Rimonabant (Hydrochloride)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant (Hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant (Hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPAG9 sperm associated antigen 9 0.085376
FAM13A family with sequence similarity 13, member A 0.0733192
ELL2 elongation factor, RNA polymerase II, 2 0.0663272
ARHGAP21 Rho GTPase activating protein 21 0.0471179
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0457674
OGA O-GlcNAcase 0.045625
GOLGA4 golgin A4 0.0375252
SOD2 superoxide dismutase 2, mitochondrial 0.0367756
MYH9 myosin, heavy chain 9, non-muscle 0.0360768
KDM3A lysine (K)-specific demethylase 3A 0.0359006
DSCAM Down syndrome cell adhesion molecule 0.0354982
TM4SF1 transmembrane 4 L six family member 1 0.0354298
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0344087
HMGB2 high mobility group box 2 0.0337496
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0332579
USP3 ubiquitin specific peptidase 3 0.0319763
NAMPT nicotinamide phosphoribosyltransferase 0.0308636
TRIO trio Rho guanine nucleotide exchange factor 0.0294892
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0293933
ZNF292 zinc finger protein 292 0.0292889
NUP58 nucleoporin 58 0.0285519
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0285306
ADM adrenomedullin 0.0283408
LCORL ligand dependent nuclear receptor corepressor-like 0.0278052
CALU calumenin 0.0274941
HELZ helicase with zinc finger 0.0267468
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0266193
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0257005
ARRDC3 arrestin domain containing 3 0.0256753
CLINT1 clathrin interactor 1 0.025671
SUCO SUN domain containing ossification factor 0.0255246
NDRG1 N-myc downstream regulated 1 0.0253265
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0244185
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0225151
NPEPPS aminopeptidase puromycin sensitive 0.0224486
LDHA lactate dehydrogenase A 0.022435
FNDC3B fibronectin type III domain containing 3B 0.0224174
MARCHF6 membrane associated ring-CH-type finger 6 0.0223597
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0218678
MXI1 MAX interactor 1, dimerization protein 0.0217381
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0214008
CHD1 chromodomain helicase DNA binding protein 1 0.0213151
ELP2 elongator acetyltransferase complex subunit 2 0.0211027
WAC WW domain containing adaptor with coiled-coil 0.0209823
WDR45B WD repeat domain 45B 0.02096
DUSP10 dual specificity phosphatase 10 0.0207745
SDC4 syndecan 4 0.020679
UBA6 ubiquitin-like modifier activating enzyme 6 0.0205592
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.020521
RAD21 RAD21 homolog (S. pombe) 0.0203315
NBAS neuroblastoma amplified sequence 0.0202786
ANXA2 annexin A2 0.0200837
APAF1 apoptotic peptidase activating factor 1 0.0200742
RBM39 RNA binding motif protein 39 0.0200565
NGLY1 N-glycanase 1 0.0197644
RNF145 ring finger protein 145 0.0195829
UGCG UDP-glucose ceramide glucosyltransferase 0.0195744
RAB8B RAB8B, member RAS oncogene family 0.0195171
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0194187
PDE4D phosphodiesterase 4D, cAMP-specific 0.0192628
YTHDC1 YTH domain containing 1 0.0192213
APOLD1 apolipoprotein L domain containing 1 0.0190916
RAB1A RAB1A, member RAS oncogene family 0.0189637
RLF rearranged L-myc fusion 0.018809
ZNF654 zinc finger protein 654 0.0187515
ATP13A3 ATPase type 13A3 0.0186915
ADAM9 ADAM metallopeptidase domain 9 0.0186054
MSI2 musashi RNA-binding protein 2 0.0184991
ANLN anillin, actin binding protein 0.0184726
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0184645
CAVIN1 caveolae associated protein 1 0.0183497
NIPBL Nipped-B homolog (Drosophila) 0.0182863
SMAD3 SMAD family member 3 0.0180276
QKI QKI, KH domain containing, RNA binding 0.0177984
BIRC6 baculoviral IAP repeat containing 6 0.0177541
LOX lysyl oxidase 0.0177055
RASA2 RAS p21 protein activator 2 0.0175959
SRP54 signal recognition particle 54kDa 0.0175782
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0175139
GPHN gephyrin 0.0173913
CNOT2 CCR4-NOT transcription complex, subunit 2 0.017331
RARS1 arginyl-tRNA synthetase 1 0.0172484
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0170286
FOXO3 forkhead box O3 0.0169911
PHIP pleckstrin homology domain interacting protein 0.0168261
DST dystonin 0.0166472
CCNL1 cyclin L1 0.0166039
TFG TRK-fused gene 0.0165371
UBE2O ubiquitin-conjugating enzyme E2O 0.0164866
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0164769
NAV2 neuron navigator 2 0.0164636
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.016444
WTAP Wilms tumor 1 associated protein 0.016387
COPA coatomer protein complex, subunit alpha 0.0161156
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0161088
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0158675
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0157672
MIS18BP1 MIS18 binding protein 1 0.0156424
BZW1 basic leucine zipper and W2 domains 1 0.0155885
FMNL2 formin-like 2 0.0155849

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.230678
FN1 fibronectin 1 -0.20148
NALF1 NALCN channel auxiliary factor 1 -0.187106
AKAP12 A kinase (PRKA) anchor protein 12 -0.168343
PRKG1 protein kinase, cGMP-dependent, type I -0.131381
HMGA2 high mobility group AT-hook 2 -0.120401
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.112022
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.110956
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.106827
MYO10 myosin X -0.105504
TMSB10 thymosin beta 10 -0.104156
COL1A1 collagen, type I, alpha 1 -0.101747
COL6A1 collagen, type VI, alpha 1 -0.0965115
HLA-B major histocompatibility complex, class I, B -0.0961081
CD44 CD44 molecule (Indian blood group) -0.093083
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0857999
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0800205
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0788454
INHBA inhibin, beta A -0.0754781
COL6A3 collagen, type VI, alpha 3 -0.0739865
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0686063
OXR1 oxidation resistance 1 -0.0682807
TGFBI transforming growth factor, beta-induced, 68kDa -0.0627793
NAV1 neuron navigator 1 -0.0598664
COL6A2 collagen, type VI, alpha 2 -0.0590699
CDH13 cadherin 13 -0.0584823
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0570733
CLMP CXADR-like membrane protein -0.0565446
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0541783
COL1A2 collagen, type I, alpha 2 -0.0541572
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0537657
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.051371
PDIA3 protein disulfide isomerase family A, member 3 -0.0480333
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0478753
POTEF POTE ankyrin domain family, member F -0.0468342
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0450434
RPS6 ribosomal protein S6 -0.0449645
GLIS3 GLIS family zinc finger 3 -0.0424166
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0412271
B2M beta-2-microglobulin -0.0410001
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0407486
CEMIP cell migration inducing protein, hyaluronan binding -0.040301
FRMD4A FERM domain containing 4A -0.0397604
HLA-A major histocompatibility complex, class I, A -0.0389661
KIAA1549L KIAA1549-like -0.038085
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.037799
FTH1 ferritin, heavy polypeptide 1 -0.0374149
PRRX1 paired related homeobox 1 -0.037239
EGR1 early growth response 1 -0.0368498
SAMD3 sterile alpha motif domain containing 3 -0.036264
FBN1 fibrillin 1 -0.0358875
TMEM165 transmembrane protein 165 -0.0353351
PRSS23 protease, serine, 23 -0.0343941
TPM4 tropomyosin 4 -0.0343513
EGFR epidermal growth factor receptor -0.0342222
FOXP1 forkhead box P1 -0.0340787
NCKAP5 NCK-associated protein 5 -0.0333156
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0331826
LTBP1 latent transforming growth factor beta binding protein 1 -0.0329985
ASPH aspartate beta-hydroxylase -0.0327892
TFPI2 tissue factor pathway inhibitor 2 -0.0323372
NPTX1 neuronal pentraxin I -0.032013
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0319363
ADGRB3 adhesion G protein-coupled receptor B3 -0.0317625
TPT1 tumor protein, translationally-controlled 1 -0.0308152
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0297921
MYADM myeloid-associated differentiation marker -0.0289603
VEGFA vascular endothelial growth factor A -0.0285946
MAML2 mastermind-like 2 (Drosophila) -0.0283049
RAI14 retinoic acid induced 14 -0.0281882
COL5A3 collagen, type V, alpha 3 -0.0279727
PKM pyruvate kinase, muscle -0.027886
SASH1 SAM and SH3 domain containing 1 -0.0274843
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0274326
ARHGAP22 Rho GTPase activating protein 22 -0.0273844
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0272657
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.026824
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0268008
WNT5A wingless-type MMTV integration site family, member 5A -0.0267351
FTL ferritin, light polypeptide -0.0266985
IGF2 insulin-like growth factor 2 -0.0259495
GREM1 gremlin 1, DAN family BMP antagonist -0.0258407
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0257237
MAML3 mastermind-like 3 (Drosophila) -0.0254286
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.025424
RPLP1 ribosomal protein, large, P1 -0.0254109
ANTXR2 anthrax toxin receptor 2 -0.0252199
CUX1 cut-like homeobox 1 -0.0249842
EXT1 exostosin glycosyltransferase 1 -0.0249761
DNER delta/notch-like EGF repeat containing -0.0244763
OSMR oncostatin M receptor -0.0243189
SLIT2 slit homolog 2 (Drosophila) -0.0239944
CD59 CD59 molecule, complement regulatory protein -0.0237313
PSD3 pleckstrin and Sec7 domain containing 3 -0.0233499
ITGA11 integrin, alpha 11 -0.0233308
MAP1B microtubule-associated protein 1B -0.0232067
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0232028
COL27A1 collagen, type XXVII, alpha 1 -0.0230511
NRP1 neuropilin 1 -0.0230491
DPYD dihydropyrimidine dehydrogenase -0.0228828