Rimonabant (Hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.15265
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.103698
KRT18 keratin 18, type I 0.0889391
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.082405
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.080208
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0759089
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0574389
FXR1 fragile X mental retardation, autosomal homolog 1 0.0552759
BHLHE40 basic helix-loop-helix family, member e40 0.054558
SRRM2 serine/arginine repetitive matrix 2 0.0493699
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0448907
SET SET nuclear proto-oncogene 0.0447717
RPS3 ribosomal protein S3 0.044528
CCNL1 cyclin L1 0.044048
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0440383
UBC ubiquitin C 0.0434123
NCKAP1 NCK-associated protein 1 0.0422582
PCBP2 poly(rC) binding protein 2 0.0419679
KMT2E lysine (K)-specific methyltransferase 2E 0.0404653
VEGFA vascular endothelial growth factor A 0.0401774
HDGF hepatoma-derived growth factor 0.0395561
TFG TRK-fused gene 0.0385387
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0379748
EPCAM epithelial cell adhesion molecule 0.03756
HSPA8 heat shock 70kDa protein 8 0.037066
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0366827
TRA2A transformer 2 alpha homolog (Drosophila) 0.0364267
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0353673
EEF2 eukaryotic translation elongation factor 2 0.0352721
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0351398
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0350963
TPM3 tropomyosin 3 0.0344487
MTMR3 myotubularin related protein 3 0.0337222
RPS12 ribosomal protein S12 0.0336024
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0332816
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0331502
RAD23B RAD23 homolog B (S. cerevisiae) 0.0320801
MATR3 matrin 3 0.031248
RPL3 ribosomal protein L3 0.0310517
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0299412
ANKRD11 ankyrin repeat domain 11 0.0297737
ARHGAP12 Rho GTPase activating protein 12 0.0296708
WAC WW domain containing adaptor with coiled-coil 0.0294744
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0292752
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0292544
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0291009
RNF145 ring finger protein 145 0.0290522
CALR calreticulin 0.0288552
DSPP dentin sialophosphoprotein 0.0281963
SRRM1 serine/arginine repetitive matrix 1 0.0281844
AKAP12 A kinase (PRKA) anchor protein 12 0.0279013
ATL2 atlastin GTPase 2 0.0278295
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0278226
USP3 ubiquitin specific peptidase 3 0.0276117
TOP2B topoisomerase (DNA) II beta 180kDa 0.0273559
TMSB4X thymosin beta 4, X-linked 0.0273154
KDM3A lysine (K)-specific demethylase 3A 0.0270483
RPL4 ribosomal protein L4 0.0263131
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0262928
POTEF POTE ankyrin domain family, member F 0.0260067
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0253692
CKAP5 cytoskeleton associated protein 5 0.0253074
PNN pinin, desmosome associated protein 0.0253001
KTN1 kinectin 1 (kinesin receptor) 0.0251136
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0251097
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0246503
BCLAF1 BCL2-associated transcription factor 1 0.0244955
RPS6 ribosomal protein S6 0.0242832
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0242644
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0240622
ASPH aspartate beta-hydroxylase 0.0239186
FAR1 fatty acyl CoA reductase 1 0.0236698
MKRN1 makorin ring finger protein 1 0.0235637
U2SURP U2 snRNP-associated SURP domain containing 0.0233609
RALB v-ral simian leukemia viral oncogene homolog B 0.0232801
MED13L mediator complex subunit 13-like 0.0231646
PUM2 pumilio RNA-binding family member 2 0.0230519
PDIA6 protein disulfide isomerase family A, member 6 0.0228418
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0225947
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0225209
TNIP1 TNFAIP3 interacting protein 1 0.0225036
PAPOLA poly(A) polymerase alpha 0.0223132
SUCO SUN domain containing ossification factor 0.0220416
GLS2 glutaminase 2 (liver, mitochondrial) 0.0214284
RPL5 ribosomal protein L5 0.0209604
CASC3 cancer susceptibility candidate 3 0.0207973
FMR1 fragile X mental retardation 1 0.0207647
UBA6 ubiquitin-like modifier activating enzyme 6 0.0206104
RPL7 ribosomal protein L7 0.0206091
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0204385
RPS17 ribosomal protein S17 0.0204338
SSRP1 structure specific recognition protein 1 0.0204231
KDM1A lysine (K)-specific demethylase 1A 0.0202351
HLA-A major histocompatibility complex, class I, A 0.0200416
MYH9 myosin, heavy chain 9, non-muscle 0.0200204
KDM6A lysine (K)-specific demethylase 6A 0.0200142
DDIT4 DNA-damage-inducible transcript 4 0.0197397
RPL7A ribosomal protein L7a 0.0196678
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0195682
NAMPT nicotinamide phosphoribosyltransferase 0.0194859

decreased expression

Symbol Name Standardized Value
NCEH1 neutral cholesterol ester hydrolase 1 -0.0994625
MACC1 metastasis associated in colon cancer 1 -0.0839213
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0813342
EZR ezrin -0.0808061
EGR1 early growth response 1 -0.0732452
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0730527
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0670559
BCL2L1 BCL2-like 1 -0.0669058
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0668893
RPL35A ribosomal protein L35a -0.0657359
VCL vinculin -0.0654163
LOC112694756 uncharaterized LOC112694756 -0.0637389
RAB7A RAB7A, member RAS oncogene family -0.0605078
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0597014
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0596883
MAML2 mastermind-like 2 (Drosophila) -0.0583998
TMSB10 thymosin beta 10 -0.0566705
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0561242
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0548503
PCLO piccolo presynaptic cytomatrix protein -0.0509323
MYO1E myosin IE -0.0491765
SQSTM1 sequestosome 1 -0.0490334
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0456697
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0455697
ADNP activity-dependent neuroprotector homeobox -0.0438598
ZBTB20 zinc finger and BTB domain containing 20 -0.0438534
NEBL nebulette -0.0435845
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0423575
ZBTB38 zinc finger and BTB domain containing 38 -0.0423498
GNAS GNAS complex locus -0.0414128
HM13 histocompatibility (minor) 13 -0.0407367
PLSCR1 phospholipid scramblase 1 -0.0402957
TGFA transforming growth factor, alpha -0.0399448
H1-0 H1.0 linker histone -0.039847
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0390553
PTPRK protein tyrosine phosphatase, receptor type, K -0.038538
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0375272
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0372609
PATJ PATJ crumbs cell polarity complex component -0.0372222
PKP4 plakophilin 4 -0.0366636
EXOC4 exocyst complex component 4 -0.0364803
JMJD1C jumonji domain containing 1C -0.0362496
TAS2R14 taste receptor, type 2, member 14 -0.0359499
GOLGB1 golgin B1 -0.0356221
MYOF myoferlin -0.0355054
CUX1 cut-like homeobox 1 -0.0354801
TXNRD1 thioredoxin reductase 1 -0.0352405
WWC1 WW and C2 domain containing 1 -0.0351203
GMDS GDP-mannose 4,6-dehydratase -0.0347532
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0346374
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0343538
RUNX1 runt-related transcription factor 1 -0.0342033
KDM7A lysine (K)-specific demethylase 7A -0.0341843
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0339728
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0333795
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0332576
ZNFX1 zinc finger, NFX1-type containing 1 -0.0332467
NF1 neurofibromin 1 -0.0326448
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0326323
MAP4 microtubule-associated protein 4 -0.0325255
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0325087
TJP1 tight junction protein 1 -0.0324396
IFRD1 interferon-related developmental regulator 1 -0.0322733
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0321864
SLC38A1 solute carrier family 38, member 1 -0.0320872
ARF1 ADP-ribosylation factor 1 -0.0318158
LPP LIM domain containing preferred translocation partner in lipoma -0.0316737
SERINC5 serine incorporator 5 -0.0314239
UBE2H ubiquitin-conjugating enzyme E2H -0.0308769
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0307839
NABP1 nucleic acid binding protein 1 -0.0305096
ZNF217 zinc finger protein 217 -0.030438
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0297527
FTH1 ferritin, heavy polypeptide 1 -0.0296439
EHBP1 EH domain binding protein 1 -0.0296323
RNF213 ring finger protein 213 -0.0294578
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0293572
PRELID2 PRELI domain containing 2 -0.0291198
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0290906
SDK1 sidekick cell adhesion molecule 1 -0.0290485
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0290379
GCC2 GRIP and coiled-coil domain containing 2 -0.0289566
CALU calumenin -0.0284993
OXSR1 oxidative stress responsive 1 -0.028464
RPS21 ribosomal protein S21 -0.0281394
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0280687
SP100 SP100 nuclear antigen -0.0280362
ZSWIM6 zinc finger, SWIM-type containing 6 -0.027899
RAB22A RAB22A, member RAS oncogene family -0.0277159
CDK13 cyclin-dependent kinase 13 -0.0276997
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0271974
SMYD3 SET and MYND domain containing 3 -0.0271605
HDLBP high density lipoprotein binding protein -0.0271442
IARS1 isoleucyl-tRNA synthetase 1 -0.0270512
FRMD5 FERM domain containing 5 -0.0270071
RIGI RNA sensor RIG-I -0.0269839
RRBP1 ribosome binding protein 1 -0.0265624
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0265019
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0263988
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0260844