Rimonabant (Hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.1088
TMSB4X thymosin beta 4, X-linked 0.106991
PDE4D phosphodiesterase 4D, cAMP-specific 0.0946658
VCL vinculin 0.0895359
ADAM10 ADAM metallopeptidase domain 10 0.0887414
PRELID2 PRELI domain containing 2 0.0536626
PDGFC platelet derived growth factor C 0.0533035
SMYD3 SET and MYND domain containing 3 0.0527246
TMEM65 transmembrane protein 65 0.0507967
PYGB phosphorylase, glycogen; brain 0.0501825
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.049239
NBEA neurobeachin 0.0482398
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0475605
PDE4B phosphodiesterase 4B, cAMP-specific 0.0465337
FLNB filamin B, beta 0.0432733
ANKRD36 ankyrin repeat domain 36 0.0414571
TGFBR3 transforming growth factor, beta receptor III 0.0412198
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0404513
EFNA5 ephrin-A5 0.0404289
BMP2K BMP2 inducible kinase 0.0363283
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0362506
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0359785
LPP LIM domain containing preferred translocation partner in lipoma 0.0347918
TTC28 tetratricopeptide repeat domain 28 0.0333184
SAMD4A sterile alpha motif domain containing 4A 0.0322605
DSCAM Down syndrome cell adhesion molecule 0.0320626
TJP1 tight junction protein 1 0.0310087
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0308386
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0307336
RPL4 ribosomal protein L4 0.0303869
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.030207
CAMTA1 calmodulin binding transcription activator 1 0.0298755
TBC1D22A TBC1 domain family, member 22A 0.0297473
USP34 ubiquitin specific peptidase 34 0.0295623
RBM26 RNA binding motif protein 26 0.029526
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0292323
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0284872
SOX6 SRY (sex determining region Y)-box 6 0.0282074
LOXL3 lysyl oxidase-like 3 0.0281006
HDAC9 histone deacetylase 9 0.027738
GLI2 GLI family zinc finger 2 0.0274211
RHBDD1 rhomboid domain containing 1 0.0271735
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.026985
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0269543
NCKAP1 NCK-associated protein 1 0.0267838
YEATS2 YEATS domain containing 2 0.0267048
PTPRG protein tyrosine phosphatase, receptor type, G 0.0266077
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0263211
SLC38A2 solute carrier family 38, member 2 0.025965
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0257757
MACF1 microtubule-actin crosslinking factor 1 0.0254937
HSPA8 heat shock 70kDa protein 8 0.0250076
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0247998
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0247369
ZMYM2 zinc finger, MYM-type 2 0.0243533
SBF2 SET binding factor 2 0.0240732
MYO5C myosin VC 0.0240673
ANKRD10 ankyrin repeat domain 10 0.0236348
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0233621
CLIP1 CAP-GLY domain containing linker protein 1 0.0230026
NCEH1 neutral cholesterol ester hydrolase 1 0.0223649
METTL15 methyltransferase like 15 0.0223544
PRPF38B pre-mRNA processing factor 38B 0.0221968
GLS2 glutaminase 2 (liver, mitochondrial) 0.0220573
SRSF1 serine/arginine-rich splicing factor 1 0.0219958
CD47 CD47 molecule 0.0219147
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0217432
CEP192 centrosomal protein 192kDa 0.0214467
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.021335
OSMR oncostatin M receptor 0.0209843
NPAS2 neuronal PAS domain protein 2 0.0208351
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0207042
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0205095
ZNF217 zinc finger protein 217 0.0203903
GSK3B glycogen synthase kinase 3 beta 0.0203737
ZBTB20 zinc finger and BTB domain containing 20 0.0200214
TRIM44 tripartite motif containing 44 0.0198872
APP amyloid beta (A4) precursor protein 0.0196764
DIAPH2 diaphanous-related formin 2 0.0195757
BTBD9 BTB (POZ) domain containing 9 0.0194237
DIDO1 death inducer-obliterator 1 0.0194186
GIGYF2 GRB10 interacting GYF protein 2 0.019367
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0193445
TRIO trio Rho guanine nucleotide exchange factor 0.019061
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0190282
ANK2 ankyrin 2, neuronal 0.0188831
EML4 echinoderm microtubule associated protein like 4 0.0187769
EXT1 exostosin glycosyltransferase 1 0.018567
RAB27B RAB27B, member RAS oncogene family 0.0183559
CTNND1 catenin (cadherin-associated protein), delta 1 0.0182801
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0181223
DENND1A DENN/MADD domain containing 1A 0.0180855
IGF1R insulin-like growth factor 1 receptor 0.018031
EIF4B eukaryotic translation initiation factor 4B 0.0180007
ARB2A ARB2 cotranscriptional regulator A 0.0179403
FER fer (fps/fes related) tyrosine kinase 0.0179342
TXNRD1 thioredoxin reductase 1 0.0179272
CARD16 caspase recruitment domain family, member 16 0.017921
TPD52 tumor protein D52 0.0179188
CEP250 centrosomal protein 250kDa 0.0178956

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.381668
PTMA prothymosin, alpha -0.158655
RPS6 ribosomal protein S6 -0.125521
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0993244
RPL35A ribosomal protein L35a -0.0895137
POTEF POTE ankyrin domain family, member F -0.0830338
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0732964
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0722963
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0694341
LOC112694756 uncharaterized LOC112694756 -0.0606147
PFN1 profilin 1 -0.0582357
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0574043
PKM pyruvate kinase, muscle -0.0555592
HMGA1 high mobility group AT-hook 1 -0.0535019
RPS8 ribosomal protein S8 -0.0529548
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0525574
HSPB1 heat shock 27kDa protein 1 -0.0517515
ENO2 enolase 2 (gamma, neuronal) -0.050225
FTL ferritin, light polypeptide -0.0487249
RPLP0 ribosomal protein, large, P0 -0.0482745
ACTG1 actin gamma 1 -0.0481136
CCND1 cyclin D1 -0.0473856
RPL34 ribosomal protein L34 -0.0459412
EEF2 eukaryotic translation elongation factor 2 -0.0453496
RPLP1 ribosomal protein, large, P1 -0.0444935
PDIA3 protein disulfide isomerase family A, member 3 -0.0438848
MT2A metallothionein 2A -0.0425237
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0415902
B2M beta-2-microglobulin -0.0411784
RPL31 ribosomal protein L31 -0.039598
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0393498
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0388309
LOC102724023 ES1 protein homolog, mitochondrial -0.0384513
RPL8 ribosomal protein L8 -0.0374298
RPS19 ribosomal protein S19 -0.0373356
RHOA ras homolog family member A -0.0373067
RAB7A RAB7A, member RAS oncogene family -0.0366919
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0360571
SSBP2 single-stranded DNA binding protein 2 -0.0352816
RPS2 ribosomal protein S2 -0.0352022
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0346527
KPNB1 karyopherin (importin) beta 1 -0.03455
KMT2E lysine (K)-specific methyltransferase 2E -0.0344973
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0343765
NAMPT nicotinamide phosphoribosyltransferase -0.0337961
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0328229
RACK1 receptor for activated C kinase 1 -0.0325916
RPS23 ribosomal protein S23 -0.0317769
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0317015
RPL28 ribosomal protein L28 -0.0305226
RPS5 ribosomal protein S5 -0.0304405
TXNIP thioredoxin interacting protein -0.0300799
PRDX2 peroxiredoxin 2 -0.0298514
RPL19 ribosomal protein L19 -0.0298266
IARS1 isoleucyl-tRNA synthetase 1 -0.0298237
TPT1 tumor protein, translationally-controlled 1 -0.0297738
RPL11 ribosomal protein L11 -0.0297309
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.028761
RPL36 ribosomal protein L36 -0.0283999
GNAS GNAS complex locus -0.0277055
RPS27 ribosomal protein S27 -0.0275985
BMP10 bone morphogenetic protein 10 -0.0274736
RPL32 ribosomal protein L32 -0.0273103
ENO1 enolase 1, (alpha) -0.0268633
S100A9 S100 calcium binding protein A9 -0.0262848
GARS1 glycyl-tRNA synthetase 1 -0.0259055
RPS13 ribosomal protein S13 -0.0244879
FBXO11 F-box protein 11 -0.0240595
EIF1 eukaryotic translation initiation factor 1 -0.0238321
ZNF207 zinc finger protein 207 -0.023574
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0235205
RPL9 ribosomal protein L9 -0.0234912
RPL12 ribosomal protein L12 -0.0231812
FAM162A family with sequence similarity 162, member A -0.0230564
RPL27A ribosomal protein L27a -0.0229955
S100A6 S100 calcium binding protein A6 -0.0227384
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0225366
IFITM3 interferon induced transmembrane protein 3 -0.0223782
DSTN destrin (actin depolymerizing factor) -0.0221329
RPS14 ribosomal protein S14 -0.0219504
YY1 YY1 transcription factor -0.0214444
LDHB lactate dehydrogenase B -0.0213987
SEPTIN7 septin 7 -0.0211924
RPS25 ribosomal protein S25 -0.0209858
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0208612
VDAC1 voltage-dependent anion channel 1 -0.020652
SOX9 SRY (sex determining region Y)-box 9 -0.0205298
TPM4 tropomyosin 4 -0.0203792
EIF5B eukaryotic translation initiation factor 5B -0.0202117
RPL30 ribosomal protein L30 -0.0201693
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0196053
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0196019
ZC3H15 zinc finger CCCH-type containing 15 -0.0194731
RPL23 ribosomal protein L23 -0.0194711
SMC3 structural maintenance of chromosomes 3 -0.0192867
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0192861
GOLGA4 golgin A4 -0.0191063
RPS20 ribosomal protein S20 -0.0190636
TMSB10 thymosin beta 10 -0.0189361
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0187648