Rimonabant (Hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0885243
CENPF centromere protein F, 350/400kDa 0.0791358
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0713762
WAC WW domain containing adaptor with coiled-coil 0.069675
TPX2 TPX2, microtubule-associated 0.0661681
ECT2 epithelial cell transforming 2 0.0650848
YAP1 Yes-associated protein 1 0.0631577
NAV2 neuron navigator 2 0.0609515
PTMA prothymosin, alpha 0.0597832
SETD5 SET domain containing 5 0.059004
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0584711
RBM39 RNA binding motif protein 39 0.057268
SMC4 structural maintenance of chromosomes 4 0.0571229
PUM2 pumilio RNA-binding family member 2 0.0564645
KMT2E lysine (K)-specific methyltransferase 2E 0.0555972
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0520463
SDC4 syndecan 4 0.0517124
ZNF292 zinc finger protein 292 0.0509338
NAP1L1 nucleosome assembly protein 1-like 1 0.0497972
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0486488
FXR1 fragile X mental retardation, autosomal homolog 1 0.0476747
SPAG9 sperm associated antigen 9 0.0470125
TRIO trio Rho guanine nucleotide exchange factor 0.0468806
DERA deoxyribose-phosphate aldolase (putative) 0.045976
NUP58 nucleoporin 58 0.0459261
ITCH itchy E3 ubiquitin protein ligase 0.0455051
TRA2A transformer 2 alpha homolog (Drosophila) 0.044699
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0437692
MIS18BP1 MIS18 binding protein 1 0.0436747
TBC1D5 TBC1 domain family, member 5 0.0429327
DIAPH3 diaphanous-related formin 3 0.0427603
ATP13A3 ATPase type 13A3 0.0425493
CKAP5 cytoskeleton associated protein 5 0.0421848
MYH9 myosin, heavy chain 9, non-muscle 0.0419789
DEK DEK proto-oncogene 0.0417074
NCAPD2 non-SMC condensin I complex, subunit D2 0.0413188
YBX3 Y box binding protein 3 0.0408448
PRR11 proline rich 11 0.0406784
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0403135
HMGB2 high mobility group box 2 0.0396872
PBX3 pre-B-cell leukemia homeobox 3 0.0395868
RDX radixin 0.0394836
INSIG1 insulin induced gene 1 0.0394512
MKI67 marker of proliferation Ki-67 0.0386595
KIF5B kinesin family member 5B 0.0385805
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0385606
RNF145 ring finger protein 145 0.0379398
NCKAP1 NCK-associated protein 1 0.0377995
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0377987
TFG TRK-fused gene 0.037528
KIAA1328 KIAA1328 0.0372958
OGA O-GlcNAcase 0.037196
SGO2 shugoshin 2 0.0369989
UGCG UDP-glucose ceramide glucosyltransferase 0.0365526
TENT2 terminal nucleotidyltransferase 2 0.0362416
CKAP2 cytoskeleton associated protein 2 0.036109
UBA6 ubiquitin-like modifier activating enzyme 6 0.0360385
APOLD1 apolipoprotein L domain containing 1 0.0359908
HJURP Holliday junction recognition protein 0.0357268
HP1BP3 heterochromatin protein 1, binding protein 3 0.0357076
PRC1 protein regulator of cytokinesis 1 0.0356801
AXL AXL receptor tyrosine kinase 0.0348582
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.034801
RAD21 RAD21 homolog (S. pombe) 0.0346122
GSK3B glycogen synthase kinase 3 beta 0.0344386
CHD1 chromodomain helicase DNA binding protein 1 0.0339578
NUP153 nucleoporin 153kDa 0.0331206
MORF4L1 mortality factor 4 like 1 0.0329611
SRP54 signal recognition particle 54kDa 0.0328039
HILPDA hypoxia inducible lipid droplet-associated 0.0326649
ANLN anillin, actin binding protein 0.0325897
COG5 component of oligomeric golgi complex 5 0.0324573
SNX14 sorting nexin 14 0.0319126
TSC22D2 TSC22 domain family, member 2 0.0318731
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0318361
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0317559
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0317511
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0316394
TPM3 tropomyosin 3 0.0315877
HELZ helicase with zinc finger 0.03152
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0313859
KIF4A kinesin family member 4A 0.0312851
CDK7 cyclin-dependent kinase 7 0.0312668
CSNK1A1 casein kinase 1, alpha 1 0.0310148
AURKA aurora kinase A 0.03083
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0308001
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0306036
ACTG1 actin gamma 1 0.0305436
SEC23A Sec23 homolog A (S. cerevisiae) 0.0303946
CANX calnexin 0.0301768
SET SET nuclear proto-oncogene 0.0300546
OLA1 Obg-like ATPase 1 0.0298817
LCORL ligand dependent nuclear receptor corepressor-like 0.0296988
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0294987
NAMPT nicotinamide phosphoribosyltransferase 0.0294247
BIRC6 baculoviral IAP repeat containing 6 0.0293366
TXNRD1 thioredoxin reductase 1 0.0291956
NPTN neuroplastin 0.0291719
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0290966
KIF23 kinesin family member 23 0.0289639

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155142
TMSB10 thymosin beta 10 -0.10605
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0837676
HMGA2 high mobility group AT-hook 2 -0.0816796
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0783123
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0668237
ZBTB20 zinc finger and BTB domain containing 20 -0.0648447
TPT1 tumor protein, translationally-controlled 1 -0.0628496
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0595439
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0541735
UBC ubiquitin C -0.051877
OSMR oncostatin M receptor -0.0512552
EFNA5 ephrin-A5 -0.0511625
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0472504
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0466726
RIGI RNA sensor RIG-I -0.0455376
PRR16 proline rich 16 -0.0451303
ANGPTL4 angiopoietin-like 4 -0.0418835
DST dystonin -0.0401722
LOC112694756 uncharaterized LOC112694756 -0.0389642
EGR1 early growth response 1 -0.0385583
GOLGB1 golgin B1 -0.0382512
SVIL supervillin -0.0380103
SLC38A2 solute carrier family 38, member 2 -0.0373422
SQSTM1 sequestosome 1 -0.0363422
ATXN1 ataxin 1 -0.0362471
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0348236
PCED1B PC-esterase domain containing 1B -0.0347673
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0342804
PKM pyruvate kinase, muscle -0.0339285
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0335416
S100A10 S100 calcium binding protein A10 -0.0316137
LRRC49 leucine rich repeat containing 49 -0.0309663
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0307906
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0301293
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0295947
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0293723
COL5A1 collagen, type V, alpha 1 -0.0289049
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0287706
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0286351
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0277437
JUN jun proto-oncogene -0.0276385
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0273927
NPAS2 neuronal PAS domain protein 2 -0.0270512
ATG10 autophagy related 10 -0.0267547
AHNAK2 AHNAK nucleoprotein 2 -0.0267354
RPS27A ribosomal protein S27a -0.0266277
SH3KBP1 SH3-domain kinase binding protein 1 -0.0264165
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0263124
AKAP12 A kinase (PRKA) anchor protein 12 -0.0259822
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.025758
RPLP1 ribosomal protein, large, P1 -0.0256138
BTG1 B-cell translocation gene 1, anti-proliferative -0.0255168
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0254767
AOPEP aminopeptidase O (putative) -0.0253863
MACF1 microtubule-actin crosslinking factor 1 -0.0252511
FTH1 ferritin, heavy polypeptide 1 -0.0251938
HDAC9 histone deacetylase 9 -0.0248146
NT5E 5'-nucleotidase, ecto (CD73) -0.0246132
ATG7 autophagy related 7 -0.0245946
HLA-A major histocompatibility complex, class I, A -0.0244653
IGFBP3 insulin-like growth factor binding protein 3 -0.0242839
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0242556
GCC2 GRIP and coiled-coil domain containing 2 -0.0241761
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0238197
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0236792
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0235949
PODXL podocalyxin-like -0.0234849
TM4SF1 transmembrane 4 L six family member 1 -0.0234611
HLA-B major histocompatibility complex, class I, B -0.0234324
GOLGA3 golgin A3 -0.0231999
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0231687
XRN1 5'-3' exoribonuclease 1 -0.0230273
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0229428
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0228923
INTS6 integrator complex subunit 6 -0.0224315
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.022422
ZC3H12B zinc finger CCCH-type containing 12B -0.0223065
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0221555
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.022104
METTL16 methyltransferase like 16 -0.0220854
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0220314
MIDN midnolin -0.0220027
CEMIP2 cell migration inducing hyaluronidase 2 -0.0219465
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0219183
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0217866
FER fer (fps/fes related) tyrosine kinase -0.0217647
FTL ferritin, light polypeptide -0.0215075
FLNB filamin B, beta -0.0214517
RPL27A ribosomal protein L27a -0.0212682
HLA-E major histocompatibility complex, class I, E -0.0209196
RAI14 retinoic acid induced 14 -0.0208021
ODF2L outer dense fiber of sperm tails 2-like -0.0208007
RPS29 ribosomal protein S29 -0.0207259
THBS1 thrombospondin 1 -0.0206644
ZNF407 zinc finger protein 407 -0.0206287
SAMD4A sterile alpha motif domain containing 4A -0.0205858
FN1 fibronectin 1 -0.0205034
PTPRK protein tyrosine phosphatase, receptor type, K -0.0204299
CAPN2 calpain 2, (m/II) large subunit -0.0203953