Rimonabant_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rimonabant perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rimonabant_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZSWIM6 zinc finger, SWIM-type containing 6 0.130126
SMAD3 SMAD family member 3 0.104326
CD44 CD44 molecule (Indian blood group) 0.0714447
OSMR oncostatin M receptor 0.067508
IGFBP3 insulin-like growth factor binding protein 3 0.0663719
SLC38A2 solute carrier family 38, member 2 0.0636983
INTS6 integrator complex subunit 6 0.0636734
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0569238
MYH9 myosin, heavy chain 9, non-muscle 0.0557896
HMGA2 high mobility group AT-hook 2 0.0553119
FLNB filamin B, beta 0.055215
FLNA filamin A, alpha 0.0536542
FMNL2 formin-like 2 0.0534348
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0493221
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0443708
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0420363
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0419331
MACF1 microtubule-actin crosslinking factor 1 0.0413017
AKAP13 A kinase (PRKA) anchor protein 13 0.0412743
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0403002
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0391644
ACTG1 actin gamma 1 0.0388077
PRKCA protein kinase C, alpha 0.0380336
LPP LIM domain containing preferred translocation partner in lipoma 0.0375728
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0373135
MBNL2 muscleblind-like splicing regulator 2 0.0372105
BCAR3 breast cancer anti-estrogen resistance 3 0.0365323
PDE8A phosphodiesterase 8A 0.0362382
LDHA lactate dehydrogenase A 0.036147
SCFD1 sec1 family domain containing 1 0.0359009
BICD1 bicaudal D homolog 1 (Drosophila) 0.0348816
LAMA5 laminin, alpha 5 0.0341833
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0340597
NT5E 5'-nucleotidase, ecto (CD73) 0.0337071
PLEC plectin 0.0331357
DIAPH1 diaphanous-related formin 1 0.0330921
RNF213 ring finger protein 213 0.0330203
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0327339
CAPRIN2 caprin family member 2 0.0322813
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0311068
AHNAK2 AHNAK nucleoprotein 2 0.0308655
AHNAK AHNAK nucleoprotein 0.0303879
MYO9B myosin IXB 0.030091
ITGB4 integrin, beta 4 0.0300024
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0299165
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0294568
WWC1 WW and C2 domain containing 1 0.0293401
AREG amphiregulin 0.0292178
THSD4 thrombospondin, type I, domain containing 4 0.0287221
HPCAL1 hippocalcin-like 1 0.0282724
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0273618
NPAS2 neuronal PAS domain protein 2 0.0273578
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0270474
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0270456
DNER delta/notch-like EGF repeat containing 0.0261741
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0259526
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0259515
GOLGB1 golgin B1 0.0258147
CMIP c-Maf inducing protein 0.0256163
EPAS1 endothelial PAS domain protein 1 0.0254317
SEPTIN9 septin 9 0.0254114
WWTR1 WW domain containing transcription regulator 1 0.0253782
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0252436
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0245354
CDK12 cyclin-dependent kinase 12 0.0242792
CEP250 centrosomal protein 250kDa 0.0240204
PDE4D phosphodiesterase 4D, cAMP-specific 0.0233387
ITGB5 integrin, beta 5 0.0231311
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0231007
CAB39 calcium binding protein 39 0.0230996
ABR active BCR-related 0.0225546
DGKD diacylglycerol kinase, delta 130kDa 0.0223133
HBEGF heparin-binding EGF-like growth factor 0.0218269
PDHX pyruvate dehydrogenase complex, component X 0.0216367
FAF2 Fas associated factor family member 2 0.0216335
LMO7 LIM domain 7 0.0214672
PRKCE protein kinase C, epsilon 0.0213992
NUMA1 nuclear mitotic apparatus protein 1 0.0213902
DENND5B DENN/MADD domain containing 5B 0.0213502
RAB28 RAB28, member RAS oncogene family 0.0212101
SFPQ splicing factor proline/glutamine-rich 0.0210109
DSCAM Down syndrome cell adhesion molecule 0.0209141
ZMYM4 zinc finger, MYM-type 4 0.0208711
MCL1 myeloid cell leukemia 1 0.0208154
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0206306
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0205967
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0205024
PCNX2 pecanex 2 0.0204424
STEAP3 STEAP family member 3, metalloreductase 0.02042
MBD5 methyl-CpG binding domain protein 5 0.0204173
DOCK1 dedicator of cytokinesis 1 0.0203667
TNRC18 trinucleotide repeat containing 18 0.0201484
TTC28 tetratricopeptide repeat domain 28 0.020117
SIK3 SIK family kinase 3 0.0200995
STIP1 stress-induced phosphoprotein 1 0.0200465
PTK2 protein tyrosine kinase 2 0.0199505
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0197956
ATP13A3 ATPase type 13A3 0.0197546
PANK3 pantothenate kinase 3 0.0196508
TXNIP thioredoxin interacting protein 0.0196256

decreased expression

Symbol Name Standardized Value
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.114633
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113263
RPLP1 ribosomal protein, large, P1 -0.0867974
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0734322
BIRC3 baculoviral IAP repeat containing 3 -0.0673922
SPAG9 sperm associated antigen 9 -0.0619722
PTMA prothymosin, alpha -0.0578521
PNISR PNN-interacting serine/arginine-rich protein -0.0534723
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0521097
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0517028
SOD2 superoxide dismutase 2, mitochondrial -0.051356
ZMYND8 zinc finger, MYND-type containing 8 -0.0489553
NUP58 nucleoporin 58 -0.0487875
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0471579
SNX14 sorting nexin 14 -0.0465849
IER3 immediate early response 3 -0.0463571
FTH1 ferritin, heavy polypeptide 1 -0.0440988
TPT1 tumor protein, translationally-controlled 1 -0.0439635
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0432758
CANX calnexin -0.0427299
SMC4 structural maintenance of chromosomes 4 -0.0420631
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0412217
BIRC6 baculoviral IAP repeat containing 6 -0.0411649
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0403687
RACK1 receptor for activated C kinase 1 -0.0387673
WAC WW domain containing adaptor with coiled-coil -0.0386788
UGCG UDP-glucose ceramide glucosyltransferase -0.0381011
RSRC2 arginine/serine-rich coiled-coil 2 -0.0380694
HELZ helicase with zinc finger -0.0377979
MATR3 matrin 3 -0.0371287
RPL35A ribosomal protein L35a -0.0370996
FNDC3A fibronectin type III domain containing 3A -0.0365215
ASXL1 additional sex combs like transcriptional regulator 1 -0.036496
GPC6 glypican 6 -0.0356665
OGA O-GlcNAcase -0.035513
SETD5 SET domain containing 5 -0.0354127
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0348155
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0347179
RAB7A RAB7A, member RAS oncogene family -0.0347176
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0346821
RPS25 ribosomal protein S25 -0.0345168
RBM39 RNA binding motif protein 39 -0.0343644
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0342669
FNDC3B fibronectin type III domain containing 3B -0.0341295
GOLGA4 golgin A4 -0.0341287
RB1CC1 RB1-inducible coiled-coil 1 -0.0338796
BTG1 B-cell translocation gene 1, anti-proliferative -0.0337356
TNPO1 transportin 1 -0.0332747
SDC4 syndecan 4 -0.0331862
MT2A metallothionein 2A -0.0324942
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0321741
NAP1L1 nucleosome assembly protein 1-like 1 -0.0319825
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0316892
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0316784
NAMPT nicotinamide phosphoribosyltransferase -0.0314834
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) -0.0313903
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0309698
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.030931
DTNA dystrobrevin, alpha -0.0308427
WTAP Wilms tumor 1 associated protein -0.0308207
MARCHF6 membrane associated ring-CH-type finger 6 -0.030685
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.030584
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0301211
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0300632
SMAP1 small ArfGAP 1 -0.0299701
RPS6 ribosomal protein S6 -0.0299087
ZNF292 zinc finger protein 292 -0.0299033
USP3 ubiquitin specific peptidase 3 -0.0299027
GOLT1B golgi transport 1B -0.0298775
MCTP1 multiple C2 domains, transmembrane 1 -0.0298507
WDR45B WD repeat domain 45B -0.0294922
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0292555
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0290711
KMT2E lysine (K)-specific methyltransferase 2E -0.0288965
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0288413
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0287788
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0287508
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.028607
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0285742
RTN4 reticulon 4 -0.0284925
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0281057
ARF1 ADP-ribosylation factor 1 -0.0278658
OASL 2'-5'-oligoadenylate synthetase-like -0.0278092
BCAS3 breast carcinoma amplified sequence 3 -0.0277655
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0277179
WBP11 WW domain binding protein 11 -0.0276688
RAB2A RAB2A, member RAS oncogene family -0.0275965
ZBTB10 zinc finger and BTB domain containing 10 -0.027569
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0271826
CDK6 cyclin-dependent kinase 6 -0.0269374
TPM4 tropomyosin 4 -0.0266755
CAPN7 calpain 7 -0.0265913
ZNF638 zinc finger protein 638 -0.0264856
NDRG1 N-myc downstream regulated 1 -0.0264366
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0263264
GLO1 glyoxalase I -0.0262961
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.026246
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0260882
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0260595
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0259884