Rimonabant (Hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.122023
MACF1 microtubule-actin crosslinking factor 1 0.0812904
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0788937
NRIP1 nuclear receptor interacting protein 1 0.0732977
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0728646
DSCAM Down syndrome cell adhesion molecule 0.0686804
MYO6 myosin VI 0.0656773
FAM3C family with sequence similarity 3, member C 0.0645597
CCNL1 cyclin L1 0.0573354
PCBP2 poly(rC) binding protein 2 0.0554212
FNDC3B fibronectin type III domain containing 3B 0.0530121
MYH9 myosin, heavy chain 9, non-muscle 0.0518766
SDC4 syndecan 4 0.0511741
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0504115
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.050226
UGCG UDP-glucose ceramide glucosyltransferase 0.0501341
PICALM phosphatidylinositol binding clathrin assembly protein 0.0500725
NAV2 neuron navigator 2 0.0494733
OGA O-GlcNAcase 0.0489047
RTN4 reticulon 4 0.0485744
ARRDC3 arrestin domain containing 3 0.0474237
CTNND1 catenin (cadherin-associated protein), delta 1 0.047084
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0469642
ZFAND3 zinc finger, AN1-type domain 3 0.0466399
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0466287
VEGFA vascular endothelial growth factor A 0.0464716
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0454036
PLAT plasminogen activator, tissue 0.0450929
GOLGA4 golgin A4 0.0443613
XPO1 exportin 1 0.0443267
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0437838
UBA6 ubiquitin-like modifier activating enzyme 6 0.0426046
TNIP1 TNFAIP3 interacting protein 1 0.0417978
TMF1 TATA element modulatory factor 1 0.0415951
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.041512
TRIO trio Rho guanine nucleotide exchange factor 0.0409872
UBE2H ubiquitin-conjugating enzyme E2H 0.0409617
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0407868
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.040225
ATP13A3 ATPase type 13A3 0.0390644
AHNAK AHNAK nucleoprotein 0.0388889
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0376941
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0363595
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0362696
TPM3 tropomyosin 3 0.0361076
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0360266
KRT8 keratin 8, type II 0.035694
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0356311
ARHGAP26 Rho GTPase activating protein 26 0.0351886
BCAR3 breast cancer anti-estrogen resistance 3 0.0350345
LAMC2 laminin, gamma 2 0.0342239
CCNY cyclin Y 0.0340573
AFAP1 actin filament associated protein 1 0.0337854
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0335169
FOSL1 FOS-like antigen 1 0.0327467
SMAD3 SMAD family member 3 0.0320647
TGM2 transglutaminase 2 0.031645
PRRC2C proline-rich coiled-coil 2C 0.0315231
CD47 CD47 molecule 0.0313814
ITCH itchy E3 ubiquitin protein ligase 0.0307858
ZNF148 zinc finger protein 148 0.0306938
CDCP1 CUB domain containing protein 1 0.0305399
KDM6A lysine (K)-specific demethylase 6A 0.0305252
MBNL2 muscleblind-like splicing regulator 2 0.0304778
SET SET nuclear proto-oncogene 0.0304563
DIAPH1 diaphanous-related formin 1 0.0304362
ARGLU1 arginine and glutamate rich 1 0.0300168
ADAM9 ADAM metallopeptidase domain 9 0.0293544
ADAM17 ADAM metallopeptidase domain 17 0.0292551
FLNB filamin B, beta 0.028828
PNN pinin, desmosome associated protein 0.028795
AFDN afadin, adherens junction formation factor 0.0286897
SEC23A Sec23 homolog A (S. cerevisiae) 0.0286659
ARHGAP29 Rho GTPase activating protein 29 0.0286259
C3 complement component 3 0.0284154
PDE8A phosphodiesterase 8A 0.0281759
TFG TRK-fused gene 0.0278682
RASA2 RAS p21 protein activator 2 0.0278168
STK24 serine/threonine kinase 24 0.0278044
SLMAP sarcolemma associated protein 0.027668
NCKAP1 NCK-associated protein 1 0.0276032
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0275718
YTHDC1 YTH domain containing 1 0.0275612
ANKRD11 ankyrin repeat domain 11 0.0274047
TSC22D2 TSC22 domain family, member 2 0.0272542
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.027163
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0270407
EIF4B eukaryotic translation initiation factor 4B 0.0269817
PTBP3 polypyrimidine tract binding protein 3 0.0267587
ANXA11 annexin A11 0.026503
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.026399
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0263439
RYK receptor-like tyrosine kinase 0.0259944
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0259224
ANO6 anoctamin 6 0.0258563
PTK2 protein tyrosine kinase 2 0.0256206
KTN1 kinectin 1 (kinesin receptor) 0.0255922
KMT2E lysine (K)-specific methyltransferase 2E 0.0255831
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.025431
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0253535

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.359048
TMSB10 thymosin beta 10 -0.140185
KRT19 keratin 19, type I -0.10743
TPT1 tumor protein, translationally-controlled 1 -0.10542
HMGA1 high mobility group AT-hook 1 -0.104292
LMO7 LIM domain 7 -0.100601
LOC102724023 ES1 protein homolog, mitochondrial -0.09744
INTS6 integrator complex subunit 6 -0.0934406
EMP1 epithelial membrane protein 1 -0.0903521
ANXA2 annexin A2 -0.0803026
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0794402
RPL35A ribosomal protein L35a -0.0761127
RPLP1 ribosomal protein, large, P1 -0.0687865
FN1 fibronectin 1 -0.0684962
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.066911
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0585296
FTH1 ferritin, heavy polypeptide 1 -0.0581655
FTL ferritin, light polypeptide -0.0559264
LOC112694756 uncharaterized LOC112694756 -0.053815
SQSTM1 sequestosome 1 -0.0509153
RPS19 ribosomal protein S19 -0.0501039
EIF1 eukaryotic translation initiation factor 1 -0.0468083
RPS6 ribosomal protein S6 -0.046669
RNF213 ring finger protein 213 -0.0457504
PLSCR1 phospholipid scramblase 1 -0.0456134
RPL34 ribosomal protein L34 -0.045126
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0444564
MYO1E myosin IE -0.0432622
SVIL supervillin -0.0428975
TJP1 tight junction protein 1 -0.0428919
TPI1 triosephosphate isomerase 1 -0.0420159
EGR1 early growth response 1 -0.0418966
HLA-B major histocompatibility complex, class I, B -0.0414666
RACK1 receptor for activated C kinase 1 -0.040771
IFITM3 interferon induced transmembrane protein 3 -0.0407547
RPS24 ribosomal protein S24 -0.0407297
MORF4L2 mortality factor 4 like 2 -0.0404295
RAB7A RAB7A, member RAS oncogene family -0.0400012
ZBTB20 zinc finger and BTB domain containing 20 -0.0398466
ARF1 ADP-ribosylation factor 1 -0.0395634
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0394797
H1-0 H1.0 linker histone -0.0387082
IGFBP3 insulin-like growth factor binding protein 3 -0.0383301
GNAS GNAS complex locus -0.0379071
TM4SF1 transmembrane 4 L six family member 1 -0.0375364
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0372739
MT2A metallothionein 2A -0.0365008
GOLGB1 golgin B1 -0.0359329
S100A10 S100 calcium binding protein A10 -0.0357839
ATF3 activating transcription factor 3 -0.0354882
LY6E lymphocyte antigen 6 complex, locus E -0.0354796
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0351438
RPL8 ribosomal protein L8 -0.0343451
LDHA lactate dehydrogenase A -0.0342024
HLA-C major histocompatibility complex, class I, C -0.0338957
CLDN1 claudin 1 -0.033842
RPL12 ribosomal protein L12 -0.033561
SH3KBP1 SH3-domain kinase binding protein 1 -0.032632
SOX4 SRY (sex determining region Y)-box 4 -0.0318151
RPL28 ribosomal protein L28 -0.031638
IFITM1 interferon induced transmembrane protein 1 -0.0314922
HDLBP high density lipoprotein binding protein -0.0308573
SGMS2 sphingomyelin synthase 2 -0.0306684
BLZF1 basic leucine zipper nuclear factor 1 -0.0304993
SP100 SP100 nuclear antigen -0.0304813
MUC16 mucin 16, cell surface associated -0.0300235
ACTG1 actin gamma 1 -0.0298989
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0297446
RPS5 ribosomal protein S5 -0.0296658
RPL31 ribosomal protein L31 -0.0295705
RPS21 ribosomal protein S21 -0.0295421
DSG2 desmoglein 2 -0.0293973
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0293013
IFI27 interferon, alpha-inducible protein 27 -0.0288386
CAV1 caveolin 1, caveolae protein, 22kDa -0.0286245
TLE4 transducin-like enhancer of split 4 -0.0285996
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.028362
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0281848
NCOA7 nuclear receptor coactivator 7 -0.0281296
RIGI RNA sensor RIG-I -0.0279588
HDAC9 histone deacetylase 9 -0.0274921
LRRC23 leucine rich repeat containing 23 -0.0273067
TMEM123 transmembrane protein 123 -0.0272654
F3 coagulation factor III (thromboplastin, tissue factor) -0.0271581
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0271094
TXNIP thioredoxin interacting protein -0.0270811
RPL32 ribosomal protein L32 -0.0269968
KLF5 Kruppel-like factor 5 (intestinal) -0.0269321
C15ORF48 chromosome 15 open reading frame 48 -0.0265771
HLA-E major histocompatibility complex, class I, E -0.0264195
MX2 MX dynamin-like GTPase 2 -0.0264027
RPS15 ribosomal protein S15 -0.0262532
RPL23 ribosomal protein L23 -0.026123
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0259899
TUBB tubulin, beta class I -0.0254721
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0253067
RPS14 ribosomal protein S14 -0.0252514
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0252368
ARHGAP5 Rho GTPase activating protein 5 -0.0252101
VDAC1 voltage-dependent anion channel 1 -0.02508