
PM20D1 peptidase M20 domain containing 1 -0.0619125
ACTG1 actin gamma 1 -0.0619042
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0594113
PRKN parkin RBR E3 ubiquitin protein ligase -0.0589447
FTL ferritin, light polypeptide -0.0569766
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0564118
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0544023
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0523382
IGFBP3 insulin-like growth factor binding protein 3 -0.0515394
SMOC1 SPARC related modular calcium binding 1 -0.0515064
FTH1 ferritin, heavy polypeptide 1 -0.05134
POTEF POTE ankyrin domain family, member F -0.0512611
P3H2 prolyl 3-hydroxylase 2 -0.050244
RPS19 ribosomal protein S19 -0.048318
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0480622
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0478731
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0463284
RPLP1 ribosomal protein, large, P1 -0.0445492
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0431886
PDE10A phosphodiesterase 10A -0.0427121
PTPRM protein tyrosine phosphatase, receptor type, M -0.0412176
AUTS2 autism susceptibility candidate 2 -0.0399102
VIM vimentin -0.0396838
LSAMP limbic system-associated membrane protein -0.0389247
NALF1 NALCN channel auxiliary factor 1 -0.0388304
EGR1 early growth response 1 -0.0388154
LOC112694756 uncharaterized LOC112694756 -0.0384257
BASP1 brain abundant, membrane attached signal protein 1 -0.0380239
NT5C2 5'-nucleotidase, cytosolic II -0.0371558
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0369022
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0368493
NDRG1 N-myc downstream regulated 1 -0.036513
MAML3 mastermind-like 3 (Drosophila) -0.0352249
RPS23 ribosomal protein S23 -0.0347531
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0347162
INTS6 integrator complex subunit 6 -0.0346476
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0345939
PKM pyruvate kinase, muscle -0.0340974
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0328393
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0316501
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0314733
LAMA5 laminin, alpha 5 -0.031451
SMAD2 SMAD family member 2 -0.0313507
RAD51B RAD51 paralog B -0.0310433
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0289644
RPL31 ribosomal protein L31 -0.0283467
EEF2 eukaryotic translation elongation factor 2 -0.0283034
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0282478
PFN1 profilin 1 -0.0281393
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0278959
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0272699
ADGRD1 adhesion G protein-coupled receptor D1 -0.0272065
RPL19 ribosomal protein L19 -0.0271713
PDIA3 protein disulfide isomerase family A, member 3 -0.0270727
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0270046
SLC38A2 solute carrier family 38, member 2 -0.0268751
PSD3 pleckstrin and Sec7 domain containing 3 -0.0266905
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0266012
CADM2 cell adhesion molecule 2 -0.0264529
NCOR2 nuclear receptor corepressor 2 -0.0257974
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0254834
MARCHF1 membrane associated ring-CH-type finger 1 -0.0254755
RPS13 ribosomal protein S13 -0.0250071
PCBP2 poly(rC) binding protein 2 -0.0246745
CTIF CBP80/20-dependent translation initiation factor -0.0246553
SDK1 sidekick cell adhesion molecule 1 -0.0241817
RAB7A RAB7A, member RAS oncogene family -0.0240727
RPL36 ribosomal protein L36 -0.0239076
RPLP0 ribosomal protein, large, P0 -0.0232297
RPL12 ribosomal protein L12 -0.0228507
ENO1 enolase 1, (alpha) -0.0222934
RPS27 ribosomal protein S27 -0.0221237
MAP7 microtubule-associated protein 7 -0.0220421
KRT19 keratin 19, type I -0.0220236
CUX1 cut-like homeobox 1 -0.0219587
XYLT1 xylosyltransferase I -0.0217823
EPHA4 EPH receptor A4 -0.0216826
RPS12 ribosomal protein S12 -0.021469
TOB1 transducer of ERBB2, 1 -0.0213423
AGTPBP1 ATP/GTP binding protein 1 -0.0211628
PCDH15 protocadherin-related 15 -0.0208649
DOCK5 dedicator of cytokinesis 5 -0.0208363
BSG basigin (Ok blood group) -0.020824
RPS14 ribosomal protein S14 -0.0208212
EIF1 eukaryotic translation initiation factor 1 -0.0206685
FNDC3A fibronectin type III domain containing 3A -0.0206622
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0204929
RPL9 ribosomal protein L9 -0.0202719