Rimonabant (Hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.152245
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.109528
SOD2 superoxide dismutase 2, mitochondrial 0.0878157
NAMPT nicotinamide phosphoribosyltransferase 0.0795591
FNDC3B fibronectin type III domain containing 3B 0.0726074
NAV2 neuron navigator 2 0.0713644
VEGFA vascular endothelial growth factor A 0.067412
TRIO trio Rho guanine nucleotide exchange factor 0.0667673
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0596165
OGA O-GlcNAcase 0.057078
ARRDC3 arrestin domain containing 3 0.0546419
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0528013
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0518961
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0494714
SDC4 syndecan 4 0.0478727
TNIP1 TNFAIP3 interacting protein 1 0.0468149
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0456612
WTAP Wilms tumor 1 associated protein 0.0445116
USP9X ubiquitin specific peptidase 9, X-linked 0.0413579
ZNF292 zinc finger protein 292 0.0412482
SMAD3 SMAD family member 3 0.0412372
MSN moesin 0.0409179
PDE10A phosphodiesterase 10A 0.0400915
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0387246
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0382715
PCBP2 poly(rC) binding protein 2 0.0377053
UBA6 ubiquitin-like modifier activating enzyme 6 0.0358427
VCL vinculin 0.0353932
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0353721
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0352665
MKI67 marker of proliferation Ki-67 0.034825
SPAG9 sperm associated antigen 9 0.0332973
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0322437
ANLN anillin, actin binding protein 0.0319867
FNIP1 folliculin interacting protein 1 0.0314416
ATP13A3 ATPase type 13A3 0.0308754
CENPF centromere protein F, 350/400kDa 0.0308438
AFDN afadin, adherens junction formation factor 0.0306081
CCNL1 cyclin L1 0.0305703
TENT5A terminal nucleotidyltransferase 5A 0.0297209
MYOF myoferlin 0.0291139
HELZ helicase with zinc finger 0.0289375
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0285056
PRELID2 PRELI domain containing 2 0.0280569
RB1CC1 RB1-inducible coiled-coil 1 0.0273494
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0273091
DSCAM Down syndrome cell adhesion molecule 0.0271151
ELL2 elongation factor, RNA polymerase II, 2 0.0269694
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0267647
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0258792
CDK19 cyclin-dependent kinase 19 0.0257714
RTN4 reticulon 4 0.0255583
TPM3 tropomyosin 3 0.0253796
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0252776
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0251437
CEP250 centrosomal protein 250kDa 0.024874
DENND5A DENN/MADD domain containing 5A 0.0247059
KDM6A lysine (K)-specific demethylase 6A 0.0243775
FAM20C family with sequence similarity 20, member C 0.0243051
UGCG UDP-glucose ceramide glucosyltransferase 0.0242675
VMP1 vacuole membrane protein 1 0.0237837
CKAP5 cytoskeleton associated protein 5 0.0233043
ZMIZ1 zinc finger, MIZ-type containing 1 0.023227
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0231363
SBF2 SET binding factor 2 0.0226575
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0220964
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0220685
DIAPH3 diaphanous-related formin 3 0.022068
SET SET nuclear proto-oncogene 0.0220258
TNS3 tensin 3 0.0215819
METTL15 methyltransferase like 15 0.0213596
ATXN1 ataxin 1 0.0213258
PICALM phosphatidylinositol binding clathrin assembly protein 0.0212231
APP amyloid beta (A4) precursor protein 0.0209807
BCLAF1 BCL2-associated transcription factor 1 0.0209716
GLS2 glutaminase 2 (liver, mitochondrial) 0.020326
NRIP1 nuclear receptor interacting protein 1 0.0201543
SHB Src homology 2 domain containing adaptor protein B 0.0199689
PLPP6 phospholipid phosphatase 6 0.0196601
ADAM17 ADAM metallopeptidase domain 17 0.0195919
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0194993
THBS1 thrombospondin 1 0.0189483
KIF4A kinesin family member 4A 0.0189307
LAMP2 lysosomal-associated membrane protein 2 0.0188304
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0187152
XPO1 exportin 1 0.0185579
ZFC3H1 zinc finger, C3H1-type containing 0.0183097
USP12 ubiquitin specific peptidase 12 0.0181438
KYNU kynureninase 0.017973
COPA coatomer protein complex, subunit alpha 0.0179487
DUSP5 dual specificity phosphatase 5 0.0178027
CADM1 cell adhesion molecule 1 0.0178012
SCAF8 SR-related CTD-associated factor 8 0.0176158
ANKRD36 ankyrin repeat domain 36 0.017487
PUM2 pumilio RNA-binding family member 2 0.0174802
RASA2 RAS p21 protein activator 2 0.0172411
YEATS2 YEATS domain containing 2 0.0172379
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0172213
TPX2 TPX2, microtubule-associated 0.0170273
PRKCSH protein kinase C substrate 80K-H 0.0167672

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.370912
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.167288
IGFBP3 insulin-like growth factor binding protein 3 -0.153778
FTL ferritin, light polypeptide -0.149105
FTH1 ferritin, heavy polypeptide 1 -0.137536
AKAP12 A kinase (PRKA) anchor protein 12 -0.120408
IER3 immediate early response 3 -0.107321
TMSB10 thymosin beta 10 -0.106884
TPT1 tumor protein, translationally-controlled 1 -0.0898784
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0843387
HLA-B major histocompatibility complex, class I, B -0.0823704
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0767279
GLIS3 GLIS family zinc finger 3 -0.0762555
BTG1 B-cell translocation gene 1, anti-proliferative -0.0750352
CD44 CD44 molecule (Indian blood group) -0.071286
HLA-A major histocompatibility complex, class I, A -0.0664406
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0639692
RPS6 ribosomal protein S6 -0.0595823
HMGA2 high mobility group AT-hook 2 -0.0580141
EGR1 early growth response 1 -0.0566704
NDRG1 N-myc downstream regulated 1 -0.055346
CDH13 cadherin 13 -0.0551844
RPS24 ribosomal protein S24 -0.0535071
LOC112694756 uncharaterized LOC112694756 -0.0515949
SFRP1 secreted frizzled-related protein 1 -0.0514106
PLIN2 perilipin 2 -0.0509478
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0509336
ZMYND8 zinc finger, MYND-type containing 8 -0.0504888
SLC38A1 solute carrier family 38, member 1 -0.0496419
ADM adrenomedullin -0.0488317
LOX lysyl oxidase -0.0458115
GNAS GNAS complex locus -0.045018
RPL35A ribosomal protein L35a -0.0440956
HMGA1 high mobility group AT-hook 1 -0.043333
RPLP1 ribosomal protein, large, P1 -0.0427816
CTSD cathepsin D -0.0420558
EIF1 eukaryotic translation initiation factor 1 -0.041865
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0408127
MT2A metallothionein 2A -0.0407954
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0406602
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0405676
HLA-E major histocompatibility complex, class I, E -0.0392494
MORF4L2 mortality factor 4 like 2 -0.0390009
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0382983
IFITM3 interferon induced transmembrane protein 3 -0.0378831
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0376429
RAI14 retinoic acid induced 14 -0.036323
RAB7A RAB7A, member RAS oncogene family -0.0349214
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0347366
VDAC1 voltage-dependent anion channel 1 -0.0334773
PDIA3 protein disulfide isomerase family A, member 3 -0.0330619
RPLP0 ribosomal protein, large, P0 -0.0328621
ENO1 enolase 1, (alpha) -0.0324282
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0316204
TUBB tubulin, beta class I -0.0315003
VCAN versican -0.0307206
CLMP CXADR-like membrane protein -0.0303307
CANX calnexin -0.0300839
TCEAL9 transcription elongation factor A like 9 -0.029991
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.029971
SQSTM1 sequestosome 1 -0.0297303
RPS8 ribosomal protein S8 -0.029711
ARL4C ADP-ribosylation factor-like 4C -0.0295062
STC1 stanniocalcin 1 -0.0292182
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0289428
EGFR epidermal growth factor receptor -0.0289006
OSBPL8 oxysterol binding protein-like 8 -0.0288408
RPS13 ribosomal protein S13 -0.0284018
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0283656
SAMD3 sterile alpha motif domain containing 3 -0.0280172
RPL27A ribosomal protein L27a -0.0276761
RPS23 ribosomal protein S23 -0.0272332
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0269265
HILPDA hypoxia inducible lipid droplet-associated -0.0263079
RPL12 ribosomal protein L12 -0.0262875
TKT transketolase -0.0260791
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.026031
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0255657
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0255292
RPS19 ribosomal protein S19 -0.0254774
RND3 Rho family GTPase 3 -0.0253867
LOC102724023 ES1 protein homolog, mitochondrial -0.0246462
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0245297
RACK1 receptor for activated C kinase 1 -0.0244261
KPNB1 karyopherin (importin) beta 1 -0.023989
EFNA5 ephrin-A5 -0.0239401
CAVIN1 caveolae associated protein 1 -0.0233551
JUN jun proto-oncogene -0.0230362
PGK1 phosphoglycerate kinase 1 -0.0229818
RPL38 ribosomal protein L38 -0.0228683
TAPBP TAP binding protein (tapasin) -0.022821
LDHA lactate dehydrogenase A -0.022771
RPS14 ribosomal protein S14 -0.0227463
KRT19 keratin 19, type I -0.022447
SP100 SP100 nuclear antigen -0.0220156
TGFBI transforming growth factor, beta-induced, 68kDa -0.0219218
RPL23 ribosomal protein L23 -0.0218257
NRN1 neuritin 1 -0.0217445
GDF15 growth differentiation factor 15 -0.0214924
RRBP1 ribosome binding protein 1 -0.0211669