Rimonabant (Hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.156528
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.121729
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.111587
OGA O-GlcNAcase 0.0773797
PRRC2C proline-rich coiled-coil 2C 0.0655608
NAP1L1 nucleosome assembly protein 1-like 1 0.0647823
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0638157
KDM3A lysine (K)-specific demethylase 3A 0.0612903
RNF145 ring finger protein 145 0.0609902
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0580184
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0554054
AHR aryl hydrocarbon receptor 0.0553092
SMOX spermine oxidase 0.0551134
SMAD3 SMAD family member 3 0.0535654
TMEM156 transmembrane protein 156 0.0517703
ETV6 ets variant 6 0.0503485
WAC WW domain containing adaptor with coiled-coil 0.0503296
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0472095
CTNND1 catenin (cadherin-associated protein), delta 1 0.0469328
CANX calnexin 0.0468298
PTMA prothymosin, alpha 0.046681
SUCO SUN domain containing ossification factor 0.0462231
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0461677
TPR translocated promoter region, nuclear basket protein 0.0460402
ETNK1 ethanolamine kinase 1 0.0459301
DSCAM Down syndrome cell adhesion molecule 0.0454166
TMSB4X thymosin beta 4, X-linked 0.0445657
RICTOR RPTOR independent companion of MTOR, complex 2 0.0444197
HELZ helicase with zinc finger 0.0429562
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0428831
MCTP2 multiple C2 domains, transmembrane 2 0.0427846
TRIO trio Rho guanine nucleotide exchange factor 0.0427485
EPS8 epidermal growth factor receptor pathway substrate 8 0.042366
MYH9 myosin, heavy chain 9, non-muscle 0.040268
RAD21 RAD21 homolog (S. pombe) 0.0392645
UBE2K ubiquitin-conjugating enzyme E2K 0.0390529
ZNF292 zinc finger protein 292 0.038658
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0386553
NEK7 NIMA-related kinase 7 0.038504
ANKRD11 ankyrin repeat domain 11 0.0380787
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0380427
OSMR oncostatin M receptor 0.0375385
PNISR PNN-interacting serine/arginine-rich protein 0.0372414
TENT2 terminal nucleotidyltransferase 2 0.0369654
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0368233
CENPF centromere protein F, 350/400kDa 0.0362946
MARCHF6 membrane associated ring-CH-type finger 6 0.036119
RAB8B RAB8B, member RAS oncogene family 0.035993
RBM39 RNA binding motif protein 39 0.0359151
MKI67 marker of proliferation Ki-67 0.0358943
FAM13A family with sequence similarity 13, member A 0.0355929
BASP1 brain abundant, membrane attached signal protein 1 0.0355901
CAB39 calcium binding protein 39 0.0355319
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0351884
CDC73 cell division cycle 73 0.0351866
AFDN afadin, adherens junction formation factor 0.0347937
APP amyloid beta (A4) precursor protein 0.0345195
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0343021
ZMYM2 zinc finger, MYM-type 2 0.0338977
HDGF hepatoma-derived growth factor 0.0338471
ITGA1 integrin, alpha 1 0.0337248
PELO pelota homolog (Drosophila) 0.033722
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0335437
ZFAND3 zinc finger, AN1-type domain 3 0.0334272
FNBP1 formin binding protein 1 0.0327588
BHLHE40 basic helix-loop-helix family, member e40 0.0323259
PUM2 pumilio RNA-binding family member 2 0.0313981
SDC4 syndecan 4 0.0313286
CSDE1 cold shock domain containing E1, RNA-binding 0.0308986
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0308145
RBM25 RNA binding motif protein 25 0.0307889
ZFR zinc finger RNA binding protein 0.0304443
SEC23A Sec23 homolog A (S. cerevisiae) 0.0303241
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0299804
EREG epiregulin 0.0297988
WTAP Wilms tumor 1 associated protein 0.029725
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0295693
COG5 component of oligomeric golgi complex 5 0.0293939
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0291301
COPA coatomer protein complex, subunit alpha 0.0291183
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0291156
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0289801
RPL26 ribosomal protein L26 0.0288376
SPRED1 sprouty-related, EVH1 domain containing 1 0.0286936
TFG TRK-fused gene 0.0286604
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0284746
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0282887
WDR45B WD repeat domain 45B 0.0282711
AKAP10 A kinase (PRKA) anchor protein 10 0.0282066
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0279331
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0277075
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0273761
RUNX2 runt-related transcription factor 2 0.0272907
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0271666
RAB1A RAB1A, member RAS oncogene family 0.0269996
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0268265
NEMF nuclear export mediator factor 0.026535
PICALM phosphatidylinositol binding clathrin assembly protein 0.026244
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0262028
PRELID2 PRELI domain containing 2 0.0260343

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.28875
FN1 fibronectin 1 -0.195618
NRG1 neuregulin 1 -0.176679
NDRG1 N-myc downstream regulated 1 -0.119785
FTH1 ferritin, heavy polypeptide 1 -0.11736
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0979956
HMGA2 high mobility group AT-hook 2 -0.0896607
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0788512
FTL ferritin, light polypeptide -0.0764957
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0626021
TMSB10 thymosin beta 10 -0.0610504
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0601744
MRPS6 mitochondrial ribosomal protein S6 -0.056507
EGR1 early growth response 1 -0.0560094
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0551197
LIMCH1 LIM and calponin homology domains 1 -0.054151
INTS6 integrator complex subunit 6 -0.0519761
IGFBP3 insulin-like growth factor binding protein 3 -0.0517031
STC2 stanniocalcin 2 -0.0515062
VIM vimentin -0.0513492
HMGA1 high mobility group AT-hook 1 -0.0502672
HILPDA hypoxia inducible lipid droplet-associated -0.0488105
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0470223
MT2A metallothionein 2A -0.0469717
PLIN2 perilipin 2 -0.0464318
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0439364
EFNA5 ephrin-A5 -0.0423924
LOC102724023 ES1 protein homolog, mitochondrial -0.0422905
GRB10 growth factor receptor-bound protein 10 -0.0413239
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0396615
PDIA3 protein disulfide isomerase family A, member 3 -0.0383301
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0378042
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0374229
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0365128
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0361847
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0347616
VCL vinculin -0.0346019
IFI27 interferon, alpha-inducible protein 27 -0.0344184
PALLD palladin, cytoskeletal associated protein -0.0338584
SPDYA speedy/RINGO cell cycle regulator family member A -0.0332906
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0326779
ACTG1 actin gamma 1 -0.0320809
PDE4D phosphodiesterase 4D, cAMP-specific -0.0320245
POTEF POTE ankyrin domain family, member F -0.031987
LOC112694756 uncharaterized LOC112694756 -0.0319576
MAP1B microtubule-associated protein 1B -0.0316226
LRRC23 leucine rich repeat containing 23 -0.0312211
RASAL2 RAS protein activator like 2 -0.0292296
RPL35A ribosomal protein L35a -0.0290123
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0281471
SLC35F3 solute carrier family 35, member F3 -0.0274957
GNAS GNAS complex locus -0.0273354
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0272315
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.027208
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0269777
RAB7A RAB7A, member RAS oncogene family -0.0261298
AEBP2 AE binding protein 2 -0.0257835
SLC38A2 solute carrier family 38, member 2 -0.0257049
TXNIP thioredoxin interacting protein -0.0253401
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0250479
RAI14 retinoic acid induced 14 -0.0247031
S100A6 S100 calcium binding protein A6 -0.0246025
IGF2 insulin-like growth factor 2 -0.0245162
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0243161
CTSD cathepsin D -0.0241841
TENM4 teneurin transmembrane protein 4 -0.0241122
ENO2 enolase 2 (gamma, neuronal) -0.0238218
IL6 interleukin 6 -0.0236697
FOSL1 FOS-like antigen 1 -0.0236028
DSTN destrin (actin depolymerizing factor) -0.0233983
TPM4 tropomyosin 4 -0.0233798
GPATCH2L G patch domain containing 2-like -0.0233521
AHRR aryl-hydrocarbon receptor repressor -0.0227739
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0225646
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0223602
BSG basigin (Ok blood group) -0.0223369
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0222482
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0219217
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.021684
MYOF myoferlin -0.0214949
PDLIM5 PDZ and LIM domain 5 -0.0207395
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0206722
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0206242
ATN1 atrophin 1 -0.0205135
S100A10 S100 calcium binding protein A10 -0.0204918
MYO1E myosin IE -0.0204626
LOX lysyl oxidase -0.020444
TGFB1 transforming growth factor, beta 1 -0.0204162
POU2F2 POU class 2 homeobox 2 -0.0203222
GLUL glutamate-ammonia ligase -0.0202995
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0201724
CUX1 cut-like homeobox 1 -0.020154
UBAP2 ubiquitin associated protein 2 -0.0200207
PRKCA protein kinase C, alpha -0.0199252
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0197253
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.019592
EPAS1 endothelial PAS domain protein 1 -0.0195532
MCL1 myeloid cell leukemia 1 -0.0193743
RNASEH2A ribonuclease H2, subunit A -0.0192173
ADIPOR2 adiponectin receptor 2 -0.0191739