Ripoptosome Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. (Gene Ontology, GO_0097342)
External Link http://amigo.geneontology.org/amigo/term/GO:0097342
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Genes

6 proteins localized to the Ripoptosome cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 5.0
FADD Fas (TNFRSF6)-associated via death domain 5.0
TICAM1 toll-like receptor adaptor molecule 1 5.0
CFLAR CASP8 and FADD-like apoptosis regulator 5.0
CASP8 caspase 8, apoptosis-related cysteine peptidase 5.0
CASP10 caspase 10, apoptosis-related cysteine peptidase 5.0