Rimonabant_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.112803
VIM vimentin 0.103016
GLIS3 GLIS family zinc finger 3 0.0967374
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0925159
HDAC9 histone deacetylase 9 0.0896237
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0880011
KYNU kynureninase 0.0802868
FLNA filamin A, alpha 0.0721771
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0670273
FTL ferritin, light polypeptide 0.0666068
INHBA inhibin, beta A 0.0612749
IER3 immediate early response 3 0.0581969
EEF2 eukaryotic translation elongation factor 2 0.0580726
HLA-A major histocompatibility complex, class I, A 0.0570235
HMGA2 high mobility group AT-hook 2 0.0537742
EPAS1 endothelial PAS domain protein 1 0.0524001
LDHA lactate dehydrogenase A 0.0507488
RNF213 ring finger protein 213 0.046754
ZBTB38 zinc finger and BTB domain containing 38 0.0466081
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0460479
DUSP10 dual specificity phosphatase 10 0.0456932
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.04509
COL6A3 collagen, type VI, alpha 3 0.0449149
INTS6 integrator complex subunit 6 0.0442835
SFTPA2 surfactant protein A2 0.043488
HLA-B major histocompatibility complex, class I, B 0.0416655
SQSTM1 sequestosome 1 0.0405593
TMSB10 thymosin beta 10 0.0403274
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0399824
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0372124
ACTG1 actin gamma 1 0.035607
ZSWIM6 zinc finger, SWIM-type containing 6 0.0347805
ZFP36L1 ZFP36 ring finger protein-like 1 0.0346117
STC1 stanniocalcin 1 0.0345678
RND3 Rho family GTPase 3 0.034557
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0340518
CALR calreticulin 0.0335213
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0325164
FTH1 ferritin, heavy polypeptide 1 0.0312208
RPS4X ribosomal protein S4, X-linked 0.0307714
FLNB filamin B, beta 0.0304888
TUBB tubulin, beta class I 0.0303606
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0298695
AHNAK AHNAK nucleoprotein 0.0296694
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0296627
GOPC golgi-associated PDZ and coiled-coil motif containing 0.0287661
BICC1 BicC family RNA binding protein 1 0.0287507
LOC112694756 uncharaterized LOC112694756 0.0285339
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0281921
TUT7 terminal uridylyl transferase 7 0.0276191
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0274183
TPT1 tumor protein, translationally-controlled 1 0.0273236
SMAD3 SMAD family member 3 0.0272656
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0265759
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0263712
SH3BP4 SH3-domain binding protein 4 0.0259764
NRP1 neuropilin 1 0.0259699
PTH2R parathyroid hormone 2 receptor 0.0258533
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0256119
COL5A1 collagen, type V, alpha 1 0.0253018
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0252497
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0252145
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0250028
SRSF3 serine/arginine-rich splicing factor 3 0.0245222
TOP1 topoisomerase (DNA) I 0.0243416
AHR aryl hydrocarbon receptor 0.0242641
LOX lysyl oxidase 0.0241228
GNAS GNAS complex locus 0.0239392
NTN4 netrin 4 0.0234337
FAM20C family with sequence similarity 20, member C 0.0233729
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0232205
NRN1 neuritin 1 0.0232106
RACK1 receptor for activated C kinase 1 0.023166
COL7A1 collagen, type VII, alpha 1 0.022816
CTSD cathepsin D 0.0227486
PPARD peroxisome proliferator-activated receptor delta 0.0226799
WDR27 WD repeat domain 27 0.0224003
IGFBP3 insulin-like growth factor binding protein 3 0.0223132
ADM adrenomedullin 0.02214
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0220206
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0219133
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0217387
TLE4 transducin-like enhancer of split 4 0.0215889
BPTF bromodomain PHD finger transcription factor 0.0212976
JAG1 jagged 1 0.0206513
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0205327
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.0204155
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0203817
SRRM2 serine/arginine repetitive matrix 2 0.020262
GMNN geminin, DNA replication inhibitor 0.0201124
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0200942
MLPH melanophilin 0.0198985
UBA1 ubiquitin-like modifier activating enzyme 1 0.019549
EXT1 exostosin glycosyltransferase 1 0.0194986
OSBPL8 oxysterol binding protein-like 8 0.0194749
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0191886
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0191709
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.018748
AGTPBP1 ATP/GTP binding protein 1 0.0186837
TRIM55 tripartite motif containing 55 0.0186057

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.13563
NAMPT nicotinamide phosphoribosyltransferase -0.134967
FRMD4A FERM domain containing 4A -0.134599
PDE10A phosphodiesterase 10A -0.126435
ELL2 elongation factor, RNA polymerase II, 2 -0.110211
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0805556
FNDC3B fibronectin type III domain containing 3B -0.0769824
ZNF292 zinc finger protein 292 -0.0757424
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0716381
CADM1 cell adhesion molecule 1 -0.0704392
RTN4 reticulon 4 -0.069312
MYH9 myosin, heavy chain 9, non-muscle -0.0691968
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0676145
NAV2 neuron navigator 2 -0.0673223
MKI67 marker of proliferation Ki-67 -0.0662294
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0623351
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0612668
DST dystonin -0.0601708
SBF2 SET binding factor 2 -0.0598971
MXI1 MAX interactor 1, dimerization protein -0.0542344
MSN moesin -0.0536602
CENPF centromere protein F, 350/400kDa -0.0529278
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0529239
TOP2A topoisomerase (DNA) II alpha 170kDa -0.052404
ANO6 anoctamin 6 -0.0501908
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0484344
SPAG9 sperm associated antigen 9 -0.0481255
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.048114
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0474215
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0460718
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0457904
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.045509
RPS2 ribosomal protein S2 -0.044941
TENT5A terminal nucleotidyltransferase 5A -0.0427192
ANLN anillin, actin binding protein -0.0422193
FRMD5 FERM domain containing 5 -0.0404391
AFF3 AF4/FMR2 family, member 3 -0.0402201
RB1CC1 RB1-inducible coiled-coil 1 -0.0401967
ESYT2 extended synaptotagmin-like protein 2 -0.0399563
GOLGA4 golgin A4 -0.0398223
SOD2 superoxide dismutase 2, mitochondrial -0.0396103
SDK1 sidekick cell adhesion molecule 1 -0.039433
CDK19 cyclin-dependent kinase 19 -0.0380622
MYOF myoferlin -0.0378462
ARRDC3 arrestin domain containing 3 -0.0369534
NGLY1 N-glycanase 1 -0.0369011
FNIP1 folliculin interacting protein 1 -0.035933
VCL vinculin -0.0354911
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0351253
PSD3 pleckstrin and Sec7 domain containing 3 -0.0348769
COL8A1 collagen, type VIII, alpha 1 -0.0335672
MMP12 matrix metallopeptidase 12 -0.0331679
CKAP5 cytoskeleton associated protein 5 -0.032967
PTMA prothymosin, alpha -0.0329234
FRMPD4 FERM and PDZ domain containing 4 -0.0326523
NAP1L1 nucleosome assembly protein 1-like 1 -0.0326204
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0320383
CDCP1 CUB domain containing protein 1 -0.0317165
JMJD1C jumonji domain containing 1C -0.0316965
RAI14 retinoic acid induced 14 -0.0316592
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.031559
ARF4 ADP-ribosylation factor 4 -0.0312065
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.031102
GPC6 glypican 6 -0.0309981
XRN1 5'-3' exoribonuclease 1 -0.030959
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0299566
AFF4 AF4/FMR2 family, member 4 -0.0299445
KIF4A kinesin family member 4A -0.0297467
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0293056
SMC4 structural maintenance of chromosomes 4 -0.0289886
RPS6 ribosomal protein S6 -0.0289235
LCORL ligand dependent nuclear receptor corepressor-like -0.0287057
ALCAM activated leukocyte cell adhesion molecule -0.0286434
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.028636
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0282682
MATR3 matrin 3 -0.0279421
PRRC2C proline-rich coiled-coil 2C -0.0278809
DLG1 discs, large homolog 1 (Drosophila) -0.0270526
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0269039
SMYD3 SET and MYND domain containing 3 -0.0268162
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0268157
RHOBTB3 Rho-related BTB domain containing 3 -0.0268123
ATP13A3 ATPase type 13A3 -0.0267029
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0266561
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0266102
CDH13 cadherin 13 -0.0264097
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0262899
PGK1 phosphoglycerate kinase 1 -0.0262662
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0260976
WDFY1 WD repeat and FYVE domain containing 1 -0.0258006
TMEM41B transmembrane protein 41B -0.0255987
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0252755
TNIP1 TNFAIP3 interacting protein 1 -0.0252634
HELZ helicase with zinc finger -0.0252532
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0252062
GLS2 glutaminase 2 (liver, mitochondrial) -0.0251426
SLC39A11 solute carrier family 39, member 11 -0.0249862
PTPRK protein tyrosine phosphatase, receptor type, K -0.0247432
KIF5B kinesin family member 5B -0.0246735
USP47 ubiquitin specific peptidase 47 -0.0246182