Rimonabant_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.237863
MT2A metallothionein 2A 0.124386
INTS6 integrator complex subunit 6 0.10158
THSD4 thrombospondin, type I, domain containing 4 0.0886226
MCL1 myeloid cell leukemia 1 0.0806501
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0738261
TMSB10 thymosin beta 10 0.0643982
PDLIM5 PDZ and LIM domain 5 0.0625595
HOMER1 homer scaffolding protein 1 0.0616375
NABP1 nucleic acid binding protein 1 0.0613185
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0593343
ZSWIM6 zinc finger, SWIM-type containing 6 0.0580512
FTL ferritin, light polypeptide 0.0530654
PDE4D phosphodiesterase 4D, cAMP-specific 0.0515302
GRAMD1B GRAM domain containing 1B 0.0507617
NSUN6 NOP2/Sun domain family, member 6 0.0500036
EGFR epidermal growth factor receptor 0.0476736
RPLP1 ribosomal protein, large, P1 0.04756
CEMIP cell migration inducing protein, hyaluronan binding 0.0463175
SEC61G Sec61 gamma subunit 0.0444975
PM20D1 peptidase M20 domain containing 1 0.0439367
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0407956
RPS3 ribosomal protein S3 0.0407313
RPL35A ribosomal protein L35a 0.0382161
DOCK5 dedicator of cytokinesis 5 0.0379628
ACTG1 actin gamma 1 0.0353734
RPL37A ribosomal protein L37a 0.0353512
VCL vinculin 0.0352075
SLTM SAFB-like, transcription modulator 0.0337164
EGR1 early growth response 1 0.0331035
SCEL sciellin 0.0330186
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0326347
RPS8 ribosomal protein S8 0.0323607
CST3 cystatin C 0.0321403
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0315442
RPS23 ribosomal protein S23 0.0312055
RPL31 ribosomal protein L31 0.0310167
RPS6 ribosomal protein S6 0.0308599
MYOF myoferlin 0.0308276
BCAR3 breast cancer anti-estrogen resistance 3 0.0305224
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0304964
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0302895
GPHN gephyrin 0.0292928
AREG amphiregulin 0.0291359
BMP6 bone morphogenetic protein 6 0.0291239
RPS12 ribosomal protein S12 0.0290664
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.028773
MCTP1 multiple C2 domains, transmembrane 1 0.0283682
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0280228
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0277185
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0276496
SLC38A2 solute carrier family 38, member 2 0.0267317
RPS29 ribosomal protein S29 0.026565
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0263755
SIK3 SIK family kinase 3 0.0263488
CATSPERB catsper channel auxiliary subunit beta 0.0262284
RPS25 ribosomal protein S25 0.0257867
FLNA filamin A, alpha 0.0256832
RPS19 ribosomal protein S19 0.0256112
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0249418
FUS FUS RNA binding protein 0.0249338
APLP2 amyloid beta (A4) precursor-like protein 2 0.024882
RIMS2 regulating synaptic membrane exocytosis 2 0.0248573
SMOC1 SPARC related modular calcium binding 1 0.0247112
MYO1E myosin IE 0.0244125
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0236882
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0229717
DSCAM Down syndrome cell adhesion molecule 0.0228552
RPLP2 ribosomal protein, large, P2 0.022661
SMYD3 SET and MYND domain containing 3 0.0226475
RPL9 ribosomal protein L9 0.0225775
EXT1 exostosin glycosyltransferase 1 0.0224352
BLZF1 basic leucine zipper nuclear factor 1 0.0223683
RPL11 ribosomal protein L11 0.0222858
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0222681
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0220301
LGALS12 lectin, galactoside-binding, soluble, 12 0.0219982
RPS17 ribosomal protein S17 0.0219129
RPL36 ribosomal protein L36 0.021841
MAML3 mastermind-like 3 (Drosophila) 0.0217858
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.021535
RPL23 ribosomal protein L23 0.0214943
SVIL supervillin 0.0212545
CMIP c-Maf inducing protein 0.0211992
RPL19 ribosomal protein L19 0.0211729
RPL12 ribosomal protein L12 0.021167
S100P S100 calcium binding protein P 0.0209666
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0208764
CTBP2 C-terminal binding protein 2 0.0208477
FOXP1 forkhead box P1 0.0207885
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0207299
AGO2 argonaute RISC catalytic component 2 0.0207263
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0206901
RAD51B RAD51 paralog B 0.0202697
VMP1 vacuole membrane protein 1 0.0199811
DST dystonin 0.0196135
BABAM2 BRISC and BRCA1 A complex member 2 0.019491
CXCL8 chemokine (C-X-C motif) ligand 8 0.0193296
TRAPPC9 trafficking protein particle complex 9 0.0193124
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0192792

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.231029
NAMPT nicotinamide phosphoribosyltransferase -0.0991703
FAM13A family with sequence similarity 13, member A -0.0962772
TXNRD1 thioredoxin reductase 1 -0.0938811
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0729676
NGLY1 N-glycanase 1 -0.0677308
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0614965
LMO7 LIM domain 7 -0.0590461
LAMC2 laminin, gamma 2 -0.0587589
SOD2 superoxide dismutase 2, mitochondrial -0.05815
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0572665
H1-0 H1.0 linker histone -0.0570025
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.056399
TMEM165 transmembrane protein 165 -0.0520116
ZMYND8 zinc finger, MYND-type containing 8 -0.047793
ARRDC3 arrestin domain containing 3 -0.0475251
PGK1 phosphoglycerate kinase 1 -0.0469679
CAMTA1 calmodulin binding transcription activator 1 -0.0457212
NDRG1 N-myc downstream regulated 1 -0.0454341
HDLBP high density lipoprotein binding protein -0.0445309
BRWD3 bromodomain and WD repeat domain containing 3 -0.0424286
RAB27B RAB27B, member RAS oncogene family -0.0415603
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0386404
TPD52 tumor protein D52 -0.0376771
OGA O-GlcNAcase -0.0375023
BRWD1 bromodomain and WD repeat domain containing 1 -0.0363225
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0357105
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0355122
IGFBP3 insulin-like growth factor binding protein 3 -0.035408
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.03441
FTH1 ferritin, heavy polypeptide 1 -0.0339616
CES1 carboxylesterase 1 -0.0339194
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.032966
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0326429
CANX calnexin -0.0318466
LAMB3 laminin, beta 3 -0.031752
GCLC glutamate-cysteine ligase, catalytic subunit -0.0317153
KDM3A lysine (K)-specific demethylase 3A -0.0316039
KDM2A lysine (K)-specific demethylase 2A -0.0314937
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0309712
SEC31A SEC31 homolog A (S. cerevisiae) -0.029947
ZC3H11A zinc finger CCCH-type containing 11A -0.0298939
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0296847
YEATS2 YEATS domain containing 2 -0.0293699
SMAD3 SMAD family member 3 -0.0293532
ANKRD10 ankyrin repeat domain 10 -0.0291393
ANO6 anoctamin 6 -0.0288567
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0278846
SLMAP sarcolemma associated protein -0.0275059
PATJ PATJ crumbs cell polarity complex component -0.0274453
RAB1A RAB1A, member RAS oncogene family -0.027383
WDR45B WD repeat domain 45B -0.0270719
LAMA4 laminin, alpha 4 -0.0269998
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0268977
MARF1 meiosis regulator and mRNA stability factor 1 -0.0268871
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0266673
ZNF292 zinc finger protein 292 -0.026621
KDM5B lysine (K)-specific demethylase 5B -0.0263283
MXI1 MAX interactor 1, dimerization protein -0.0262943
BIRC6 baculoviral IAP repeat containing 6 -0.0260286
NDE1 nudE neurodevelopment protein 1 -0.0259533
OSMR oncostatin M receptor -0.0254404
KCMF1 potassium channel modulatory factor 1 -0.0253767
SREBF2 sterol regulatory element binding transcription factor 2 -0.0253026
LRP1B low density lipoprotein receptor-related protein 1B -0.0246933
PHF21A PHD finger protein 21A -0.0244187
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0243909
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0241495
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0236542
SUCO SUN domain containing ossification factor -0.0235355
ANXA2 annexin A2 -0.0234057
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.023401
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0232834
CAB39 calcium binding protein 39 -0.0232433
HOOK2 hook microtubule-tethering protein 2 -0.0232364
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0229239
ABLIM1 actin binding LIM protein 1 -0.022885
UVRAG UV radiation resistance associated -0.022835
ZMYM2 zinc finger, MYM-type 2 -0.0223834
RASA2 RAS p21 protein activator 2 -0.0222773
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0221051
TLK1 tousled-like kinase 1 -0.0220401
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0219781
KMT2A lysine (K)-specific methyltransferase 2A -0.0217381
BIRC3 baculoviral IAP repeat containing 3 -0.0213857
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0211074
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0210667
ATP13A3 ATPase type 13A3 -0.0208819
LDHA lactate dehydrogenase A -0.0206062
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0205038
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0204142
NIPBL Nipped-B homolog (Drosophila) -0.0203542
DSPP dentin sialophosphoprotein -0.0202213
BBX bobby sox homolog (Drosophila) -0.0201208
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -0.0200456
BZW1 basic leucine zipper and W2 domains 1 -0.0199558
HBP1 HMG-box transcription factor 1 -0.0198158
AHNAK AHNAK nucleoprotein -0.0197783
TENT5A terminal nucleotidyltransferase 5A -0.0195776
NCKAP1 NCK-associated protein 1 -0.0192917