Rimonabant (Hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

148 genes differentially expressed following the Rimonabant (Hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.184491
VIM vimentin 0.173167
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.169741
PYGL phosphorylase, glycogen, liver 0.136693
COL5A2 collagen, type V, alpha 2 0.134616
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.131735
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.12603
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.11553
KMT2E lysine (K)-specific methyltransferase 2E 0.112953
NLGN1 neuroligin 1 0.110063
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.105146
IGFBP5 insulin-like growth factor binding protein 5 0.10469
EFNA5 ephrin-A5 0.10452
SETD5 SET domain containing 5 0.100474
ASPH aspartate beta-hydroxylase 0.0975425
OGA O-GlcNAcase 0.0943768
EEF2 eukaryotic translation elongation factor 2 0.094053
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0915478
MYOF myoferlin 0.0884233
SLC38A2 solute carrier family 38, member 2 0.0868386
PDE4D phosphodiesterase 4D, cAMP-specific 0.086351
LDHA lactate dehydrogenase A 0.0824785
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0806103
RBM39 RNA binding motif protein 39 0.078433
PSD3 pleckstrin and Sec7 domain containing 3 0.075161
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0729057
BASP1 brain abundant, membrane attached signal protein 1 0.0728899
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0726945
TMSB10 thymosin beta 10 0.0710177
PM20D1 peptidase M20 domain containing 1 0.0642172
NAMPT nicotinamide phosphoribosyltransferase 0.0634023
MXI1 MAX interactor 1, dimerization protein 0.0616381
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0582133
RAB7A RAB7A, member RAS oncogene family 0.0571434
SOD2 superoxide dismutase 2, mitochondrial 0.0570864
PDE8A phosphodiesterase 8A 0.0559593
FLNB filamin B, beta 0.0536789
NUMB numb homolog (Drosophila) 0.0529407
FTL ferritin, light polypeptide 0.0511359
TRIO trio Rho guanine nucleotide exchange factor 0.0508474
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0477471
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0468604
GRB10 growth factor receptor-bound protein 10 0.0464193
HELZ helicase with zinc finger 0.0451436
HOOK2 hook microtubule-tethering protein 2 0.0384795
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0381859
DSCAM Down syndrome cell adhesion molecule 0.0360424
RACK1 receptor for activated C kinase 1 0.033877
STC1 stanniocalcin 1 0.0338265
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0310335
TBC1D22A TBC1 domain family, member 22A 0.0304818
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0300533
GOLGA4 golgin A4 0.0295285
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0288345
AVL9 AVL9 homolog (S. cerevisiase) 0.0265219
EGFR epidermal growth factor receptor 0.0243574
HDLBP high density lipoprotein binding protein 0.0237028
GLG1 golgi glycoprotein 1 0.0212873
ELL2 elongation factor, RNA polymerase II, 2 0.0210848
CAMTA1 calmodulin binding transcription activator 1 0.0182039
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0169601
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0162594
TXNRD1 thioredoxin reductase 1 0.0144001
GCLC glutamate-cysteine ligase, catalytic subunit 0.0143833
FBXO42 F-box protein 42 0.0133155
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0116314
MYO1E myosin IE 0.0108755
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0095821
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00860848
KDM6A lysine (K)-specific demethylase 6A 0.00715264
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0070441
ARGLU1 arginine and glutamate rich 1 0.00676764
SPAG9 sperm associated antigen 9 0.00662538
OXSR1 oxidative stress responsive 1 0.00339058
RPS6 ribosomal protein S6 6.47044E-4

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.155218
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.144496
RBM25 RNA binding motif protein 25 -0.137375
ITGA6 integrin, alpha 6 -0.132634
RPLP1 ribosomal protein, large, P1 -0.132077
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.120393
SNX9 sorting nexin 9 -0.113141
HMGA2 high mobility group AT-hook 2 -0.112989
LAMA4 laminin, alpha 4 -0.111222
ZBTB20 zinc finger and BTB domain containing 20 -0.108598
ATP11A ATPase, class VI, type 11A -0.105403
PEG10 paternally expressed 10 -0.104267
NAV2 neuron navigator 2 -0.102589
EIF1 eukaryotic translation initiation factor 1 -0.0991496
LMO7 LIM domain 7 -0.0958109
PTMA prothymosin, alpha -0.0941687
RPS8 ribosomal protein S8 -0.0931808
GMDS GDP-mannose 4,6-dehydratase -0.0884165
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0875143
SRRM2 serine/arginine repetitive matrix 2 -0.0867476
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0866832
RPL26 ribosomal protein L26 -0.084909
JMJD1C jumonji domain containing 1C -0.0787742
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0769422
FNDC3A fibronectin type III domain containing 3A -0.0761604
GOLGB1 golgin B1 -0.0739983
BBX bobby sox homolog (Drosophila) -0.0722508
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0707882
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0699575
EXT1 exostosin glycosyltransferase 1 -0.068989
ANKRD17 ankyrin repeat domain 17 -0.0687638
ARRDC3 arrestin domain containing 3 -0.06834
CXCL8 chemokine (C-X-C motif) ligand 8 -0.06642
WASF2 WAS protein family, member 2 -0.0651053
STAG2 stromal antigen 2 -0.0648848
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0638554
NALF1 NALCN channel auxiliary factor 1 -0.0598197
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.059683
ANXA2 annexin A2 -0.0572116
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0555457
NKD1 naked cuticle homolog 1 (Drosophila) -0.0542779
MAML2 mastermind-like 2 (Drosophila) -0.0540558
PTK2 protein tyrosine kinase 2 -0.0520318
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0511836
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0501961
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0492998
ATXN1 ataxin 1 -0.0489204
EZR ezrin -0.0462725
ERBIN erbb2 interacting protein -0.0449452
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0435411
FNDC3B fibronectin type III domain containing 3B -0.0423138
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0415164
NDRG1 N-myc downstream regulated 1 -0.0402167
CEMIP cell migration inducing protein, hyaluronan binding -0.0380975
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0361112
MAP4 microtubule-associated protein 4 -0.0336137
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0286445
PRKCA protein kinase C, alpha -0.028155
CARD16 caspase recruitment domain family, member 16 -0.0281322
PDE10A phosphodiesterase 10A -0.0269262
MACF1 microtubule-actin crosslinking factor 1 -0.023557
USP9X ubiquitin specific peptidase 9, X-linked -0.0224538
PGK1 phosphoglycerate kinase 1 -0.0186767
RPLP2 ribosomal protein, large, P2 -0.0175469
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0172192
EPN2 epsin 2 -0.0152135
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0148212
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0136424
FTH1 ferritin, heavy polypeptide 1 -0.00997799
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.00934708
FN1 fibronectin 1 -0.00921933
BIRC6 baculoviral IAP repeat containing 6 -0.00603368
DST dystonin -0.00397313