Rimonabant (Hydrochloride)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.101325
PGK1 phosphoglycerate kinase 1 0.0910514
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0802563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0785928
FAM20C family with sequence similarity 20, member C 0.0785481
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0723953
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.068442
STC1 stanniocalcin 1 0.0651228
NAMPT nicotinamide phosphoribosyltransferase 0.0612375
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0612116
ANKRD11 ankyrin repeat domain 11 0.0604064
ZNF292 zinc finger protein 292 0.0600827
COL7A1 collagen, type VII, alpha 1 0.0594061
AHNAK AHNAK nucleoprotein 0.0588419
DSCAM Down syndrome cell adhesion molecule 0.0550124
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0549317
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0529246
SDC4 syndecan 4 0.0513307
KDM3A lysine (K)-specific demethylase 3A 0.0503676
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0498231
ASPH aspartate beta-hydroxylase 0.0465519
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0464276
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0447403
THBS1 thrombospondin 1 0.0444099
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0444097
HMGB2 high mobility group box 2 0.0432131
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0431618
CENPF centromere protein F, 350/400kDa 0.0429719
NAV2 neuron navigator 2 0.0408985
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0400385
INSIG2 insulin induced gene 2 0.0397223
RPL4 ribosomal protein L4 0.038509
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0382268
PTMA prothymosin, alpha 0.0377925
PTK2 protein tyrosine kinase 2 0.0371974
MKI67 marker of proliferation Ki-67 0.0369342
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.036113
BHLHE40 basic helix-loop-helix family, member e40 0.0357402
AFAP1 actin filament associated protein 1 0.0357336
ANLN anillin, actin binding protein 0.0355858
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0355118
APP amyloid beta (A4) precursor protein 0.0354507
XPO1 exportin 1 0.0352745
ZFAND3 zinc finger, AN1-type domain 3 0.0350859
SMAD3 SMAD family member 3 0.0350132
NPAS2 neuronal PAS domain protein 2 0.0349273
OGA O-GlcNAcase 0.0344375
NCKAP1 NCK-associated protein 1 0.0326308
VEGFA vascular endothelial growth factor A 0.032376
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0311945
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0310871
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0309852
RAD21 RAD21 homolog (S. pombe) 0.0304715
MACF1 microtubule-actin crosslinking factor 1 0.0303457
SPRED1 sprouty-related, EVH1 domain containing 1 0.0302582
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0302277
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0302173
FXR1 fragile X mental retardation, autosomal homolog 1 0.0301766
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0301
ATP13A3 ATPase type 13A3 0.0296789
FLNB filamin B, beta 0.0295584
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0294971
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0294782
WTAP Wilms tumor 1 associated protein 0.0292311
SUCO SUN domain containing ossification factor 0.029119
QKI QKI, KH domain containing, RNA binding 0.0289635
FNDC3B fibronectin type III domain containing 3B 0.0287466
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0282903
CORO1C coronin, actin binding protein, 1C 0.0282355
TPX2 TPX2, microtubule-associated 0.0282345
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0280104
YEATS2 YEATS domain containing 2 0.0279545
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0278797
MORF4L1 mortality factor 4 like 1 0.0277867
FMNL2 formin-like 2 0.0277525
CENPE centromere protein E, 312kDa 0.0276308
SET SET nuclear proto-oncogene 0.0273293
CDK19 cyclin-dependent kinase 19 0.0272588
TPM3 tropomyosin 3 0.0272533
WWTR1 WW domain containing transcription regulator 1 0.0268832
NRIP1 nuclear receptor interacting protein 1 0.0266455
MCTP2 multiple C2 domains, transmembrane 2 0.0266383
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0263798
NAP1L1 nucleosome assembly protein 1-like 1 0.0261763
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0258378
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0256867
CKAP5 cytoskeleton associated protein 5 0.0255065
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0254996
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0253841
AFDN afadin, adherens junction formation factor 0.0252632
TGM2 transglutaminase 2 0.0252547
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0249891
TOP2B topoisomerase (DNA) II beta 180kDa 0.0248967
MAP2K1 mitogen-activated protein kinase kinase 1 0.0242149
RAD23B RAD23 homolog B (S. cerevisiae) 0.0240252
PCBP2 poly(rC) binding protein 2 0.0238501
KMT2E lysine (K)-specific methyltransferase 2E 0.023833
NBAS neuroblastoma amplified sequence 0.0237823
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0236734
APOLD1 apolipoprotein L domain containing 1 0.0233906

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.2444
VIM vimentin -0.196311
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194675
FTL ferritin, light polypeptide -0.164141
NDRG1 N-myc downstream regulated 1 -0.130175
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.126119
EGR1 early growth response 1 -0.095683
B2M beta-2-microglobulin -0.0912013
COL1A2 collagen, type I, alpha 2 -0.0898455
TMSB10 thymosin beta 10 -0.0892908
HLA-B major histocompatibility complex, class I, B -0.089224
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.088575
RAB7A RAB7A, member RAS oncogene family -0.0844635
PDIA3 protein disulfide isomerase family A, member 3 -0.0843321
TGFBI transforming growth factor, beta-induced, 68kDa -0.0721951
IGFBP3 insulin-like growth factor binding protein 3 -0.0698753
CDH13 cadherin 13 -0.0626349
FTH1 ferritin, heavy polypeptide 1 -0.0611195
COL1A1 collagen, type I, alpha 1 -0.0550746
IFI6 interferon, alpha-inducible protein 6 -0.0533979
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0528697
HLA-A major histocompatibility complex, class I, A -0.0497558
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0442357
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0418104
IFITM3 interferon induced transmembrane protein 3 -0.0417003
LOC102724023 ES1 protein homolog, mitochondrial -0.0400455
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0395273
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.039042
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0379881
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0378792
TENT5A terminal nucleotidyltransferase 5A -0.0375875
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0369333
RPLP1 ribosomal protein, large, P1 -0.036336
LOX lysyl oxidase -0.0358861
CADM1 cell adhesion molecule 1 -0.0352951
MMP12 matrix metallopeptidase 12 -0.0342554
PFN1 profilin 1 -0.0338562
FOSL1 FOS-like antigen 1 -0.0333077
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0331626
NRP1 neuropilin 1 -0.0328826
ARL4C ADP-ribosylation factor-like 4C -0.0322457
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0312901
PLIN2 perilipin 2 -0.0298149
GLIS3 GLIS family zinc finger 3 -0.0296867
MT2A metallothionein 2A -0.0296674
EML5 echinoderm microtubule associated protein like 5 -0.029637
ADNP activity-dependent neuroprotector homeobox -0.0296035
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0294774
ADM adrenomedullin -0.0290603
RND3 Rho family GTPase 3 -0.0285948
FRMD4A FERM domain containing 4A -0.0278052
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0273646
CD109 CD109 molecule -0.0271114
IFI16 interferon, gamma-inducible protein 16 -0.0270856
MYO1E myosin IE -0.0267095
EPAS1 endothelial PAS domain protein 1 -0.0266521
RNASEH2A ribonuclease H2, subunit A -0.0263508
VDAC1 voltage-dependent anion channel 1 -0.0263179
CYB5R3 cytochrome b5 reductase 3 -0.0262838
HMGA1 high mobility group AT-hook 1 -0.0262057
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0257995
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0254576
JUN jun proto-oncogene -0.0251635
ANXA5 annexin A5 -0.0251019
LOXL2 lysyl oxidase-like 2 -0.0249772
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0248171
DLG1 discs, large homolog 1 (Drosophila) -0.0247915
HLA-C major histocompatibility complex, class I, C -0.0241435
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0241243
MORF4L2 mortality factor 4 like 2 -0.0240913
SP100 SP100 nuclear antigen -0.0240834
GNAS GNAS complex locus -0.0234761
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0233877
MEF2A myocyte enhancer factor 2A -0.0233505
RPL35A ribosomal protein L35a -0.0231124
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0230208
BTG1 B-cell translocation gene 1, anti-proliferative -0.0228935
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0228375
ECE1 endothelin converting enzyme 1 -0.0224441
COLEC10 collectin sub-family member 10 (C-type lectin) -0.0224219
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0222979
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0222405
SQSTM1 sequestosome 1 -0.0221845
FBXO32 F-box protein 32 -0.0221786
FHIT fragile histidine triad -0.0221132
POTEF POTE ankyrin domain family, member F -0.0220364
BLZF1 basic leucine zipper nuclear factor 1 -0.0220266
MYADM myeloid-associated differentiation marker -0.0219301
CST3 cystatin C -0.0218818
RPS19 ribosomal protein S19 -0.0218056
RALY RALY heterogeneous nuclear ribonucleoprotein -0.021698
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0214215
IFITM1 interferon induced transmembrane protein 1 -0.0211115
F3 coagulation factor III (thromboplastin, tissue factor) -0.0211018
LOC112694756 uncharaterized LOC112694756 -0.0210822
INHBA inhibin, beta A -0.0210794
SLIT2 slit homolog 2 (Drosophila) -0.0209302
CLMP CXADR-like membrane protein -0.0206416
SHISA5 shisa family member 5 -0.0206297
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0205719