Rimonabant_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PALM2AKAP2 PALM2 and AKAP2 fusion 0.124475
LMO7 LIM domain 7 0.110636
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.103705
TIMP3 TIMP metallopeptidase inhibitor 3 0.0912604
BCAR3 breast cancer anti-estrogen resistance 3 0.0839749
SLC35F3 solute carrier family 35, member F3 0.0772526
PDLIM5 PDZ and LIM domain 5 0.074014
PDE4D phosphodiesterase 4D, cAMP-specific 0.0735733
LAMA5 laminin, alpha 5 0.0722481
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0694632
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0666824
PLEC plectin 0.0623959
RASAL2 RAS protein activator like 2 0.0614615
INTS6 integrator complex subunit 6 0.061146
AKAP13 A kinase (PRKA) anchor protein 13 0.0564679
MACF1 microtubule-actin crosslinking factor 1 0.054058
SULF2 sulfatase 2 0.0540033
PODXL podocalyxin-like 0.0527273
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.051915
LAMC2 laminin, gamma 2 0.0518393
FLNB filamin B, beta 0.0498853
HMGA2 high mobility group AT-hook 2 0.0489284
NCOR2 nuclear receptor corepressor 2 0.0481397
AMOTL1 angiomotin like 1 0.0470569
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0463028
ZSWIM6 zinc finger, SWIM-type containing 6 0.0417275
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.041697
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0416647
HSPG2 heparan sulfate proteoglycan 2 0.0411019
PLS3 plastin 3 0.0403711
RCOR1 REST corepressor 1 0.040329
RABGAP1L RAB GTPase activating protein 1-like 0.040024
RNF217 ring finger protein 217 0.0397477
PLXNA2 plexin A2 0.0396142
MSN moesin 0.039435
PRSS23 protease, serine, 23 0.0384517
PICALM phosphatidylinositol binding clathrin assembly protein 0.0383955
DOCK5 dedicator of cytokinesis 5 0.0378897
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0374296
FLNA filamin A, alpha 0.0371523
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0369094
ANO1 anoctamin 1, calcium activated chloride channel 0.0368422
MPRIP myosin phosphatase Rho interacting protein 0.0366869
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0365302
GRB10 growth factor receptor-bound protein 10 0.0363546
ACTN4 actinin, alpha 4 0.0362104
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.035251
EGR1 early growth response 1 0.0345793
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0338586
LUZP1 leucine zipper protein 1 0.0335827
ALCAM activated leukocyte cell adhesion molecule 0.0335713
HLA-B major histocompatibility complex, class I, B 0.0334999
BCL2L1 BCL2-like 1 0.0330235
EXT1 exostosin glycosyltransferase 1 0.032883
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0326738
KIAA1671 KIAA1671 0.0326636
TSC22D1 TSC22 domain family, member 1 0.0325598
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0325068
EGFR epidermal growth factor receptor 0.03235
MTSS1 metastasis suppressor 1 0.0320417
DPYD dihydropyrimidine dehydrogenase 0.0319725
MYH9 myosin, heavy chain 9, non-muscle 0.0313838
IFI44L interferon-induced protein 44-like 0.0312499
SIK3 SIK family kinase 3 0.0302358
ACTN1 actinin, alpha 1 0.0300941
CMIP c-Maf inducing protein 0.0295108
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0291449
DPYSL2 dihydropyrimidinase-like 2 0.0287491
FLG filaggrin 0.028014
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0278084
JAG1 jagged 1 0.0269542
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0266054
PYGL phosphorylase, glycogen, liver 0.0263382
MECOM MDS1 and EVI1 complex locus 0.0261477
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0257611
MT2A metallothionein 2A 0.0255109
IFI6 interferon, alpha-inducible protein 6 0.0255014
AGO2 argonaute RISC catalytic component 2 0.0254203
MCL1 myeloid cell leukemia 1 0.0253261
ECE1 endothelin converting enzyme 1 0.0249282
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0249231
PCDH1 protocadherin 1 0.0245894
THSD4 thrombospondin, type I, domain containing 4 0.0243734
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0241084
ACTG1 actin gamma 1 0.0240647
TGM2 transglutaminase 2 0.0240602
MBNL1 muscleblind-like splicing regulator 1 0.0239656
CLIC4 chloride intracellular channel 4 0.0239544
ZMIZ1 zinc finger, MIZ-type containing 1 0.0238561
SEPTIN9 septin 9 0.023637
NDRG1 N-myc downstream regulated 1 0.0232156
DOK5 docking protein 5 0.0231862
TJP1 tight junction protein 1 0.0231561
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0230149
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.022897
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.02249
NTSR1 neurotensin receptor 1 (high affinity) 0.0223656
SVIL supervillin 0.022281
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0221552
HDAC9 histone deacetylase 9 0.0221479

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.115086
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105672
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0858838
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0766378
PTMA prothymosin, alpha -0.075129
GOLGA4 golgin A4 -0.0720826
RBM39 RNA binding motif protein 39 -0.0684593
CLU clusterin -0.068394
CANX calnexin -0.0650651
ANLN anillin, actin binding protein -0.0602147
EMP1 epithelial membrane protein 1 -0.0598675
MYOF myoferlin -0.0573431
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0564494
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0558114
OGA O-GlcNAcase -0.0557713
CUL4B cullin 4B -0.0550361
KRT17 keratin 17, type I -0.0506564
KDM3A lysine (K)-specific demethylase 3A -0.0494446
MORF4L2 mortality factor 4 like 2 -0.0481978
COPB1 coatomer protein complex, subunit beta 1 -0.048142
ITCH itchy E3 ubiquitin protein ligase -0.0478377
TMSB4X thymosin beta 4, X-linked -0.0476273
PGK1 phosphoglycerate kinase 1 -0.0468195
H1-0 H1.0 linker histone -0.0457526
ENO1 enolase 1, (alpha) -0.0438719
SEC31A SEC31 homolog A (S. cerevisiae) -0.0430127
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0413185
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0406071
SPAG9 sperm associated antigen 9 -0.040438
CAV1 caveolin 1, caveolae protein, 22kDa -0.0397981
ANXA2 annexin A2 -0.0397927
MEF2A myocyte enhancer factor 2A -0.0390555
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0389015
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.038685
ESYT2 extended synaptotagmin-like protein 2 -0.037643
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0368142
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0363258
SUCO SUN domain containing ossification factor -0.0359535
RLF rearranged L-myc fusion -0.0358577
ANXA1 annexin A1 -0.0358051
DSTN destrin (actin depolymerizing factor) -0.0353816
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0351293
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0351032
DLG1 discs, large homolog 1 (Drosophila) -0.0345506
SQLE squalene epoxidase -0.0344708
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0339645
S100A10 S100 calcium binding protein A10 -0.0339132
CALU calumenin -0.0335557
NPEPPS aminopeptidase puromycin sensitive -0.0334002
LMAN1 lectin, mannose-binding, 1 -0.0329972
ZNF292 zinc finger protein 292 -0.0325091
COG5 component of oligomeric golgi complex 5 -0.0317607
MXI1 MAX interactor 1, dimerization protein -0.0313119
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0309076
KDM5B lysine (K)-specific demethylase 5B -0.0305262
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0305226
SRP54 signal recognition particle 54kDa -0.030354
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0302371
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0297925
ARRDC3 arrestin domain containing 3 -0.029726
MARCHF6 membrane associated ring-CH-type finger 6 -0.0295674
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0293804
SBF2 SET binding factor 2 -0.0290521
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0287901
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.028665
DENND4C DENN/MADD domain containing 4C -0.0285929
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0281396
RAD21 RAD21 homolog (S. pombe) -0.0279449
GNAS GNAS complex locus -0.0277364
NAP1L1 nucleosome assembly protein 1-like 1 -0.0275231
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0274227
TRIO trio Rho guanine nucleotide exchange factor -0.0273062
PNISR PNN-interacting serine/arginine-rich protein -0.027113
KIAA1217 KIAA1217 -0.0270244
STAU1 staufen double-stranded RNA binding protein 1 -0.0269982
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0269088
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0268691
PDIA3 protein disulfide isomerase family A, member 3 -0.0263875
KMT2E lysine (K)-specific methyltransferase 2E -0.0262781
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0261999
METTL15 methyltransferase like 15 -0.026164
TKT transketolase -0.0260368
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0259333
BZW2 basic leucine zipper and W2 domains 2 -0.0259293
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0256273
RAB1A RAB1A, member RAS oncogene family -0.0253436
MATR3 matrin 3 -0.0253275
BHLHE40 basic helix-loop-helix family, member e40 -0.0253203
HDLBP high density lipoprotein binding protein -0.0248808
ANKRD33B ankyrin repeat domain 33B -0.0247074
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0246348
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0245342
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0244418
LNPEP leucyl/cystinyl aminopeptidase -0.0244364
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0243175
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0242809
XPO1 exportin 1 -0.024274
ARF1 ADP-ribosylation factor 1 -0.024178
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0241657
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0240937