Rimonabant_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.222357
UBC ubiquitin C 0.149468
TMSB10 thymosin beta 10 0.112113
EEF2 eukaryotic translation elongation factor 2 0.102489
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0803337
JUN jun proto-oncogene 0.0796646
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0739114
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0690227
AHNAK AHNAK nucleoprotein 0.0682658
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0681442
RPS27A ribosomal protein S27a 0.059902
ENO1 enolase 1, (alpha) 0.0579929
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0568061
CALR calreticulin 0.0530426
POTEF POTE ankyrin domain family, member F 0.0413549
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0352568
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0349405
RPL23 ribosomal protein L23 0.0342267
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0340798
LOC112694756 uncharaterized LOC112694756 0.0313791
PCBP2 poly(rC) binding protein 2 0.0304219
NPAS2 neuronal PAS domain protein 2 0.0295601
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0295136
PRELID2 PRELI domain containing 2 0.0286726
DST dystonin 0.027831
PKM pyruvate kinase, muscle 0.0277177
MYOF myoferlin 0.0276808
ENO2 enolase 2 (gamma, neuronal) 0.0274354
MCL1 myeloid cell leukemia 1 0.027024
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0265065
PLK2 polo-like kinase 2 0.0261697
LDHA lactate dehydrogenase A 0.0260887
EIF4A1 eukaryotic translation initiation factor 4A1 0.0260197
PDIA4 protein disulfide isomerase family A, member 4 0.0259568
INTS6 integrator complex subunit 6 0.0257424
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0256558
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0253107
NEK10 NIMA-related kinase 10 0.0248352
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0247715
CTBP2 C-terminal binding protein 2 0.0243234
APLP2 amyloid beta (A4) precursor-like protein 2 0.0241009
PTPRF protein tyrosine phosphatase, receptor type, F 0.0240081
CMIP c-Maf inducing protein 0.0239946
SFPQ splicing factor proline/glutamine-rich 0.0232965
RUNX1 runt-related transcription factor 1 0.0226123
RAB7A RAB7A, member RAS oncogene family 0.0221239
PLEC plectin 0.021794
ACTG1 actin gamma 1 0.0217225
ZSWIM6 zinc finger, SWIM-type containing 6 0.0216811
TGM2 transglutaminase 2 0.0215809
WDR27 WD repeat domain 27 0.0212903
AARS1 alanyl-tRNA synthetase 1 0.0206333
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0204623
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0202434
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0202137
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0201695
BCAR3 breast cancer anti-estrogen resistance 3 0.0201633
ZNF638 zinc finger protein 638 0.0200488
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0198978
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0198067
HOMER1 homer scaffolding protein 1 0.0197344
MOK MOK protein kinase 0.0197223
NIBAN2 niban apoptosis regulator 2 0.0194306
HDAC9 histone deacetylase 9 0.0193756
TNRC18 trinucleotide repeat containing 18 0.0187692
TSC22D1 TSC22 domain family, member 1 0.01862
CERS2 ceramide synthase 2 0.0185667
FLNB filamin B, beta 0.0185523
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0184241
ACTN4 actinin, alpha 4 0.0184031
TIMP2 TIMP metallopeptidase inhibitor 2 0.0176462
SPDYA speedy/RINGO cell cycle regulator family member A 0.0175887
PCDH1 protocadherin 1 0.0175241
FLNA filamin A, alpha 0.0174948
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.017086
HILPDA hypoxia inducible lipid droplet-associated 0.0168819
UBA1 ubiquitin-like modifier activating enzyme 1 0.0168276
MBNL2 muscleblind-like splicing regulator 2 0.0167195
PFKL phosphofructokinase, liver 0.0166983
CALU calumenin 0.0165788
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0165547
HSPG2 heparan sulfate proteoglycan 2 0.0165387
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0164753
MYH9 myosin, heavy chain 9, non-muscle 0.0164616
CSMD3 CUB and Sushi multiple domains 3 0.0164247
MLPH melanophilin 0.0163367
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0162437
DLG1 discs, large homolog 1 (Drosophila) 0.0161854
SND1 staphylococcal nuclease and tudor domain containing 1 0.016019
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0158247
EEF1G eukaryotic translation elongation factor 1 gamma 0.0157383
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0157167
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0156649
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0156133
ZDHHC14 zinc finger, DHHC-type containing 14 0.0155764
RPS4X ribosomal protein S4, X-linked 0.0154727
FMNL2 formin-like 2 0.0154561
CTIF CBP80/20-dependent translation initiation factor 0.0153524
HDLBP high density lipoprotein binding protein 0.0153446
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0152851

decreased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 -0.177811
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0860424
CENPF centromere protein F, 350/400kDa -0.0773902
TMSB4X thymosin beta 4, X-linked -0.0729941
TP63 tumor protein p63 -0.064273
RPS2 ribosomal protein S2 -0.0614116
RPS6 ribosomal protein S6 -0.0597349
MT2A metallothionein 2A -0.0542801
NAMPT nicotinamide phosphoribosyltransferase -0.0522871
HLA-B major histocompatibility complex, class I, B -0.0500886
ARHGAP5 Rho GTPase activating protein 5 -0.0484911
KMT2E lysine (K)-specific methyltransferase 2E -0.0433947
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0416441
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0413368
MKI67 marker of proliferation Ki-67 -0.0413007
SPAG9 sperm associated antigen 9 -0.0398885
ZMYND8 zinc finger, MYND-type containing 8 -0.0386693
RIGI RNA sensor RIG-I -0.0353586
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0346204
RPL38 ribosomal protein L38 -0.03426
USP34 ubiquitin specific peptidase 34 -0.0340501
RPL35A ribosomal protein L35a -0.0330139
TPT1 tumor protein, translationally-controlled 1 -0.0329189
KPNB1 karyopherin (importin) beta 1 -0.0328338
CLTC clathrin, heavy chain (Hc) -0.0327495
RPL12 ribosomal protein L12 -0.0319853
BIRC2 baculoviral IAP repeat containing 2 -0.0316107
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0304467
YEATS2 YEATS domain containing 2 -0.030311
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0291668
RPS19 ribosomal protein S19 -0.02902
CEP170 centrosomal protein 170kDa -0.0289634
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0288162
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0280009
GCLM glutamate-cysteine ligase, modifier subunit -0.0276823
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0273666
ZNF217 zinc finger protein 217 -0.0271808
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0269246
RPL26 ribosomal protein L26 -0.0268022
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0265851
ZNF292 zinc finger protein 292 -0.0261568
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.025975
MIS18BP1 MIS18 binding protein 1 -0.0259739
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0258883
KIAA1958 KIAA1958 -0.0256816
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0254778
BZW1 basic leucine zipper and W2 domains 1 -0.025186
IFIH1 interferon induced with helicase C domain 1 -0.0250203
XPO1 exportin 1 -0.024925
CKAP5 cytoskeleton associated protein 5 -0.0245075
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0244317
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0243606
RPLP0 ribosomal protein, large, P0 -0.0242464
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0238419
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0236341
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0235413
RPL11 ribosomal protein L11 -0.0233526
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.022983
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0227485
SRGN serglycin -0.0226161
RLF rearranged L-myc fusion -0.022604
FERMT1 fermitin family member 1 -0.0225326
UBQLN1 ubiquilin 1 -0.0224865
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0224365
EIF1 eukaryotic translation initiation factor 1 -0.0224167
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0223881
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0223683
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0222665
PRRC2C proline-rich coiled-coil 2C -0.0220549
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0215667
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.021475
NCOR1 nuclear receptor corepressor 1 -0.0213614
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0213555
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0212815
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0212418
CDCP1 CUB domain containing protein 1 -0.0211994
WSB1 WD repeat and SOCS box containing 1 -0.0211676
ZFR zinc finger RNA binding protein -0.0211451
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0210549
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0210015
CKAP2 cytoskeleton associated protein 2 -0.0208395
EHBP1 EH domain binding protein 1 -0.0207815
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0207574
PLAUR plasminogen activator, urokinase receptor -0.02066
BMERB1 bMERB domain containing 1 -0.0205208
KTN1 kinectin 1 (kinesin receptor) -0.0204115
NEK7 NIMA-related kinase 7 -0.0203637
BRWD3 bromodomain and WD repeat domain containing 3 -0.0202175
PNISR PNN-interacting serine/arginine-rich protein -0.0201802
SNX14 sorting nexin 14 -0.0198585
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0198523
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0196898
SENP6 SUMO1/sentrin specific peptidase 6 -0.0195192
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0195184
TMEM41B transmembrane protein 41B -0.0194213
UBXN4 UBX domain protein 4 -0.0194091
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0193926
KIF14 kinesin family member 14 -0.0189792
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0189645
RBM39 RNA binding motif protein 39 -0.0188552