Rimonabant (Hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0731616
WAC WW domain containing adaptor with coiled-coil 0.0607728
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0599649
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0589978
RPL3 ribosomal protein L3 0.0529425
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0505733
RPS3 ribosomal protein S3 0.0491006
DSCAM Down syndrome cell adhesion molecule 0.0480658
OGA O-GlcNAcase 0.0477865
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0473282
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0465605
PTMA prothymosin, alpha 0.0458611
KMT2C lysine (K)-specific methyltransferase 2C 0.0457969
HSPA8 heat shock 70kDa protein 8 0.0446948
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0446625
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0435798
LAMB3 laminin, beta 3 0.0403834
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0390343
SET SET nuclear proto-oncogene 0.0388742
KDM6A lysine (K)-specific demethylase 6A 0.0388295
MYO5B myosin VB 0.0381976
PRRC2C proline-rich coiled-coil 2C 0.0364292
ECPAS Ecm29 proteasome adaptor and scaffold 0.0362131
EREG epiregulin 0.0361652
ANKRD11 ankyrin repeat domain 11 0.0355511
NCKAP1 NCK-associated protein 1 0.0353372
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0352365
VEGFA vascular endothelial growth factor A 0.0349899
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0349524
PUM1 pumilio RNA-binding family member 1 0.0345292
TOP2B topoisomerase (DNA) II beta 180kDa 0.0342865
EIF4B eukaryotic translation initiation factor 4B 0.0341463
SFPQ splicing factor proline/glutamine-rich 0.0341377
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0339505
TPR translocated promoter region, nuclear basket protein 0.0334596
RBM26 RNA binding motif protein 26 0.0332416
RPL4 ribosomal protein L4 0.032522
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0322553
UBE3C ubiquitin protein ligase E3C 0.0320559
PDIA6 protein disulfide isomerase family A, member 6 0.0315445
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0314228
SRRM1 serine/arginine repetitive matrix 1 0.0311849
ANXA1 annexin A1 0.031015
SRRM2 serine/arginine repetitive matrix 2 0.0307429
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0305592
FLOT1 flotillin 1 0.0300026
ADAM9 ADAM metallopeptidase domain 9 0.0299489
NUP58 nucleoporin 58 0.0298592
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.029807
YTHDC1 YTH domain containing 1 0.029727
DSPP dentin sialophosphoprotein 0.0294251
FMNL2 formin-like 2 0.0289193
RPS27A ribosomal protein S27a 0.0289102
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0286444
UBA6 ubiquitin-like modifier activating enzyme 6 0.028634
SRSF11 serine/arginine-rich splicing factor 11 0.0285953
FXR1 fragile X mental retardation, autosomal homolog 1 0.0283558
ANKRD10 ankyrin repeat domain 10 0.0282996
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0282971
FAR1 fatty acyl CoA reductase 1 0.0282047
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0276237
PSAT1 phosphoserine aminotransferase 1 0.0276098
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0274713
RPS17 ribosomal protein S17 0.0273315
RLF rearranged L-myc fusion 0.0271113
ESRP1 epithelial splicing regulatory protein 1 0.0264267
PNN pinin, desmosome associated protein 0.0263523
AHNAK AHNAK nucleoprotein 0.0262819
KDM3A lysine (K)-specific demethylase 3A 0.0262023
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0261588
RAB6A RAB6A, member RAS oncogene family 0.0261468
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0261426
MYH9 myosin, heavy chain 9, non-muscle 0.0258429
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0257174
RPS18 ribosomal protein S18 0.0253602
PARD3 par-3 family cell polarity regulator 0.025336
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0253133
PTK2 protein tyrosine kinase 2 0.0252688
MACF1 microtubule-actin crosslinking factor 1 0.0252464
SCAF8 SR-related CTD-associated factor 8 0.0249808
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0249221
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.024785
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0246588
PPME1 protein phosphatase methylesterase 1 0.0245051
RPL37A ribosomal protein L37a 0.0244898
KLC1 kinesin light chain 1 0.0244052
EIF3A eukaryotic translation initiation factor 3, subunit A 0.024084
RBM39 RNA binding motif protein 39 0.023951
NBAS neuroblastoma amplified sequence 0.0238759
FOXJ3 forkhead box J3 0.0237356
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0237207
TPM3 tropomyosin 3 0.0237173
DDIT4 DNA-damage-inducible transcript 4 0.0236853
HELZ helicase with zinc finger 0.023505
INSIG2 insulin induced gene 2 0.0234999
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0234877
SAMD4A sterile alpha motif domain containing 4A 0.0234762
MARCHF6 membrane associated ring-CH-type finger 6 0.0234307
RNF145 ring finger protein 145 0.0233679
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0233

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.243919
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.20961
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.14287
EGR1 early growth response 1 -0.132015
EGFR epidermal growth factor receptor -0.127213
TMSB10 thymosin beta 10 -0.104974
RPL35A ribosomal protein L35a -0.0888383
ACTG1 actin gamma 1 -0.0816259
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0670456
LOC112694756 uncharaterized LOC112694756 -0.0656696
FHL2 four and a half LIM domains 2 -0.0633315
RPLP1 ribosomal protein, large, P1 -0.0608202
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.060199
RPLP0 ribosomal protein, large, P0 -0.0599791
RPS6 ribosomal protein S6 -0.0559013
RPS24 ribosomal protein S24 -0.0557375
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0544646
VCL vinculin -0.0535933
FERMT1 fermitin family member 1 -0.0527959
RAD51B RAD51 paralog B -0.0523629
TXNRD1 thioredoxin reductase 1 -0.0522993
GPHN gephyrin -0.0519992
TXNIP thioredoxin interacting protein -0.0509962
HMGA1 high mobility group AT-hook 1 -0.0503107
EEF2 eukaryotic translation elongation factor 2 -0.0501447
IARS1 isoleucyl-tRNA synthetase 1 -0.0499339
RPL34 ribosomal protein L34 -0.0481077
LMO7 LIM domain 7 -0.046575
NCEH1 neutral cholesterol ester hydrolase 1 -0.0461951
NT5DC3 5'-nucleotidase domain containing 3 -0.0436444
FAT1 FAT atypical cadherin 1 -0.043096
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0420676
HILPDA hypoxia inducible lipid droplet-associated -0.0419429
LAMC2 laminin, gamma 2 -0.0416165
RAB7A RAB7A, member RAS oncogene family -0.040878
ARF1 ADP-ribosylation factor 1 -0.04035
TPM4 tropomyosin 4 -0.0389335
RPS21 ribosomal protein S21 -0.037189
EZR ezrin -0.0367529
RPS28 ribosomal protein S28 -0.0351027
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0345849
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0342819
FTH1 ferritin, heavy polypeptide 1 -0.0341434
CCSER1 coiled-coil serine-rich protein 1 -0.0336004
RPS19 ribosomal protein S19 -0.0333882
ATXN1 ataxin 1 -0.033375
RPL32 ribosomal protein L32 -0.0333074
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0332226
IGFBP3 insulin-like growth factor binding protein 3 -0.0323521
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0315619
HMGA2 high mobility group AT-hook 2 -0.0313028
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0312354
LDHA lactate dehydrogenase A -0.0310324
GDF15 growth differentiation factor 15 -0.0307161
KLF6 Kruppel-like factor 6 -0.0307114
MTAP methylthioadenosine phosphorylase -0.0304171
HM13 histocompatibility (minor) 13 -0.0299688
FTL ferritin, light polypeptide -0.029515
NT5E 5'-nucleotidase, ecto (CD73) -0.0285853
ITPKC inositol-trisphosphate 3-kinase C -0.0285378
TUBB tubulin, beta class I -0.0284877
RPS2 ribosomal protein S2 -0.0284556
RPL12 ribosomal protein L12 -0.0281569
EVA1C eva-1 homolog C (C. elegans) -0.0275475
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0272899
CD36 CD36 molecule (thrombospondin receptor) -0.0264546
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0264215
EIF1 eukaryotic translation initiation factor 1 -0.0258362
TCF12 transcription factor 12 -0.0249468
RPS8 ribosomal protein S8 -0.0248204
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0247004
JMJD1C jumonji domain containing 1C -0.0244254
TNPO3 transportin 3 -0.0238655
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0237856
SH3RF2 SH3 domain containing ring finger 2 -0.0236418
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0235847
ATP5F1B ATP synthase F1 subunit beta -0.0234816
ACTN4 actinin, alpha 4 -0.0231318
HLA-A major histocompatibility complex, class I, A -0.023075
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0223961
SQSTM1 sequestosome 1 -0.0220066
KPNB1 karyopherin (importin) beta 1 -0.0218596
EXOC6B exocyst complex component 6B -0.0216539
S100A10 S100 calcium binding protein A10 -0.0216109
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0215373
FHIT fragile histidine triad -0.0210809
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0210028
SPATA13 spermatogenesis associated 13 -0.0209941
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0208706
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0208649
KIAA0040 KIAA0040 -0.0208602
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0204835
SMYD3 SET and MYND domain containing 3 -0.0204422
MYO1E myosin IE -0.0204272
CENPF centromere protein F, 350/400kDa -0.020419
RPS16 ribosomal protein S16 -0.02027
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0201445
FAM3C family with sequence similarity 3, member C -0.0200281
SYAP1 synapse associated protein 1 -0.0197563
PFKP phosphofructokinase, platelet -0.0194847