Rimonabant_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.121044
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.117236
LMO7 LIM domain 7 0.0956167
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0754646
CEMIP cell migration inducing protein, hyaluronan binding 0.0640674
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0431817
MUC13 mucin 13, cell surface associated 0.0407245
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0400111
KDM7A lysine (K)-specific demethylase 7A 0.0379648
MACF1 microtubule-actin crosslinking factor 1 0.0345777
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0320349
GMDS GDP-mannose 4,6-dehydratase 0.0319622
FOXO1 forkhead box O1 0.0311002
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0307681
SRRM2 serine/arginine repetitive matrix 2 0.0307329
MYO5B myosin VB 0.0290019
ABHD2 abhydrolase domain containing 2 0.0290013
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0284214
BTBD9 BTB (POZ) domain containing 9 0.0282469
EEF2 eukaryotic translation elongation factor 2 0.0281193
RIGI RNA sensor RIG-I 0.0280727
APP amyloid beta (A4) precursor protein 0.0268725
PLEC plectin 0.0260601
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0260335
KLF3 Kruppel-like factor 3 (basic) 0.0259616
MYO1E myosin IE 0.0258318
ESRP1 epithelial splicing regulatory protein 1 0.0253867
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0249819
UBE2H ubiquitin-conjugating enzyme E2H 0.0240331
RNF145 ring finger protein 145 0.0237487
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0232071
TNRC18 trinucleotide repeat containing 18 0.0232023
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0226055
USP6NL USP6 N-terminal like 0.0225943
SOX9 SRY (sex determining region Y)-box 9 0.0223719
CTBP2 C-terminal binding protein 2 0.0223223
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.022264
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0217344
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0214204
NKD1 naked cuticle homolog 1 (Drosophila) 0.0211934
ABHD17C abhydrolase domain containing 17C 0.0210346
NEBL nebulette 0.0208263
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0207001
SNX9 sorting nexin 9 0.0203778
MYH9 myosin, heavy chain 9, non-muscle 0.0203181
RPL3 ribosomal protein L3 0.0202091
VEGFA vascular endothelial growth factor A 0.0198276
TGFBR3 transforming growth factor, beta receptor III 0.0197647
MED13 mediator complex subunit 13 0.0194939
ZNRF3 zinc and ring finger 3 0.0193746
TACC2 transforming, acidic coiled-coil containing protein 2 0.0188926
ZFAND3 zinc finger, AN1-type domain 3 0.0188338
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0186513
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0185232
HYOU1 hypoxia up-regulated 1 0.0184978
CMIP c-Maf inducing protein 0.0183782
AFF1 AF4/FMR2 family, member 1 0.018134
ADGRV1 adhesion G protein-coupled receptor V1 0.018048
SDCBP2 syndecan binding protein (syntenin) 2 0.0179464
RNF43 ring finger protein 43 0.0174788
UBN2 ubinuclein 2 0.0172315
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0170677
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0169635
BCAS3 breast carcinoma amplified sequence 3 0.0168627
KANK1 KN motif and ankyrin repeat domains 1 0.0162343
ANKRD11 ankyrin repeat domain 11 0.0162322
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0160514
GAK cyclin G associated kinase 0.015968
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0159186
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0157827
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0155583
ANKRD17 ankyrin repeat domain 17 0.0154415
CTNND1 catenin (cadherin-associated protein), delta 1 0.0153734
ARHGAP26 Rho GTPase activating protein 26 0.0153271
SHB Src homology 2 domain containing adaptor protein B 0.0153228
TLN1 talin 1 0.0152442
CUX1 cut-like homeobox 1 0.0151923
AFDN afadin, adherens junction formation factor 0.0151476
UNC13B unc-13 homolog B (C. elegans) 0.0151104
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.0151029
PDZD8 PDZ domain containing 8 0.0150569
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0150451
HDLBP high density lipoprotein binding protein 0.0150304
PLS1 plastin 1 0.0150271
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.01497
ACADVL acyl-CoA dehydrogenase, very long chain 0.0149372
FNDC3A fibronectin type III domain containing 3A 0.0148752
EPB41 erythrocyte membrane protein band 4.1 0.0148219
AKAP13 A kinase (PRKA) anchor protein 13 0.0147963
SEPTIN9 septin 9 0.0147723
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.0147138
ARHGAP42 Rho GTPase activating protein 42 0.0147121
SSH2 slingshot protein phosphatase 2 0.0146842
CLIP2 CAP-GLY domain containing linker protein 2 0.014584
ONECUT3 one cut homeobox 3 0.0144872
ABR active BCR-related 0.0144792
JMY junction mediating and regulatory protein, p53 cofactor 0.0143968
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0142748
CALR calreticulin 0.0141847
CD44 CD44 molecule (Indian blood group) 0.0141536

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.202695
TMSB10 thymosin beta 10 -0.188995
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.170845
PTMA prothymosin, alpha -0.16991
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.139449
RPS6 ribosomal protein S6 -0.126852
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0822612
TPT1 tumor protein, translationally-controlled 1 -0.0816439
NALF1 NALCN channel auxiliary factor 1 -0.0795216
VCL vinculin -0.0776563
RPS8 ribosomal protein S8 -0.0768456
RPL35A ribosomal protein L35a -0.0757393
ANXA2 annexin A2 -0.0691608
KRT18 keratin 18, type I -0.0617119
RPLP1 ribosomal protein, large, P1 -0.0613974
GREB1L growth regulation by estrogen in breast cancer-like -0.0599833
RPL9 ribosomal protein L9 -0.0593936
RPL37A ribosomal protein L37a -0.0577299
RPL23 ribosomal protein L23 -0.0574888
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0552449
ASPH aspartate beta-hydroxylase -0.0540661
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0523092
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.051217
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0504812
FHIT fragile histidine triad -0.0490449
RPL11 ribosomal protein L11 -0.0490359
SLC35F3 solute carrier family 35, member F3 -0.0480464
PGK1 phosphoglycerate kinase 1 -0.0475592
POTEF POTE ankyrin domain family, member F -0.0474217
MAML2 mastermind-like 2 (Drosophila) -0.0474031
RPS19 ribosomal protein S19 -0.0472057
RPL34 ribosomal protein L34 -0.0467985
RPS24 ribosomal protein S24 -0.0465732
ENO1 enolase 1, (alpha) -0.0453637
LDHA lactate dehydrogenase A -0.0449373
RPS12 ribosomal protein S12 -0.0444744
ACTG1 actin gamma 1 -0.0439522
RPLP0 ribosomal protein, large, P0 -0.0433524
KRT19 keratin 19, type I -0.0433153
FTL ferritin, light polypeptide -0.042566
RPLP2 ribosomal protein, large, P2 -0.041815
LAMA4 laminin, alpha 4 -0.0411879
RPS27A ribosomal protein S27a -0.041158
PRELID2 PRELI domain containing 2 -0.0405204
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0402205
SBF2 SET binding factor 2 -0.0402045
EPCAM epithelial cell adhesion molecule -0.0400895
RPL12 ribosomal protein L12 -0.0396885
RPS23 ribosomal protein S23 -0.038604
S100A6 S100 calcium binding protein A6 -0.0382378
PTPRB protein tyrosine phosphatase, receptor type, B -0.0379748
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0371264
RPL31 ribosomal protein L31 -0.0364898
HMGA1 high mobility group AT-hook 1 -0.0358787
RPL26 ribosomal protein L26 -0.0350252
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.034438
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0340631
DENND1A DENN/MADD domain containing 1A -0.0339425
RPL36 ribosomal protein L36 -0.033148
FAM13A family with sequence similarity 13, member A -0.0328219
RPL7A ribosomal protein L7a -0.0326775
DIAPH3 diaphanous-related formin 3 -0.0325416
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0321037
RPS13 ribosomal protein S13 -0.031723
IER3 immediate early response 3 -0.0313481
FTH1 ferritin, heavy polypeptide 1 -0.031164
AGR2 anterior gradient 2 -0.0311522
S100A10 S100 calcium binding protein A10 -0.0308778
PKM pyruvate kinase, muscle -0.0306055
TAS2R14 taste receptor, type 2, member 14 -0.0303676
NAP1L1 nucleosome assembly protein 1-like 1 -0.0297236
PNISR PNN-interacting serine/arginine-rich protein -0.0295248
CALB1 calbindin 1, 28kDa -0.0293393
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0292089
RAD51B RAD51 paralog B -0.0289795
RPL7 ribosomal protein L7 -0.0286053
S100P S100 calcium binding protein P -0.0283582
YBX1 Y box binding protein 1 -0.0275096
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0275086
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.027449
EXOC4 exocyst complex component 4 -0.0274196
RPS25 ribosomal protein S25 -0.0272921
RPS3 ribosomal protein S3 -0.0272364
RPL5 ribosomal protein L5 -0.0271704
RPS21 ribosomal protein S21 -0.0271337
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0268768
F3 coagulation factor III (thromboplastin, tissue factor) -0.0264324
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0261447
RPS11 ribosomal protein S11 -0.0259809
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0259043
LOC112694756 uncharaterized LOC112694756 -0.0258506
RPL27A ribosomal protein L27a -0.0258035
MT2A metallothionein 2A -0.0256516
PDE4D phosphodiesterase 4D, cAMP-specific -0.025548
TFF3 trefoil factor 3 (intestinal) -0.0254236
PFN1 profilin 1 -0.0254066
RPS14 ribosomal protein S14 -0.0253023
RNF217 ring finger protein 217 -0.0252763
PERP PERP, TP53 apoptosis effector -0.0251228
THSD4 thrombospondin, type I, domain containing 4 -0.0250114