Rimonabant_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0747263
SOX6 SRY (sex determining region Y)-box 6 0.0685747
TXNRD1 thioredoxin reductase 1 0.0624888
FLNB filamin B, beta 0.0584452
TJP1 tight junction protein 1 0.0526795
RPL3 ribosomal protein L3 0.0522961
BMP2K BMP2 inducible kinase 0.0487288
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.048367
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0474096
AHNAK AHNAK nucleoprotein 0.0459881
PDGFC platelet derived growth factor C 0.0456311
PYGB phosphorylase, glycogen; brain 0.0440852
PRELID2 PRELI domain containing 2 0.0423145
HDAC9 histone deacetylase 9 0.0421128
ADAM10 ADAM metallopeptidase domain 10 0.040357
EZR ezrin 0.0386404
LOXL3 lysyl oxidase-like 3 0.0379736
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0358485
EEF2 eukaryotic translation elongation factor 2 0.0355874
ECT2 epithelial cell transforming 2 0.0343877
TMEM65 transmembrane protein 65 0.0338124
NBEA neurobeachin 0.0320851
EGFR epidermal growth factor receptor 0.0309847
DPYD dihydropyrimidine dehydrogenase 0.0305364
PDE4B phosphodiesterase 4B, cAMP-specific 0.0304248
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0298335
TGFBR3 transforming growth factor, beta receptor III 0.0284688
GLI2 GLI family zinc finger 2 0.0282571
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0272666
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0244725
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0243913
GLI3 GLI family zinc finger 3 0.0241789
FAT1 FAT atypical cadherin 1 0.0240849
ZEB1 zinc finger E-box binding homeobox 1 0.0240028
GSE1 Gse1 coiled-coil protein 0.0239548
ZNF608 zinc finger protein 608 0.023315
NUP58 nucleoporin 58 0.0222421
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0221608
MYO5C myosin VC 0.0210834
LOC112694756 uncharaterized LOC112694756 0.020704
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0206661
RAB27B RAB27B, member RAS oncogene family 0.0199217
NCEH1 neutral cholesterol ester hydrolase 1 0.0198548
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0197261
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0197051
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0196882
MACROD2 MACRO domain containing 2 0.0188661
HEG1 heart development protein with EGF-like domains 1 0.0187897
ZNF292 zinc finger protein 292 0.0185013
KDM4C lysine (K)-specific demethylase 4C 0.0184665
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0184357
NCKAP1 NCK-associated protein 1 0.0182304
FBLN2 fibulin 2 0.0177294
TBC1D5 TBC1 domain family, member 5 0.0173106
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.0171662
LPP LIM domain containing preferred translocation partner in lipoma 0.0170409
PARD3 par-3 family cell polarity regulator 0.0168854
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0168764
PLK2 polo-like kinase 2 0.0167827
KLF3 Kruppel-like factor 3 (basic) 0.0167688
ITGA6 integrin, alpha 6 0.0166717
CDC73 cell division cycle 73 0.016622
SDK1 sidekick cell adhesion molecule 1 0.0164431
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.016403
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0163743
ZMYM2 zinc finger, MYM-type 2 0.0162596
FHIT fragile histidine triad 0.0161391
TXNIP thioredoxin interacting protein 0.016095
PTBP2 polypyrimidine tract binding protein 2 0.0157708
ATP9B ATPase, class II, type 9B 0.0157641
VCL vinculin 0.0157409
CCDC68 coiled-coil domain containing 68 0.0156359
SEPTIN11 septin 11 0.0155895
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0155311
SMAD6 SMAD family member 6 0.015514
CCNL1 cyclin L1 0.0154245
TSC22D1 TSC22 domain family, member 1 0.0154167
MBD5 methyl-CpG binding domain protein 5 0.0150727
EVI5 ecotropic viral integration site 5 0.0147612
AHCYL2 adenosylhomocysteinase-like 2 0.014631
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0144859
GLS2 glutaminase 2 (liver, mitochondrial) 0.0143841
ANK2 ankyrin 2, neuronal 0.0143226
CHD7 chromodomain helicase DNA binding protein 7 0.01432
CREB5 cAMP responsive element binding protein 5 0.0141306
PCGF5 polycomb group ring finger 5 0.0140814
ARID1A AT rich interactive domain 1A (SWI-like) 0.0140224
CD47 CD47 molecule 0.0139892
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0139265
PKM pyruvate kinase, muscle 0.0139172
ZBTB38 zinc finger and BTB domain containing 38 0.0137107
CDK19 cyclin-dependent kinase 19 0.0136099
FAM13A family with sequence similarity 13, member A 0.0135041
BLTP1 bridge-like lipid transfer protein family member 1 0.0134183
KLC1 kinesin light chain 1 0.0133646
HJURP Holliday junction recognition protein 0.0133321
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0132825
RNF145 ring finger protein 145 0.0132504
HELZ helicase with zinc finger 0.0132372
YEATS2 YEATS domain containing 2 0.0132006

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.387174
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157323
TPT1 tumor protein, translationally-controlled 1 -0.134158
RPS6 ribosomal protein S6 -0.114162
RPL35A ribosomal protein L35a -0.0979192
RPS8 ribosomal protein S8 -0.0917865
RPL31 ribosomal protein L31 -0.0842808
RPLP1 ribosomal protein, large, P1 -0.0755832
RPS13 ribosomal protein S13 -0.0733646
RPL34 ribosomal protein L34 -0.0733324
RPL37A ribosomal protein L37a -0.063409
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0632188
RPL9 ribosomal protein L9 -0.0625005
RPS23 ribosomal protein S23 -0.0610829
RPS3 ribosomal protein S3 -0.0596697
RPS25 ribosomal protein S25 -0.0593714
RPS27A ribosomal protein S27a -0.0586895
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0569041
RPLP2 ribosomal protein, large, P2 -0.0551229
RPL26 ribosomal protein L26 -0.0535182
NAP1L1 nucleosome assembly protein 1-like 1 -0.0528057
RPS24 ribosomal protein S24 -0.0518219
RPS29 ribosomal protein S29 -0.0490983
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0489632
RPL19 ribosomal protein L19 -0.0479048
EIF1 eukaryotic translation initiation factor 1 -0.0472386
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0471707
RPS19 ribosomal protein S19 -0.0471075
RPL11 ribosomal protein L11 -0.0431031
RPLP0 ribosomal protein, large, P0 -0.0429374
FOXP1 forkhead box P1 -0.0421078
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0416134
FTL ferritin, light polypeptide -0.0415651
ACTG1 actin gamma 1 -0.0402382
RPL38 ribosomal protein L38 -0.0398266
S100A9 S100 calcium binding protein A9 -0.0397841
MYL12B myosin, light chain 12B, regulatory -0.0378643
RPL13A ribosomal protein L13a -0.0377132
RPL7A ribosomal protein L7a -0.0374663
RPL30 ribosomal protein L30 -0.0367065
KPNB1 karyopherin (importin) beta 1 -0.0362368
RPS21 ribosomal protein S21 -0.0357135
S100A6 S100 calcium binding protein A6 -0.0355255
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0347128
RPL27A ribosomal protein L27a -0.0338525
RPS12 ribosomal protein S12 -0.033778
RPL23 ribosomal protein L23 -0.0335835
RPL36 ribosomal protein L36 -0.0331171
ZMYND8 zinc finger, MYND-type containing 8 -0.0323168
RPS16 ribosomal protein S16 -0.0322999
HLA-B major histocompatibility complex, class I, B -0.0313741
S100A10 S100 calcium binding protein A10 -0.0312256
RPL12 ribosomal protein L12 -0.0301492
RPL8 ribosomal protein L8 -0.0294022
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0291079
RPL37 ribosomal protein L37 -0.0282354
RPL5 ribosomal protein L5 -0.0281854
VIM vimentin -0.0280398
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.027719
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0274195
RPL10A ribosomal protein L10a -0.0272568
WSB1 WD repeat and SOCS box containing 1 -0.0262723
TUBB4B tubulin, beta 4B class IVb -0.026269
IFITM3 interferon induced transmembrane protein 3 -0.0259646
RPL36A ribosomal protein L36a -0.0258698
PSD3 pleckstrin and Sec7 domain containing 3 -0.0258321
FNDC3B fibronectin type III domain containing 3B -0.0255149
RPS28 ribosomal protein S28 -0.0251285
RPL15 ribosomal protein L15 -0.0251208
RPS27 ribosomal protein S27 -0.0249069
RPS17 ribosomal protein S17 -0.024288
RPS11 ribosomal protein S11 -0.0237653
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.023704
RPL28 ribosomal protein L28 -0.0235567
LOC102724023 ES1 protein homolog, mitochondrial -0.023452
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0229649
RPS5 ribosomal protein S5 -0.0228483
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0228205
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0225578
TMSB10 thymosin beta 10 -0.0221857
HSPB1 heat shock 27kDa protein 1 -0.0220357
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0219422
RPS14 ribosomal protein S14 -0.0219255
ASPH aspartate beta-hydroxylase -0.0218808
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0218792
ENO2 enolase 2 (gamma, neuronal) -0.0218348
NOP56 NOP56 ribonucleoprotein -0.0215509
RPL35 ribosomal protein L35 -0.0213471
RPS15 ribosomal protein S15 -0.0212227
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0206308
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0204729
HMGB1 high mobility group box 1 -0.0204588
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0204381
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.020416
RPS10 ribosomal protein S10 -0.0202283
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0200799
RPS20 ribosomal protein S20 -0.0200214
VDAC1 voltage-dependent anion channel 1 -0.0198735
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0195099
RPL7 ribosomal protein L7 -0.0192234