Ripasudil Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9863672
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Genes

199 proteins with high or low expression in Ripasudil relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
KLHL23 kelch-like family member 23 1.33
PIP prolactin-induced protein 0.67
H3C1 H3 clustered histone 1 0.65
ADAM19 ADAM metallopeptidase domain 19 0.54
BCL6 B-cell CLL/lymphoma 6 0.54
ALPK3 alpha-kinase 3 0.52
DUSP6 dual specificity phosphatase 6 0.52
METRN meteorin, glial cell differentiation regulator 0.45
SENP7 SUMO1/sentrin specific peptidase 7 0.45
GATA2 GATA binding protein 2 0.44
TOR1AIP2 torsin A interacting protein 2 0.44
MCOLN2 mucolipin 2 0.43
ODF2L outer dense fiber of sperm tails 2-like 0.43
PROS1 protein S (alpha) 0.43
RFXAP regulatory factor X-associated protein 0.42
DENND5B DENN/MADD domain containing 5B 0.42
ABHD11 abhydrolase domain containing 11 0.41
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.4
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.4
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 0.39
FOXC1 forkhead box C1 0.39
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.38
AASDH aminoadipate-semialdehyde dehydrogenase 0.38
LINS1 lines homolog 1 0.38
VSNL1 visinin-like 1 0.38
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 0.38
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.37
UBE2A ubiquitin-conjugating enzyme E2A 0.37
MAGEA2 melanoma antigen family A2 0.36
EIF5A2 eukaryotic translation initiation factor 5A2 0.36
TP53 tumor protein p53 0.36
ZER1 zyg-11 related, cell cycle regulator 0.36
SMTN smoothelin 0.35
COMMD6 COMM domain containing 6 0.35
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.35
ZFHX4 zinc finger homeobox 4 0.34
IFIH1 interferon induced with helicase C domain 1 0.34
TMEM94 transmembrane protein 94 0.34
CDC25A cell division cycle 25A 0.33
EHF ets homologous factor 0.33
DEDD death effector domain containing 0.33
FCHSD2 FCH and double SH3 domains 2 0.32
STAB1 stabilin 1 0.32
TEN1 TEN1 CST complex subunit 0.32
SESTD1 SEC14 and spectrin domains 1 0.32
WDR54 WD repeat domain 54 0.31
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.31
MPV17 MpV17 mitochondrial inner membrane protein 0.31
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.31
NFU1 NFU1 iron-sulfur cluster scaffold 0.31
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.31
RBL2 retinoblastoma-like 2 0.31
ZNF672 zinc finger protein 672 0.31
TET2 tet methylcytosine dioxygenase 2 0.31
ZNF320 zinc finger protein 320 0.31
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 0.3
HIST1H1T histone cluster 1, H1t 0.3
FCHO1 FCH domain only 1 0.3
ERBB3 erb-b2 receptor tyrosine kinase 3 0.3
MORC4 MORC family CW-type zinc finger 4 0.29
FAM117B family with sequence similarity 117, member B 0.29
PKN3 protein kinase N3 0.29
TIAM1 T-cell lymphoma invasion and metastasis 1 0.29
PDE7A phosphodiesterase 7A 0.29
SLC16A6 solute carrier family 16, member 6 0.29
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.28
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.28
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.28
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.28
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.27
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.27
ACTL8 actin-like 8 0.27
ABITRAM actin binding transcription modulator 0.27
AXIN2 axin 2 0.27
CNTNAP3 contactin associated protein-like 3 0.27
CMC4 C-x(9)-C motif containing 4 0.26
AMOT angiomotin 0.26
ARL16 ADP-ribosylation factor-like 16 0.26
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 0.26
RPS26 ribosomal protein S26 0.25
NRIP1 nuclear receptor interacting protein 1 0.25
TTC12 tetratricopeptide repeat domain 12 0.25
VCAN versican 0.25
ZSCAN31 zinc finger and SCAN domain containing 31 0.25
GATD1 glutamine amidotransferase class 1 domain containing 1 0.25
RNF141 ring finger protein 141 0.25
PSRC1 proline/serine-rich coiled-coil 1 0.25
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.25
CCDC14 coiled-coil domain containing 14 0.25
TEX9 testis expressed 9 0.25
ZC3H14 zinc finger CCCH-type containing 14 0.25
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.24
BRMS1L breast cancer metastasis-suppressor 1-like 0.24
GSKIP GSK3B interacting protein 0.24
LIX1L Lix1 homolog (chicken) like 0.24
C20ORF194 chromosome 20 open reading frame 194 0.24
METAP2 methionyl aminopeptidase 2 0.24
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 0.24
PTPRD protein tyrosine phosphatase, receptor type, D 0.24
RFLNB refilin B 0.24

low expression

Symbol Name Standardized Value
JUN jun proto-oncogene -0.9
OBSL1 obscurin-like 1 -0.84
CCN1 cellular communication network factor 1 -0.61
F3 coagulation factor III (thromboplastin, tissue factor) -0.6
CPA4 carboxypeptidase A4 -0.59
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.59
HSPA12B heat shock 70kD protein 12B -0.58
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -0.57
RIPK4 receptor-interacting serine-threonine kinase 4 -0.55
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -0.54
BHLHA15 basic helix-loop-helix family, member a15 -0.52
BAIAP2 BAI1-associated protein 2 -0.52
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -0.51
KMT2C lysine (K)-specific methyltransferase 2C -0.49
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -0.47
TUFT1 tuftelin 1 -0.47
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.47
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.46
VSIR V-set immunoregulatory receptor -0.46
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.45
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -0.44
PRKCH protein kinase C, eta -0.44
STC2 stanniocalcin 2 -0.44
MOSPD1 motile sperm domain containing 1 -0.43
BCAR3 breast cancer anti-estrogen resistance 3 -0.43
ZNF776 zinc finger protein 776 -0.42
ANGPTL4 angiopoietin-like 4 -0.42
LAMB3 laminin, beta 3 -0.41
FHL2 four and a half LIM domains 2 -0.4
AXL AXL receptor tyrosine kinase -0.38
CCNE1 cyclin E1 -0.37
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.37
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -0.37
MAST1 microtubule associated serine/threonine kinase 1 -0.36
TIGD5 tigger transposable element derived 5 -0.36
TM7SF3 transmembrane 7 superfamily member 3 -0.36
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -0.36
PLD6 phospholipase D family, member 6 -0.36
TACSTD2 tumor-associated calcium signal transducer 2 -0.36
SNAP91 synaptosomal-associated protein, 91kDa -0.35
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.35
MSMO1 methylsterol monooxygenase 1 -0.34
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.34
FLII flightless I homolog (Drosophila) -0.34
PDZD11 PDZ domain containing 11 -0.34
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -0.33
CCDC73 coiled-coil domain containing 73 -0.33
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -0.33
HEXA hexosaminidase A (alpha polypeptide) -0.32
SAPCD2 suppressor APC domain containing 2 -0.32
CCN2 cellular communication network factor 2 -0.32
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 -0.32
MT2A metallothionein 2A -0.32
HRH1 histamine receptor H1 -0.31
ZNF775 zinc finger protein 775 -0.31
FOSL2 FOS-like antigen 2 -0.31
EPHA2 EPH receptor A2 -0.31
EYS eyes shut homolog (Drosophila) -0.31
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -0.31
MPRIP myosin phosphatase Rho interacting protein -0.3
SDC4 syndecan 4 -0.3
KPNA5 karyopherin alpha 5 (importin alpha 6) -0.3
TIMP2 TIMP metallopeptidase inhibitor 2 -0.3
SPRED2 sprouty-related, EVH1 domain containing 2 -0.3
INHBA inhibin, beta A -0.3
ANO8 anoctamin 8 -0.29
COQ4 coenzyme Q4 -0.29
LENG9 leukocyte receptor cluster (LRC) member 9 -0.28
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.28
PAWR PRKC, apoptosis, WT1, regulator -0.28
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.28
MYOM3 myomesin 3 -0.28
FN1 fibronectin 1 -0.27
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -0.27
SLC38A2 solute carrier family 38, member 2 -0.27
MEST mesoderm specific transcript -0.27
PTBP1 polypyrimidine tract binding protein 1 -0.27
TM2D3 TM2 domain containing 3 -0.27
JUND jun D proto-oncogene -0.27
DAAM1 dishevelled associated activator of morphogenesis 1 -0.26
ZBTB49 zinc finger and BTB domain containing 49 -0.26
PDLIM2 PDZ and LIM domain 2 (mystique) -0.26
TIMP1 TIMP metallopeptidase inhibitor 1 -0.26
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.26
C12ORF4 chromosome 12 open reading frame 4 -0.26
SPHK2 sphingosine kinase 2 -0.25
CRYBG2 crystallin beta-gamma domain containing 2 -0.25
C12ORF60 chromosome 12 open reading frame 60 -0.25
LDLR low density lipoprotein receptor -0.25
FOSL1 FOS-like antigen 1 -0.25
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.25
TRIM16 tripartite motif containing 16 -0.25
GGACT gamma-glutamylamine cyclotransferase -0.25
CNN3 calponin 3, acidic -0.24
FAM219A family with sequence similarity 219, member A -0.24
FGB fibrinogen beta chain -0.24
IRS2 insulin receptor substrate 2 -0.24
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.24
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -0.24