Rimonabant (Hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.101719
PTMA prothymosin, alpha 0.0699733
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.068463
ZNF292 zinc finger protein 292 0.0531405
OGA O-GlcNAcase 0.0515162
SEPTIN9 septin 9 0.0505192
MYH9 myosin, heavy chain 9, non-muscle 0.048238
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0475599
FBL fibrillarin 0.0463353
FMNL2 formin-like 2 0.0422435
SMAD3 SMAD family member 3 0.0416467
ATP13A3 ATPase type 13A3 0.0406425
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0385505
ANLN anillin, actin binding protein 0.03764
AFAP1 actin filament associated protein 1 0.0363298
SPAG9 sperm associated antigen 9 0.0356901
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0348606
MATR3 matrin 3 0.0345719
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0334598
ADAM17 ADAM metallopeptidase domain 17 0.0327006
XPO1 exportin 1 0.0325616
ARRDC3 arrestin domain containing 3 0.032069
GOLGA4 golgin A4 0.0317882
TPM3 tropomyosin 3 0.0311946
USP3 ubiquitin specific peptidase 3 0.030163
DDIT4 DNA-damage-inducible transcript 4 0.0300341
ESYT2 extended synaptotagmin-like protein 2 0.029923
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0288919
CDK19 cyclin-dependent kinase 19 0.0287509
NAP1L1 nucleosome assembly protein 1-like 1 0.0286212
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0282391
KTN1 kinectin 1 (kinesin receptor) 0.0280865
UBA2 ubiquitin-like modifier activating enzyme 2 0.028014
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0274699
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0270361
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0268921
SUCO SUN domain containing ossification factor 0.0267923
RNF145 ring finger protein 145 0.0267675
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.026681
VEGFA vascular endothelial growth factor A 0.0266016
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.0265653
YAP1 Yes-associated protein 1 0.0265116
PCBP2 poly(rC) binding protein 2 0.0263419
BIRC2 baculoviral IAP repeat containing 2 0.0261156
CCNL1 cyclin L1 0.0253849
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0252691
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0248415
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0236411
UBA6 ubiquitin-like modifier activating enzyme 6 0.0234299
NUP58 nucleoporin 58 0.0227993
TNIP1 TNFAIP3 interacting protein 1 0.0226821
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0224895
KDM2A lysine (K)-specific demethylase 2A 0.0224176
PNISR PNN-interacting serine/arginine-rich protein 0.0223613
KMT2E lysine (K)-specific methyltransferase 2E 0.0222218
EIF4B eukaryotic translation initiation factor 4B 0.0220957
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0219855
SET SET nuclear proto-oncogene 0.021638
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0215878
FOSL1 FOS-like antigen 1 0.0215262
FXR1 fragile X mental retardation, autosomal homolog 1 0.0214687
YEATS2 YEATS domain containing 2 0.0213547
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0213448
CHD1 chromodomain helicase DNA binding protein 1 0.0212118
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0211806
CKAP5 cytoskeleton associated protein 5 0.0211542
SNX14 sorting nexin 14 0.0209872
MED13L mediator complex subunit 13-like 0.0207611
USP24 ubiquitin specific peptidase 24 0.0207458
RAB6A RAB6A, member RAS oncogene family 0.0205531
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0205179
PUM2 pumilio RNA-binding family member 2 0.0204065
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0202978
KDM6A lysine (K)-specific demethylase 6A 0.0202833
RPL3 ribosomal protein L3 0.0202522
NAP1L4 nucleosome assembly protein 1-like 4 0.0201772
MSN moesin 0.0201121
UGCG UDP-glucose ceramide glucosyltransferase 0.0200808
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0200157
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0198185
CTBP2 C-terminal binding protein 2 0.0197532
ZCCHC7 zinc finger, CCHC domain containing 7 0.0197388
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0195974
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.019594
HPCAL1 hippocalcin-like 1 0.0192447
BIRC6 baculoviral IAP repeat containing 6 0.0191971
UBE2O ubiquitin-conjugating enzyme E2O 0.0191447
CASC3 cancer susceptibility candidate 3 0.0190513
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0188756
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0188494
TNRC6A trinucleotide repeat containing 6A 0.0188264
NAV2 neuron navigator 2 0.0187872
NUP153 nucleoporin 153kDa 0.0187653
FAR1 fatty acyl CoA reductase 1 0.0186631
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0185443
PDE8A phosphodiesterase 8A 0.0185391
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0185284
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0184278
NOP58 NOP58 ribonucleoprotein 0.018391
HELZ helicase with zinc finger 0.0181879

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.320494
VIM vimentin -0.265563
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.228695
RPS16 ribosomal protein S16 -0.120609
TMSB10 thymosin beta 10 -0.0875593
EGR1 early growth response 1 -0.0843848
TM4SF1 transmembrane 4 L six family member 1 -0.0829575
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0700067
LOC112694756 uncharaterized LOC112694756 -0.0675958
THSD4 thrombospondin, type I, domain containing 4 -0.0623932
MYO1E myosin IE -0.0600836
EXT1 exostosin glycosyltransferase 1 -0.059263
AKAP12 A kinase (PRKA) anchor protein 12 -0.0586393
CD44 CD44 molecule (Indian blood group) -0.0578644
CARD18 caspase recruitment domain family, member 18 -0.0566115
AHNAK AHNAK nucleoprotein -0.0550053
ACTN4 actinin, alpha 4 -0.0536274
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0532607
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0528216
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0520675
INTS6 integrator complex subunit 6 -0.0505307
SLC35F3 solute carrier family 35, member F3 -0.0499637
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0479939
MAP1B microtubule-associated protein 1B -0.0473286
SAMD4B sterile alpha motif domain containing 4B -0.0471876
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0468142
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0455771
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0453172
EGFR epidermal growth factor receptor -0.0437009
RAB7A RAB7A, member RAS oncogene family -0.0435522
UBC ubiquitin C -0.0434395
ZNF780B zinc finger protein 780B -0.0433814
HMGA2 high mobility group AT-hook 2 -0.0429607
MED29 mediator complex subunit 29 -0.0417785
OSMR oncostatin M receptor -0.0409975
ZBTB20 zinc finger and BTB domain containing 20 -0.0406168
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0405672
RPS24 ribosomal protein S24 -0.0404596
NUP98 nucleoporin 98kDa -0.0400658
NF1 neurofibromin 1 -0.0398565
FHL2 four and a half LIM domains 2 -0.0396649
MSRB3 methionine sulfoxide reductase B3 -0.0395181
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0391014
ZNF644 zinc finger protein 644 -0.0387154
MCL1 myeloid cell leukemia 1 -0.0380886
TPM1 tropomyosin 1 (alpha) -0.0371053
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0361896
EHBP1 EH domain binding protein 1 -0.0355257
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0353931
RPL35A ribosomal protein L35a -0.0344285
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.034248
BMAL2 basic helix-loop-helix ARNT like 2 -0.0341848
SPRED2 sprouty-related, EVH1 domain containing 2 -0.034137
CTSD cathepsin D -0.0339689
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0336058
RASAL2 RAS protein activator like 2 -0.033386
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0333232
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0328334
ASPH aspartate beta-hydroxylase -0.0324538
PHF14 PHD finger protein 14 -0.0319644
IARS1 isoleucyl-tRNA synthetase 1 -0.0316271
HDAC9 histone deacetylase 9 -0.0315461
FTL ferritin, light polypeptide -0.0313814
ATG7 autophagy related 7 -0.0311896
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0309683
ELL2 elongation factor, RNA polymerase II, 2 -0.0309179
ATM ATM serine/threonine kinase -0.030464
RSU1 Ras suppressor protein 1 -0.0304095
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0299826
LOC102724023 ES1 protein homolog, mitochondrial -0.0296851
EIF1 eukaryotic translation initiation factor 1 -0.0287945
AHNAK2 AHNAK nucleoprotein 2 -0.0283756
EPAS1 endothelial PAS domain protein 1 -0.028195
SLC38A2 solute carrier family 38, member 2 -0.0280724
LPP LIM domain containing preferred translocation partner in lipoma -0.0275471
DST dystonin -0.0269367
NPAS2 neuronal PAS domain protein 2 -0.0269238
CD59 CD59 molecule, complement regulatory protein -0.0267828
MORF4L2 mortality factor 4 like 2 -0.0266645
ATF6 activating transcription factor 6 -0.0266502
SMYD3 SET and MYND domain containing 3 -0.0266187
ZNF407 zinc finger protein 407 -0.0264981
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0264795
TCF12 transcription factor 12 -0.0264266
JUN jun proto-oncogene -0.0263171
CDK13 cyclin-dependent kinase 13 -0.0261199
CARS1 cysteinyl-tRNA synthetase 1 -0.02603
ZNF546 zinc finger protein 546 -0.0260234
PDLIM5 PDZ and LIM domain 5 -0.0259408
GOLGB1 golgin B1 -0.025033
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0250261
MCTP1 multiple C2 domains, transmembrane 1 -0.0249919
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0249766
NABP1 nucleic acid binding protein 1 -0.0249135
NCOA7 nuclear receptor coactivator 7 -0.0248667
UBAP2 ubiquitin associated protein 2 -0.0244557
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0243947
DOCK1 dedicator of cytokinesis 1 -0.024255
NCEH1 neutral cholesterol ester hydrolase 1 -0.0241713
RPLP1 ribosomal protein, large, P1 -0.0241057