Rimonabant_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.136851
TGFBI transforming growth factor, beta-induced, 68kDa 0.11696
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.104258
KYNU kynureninase 0.0788011
PRELID2 PRELI domain containing 2 0.072468
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0722893
FLNA filamin A, alpha 0.0708072
MYH9 myosin, heavy chain 9, non-muscle 0.0660888
FN1 fibronectin 1 0.0600675
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0571421
COL5A1 collagen, type V, alpha 1 0.0551808
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0541311
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0535003
C1D C1D nuclear receptor corepressor 0.0524854
ATXN1 ataxin 1 0.050585
MACF1 microtubule-actin crosslinking factor 1 0.0502373
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0485749
FNDC3B fibronectin type III domain containing 3B 0.0485681
PLEC plectin 0.0469467
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0466602
CALU calumenin 0.0446196
ZSWIM6 zinc finger, SWIM-type containing 6 0.0442644
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0442078
LOXL2 lysyl oxidase-like 2 0.0439758
COL6A1 collagen, type VI, alpha 1 0.0432675
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0420702
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0418723
GLIS3 GLIS family zinc finger 3 0.0414582
NRP1 neuropilin 1 0.0406691
ZBTB20 zinc finger and BTB domain containing 20 0.0401889
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0392697
HIPK2 homeodomain interacting protein kinase 2 0.0386356
MAP4 microtubule-associated protein 4 0.0382535
ANKRD11 ankyrin repeat domain 11 0.0374734
PRKCA protein kinase C, alpha 0.0371965
GOLGA3 golgin A3 0.0370916
IGFBP7 insulin-like growth factor binding protein 7 0.0370741
NAMPT nicotinamide phosphoribosyltransferase 0.0370583
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0368716
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0367578
SKAP2 src kinase associated phosphoprotein 2 0.0359785
CHD9 chromodomain helicase DNA binding protein 9 0.034711
DNAH11 dynein, axonemal, heavy chain 11 0.0342523
INTS6 integrator complex subunit 6 0.0341301
FNDC3A fibronectin type III domain containing 3A 0.0340785
WARS1 tryptophanyl-tRNA synthetase 1 0.0340272
PID1 phosphotyrosine interaction domain containing 1 0.033965
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0333814
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0332743
CERT1 ceramide transporter 1 0.0329144
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0328162
ECE1 endothelin converting enzyme 1 0.0324486
CLTC clathrin, heavy chain (Hc) 0.0324086
STC1 stanniocalcin 1 0.0323893
HDLBP high density lipoprotein binding protein 0.0320202
JPH2 junctophilin 2 0.0314088
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0313848
VMP1 vacuole membrane protein 1 0.0311466
GOLGB1 golgin B1 0.031089
AKAP9 A kinase (PRKA) anchor protein 9 0.0309754
RIGI RNA sensor RIG-I 0.0304626
EGFR epidermal growth factor receptor 0.030364
LOX lysyl oxidase 0.0301283
FTH1 ferritin, heavy polypeptide 1 0.0299015
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0297044
ANTXR2 anthrax toxin receptor 2 0.0292874
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0292632
HIP1 huntingtin interacting protein 1 0.029161
ANO10 anoctamin 10 0.0288798
GLG1 golgi glycoprotein 1 0.0287163
SND1 staphylococcal nuclease and tudor domain containing 1 0.0287084
RNF24 ring finger protein 24 0.0286853
COL4A2 collagen, type IV, alpha 2 0.0285998
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0285101
SAMD4A sterile alpha motif domain containing 4A 0.0283599
TRRAP transformation/transcription domain-associated protein 0.0282662
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0281532
UBN2 ubinuclein 2 0.0279044
FBXL7 F-box and leucine-rich repeat protein 7 0.0279006
BBS9 Bardet-Biedl syndrome 9 0.0278817
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0277345
DIAPH3 diaphanous-related formin 3 0.0274232
SQSTM1 sequestosome 1 0.0271043
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0269294
LOC112694756 uncharaterized LOC112694756 0.026813
AHR aryl hydrocarbon receptor 0.0267576
FER fer (fps/fes related) tyrosine kinase 0.0266251
MYO1E myosin IE 0.0262598
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0260199
CEMIP cell migration inducing protein, hyaluronan binding 0.0260141
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.025498
EXOC4 exocyst complex component 4 0.0253555
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0253037
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0252677
GSE1 Gse1 coiled-coil protein 0.0251812
PDIA4 protein disulfide isomerase family A, member 4 0.0250577
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0249377
STC2 stanniocalcin 2 0.0247777
TNRC6B trinucleotide repeat containing 6B 0.0247037
TJP1 tight junction protein 1 0.0246491

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.163689
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0864429
TMSB10 thymosin beta 10 -0.0797749
PGK1 phosphoglycerate kinase 1 -0.0725221
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0704632
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0627559
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0625844
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0536649
HLA-A major histocompatibility complex, class I, A -0.0503867
TENT5A terminal nucleotidyltransferase 5A -0.0496402
HLA-B major histocompatibility complex, class I, B -0.0475424
VIM vimentin -0.0472229
MEF2A myocyte enhancer factor 2A -0.0447473
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0436411
COL5A2 collagen, type V, alpha 2 -0.0428572
JMJD1C jumonji domain containing 1C -0.0425681
CDH13 cadherin 13 -0.0418726
WSB1 WD repeat and SOCS box containing 1 -0.0404813
PTMA prothymosin, alpha -0.0404572
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.040351
AKAP12 A kinase (PRKA) anchor protein 12 -0.0378693
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0370886
F3 coagulation factor III (thromboplastin, tissue factor) -0.0365346
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0364728
CAVIN1 caveolae associated protein 1 -0.0363969
TRIO trio Rho guanine nucleotide exchange factor -0.0362751
MMP12 matrix metallopeptidase 12 -0.0361897
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.035826
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0354998
S100A6 S100 calcium binding protein A6 -0.0346761
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0340957
NRXN3 neurexin 3 -0.0335477
VEGFC vascular endothelial growth factor C -0.0333688
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0321017
SBF2 SET binding factor 2 -0.0319862
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0318974
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0317778
PLAUR plasminogen activator, urokinase receptor -0.0309295
RPS27A ribosomal protein S27a -0.0308934
ARRDC3 arrestin domain containing 3 -0.0307402
GOLGA4 golgin A4 -0.0297451
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0292371
RPL37A ribosomal protein L37a -0.0291861
PDE4D phosphodiesterase 4D, cAMP-specific -0.0287229
CDC73 cell division cycle 73 -0.0286521
KAZN kazrin, periplakin interacting protein -0.0282135
DST dystonin -0.0276672
RAI14 retinoic acid induced 14 -0.0275624
RASA3 RAS p21 protein activator 3 -0.0272106
MBD5 methyl-CpG binding domain protein 5 -0.0268811
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0264697
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0261512
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0260278
AFF4 AF4/FMR2 family, member 4 -0.0257419
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0252389
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0251069
CTNNBL1 catenin, beta like 1 -0.0250095
B2M beta-2-microglobulin -0.0249237
SPDYA speedy/RINGO cell cycle regulator family member A -0.0248341
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0248285
BIRC6 baculoviral IAP repeat containing 6 -0.0247372
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0245642
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0243077
KDM3A lysine (K)-specific demethylase 3A -0.0242934
KIF16B kinesin family member 16B -0.0240689
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.024033
VDAC1 voltage-dependent anion channel 1 -0.0239667
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0239327
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0236764
TMSB4X thymosin beta 4, X-linked -0.0235156
NABP1 nucleic acid binding protein 1 -0.0233837
ENO1 enolase 1, (alpha) -0.0233416
RAB8B RAB8B, member RAS oncogene family -0.0233308
PDIA3 protein disulfide isomerase family A, member 3 -0.0232963
HILPDA hypoxia inducible lipid droplet-associated -0.0232138
COL3A1 collagen, type III, alpha 1 -0.0231361
WDFY1 WD repeat and FYVE domain containing 1 -0.023018
TMEM263 transmembrane protein 263 -0.0227577
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0226124
USP37 ubiquitin specific peptidase 37 -0.0225823
STK4 serine/threonine kinase 4 -0.0225541
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0225338
JUN jun proto-oncogene -0.0224111
YEATS2 YEATS domain containing 2 -0.0218303
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -0.0217953
RAP1B RAP1B, member of RAS oncogene family -0.0216837
S100A10 S100 calcium binding protein A10 -0.0214617
RPS8 ribosomal protein S8 -0.0212367
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0212296
FAM162A family with sequence similarity 162, member A -0.0211455
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0210769
SERINC3 serine incorporator 3 -0.0210751
IGF2 insulin-like growth factor 2 -0.0210457
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0210212
NAP1L1 nucleosome assembly protein 1-like 1 -0.0209608
NDRG1 N-myc downstream regulated 1 -0.0208877
TSC22D2 TSC22 domain family, member 2 -0.0208727
TNNC1 troponin C type 1 (slow) -0.0207444
TBC1D15 TBC1 domain family, member 15 -0.0206059
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0204902