Rimonabant (Hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.214199
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.176084
VIM vimentin 0.11684
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0887741
AKAP12 A kinase (PRKA) anchor protein 12 0.0876308
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0776672
RPS3 ribosomal protein S3 0.0760229
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0679303
CANX calnexin 0.0676881
PGK1 phosphoglycerate kinase 1 0.0649585
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0622463
NAMPT nicotinamide phosphoribosyltransferase 0.0600352
PTMA prothymosin, alpha 0.0587377
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0583833
MT2A metallothionein 2A 0.0561516
TM4SF1 transmembrane 4 L six family member 1 0.0522869
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.052249
SLC39A11 solute carrier family 39, member 11 0.0509378
KDM3A lysine (K)-specific demethylase 3A 0.0487779
GARS1 glycyl-tRNA synthetase 1 0.046395
NAP1L1 nucleosome assembly protein 1-like 1 0.0463299
UBC ubiquitin C 0.0459319
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0450065
ELL2 elongation factor, RNA polymerase II, 2 0.0448982
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0448546
HSPA8 heat shock 70kDa protein 8 0.044114
SFTPA2 surfactant protein A2 0.0439107
SPAG9 sperm associated antigen 9 0.0428889
EIF1 eukaryotic translation initiation factor 1 0.0428039
NAV2 neuron navigator 2 0.0423834
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0422255
RPL4 ribosomal protein L4 0.04176
PRRC2C proline-rich coiled-coil 2C 0.0415861
OGA O-GlcNAcase 0.041093
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0408679
PRELID2 PRELI domain containing 2 0.0402063
ANLN anillin, actin binding protein 0.0393322
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0386222
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0383573
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0381559
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0377875
MYH9 myosin, heavy chain 9, non-muscle 0.0371199
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0365076
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0356136
CSDE1 cold shock domain containing E1, RNA-binding 0.034867
ZFAND3 zinc finger, AN1-type domain 3 0.0347737
FMNL2 formin-like 2 0.0346231
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0344579
SUCO SUN domain containing ossification factor 0.034086
LAMP2 lysosomal-associated membrane protein 2 0.0338585
ADAM17 ADAM metallopeptidase domain 17 0.0337368
TXNRD1 thioredoxin reductase 1 0.0335724
MKI67 marker of proliferation Ki-67 0.033475
NCKAP1 NCK-associated protein 1 0.0320901
RNF145 ring finger protein 145 0.0306621
RPS27A ribosomal protein S27a 0.0303433
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.030076
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0299878
POM121 POM121 transmembrane nucleoporin 0.0299447
ANKRD11 ankyrin repeat domain 11 0.0295593
SOD2 superoxide dismutase 2, mitochondrial 0.0295129
TPT1 tumor protein, translationally-controlled 1 0.0289219
AHNAK AHNAK nucleoprotein 0.028642
EGLN1 egl-9 family hypoxia-inducible factor 1 0.028286
RPL3 ribosomal protein L3 0.0282235
SERINC1 serine incorporator 1 0.0281708
RPL14 ribosomal protein L14 0.028073
MSI2 musashi RNA-binding protein 2 0.0279723
ESYT2 extended synaptotagmin-like protein 2 0.0279476
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0274481
MAP2K1 mitogen-activated protein kinase kinase 1 0.0272061
TPM3 tropomyosin 3 0.0271857
TNIP1 TNFAIP3 interacting protein 1 0.0269843
ZNF292 zinc finger protein 292 0.026977
TRIM33 tripartite motif containing 33 0.0269688
IFRD1 interferon-related developmental regulator 1 0.0268697
CEP250 centrosomal protein 250kDa 0.0268573
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0268389
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0267992
ABI1 abl-interactor 1 0.0266719
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.026583
ANXA2 annexin A2 0.0263757
RPL23 ribosomal protein L23 0.0262896
AFF1 AF4/FMR2 family, member 1 0.0262849
HMGB2 high mobility group box 2 0.026216
ATP13A3 ATPase type 13A3 0.0261836
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0261274
TPX2 TPX2, microtubule-associated 0.0259153
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0259088
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.02569
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0254315
HELZ helicase with zinc finger 0.0253694
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0253676
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0253284
CTTN cortactin 0.0252735
SET SET nuclear proto-oncogene 0.0252205
TOP2B topoisomerase (DNA) II beta 180kDa 0.0252141
EIF4H eukaryotic translation initiation factor 4H 0.0252016
CALU calumenin 0.0251278
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0250697

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.167835
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.148762
NRG3 neuregulin 3 -0.1101
LSAMP limbic system-associated membrane protein -0.108034
NLGN1 neuroligin 1 -0.0828932
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0813749
FMN1 formin 1 -0.0772136
POTEF POTE ankyrin domain family, member F -0.0718073
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0666009
RPL35A ribosomal protein L35a -0.0615679
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0614286
LOC112694756 uncharaterized LOC112694756 -0.0535786
RAB7A RAB7A, member RAS oncogene family -0.0516152
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.048
TOB2 transducer of ERBB2, 2 -0.0431401
LINC02798 long intergenic non-protein coding RNA 2798 -0.0419636
AKAP9 A kinase (PRKA) anchor protein 9 -0.0401033
SOX6 SRY (sex determining region Y)-box 6 -0.0366806
DST dystonin -0.0362932
ZCCHC7 zinc finger, CCHC domain containing 7 -0.036004
HMGA1 high mobility group AT-hook 1 -0.0359785
ZBTB20 zinc finger and BTB domain containing 20 -0.0359179
GOLGB1 golgin B1 -0.0357636
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0355707
IGFBP3 insulin-like growth factor binding protein 3 -0.0338156
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0327135
CYB5R3 cytochrome b5 reductase 3 -0.0322796
MACROD2 MACRO domain containing 2 -0.0309629
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0304683
HDAC9 histone deacetylase 9 -0.0289697
MAML3 mastermind-like 3 (Drosophila) -0.0284967
TOR1AIP2 torsin A interacting protein 2 -0.0284858
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0283489
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0278611
ANKRD17 ankyrin repeat domain 17 -0.027721
LPP LIM domain containing preferred translocation partner in lipoma -0.0276413
RAD51B RAD51 paralog B -0.0275348
RUNX1 runt-related transcription factor 1 -0.0274946
BPTF bromodomain PHD finger transcription factor -0.0270322
CDK6 cyclin-dependent kinase 6 -0.0269382
ACTG1 actin gamma 1 -0.0269277
GPHN gephyrin -0.0262148
RNF213 ring finger protein 213 -0.0257048
TAPBP TAP binding protein (tapasin) -0.0250155
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0246933
FRMD4A FERM domain containing 4A -0.0244987
WNT2B wingless-type MMTV integration site family, member 2B -0.0244842
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0244368
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0241296
TAS2R14 taste receptor, type 2, member 14 -0.023955
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0238519
BICD1 bicaudal D homolog 1 (Drosophila) -0.0237255
FRMD5 FERM domain containing 5 -0.0235483
SP100 SP100 nuclear antigen -0.0234267
ERBIN erbb2 interacting protein -0.0232843
WDR27 WD repeat domain 27 -0.0230557
EHBP1 EH domain binding protein 1 -0.0230387
OPHN1 oligophrenin 1 -0.0230208
EXOC4 exocyst complex component 4 -0.0228899
TUT4 terminal uridylyl transferase 4 -0.022668
CUX1 cut-like homeobox 1 -0.022656
PTPRG protein tyrosine phosphatase, receptor type, G -0.0226478
EGR1 early growth response 1 -0.0225879
VDAC1 voltage-dependent anion channel 1 -0.0224879
ZNF644 zinc finger protein 644 -0.0223024
SHISA5 shisa family member 5 -0.0221045
SVIL supervillin -0.0219052
MAML2 mastermind-like 2 (Drosophila) -0.0218553
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0217907
INTS6 integrator complex subunit 6 -0.0217453
HIRA histone cell cycle regulator -0.0217207
ENO2 enolase 2 (gamma, neuronal) -0.0215185
CTSD cathepsin D -0.021494
COMMD10 COMM domain containing 10 -0.0214082
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0212446
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0210769
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0209951
CDK13 cyclin-dependent kinase 13 -0.0209848
NDRG1 N-myc downstream regulated 1 -0.0208105
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0205337
FGGY FGGY carbohydrate kinase domain containing -0.0204032
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -0.0203973
SKIL SKI-like proto-oncogene -0.0202965
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0202025
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0199606
SOX10 SRY (sex determining region Y)-box 10 -0.0197392
CADM1 cell adhesion molecule 1 -0.0197194
RPTOR regulatory associated protein of MTOR, complex 1 -0.0195494
SCFD1 sec1 family domain containing 1 -0.0194842
SOX5 SRY (sex determining region Y)-box 5 -0.0194811
GPATCH2L G patch domain containing 2-like -0.0194758
ENTHD1 ENTH domain containing 1 -0.0194381
KPNB1 karyopherin (importin) beta 1 -0.0193886
PAX3 paired box 3 -0.0193519
KRIT1 KRIT1, ankyrin repeat containing -0.0193501
NKTR natural killer cell triggering receptor -0.0192622
AGO3 argonaute RISC catalytic component 3 -0.0191483
ULK4 unc-51 like kinase 4 -0.0189754
KIF5C kinesin family member 5C -0.0187213
PRKD1 protein kinase D1 -0.0185556