Rimonabant Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/104850
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Genes

198 proteins with high or low expression in Rimonabant relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MBP myelin basic protein 0.89
MRPL57 mitochondrial ribosomal protein L57 0.79
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 0.75
PRELID3B PRELI domain containing 3B 0.67
NIBAN1 niban apoptosis regulator 1 0.66
RPL34 ribosomal protein L34 0.65
TOX2 TOX high mobility group box family member 2 0.64
DOHH deoxyhypusine hydroxylase/monooxygenase 0.63
ZNF226 zinc finger protein 226 0.6
SERINC5 serine incorporator 5 0.59
ZMYM5 zinc finger, MYM-type 5 0.59
RPL36A ribosomal protein L36a 0.58
APOB apolipoprotein B 0.56
ZNF564 zinc finger protein 564 0.55
LMBRD1 LMBR1 domain containing 1 0.52
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) 0.52
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.52
MEST mesoderm specific transcript 0.51
DOLK dolichol kinase 0.51
NRP1 neuropilin 1 0.51
UPP1 uridine phosphorylase 1 0.51
LIPA lipase A, lysosomal acid, cholesterol esterase 0.49
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.47
PRELID1 PRELI domain containing 1 0.46
N4BP2L2 NEDD4 binding protein 2-like 2 0.46
MT1L metallothionein 1L (gene/pseudogene) 0.46
LDHD lactate dehydrogenase D 0.43
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.43
TMEM98 transmembrane protein 98 0.43
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 0.43
ZNF397 zinc finger protein 397 0.43
SLFN5 schlafen family member 5 0.42
LASP1 LIM and SH3 protein 1 0.42
PDGFC platelet derived growth factor C 0.42
MCFD2 multiple coagulation factor deficiency 2 0.42
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.41
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 0.41
GDF15 growth differentiation factor 15 0.41
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 0.41
JDP2 Jun dimerization protein 2 0.4
MPDU1 mannose-P-dolichol utilization defect 1 0.4
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.4
RPL26 ribosomal protein L26 0.4
CKS2 CDC28 protein kinase regulatory subunit 2 0.39
MARCKS myristoylated alanine-rich protein kinase C substrate 0.39
PCDH1 protocadherin 1 0.38
DYNLL2 dynein, light chain, LC8-type 2 0.38
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.38
PAQR4 progestin and adipoQ receptor family member IV 0.38
IFRD1 interferon-related developmental regulator 1 0.38
ALAS1 5'-aminolevulinate synthase 1 0.38
ZNF362 zinc finger protein 362 0.38
COA3 cytochrome c oxidase assembly factor 3 0.37
ERP29 endoplasmic reticulum protein 29 0.37
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.37
CEBPZOS CEBPZ opposite strand 0.36
LEPROTL1 leptin receptor overlapping transcript-like 1 0.36
TM7SF3 transmembrane 7 superfamily member 3 0.36
FAM241B family with sequence similarity 241 member B 0.35
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.35
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 0.35
ZNF446 zinc finger protein 446 0.35
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.35
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.34
EMP3 epithelial membrane protein 3 0.34
MT1X metallothionein 1X 0.34
ATF1 activating transcription factor 1 0.34
C2ORF42 chromosome 2 open reading frame 42 0.34
NFYB nuclear transcription factor Y, beta 0.33
GAS8 growth arrest-specific 8 0.33
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.33
TFG TRK-fused gene 0.33
DENND5A DENN/MADD domain containing 5A 0.33
ELOB elongin B 0.33
CHKB choline kinase beta 0.32
KIF21B kinesin family member 21B 0.32
ZNF22 zinc finger protein 22 0.32
TMEM41B transmembrane protein 41B 0.32
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.32
CALB2 calbindin 2 0.32
TNNC2 troponin C type 2 (fast) 0.32
GTPBP2 GTP binding protein 2 0.32
RPL36 ribosomal protein L36 0.32
LSM1 LSM1, U6 small nuclear RNA associated 0.32
SLC25A30 solute carrier family 25, member 30 0.31
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.31
MRPL51 mitochondrial ribosomal protein L51 0.31
LAMA3 laminin, alpha 3 0.31
NRM nurim (nuclear envelope membrane protein) 0.31
NHSL1 NHS-like 1 0.31
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.31
TRIB3 tribbles pseudokinase 3 0.31
ZNF35 zinc finger protein 35 0.31
PLEKHJ1 pleckstrin homology domain containing, family J member 1 0.31
COL7A1 collagen, type VII, alpha 1 0.31
ENO1 enolase 1, (alpha) 0.3
ADIPOR1 adiponectin receptor 1 0.3
CLTA clathrin, light chain A 0.3
GGT7 gamma-glutamyltransferase 7 0.3

low expression

Symbol Name Standardized Value
DIPK1B divergent protein kinase domain 1B -2.0
TMX2 thioredoxin-related transmembrane protein 2 -1.7
DHRS2 dehydrogenase/reductase (SDR family) member 2 -1.43
RNF145 ring finger protein 145 -1.01
CALU calumenin -0.92
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -0.91
TMEM161A transmembrane protein 161A -0.89
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -0.88
TMEM205 transmembrane protein 205 -0.87
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -0.85
DHDDS dehydrodolichyl diphosphate synthase -0.82
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -0.8
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.78
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -0.74
NCAM1 neural cell adhesion molecule 1 -0.71
MYORG myogenesis regulating glycosidase (putative) -0.68
TMEM230 transmembrane protein 230 -0.67
NOVA1 neuro-oncological ventral antigen 1 -0.66
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 -0.65
KCTD17 potassium channel tetramerization domain containing 17 -0.64
ZBED8L ZBED8 like -0.62
SYTL2 synaptotagmin-like 2 -0.61
C12ORF60 chromosome 12 open reading frame 60 -0.58
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -0.57
NCBP2AS2 NCBP2 antisense 2 (head to head) -0.57
SFI1 Sfi1 homolog, spindle assembly associated (yeast) -0.56
TSPAN5 tetraspanin 5 -0.56
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.55
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor -0.54
INPP5J inositol polyphosphate-5-phosphatase J -0.53
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) -0.51
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.5
ARMC7 armadillo repeat containing 7 -0.5
BORCS5 BLOC-1 related complex subunit 5 -0.5
TTLL4 tubulin tyrosine ligase-like family member 4 -0.5
ENDOG endonuclease G -0.5
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -0.49
GID8 GID complex subunit 8 -0.48
TMEM259 transmembrane protein 259 -0.47
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.46
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.46
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -0.46
BTBD11 BTB (POZ) domain containing 11 -0.45
DBF4 DBF4 zinc finger -0.44
HIPK2 homeodomain interacting protein kinase 2 -0.42
MAGEA2 melanoma antigen family A2 -0.42
ZNF124 zinc finger protein 124 -0.42
ARHGAP44 Rho GTPase activating protein 44 -0.42
GRTP1 growth hormone regulated TBC protein 1 -0.42
DES desmin -0.42
GAS2L3 growth arrest-specific 2 like 3 -0.42
MCOLN2 mucolipin 2 -0.41
TMC4 transmembrane channel-like 4 -0.4
RGN regucalcin -0.4
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -0.39
ADAM19 ADAM metallopeptidase domain 19 -0.39
UBE2C ubiquitin-conjugating enzyme E2C -0.38
HPCAL4 hippocalcin like 4 -0.38
RAB33B RAB33B, member RAS oncogene family -0.38
LRRC28 leucine rich repeat containing 28 -0.38
HSH2D hematopoietic SH2 domain containing -0.37
MED7 mediator complex subunit 7 -0.37
PKM pyruvate kinase, muscle -0.37
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -0.37
LINGO1 leucine rich repeat and Ig domain containing 1 -0.37
TMC5 transmembrane channel-like 5 -0.37
BCL7A B-cell CLL/lymphoma 7A -0.36
DSTYK dual serine/threonine and tyrosine protein kinase -0.36
CREG1 cellular repressor of E1A-stimulated genes 1 -0.35
PCLO piccolo presynaptic cytomatrix protein -0.35
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -0.35
FUNDC1 FUN14 domain containing 1 -0.35
SDHAF3 succinate dehydrogenase complex assembly factor 3 -0.35
LYST lysosomal trafficking regulator -0.35
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.35
FAM124A family with sequence similarity 124A -0.34
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.34
TMPPE transmembrane protein with metallophosphoesterase domain -0.34
RCAN3 RCAN family member 3 -0.34
ZRANB1 zinc finger, RAN-binding domain containing 1 -0.34
SP110 SP110 nuclear body protein -0.34
PDE2A phosphodiesterase 2A, cGMP-stimulated -0.34
FAM102B family with sequence similarity 102, member B -0.33
NEU1 sialidase 1 (lysosomal sialidase) -0.33
CD274 CD274 molecule -0.33
TOR4A torsin family 4, member A -0.33
XDH xanthine dehydrogenase -0.33
SDF2 stromal cell-derived factor 2 -0.33
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -0.33
RAD51 RAD51 recombinase -0.33
ABHD18 abhydrolase domain containing 18 -0.32
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -0.32
FGFBP1 fibroblast growth factor binding protein 1 -0.32
HGH1 HGH1 homolog (S. cerevisiae) -0.32
CA8 carbonic anhydrase VIII -0.32
SPATA2L spermatogenesis associated 2-like -0.32
C12ORF66 chromosome 12 open reading frame 66 -0.31
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D -0.31
ARSK arylsulfatase family, member K -0.31