Rimonabant_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rimonabant_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GLCCI1 glucocorticoid induced 1 0.0842491
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0782468
TLE4 transducin-like enhancer of split 4 0.069168
MEIS2 Meis homeobox 2 0.068174
SLIT2 slit homolog 2 (Drosophila) 0.0650496
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0619501
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0616249
CLTC clathrin, heavy chain (Hc) 0.0565571
PTPRK protein tyrosine phosphatase, receptor type, K 0.0550814
MRTFA myocardin related transcription factor A 0.0523341
TPST1 tyrosylprotein sulfotransferase 1 0.0517609
IGF2 insulin-like growth factor 2 0.0475661
ZNF609 zinc finger protein 609 0.0474561
TPR translocated promoter region, nuclear basket protein 0.0471498
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0467442
APP amyloid beta (A4) precursor protein 0.0466536
SRRM2 serine/arginine repetitive matrix 2 0.0462739
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0462007
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0449505
PLPP1 phospholipid phosphatase 1 0.044122
MAP1B microtubule-associated protein 1B 0.043593
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0431785
FMN1 formin 1 0.0431268
ZSWIM6 zinc finger, SWIM-type containing 6 0.0415472
FLNA filamin A, alpha 0.0415167
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0406422
PLAT plasminogen activator, tissue 0.0405403
DST dystonin 0.0402406
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0397433
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0391536
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0387475
DUSP10 dual specificity phosphatase 10 0.0383605
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0382099
SETBP1 SET binding protein 1 0.0377387
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0375783
SP100 SP100 nuclear antigen 0.0371605
DGKH diacylglycerol kinase, eta 0.0368014
MEF2D myocyte enhancer factor 2D 0.0366284
HOMER1 homer scaffolding protein 1 0.0357072
FOXP1 forkhead box P1 0.035437
PKM pyruvate kinase, muscle 0.035222
PCDH9 protocadherin 9 0.0343151
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0340291
MYO6 myosin VI 0.0338429
CENPF centromere protein F, 350/400kDa 0.0334729
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0334342
ARHGAP24 Rho GTPase activating protein 24 0.0326501
SET SET nuclear proto-oncogene 0.032453
VEGFA vascular endothelial growth factor A 0.0320155
ATP10D ATPase, class V, type 10D 0.031931
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.031222
STK38L serine/threonine kinase 38 like 0.0310979
UBE2H ubiquitin-conjugating enzyme E2H 0.0307833
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0302404
PCM1 pericentriolar material 1 0.030126
KDM6A lysine (K)-specific demethylase 6A 0.0300459
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0300144
MMP2 matrix metallopeptidase 2 0.0300054
MED13 mediator complex subunit 13 0.0298731
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0297261
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0296955
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0296095
RC3H1 ring finger and CCCH-type domains 1 0.0294454
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.0290515
PKP4 plakophilin 4 0.0288505
ZFC3H1 zinc finger, C3H1-type containing 0.0287996
AOPEP aminopeptidase O (putative) 0.0285681
KLHL13 kelch-like family member 13 0.0284959
LARP4B La ribonucleoprotein domain family, member 4B 0.0281343
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0281336
DCAF7 DDB1 and CUL4 associated factor 7 0.0281231
NRP1 neuropilin 1 0.0277815
PTPRE protein tyrosine phosphatase, receptor type, E 0.0277773
ITGAV integrin, alpha V 0.0273775
ADAR adenosine deaminase, RNA-specific 0.0273746
RIGI RNA sensor RIG-I 0.0273397
THBS1 thrombospondin 1 0.0272635
RET ret proto-oncogene 0.02706
TSHZ2 teashirt zinc finger homeobox 2 0.0264945
AUTS2 autism susceptibility candidate 2 0.0264931
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0263951
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.026392
MTSS2 MTSS I-BAR domain containing 2 0.0260066
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.025913
EEF2 eukaryotic translation elongation factor 2 0.0258946
PLEC plectin 0.0255741
DSTN destrin (actin depolymerizing factor) 0.0255026
BIRC6 baculoviral IAP repeat containing 6 0.0254621
LCOR ligand dependent nuclear receptor corepressor 0.0252921
SYNPO2 synaptopodin 2 0.0250702
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.025005
RNF213 ring finger protein 213 0.0248904
CDK19 cyclin-dependent kinase 19 0.0248253
ZRANB1 zinc finger, RAN-binding domain containing 1 0.0247645
FHL2 four and a half LIM domains 2 0.024592
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.0244871
FHIT fragile histidine triad 0.0243045
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0242157
FERMT2 fermitin family member 2 0.0240004
NFE2L1 nuclear factor, erythroid 2-like 1 0.0239816

decreased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein -0.207124
NRG1 neuregulin 1 -0.107087
PTPRD protein tyrosine phosphatase, receptor type, D -0.104393
PTMA prothymosin, alpha -0.0851143
TRIB2 tribbles pseudokinase 2 -0.0727554
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0656528
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0652255
EXT1 exostosin glycosyltransferase 1 -0.0650536
VCL vinculin -0.0649297
RPL23 ribosomal protein L23 -0.0623077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0600934
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0592413
RPTOR regulatory associated protein of MTOR, complex 1 -0.0586402
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0580776
RPS24 ribosomal protein S24 -0.0556848
MAML2 mastermind-like 2 (Drosophila) -0.0544907
FRMD4A FERM domain containing 4A -0.0524737
AKAP12 A kinase (PRKA) anchor protein 12 -0.0519809
RPL19 ribosomal protein L19 -0.0516355
RPS6 ribosomal protein S6 -0.0515064
ATRNL1 attractin-like 1 -0.050621
SMYD3 SET and MYND domain containing 3 -0.0484012
RPL37A ribosomal protein L37a -0.0481046
TPT1 tumor protein, translationally-controlled 1 -0.0469024
ENO1 enolase 1, (alpha) -0.0461524
GPC5 glypican 5 -0.0454033
PIBF1 progesterone immunomodulatory binding factor 1 -0.045234
PRKG1 protein kinase, cGMP-dependent, type I -0.0446464
GMDS GDP-mannose 4,6-dehydratase -0.0446037
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0436205
CADM2 cell adhesion molecule 2 -0.0414739
COL4A6 collagen, type IV, alpha 6 -0.040806
RNF150 ring finger protein 150 -0.0402974
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0385257
DTNA dystrobrevin, alpha -0.0384251
RPL34 ribosomal protein L34 -0.0378885
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0366163
NREP neuronal regeneration related protein -0.0359104
EGFR epidermal growth factor receptor -0.0358269
RPL31 ribosomal protein L31 -0.0353577
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0349221
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0347151
RPLP1 ribosomal protein, large, P1 -0.0342596
MORF4L2 mortality factor 4 like 2 -0.033825
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0336048
ACBD6 acyl-CoA binding domain containing 6 -0.0334627
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0333481
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0330234
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0327586
DNAH14 dynein, axonemal, heavy chain 14 -0.0326458
ANTXR1 anthrax toxin receptor 1 -0.0325871
RPL26 ribosomal protein L26 -0.0323397
IGFBP3 insulin-like growth factor binding protein 3 -0.0322221
RPS12 ribosomal protein S12 -0.0319842
RPL9 ribosomal protein L9 -0.031983
RPLP0 ribosomal protein, large, P0 -0.0319377
RPL13A ribosomal protein L13a -0.0315997
FNDC3B fibronectin type III domain containing 3B -0.0314186
ARHGAP32 Rho GTPase activating protein 32 -0.0312499
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0312164
CSMD3 CUB and Sushi multiple domains 3 -0.0311551
RBBP6 retinoblastoma binding protein 6 -0.0310006
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0304634
EPAS1 endothelial PAS domain protein 1 -0.0304496
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0302886
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0300324
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0296458
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0295614
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0295175
PTPRM protein tyrosine phosphatase, receptor type, M -0.0292353
RPS27 ribosomal protein S27 -0.029213
ATXN10 ataxin 10 -0.0286937
HELZ helicase with zinc finger -0.02831
ZNF124 zinc finger protein 124 -0.0282342
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0280898
RPL28 ribosomal protein L28 -0.0280337
NPR2 natriuretic peptide receptor 2 -0.0279267
SOD2 superoxide dismutase 2, mitochondrial -0.0278573
SBF2 SET binding factor 2 -0.0277807
EIF1 eukaryotic translation initiation factor 1 -0.0276433
VIM vimentin -0.0276196
DENND4A DENN/MADD domain containing 4A -0.0275058
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0272809
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0271834
NBEAL1 neurobeachin-like 1 -0.0271336
NCAM2 neural cell adhesion molecule 2 -0.0270431
CDH13 cadherin 13 -0.0269472
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0268962
PCNP PEST proteolytic signal containing nuclear protein -0.0268936
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0268635
MCL1 myeloid cell leukemia 1 -0.0268122
IER3 immediate early response 3 -0.0267356
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0266839
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0265637
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0265504
TM9SF3 transmembrane 9 superfamily member 3 -0.0263947
AHR aryl hydrocarbon receptor -0.0260891
RAD21 RAD21 homolog (S. pombe) -0.0259891
RPS19 ribosomal protein S19 -0.0259516
H1-0 H1.0 linker histone -0.0258505