Rimonabant (Hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ETNK1 ethanolamine kinase 1 0.0598483
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0571629
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0531834
OGA O-GlcNAcase 0.0460004
ESYT2 extended synaptotagmin-like protein 2 0.0443424
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0442485
ANLN anillin, actin binding protein 0.0426253
NKD1 naked cuticle homolog 1 (Drosophila) 0.042049
MYH9 myosin, heavy chain 9, non-muscle 0.0411857
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0403541
DST dystonin 0.039637
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0377896
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.03716
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0357073
NAV2 neuron navigator 2 0.034253
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.033993
BIRC6 baculoviral IAP repeat containing 6 0.0322411
AHNAK AHNAK nucleoprotein 0.0319836
MACF1 microtubule-actin crosslinking factor 1 0.031958
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0317602
KIZ kizuna centrosomal protein 0.0303084
AFDN afadin, adherens junction formation factor 0.0301621
SBF2 SET binding factor 2 0.0297189
BRWD3 bromodomain and WD repeat domain containing 3 0.0287257
USP34 ubiquitin specific peptidase 34 0.028553
KMT2C lysine (K)-specific methyltransferase 2C 0.0284061
USP9X ubiquitin specific peptidase 9, X-linked 0.0282882
HDAC4 histone deacetylase 4 0.0279913
UBA6 ubiquitin-like modifier activating enzyme 6 0.0278818
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02781
RERE arginine-glutamic acid dipeptide (RE) repeats 0.027175
ATXN1 ataxin 1 0.0264286
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0260129
HELZ helicase with zinc finger 0.0258744
RUNX1 runt-related transcription factor 1 0.0250231
ABHD2 abhydrolase domain containing 2 0.0249629
ARGLU1 arginine and glutamate rich 1 0.0247881
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.024754
ANKRD10 ankyrin repeat domain 10 0.0242997
EIF4B eukaryotic translation initiation factor 4B 0.0242614
ITPRID2 ITPR interacting domain containing 2 0.0241102
PDGFA platelet-derived growth factor alpha polypeptide 0.0237632
MAML2 mastermind-like 2 (Drosophila) 0.0235085
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0235077
KDM3A lysine (K)-specific demethylase 3A 0.0234554
JMJD1C jumonji domain containing 1C 0.0234337
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0234188
CD46 CD46 molecule, complement regulatory protein 0.0232869
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0232377
LMO7 LIM domain 7 0.0230503
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0229781
ZNF292 zinc finger protein 292 0.0229605
DIAPH3 diaphanous-related formin 3 0.0229515
ANO6 anoctamin 6 0.0229488
DSPP dentin sialophosphoprotein 0.0228339
NF1 neurofibromin 1 0.0228272
COPA coatomer protein complex, subunit alpha 0.0226983
WDFY2 WD repeat and FYVE domain containing 2 0.0226696
DSCAM Down syndrome cell adhesion molecule 0.0224883
KDM6A lysine (K)-specific demethylase 6A 0.0223941
YEATS2 YEATS domain containing 2 0.0222962
OSBPL3 oxysterol binding protein-like 3 0.0222915
TMCC1 transmembrane and coiled-coil domain family 1 0.0222791
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0222028
CEP95 centrosomal protein 95kDa 0.0221191
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0220957
TBC1D22A TBC1 domain family, member 22A 0.0220781
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0217365
MARCHF6 membrane associated ring-CH-type finger 6 0.0216281
RBM26 RNA binding motif protein 26 0.021442
PICALM phosphatidylinositol binding clathrin assembly protein 0.0208447
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0205532
PROX1 prospero homeobox 1 0.0205518
ECT2 epithelial cell transforming 2 0.0204971
ITGA6 integrin, alpha 6 0.0204232
CCDC82 coiled-coil domain containing 82 0.02036
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0202859
ZMYM2 zinc finger, MYM-type 2 0.0201811
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0201009
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0197087
AOPEP aminopeptidase O (putative) 0.0196889
ZFC3H1 zinc finger, C3H1-type containing 0.019463
CANX calnexin 0.0193061
SUCO SUN domain containing ossification factor 0.0192936
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0192247
RICTOR RPTOR independent companion of MTOR, complex 2 0.0192109
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0191311
CDH13 cadherin 13 0.0190858
ZNF638 zinc finger protein 638 0.0189784
FNIP1 folliculin interacting protein 1 0.0188617
APP amyloid beta (A4) precursor protein 0.0187792
CEMIP2 cell migration inducing hyaluronidase 2 0.0186376
MED13 mediator complex subunit 13 0.0186305
CTNND1 catenin (cadherin-associated protein), delta 1 0.0184291
TRIO trio Rho guanine nucleotide exchange factor 0.0184249
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0183534
NCKAP1 NCK-associated protein 1 0.0183162
PUM2 pumilio RNA-binding family member 2 0.0183137
RBM39 RNA binding motif protein 39 0.0182816
KANSL1 KAT8 regulatory NSL complex subunit 1 0.018163

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.237196
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.18412
TMSB10 thymosin beta 10 -0.183925
RPL35A ribosomal protein L35a -0.181181
RPS6 ribosomal protein S6 -0.160199
TPT1 tumor protein, translationally-controlled 1 -0.135794
PTMA prothymosin, alpha -0.125838
RPS19 ribosomal protein S19 -0.118772
RPLP1 ribosomal protein, large, P1 -0.105119
MT2A metallothionein 2A -0.100346
FTL ferritin, light polypeptide -0.0973806
RPS8 ribosomal protein S8 -0.0919214
RPL23 ribosomal protein L23 -0.0902855
RPLP2 ribosomal protein, large, P2 -0.0802025
RPL31 ribosomal protein L31 -0.0796749
RPL37A ribosomal protein L37a -0.0767848
RPS13 ribosomal protein S13 -0.0759967
VIM vimentin -0.075624
CCND1 cyclin D1 -0.0724404
RPL26 ribosomal protein L26 -0.0716634
RPS23 ribosomal protein S23 -0.0699268
RPL12 ribosomal protein L12 -0.0679695
EGR1 early growth response 1 -0.0667117
RPS24 ribosomal protein S24 -0.0665016
HMGA1 high mobility group AT-hook 1 -0.0630028
RPS25 ribosomal protein S25 -0.0629922
RPL19 ribosomal protein L19 -0.0617897
LOC102724023 ES1 protein homolog, mitochondrial -0.0613039
RPL11 ribosomal protein L11 -0.0612765
RPS3 ribosomal protein S3 -0.0609812
RPL9 ribosomal protein L9 -0.0564187
RPS21 ribosomal protein S21 -0.0536835
RPS12 ribosomal protein S12 -0.0529857
RPS5 ribosomal protein S5 -0.0520656
RPS14 ribosomal protein S14 -0.0519321
RPL34 ribosomal protein L34 -0.0516552
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0514444
RPLP0 ribosomal protein, large, P0 -0.0511609
RPS27A ribosomal protein S27a -0.0510612
RPL36A ribosomal protein L36a -0.0504684
RPL32 ribosomal protein L32 -0.050062
RPL28 ribosomal protein L28 -0.0493127
ACTG1 actin gamma 1 -0.0488271
RPL5 ribosomal protein L5 -0.0474384
RPS11 ribosomal protein S11 -0.0467407
RPS17 ribosomal protein S17 -0.0466178
RPL36 ribosomal protein L36 -0.0465906
RPS29 ribosomal protein S29 -0.0451835
EIF1 eukaryotic translation initiation factor 1 -0.0451486
RPS16 ribosomal protein S16 -0.045077
RPL35 ribosomal protein L35 -0.0446882
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0435924
RBP1 retinol binding protein 1, cellular -0.0431781
PFN1 profilin 1 -0.0429453
RACK1 receptor for activated C kinase 1 -0.0409375
RPL38 ribosomal protein L38 -0.0406461
S100A10 S100 calcium binding protein A10 -0.0399283
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0381865
RPL37 ribosomal protein L37 -0.0381357
RPS10 ribosomal protein S10 -0.0380075
RPS15 ribosomal protein S15 -0.0379158
RPL7A ribosomal protein L7a -0.0376993
RPL8 ribosomal protein L8 -0.0374218
EIF5B eukaryotic translation initiation factor 5B -0.0367382
RPL27A ribosomal protein L27a -0.0359015
SDK1 sidekick cell adhesion molecule 1 -0.0349924
TUBA1B tubulin, alpha 1b -0.0348314
POTEF POTE ankyrin domain family, member F -0.0346521
TUBB4B tubulin, beta 4B class IVb -0.0337647
TPI1 triosephosphate isomerase 1 -0.0329692
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0326662
ATP5F1B ATP synthase F1 subunit beta -0.0322055
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0320347
RPS20 ribosomal protein S20 -0.0311913
RPL30 ribosomal protein L30 -0.0307429
HMGB1 high mobility group box 1 -0.0305512
CBX3 chromobox homolog 3 -0.0304013
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.0302167
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.030118
RPS27 ribosomal protein S27 -0.028987
PKM pyruvate kinase, muscle -0.0288812
RPL18 ribosomal protein L18 -0.0284925
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0282597
RPL10A ribosomal protein L10a -0.0281818
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0277573
YBX1 Y box binding protein 1 -0.0275544
ENO1 enolase 1, (alpha) -0.0274024
RPL15 ribosomal protein L15 -0.0270887
FTH1 ferritin, heavy polypeptide 1 -0.026915
GNAS GNAS complex locus -0.0268255
PA2G4 proliferation-associated 2G4, 38kDa -0.0267969
VDAC1 voltage-dependent anion channel 1 -0.026575
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0264643
ASTN2 astrotactin 2 -0.0263456
RPL7 ribosomal protein L7 -0.0261338
RPL27 ribosomal protein L27 -0.0259572
NOP56 NOP56 ribonucleoprotein -0.0258408
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0257267
RPS4X ribosomal protein S4, X-linked -0.0256686
B2M beta-2-microglobulin -0.0251159