| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rimonabant perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rimonabant_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.164672 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.144111 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.131083 |
| SQSTM1 | sequestosome 1 | 0.123491 |
| RPL11 | ribosomal protein L11 | 0.123211 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.114398 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.106267 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.105092 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.103619 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.100257 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0949441 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0902435 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0830379 |
| EGFR | epidermal growth factor receptor | 0.0827109 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0816761 |
| FN1 | fibronectin 1 | 0.0806321 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0805733 |
| MYO1E | myosin IE | 0.0796949 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0791088 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0771468 |
| CDK6 | cyclin-dependent kinase 6 | 0.076653 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0762905 |
| GLIS3 | GLIS family zinc finger 3 | 0.0705875 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0666628 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0661484 |
| CTBP2 | C-terminal binding protein 2 | 0.0628466 |
| FLNB | filamin B, beta | 0.0622496 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0602749 |
| ANO6 | anoctamin 6 | 0.0602345 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0596744 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0592368 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0584729 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0573269 |
| GOLGA4 | golgin A4 | 0.0562632 |
| STC1 | stanniocalcin 1 | 0.0548548 |
| STK24 | serine/threonine kinase 24 | 0.0545241 |
| PRKCE | protein kinase C, epsilon | 0.0536542 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.053612 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0529059 |
| MYO10 | myosin X | 0.0504889 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0502354 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0498288 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0497683 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0490383 |
| FMNL2 | formin-like 2 | 0.0485871 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0480259 |
| R3HDM2 | R3H domain containing 2 | 0.0472653 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0458919 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.045296 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0430334 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0429699 |
| RPL4 | ribosomal protein L4 | 0.0415945 |
| INHBA | inhibin, beta A | 0.0411278 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0406738 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0395817 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0392369 |
| KIAA1217 | KIAA1217 | 0.0388121 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0374275 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0373738 |
| BBX | bobby sox homolog (Drosophila) | 0.036497 |
| CCNY | cyclin Y | 0.0364564 |
| RACK1 | receptor for activated C kinase 1 | 0.036052 |
| RPL13A | ribosomal protein L13a | 0.0341452 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0340655 |
| CLINT1 | clathrin interactor 1 | 0.0337902 |
| ATXN1 | ataxin 1 | 0.032047 |
| CDK17 | cyclin-dependent kinase 17 | 0.0318972 |
| RAD51B | RAD51 paralog B | 0.0313911 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0313351 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0309574 |
| GOLGB1 | golgin B1 | 0.0306795 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0297384 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0296372 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.029607 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0279241 |
| RPL9 | ribosomal protein L9 | 0.0261487 |
| CUX1 | cut-like homeobox 1 | 0.0253813 |
| PTK2 | protein tyrosine kinase 2 | 0.0250532 |
| HMGA2 | high mobility group AT-hook 2 | 0.0239474 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0233921 |
| VCL | vinculin | 0.0231847 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0230884 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0220136 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0212741 |
| RPS5 | ribosomal protein S5 | 0.0206736 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0202865 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0201425 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0183485 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0180671 |
| PARD3 | par-3 family cell polarity regulator | 0.017889 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0156918 |
| SMAD3 | SMAD family member 3 | 0.0150826 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0150343 |
| HDLBP | high density lipoprotein binding protein | 0.0149033 |
| EZR | ezrin | 0.0147483 |
| SMYD3 | SET and MYND domain containing 3 | 0.0140447 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0126276 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0122412 |
| TCF12 | transcription factor 12 | 0.0117315 |
| FMN1 | formin 1 | 0.0114487 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.15302 |
| PDE10A | phosphodiesterase 10A | -0.130852 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.121444 |
| LAMA4 | laminin, alpha 4 | -0.116998 |
| EFNA5 | ephrin-A5 | -0.113488 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.101773 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0986497 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0936043 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0890955 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.087988 |
| POTEF | POTE ankyrin domain family, member F | -0.081013 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0790488 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0781373 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0775326 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0770355 |
| RSF1 | remodeling and spacing factor 1 | -0.0766173 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0764269 |
| PTMA | prothymosin, alpha | -0.0763778 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0725504 |
| NAV2 | neuron navigator 2 | -0.0701123 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0698507 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0660299 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0655773 |
| SBF2 | SET binding factor 2 | -0.0644875 |
| AOPEP | aminopeptidase O (putative) | -0.0639163 |
| ASPH | aspartate beta-hydroxylase | -0.0636168 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0628211 |
| GPC6 | glypican 6 | -0.0615522 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0597383 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0578092 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0571069 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0559805 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0556271 |
| DSCAM | Down syndrome cell adhesion molecule | -0.054231 |
| NBEAL1 | neurobeachin-like 1 | -0.0540081 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0515615 |
| TXNRD1 | thioredoxin reductase 1 | -0.0510237 |
| JMJD1C | jumonji domain containing 1C | -0.0506345 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0501706 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0500923 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0493391 |
| CERT1 | ceramide transporter 1 | -0.04858 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0471491 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0468224 |
| PRELID2 | PRELI domain containing 2 | -0.0462433 |
| RPS8 | ribosomal protein S8 | -0.0462014 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0403259 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0402732 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0397899 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0396861 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0396111 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0384736 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0376461 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0372759 |
| PKM | pyruvate kinase, muscle | -0.0365153 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0365015 |
| SLTM | SAFB-like, transcription modulator | -0.0347404 |
| ZNF292 | zinc finger protein 292 | -0.0341099 |
| CDH13 | cadherin 13 | -0.0327174 |
| RPS3 | ribosomal protein S3 | -0.0321875 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0317373 |
| FNIP1 | folliculin interacting protein 1 | -0.0313438 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0312478 |
| RUNX1 | runt-related transcription factor 1 | -0.0308396 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0305755 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0296947 |
| SRPK2 | SRSF protein kinase 2 | -0.0274549 |
| TPM4 | tropomyosin 4 | -0.0273692 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0267307 |
| MED13 | mediator complex subunit 13 | -0.0260256 |
| PRKD3 | protein kinase D3 | -0.025852 |
| DST | dystonin | -0.0258052 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0255885 |
| TNS3 | tensin 3 | -0.0244095 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0243049 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0236087 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0229532 |
| APP | amyloid beta (A4) precursor protein | -0.0226612 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0223691 |
| SETD5 | SET domain containing 5 | -0.0214044 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0213754 |
| LMO7 | LIM domain 7 | -0.0213003 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.019749 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0196911 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0196233 |
| RPL35A | ribosomal protein L35a | -0.0191137 |
| RPLP1 | ribosomal protein, large, P1 | -0.0188803 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0167996 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0159255 |
| RIGI | RNA sensor RIG-I | -0.0154043 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0151123 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0148876 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0140145 |
| TMSB10 | thymosin beta 10 | -0.0122558 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.010819 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.00890262 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.00884461 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.00852649 |
| RPS6 | ribosomal protein S6 | -0.00735466 |
| NF1 | neurofibromin 1 | -0.00651238 |
