Rimonabant_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0823852
PM20D1 peptidase M20 domain containing 1 0.0763584
MCL1 myeloid cell leukemia 1 0.0746073
DST dystonin 0.0722783
COL5A2 collagen, type V, alpha 2 0.0696211
PDE4D phosphodiesterase 4D, cAMP-specific 0.0568796
COL8A1 collagen, type VIII, alpha 1 0.0542871
IGFBP3 insulin-like growth factor binding protein 3 0.05197
PRELID2 PRELI domain containing 2 0.0514742
PCBP2 poly(rC) binding protein 2 0.0504063
CTIF CBP80/20-dependent translation initiation factor 0.0495029
RPL3 ribosomal protein L3 0.0482727
NCOR2 nuclear receptor corepressor 2 0.0481991
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0480349
EEF2 eukaryotic translation elongation factor 2 0.046219
FLNA filamin A, alpha 0.0436722
SMOC1 SPARC related modular calcium binding 1 0.0424121
RPS12 ribosomal protein S12 0.0414852
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0389554
PKM pyruvate kinase, muscle 0.0380101
PTPRM protein tyrosine phosphatase, receptor type, M 0.0352316
LAMA5 laminin, alpha 5 0.0347855
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0347507
RAD51B RAD51 paralog B 0.0340475
DOCK5 dedicator of cytokinesis 5 0.0338335
LSAMP limbic system-associated membrane protein 0.0331534
MSN moesin 0.0330879
POTEF POTE ankyrin domain family, member F 0.0328178
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0317487
ZSWIM6 zinc finger, SWIM-type containing 6 0.0313901
FLNB filamin B, beta 0.0312672
SDK1 sidekick cell adhesion molecule 1 0.0308855
MYH9 myosin, heavy chain 9, non-muscle 0.0307205
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0306964
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0305341
BMP6 bone morphogenetic protein 6 0.0304772
RPS17 ribosomal protein S17 0.0298012
NDRG1 N-myc downstream regulated 1 0.0294028
RPS19 ribosomal protein S19 0.0292258
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0290437
MAML3 mastermind-like 3 (Drosophila) 0.0287436
INTS6 integrator complex subunit 6 0.0285009
PTEN phosphatase and tensin homolog 0.0278424
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0277818
UBC ubiquitin C 0.0276857
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0272868
IRS2 insulin receptor substrate 2 0.0270726
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0267118
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.026711
RPS3 ribosomal protein S3 0.0263137
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0261717
VMP1 vacuole membrane protein 1 0.0261456
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0261177
FMNL2 formin-like 2 0.0259005
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0258387
AUTS2 autism susceptibility candidate 2 0.02565
FN1 fibronectin 1 0.0256447
PDE10A phosphodiesterase 10A 0.0253624
DENND1A DENN/MADD domain containing 1A 0.0251904
COL4A6 collagen, type IV, alpha 6 0.0245184
RPS4X ribosomal protein S4, X-linked 0.0238345
CTBP2 C-terminal binding protein 2 0.0236957
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0233821
ESYT2 extended synaptotagmin-like protein 2 0.0233347
RACK1 receptor for activated C kinase 1 0.0231885
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0229123
TPM3 tropomyosin 3 0.0226306
SRRM2 serine/arginine repetitive matrix 2 0.0224862
CSRP1 cysteine and glycine-rich protein 1 0.0224233
GPC6 glypican 6 0.022402
RPL37A ribosomal protein L37a 0.0223577
RPL9 ribosomal protein L9 0.0223409
MAP7 microtubule-associated protein 7 0.0221585
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0219821
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0217167
TENM2 teneurin transmembrane protein 2 0.0216493
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0215814
RPL23 ribosomal protein L23 0.0211659
XYLT1 xylosyltransferase I 0.0209532
ZMIZ1 zinc finger, MIZ-type containing 1 0.020858
TNRC18 trinucleotide repeat containing 18 0.0206921
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0205793
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0204493
EIF5 eukaryotic translation initiation factor 5 0.0204148
LMNA lamin A/C 0.0202561
MACF1 microtubule-actin crosslinking factor 1 0.0200215
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.01985
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0196159
FAT1 FAT atypical cadherin 1 0.0195847
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0194132
DOCK4 dedicator of cytokinesis 4 0.0193484
RPS27A ribosomal protein S27a 0.0191262
CHL1 cell adhesion molecule L1-like 0.0191246
HDAC4 histone deacetylase 4 0.0189689
FAM168A family with sequence similarity 168, member A 0.0184077
PCDH9 protocadherin 9 0.0182264
RPL21 ribosomal protein L21 0.0180127
RPS23 ribosomal protein S23 0.0176293
TBXT T-box transcription factor T 0.0175813
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0175594

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.228382
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.158096
GDA guanine deaminase -0.150966
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.146325
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.114674
CXCL8 chemokine (C-X-C motif) ligand 8 -0.105463
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.10286
SMYD3 SET and MYND domain containing 3 -0.100516
TFPI2 tissue factor pathway inhibitor 2 -0.0921858
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0898549
ASPH aspartate beta-hydroxylase -0.0829214
EFNA5 ephrin-A5 -0.080695
ELL2 elongation factor, RNA polymerase II, 2 -0.0804676
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0768771
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0712943
TXNRD1 thioredoxin reductase 1 -0.0710961
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0647607
CANX calnexin -0.059856
TM4SF1 transmembrane 4 L six family member 1 -0.0593141
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0573795
BZW1 basic leucine zipper and W2 domains 1 -0.0562662
NCOA7 nuclear receptor coactivator 7 -0.0548248
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0532633
NEK7 NIMA-related kinase 7 -0.0508762
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0450903
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0437422
BMERB1 bMERB domain containing 1 -0.0437094
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0436854
SPAG9 sperm associated antigen 9 -0.0434299
MYOF myoferlin -0.0427763
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0415241
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0415113
NPAS2 neuronal PAS domain protein 2 -0.0409891
SAMD4A sterile alpha motif domain containing 4A -0.0403224
PSD3 pleckstrin and Sec7 domain containing 3 -0.0403059
TRIO trio Rho guanine nucleotide exchange factor -0.0400152
TGFBI transforming growth factor, beta-induced, 68kDa -0.0397051
AKR1C1 aldo-keto reductase family 1, member C1 -0.0365433
ANXA2 annexin A2 -0.0340468
S100A6 S100 calcium binding protein A6 -0.0328825
STC1 stanniocalcin 1 -0.0328795
PGK1 phosphoglycerate kinase 1 -0.0327018
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0325198
OGA O-GlcNAcase -0.031715
ENAH enabled homolog (Drosophila) -0.0315504
RPLP0 ribosomal protein, large, P0 -0.0315434
ARF1 ADP-ribosylation factor 1 -0.0314406
TNPO1 transportin 1 -0.0306878
OSMR oncostatin M receptor -0.0306453
PTMA prothymosin, alpha -0.0304122
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0298778
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0298405
RBM39 RNA binding motif protein 39 -0.0296873
TMSB4X thymosin beta 4, X-linked -0.0294542
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0285855
NRCAM neuronal cell adhesion molecule -0.0284176
LAMA1 laminin, alpha 1 -0.0283952
FNDC3A fibronectin type III domain containing 3A -0.0278068
PCBP3 poly(rC) binding protein 3 -0.0276934
ATAD1 ATPase family, AAA domain containing 1 -0.02742
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0271052
KDM3A lysine (K)-specific demethylase 3A -0.026801
PTGR1 prostaglandin reductase 1 -0.0264626
LMAN1 lectin, mannose-binding, 1 -0.0263501
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0259269
MORF4L2 mortality factor 4 like 2 -0.0258508
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.025801
PHF20 PHD finger protein 20 -0.0257886
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0253257
KYNU kynureninase -0.0252124
CTSC cathepsin C -0.0249965
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0247011
ZBTB38 zinc finger and BTB domain containing 38 -0.0246522
RTN4 reticulon 4 -0.0244342
NAP1L1 nucleosome assembly protein 1-like 1 -0.0243652
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0243364
NIPBL Nipped-B homolog (Drosophila) -0.024331
IARS1 isoleucyl-tRNA synthetase 1 -0.0241531
GOLGA4 golgin A4 -0.0241014
CD44 CD44 molecule (Indian blood group) -0.0240918
BRWD3 bromodomain and WD repeat domain containing 3 -0.024071
VDAC1 voltage-dependent anion channel 1 -0.0239826
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0239788
FAF1 Fas (TNFRSF6) associated factor 1 -0.0238186
TMX4 thioredoxin-related transmembrane protein 4 -0.023698
RPS24 ribosomal protein S24 -0.0235905
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0234381
ACBD6 acyl-CoA binding domain containing 6 -0.0234059
RGS2 regulator of G-protein signaling 2 -0.0233861
ZNF804A zinc finger protein 804A -0.0228884
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0228469
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0228443
CHML choroideremia-like (Rab escort protein 2) -0.022835
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0227825
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0226466
FRMD4B FERM domain containing 4B -0.0222987
INHBA inhibin, beta A -0.0219568
LIMCH1 LIM and calponin homology domains 1 -0.0219012
ABLIM1 actin binding LIM protein 1 -0.0216051
FBXL13 F-box and leucine-rich repeat protein 13 -0.0215847