Ripoptosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. (Gene Ontology, GO_0097342)
External Link http://amigo.geneontology.org/amigo/term/GO:0097342
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Genes

957 proteins co-occuring with the Ripoptosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MLKL mixed lineage kinase domain-like 3.951
RIPK3 receptor-interacting serine-threonine kinase 3 3.905
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 3.902
CASP8 caspase 8, apoptosis-related cysteine peptidase 3.428
FADD Fas (TNFRSF6)-associated via death domain 3.388
PCSK1 proprotein convertase subtilisin/kexin type 1 3.316
TRADD TNFRSF1A-associated via death domain 3.251
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 3.212
CFLAR CASP8 and FADD-like apoptosis regulator 3.092
BIRC2 baculoviral IAP repeat containing 2 3.073
CYLD cylindromatosis (turban tumor syndrome) 2.992
DIABLO diablo, IAP-binding mitochondrial protein 2.934
TNF tumor necrosis factor 2.784
PGAM5 phosphoglycerate mutase family member 5 2.767
MAP3K13 mitogen-activated protein kinase kinase kinase 13 2.741
ZBP1 Z-DNA binding protein 1 2.729
MAP3K12 mitogen-activated protein kinase kinase kinase 12 2.717
FASLG Fas ligand (TNF superfamily, member 6) 2.579
CASP1 caspase 1, apoptosis-related cysteine peptidase 2.574
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.567
GSDMD gasdermin D 2.554
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.542
TLR3 toll-like receptor 3 2.539
BIRC3 baculoviral IAP repeat containing 3 2.522
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.479
RNF31 ring finger protein 31 2.37
GSDME gasdermin E 2.369
GSDMA gasdermin A 2.353
FASN fatty acid synthase 2.316
TLR4 toll-like receptor 4 2.308
IL1B interleukin 1, beta 2.298
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.295
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 2.277
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.259
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2.246
NLRP3 NLR family, pyrin domain containing 3 2.237
TRAF5 TNF receptor-associated factor 5 2.237
IL18 interleukin 18 2.223
CHUK conserved helix-loop-helix ubiquitous kinase 2.216
SHARPIN SHANK-associated RH domain interactor 2.215
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 2.211
HMGB1 high mobility group box 1 2.205
BCL2 B-cell CLL/lymphoma 2 2.197
GPX4 glutathione peroxidase 4 2.194
APAF1 apoptotic peptidase activating factor 1 2.185
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.174
MAP3K7 mitogen-activated protein kinase kinase kinase 7 2.17
CYCS cytochrome c, somatic 2.154
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.153
IFNB1 interferon, beta 1, fibroblast 2.142
BAX BCL2-associated X protein 2.137
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 2.126
AIM2 absent in melanoma 2 2.107
PPIF peptidylprolyl isomerase F 2.09
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.061
PARP1 poly (ADP-ribose) polymerase 1 2.048
PELI1 pellino E3 ubiquitin protein ligase 1 2.04
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.033
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.032
BCL2L1 BCL2-like 1 2.002
BECN1 beclin 1, autophagy related 2.0
TP53 tumor protein p53 1.998
ANXA5 annexin A5 1.998
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 1.983
DNM1L dynamin 1-like 1.981
NLRC4 NLR family, CARD domain containing 4 1.962
ATG5 autophagy related 5 1.944
OTULIN OTU deubiquitinase with linear linkage specificity 1.926
IL6 interleukin 6 1.925
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.923
PYCARD PYD and CARD domain containing 1.918
NLRP1 NLR family, pyrin domain containing 1 1.905
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.883
MCL1 myeloid cell leukemia 1 1.882
CLEC4E C-type lectin domain family 4, member E 1.881
IFNG interferon, gamma 1.88
CDC37 cell division cycle 37 1.877
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.874
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.863
CD8A CD8a molecule 1.858
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.844
SQSTM1 sequestosome 1 1.839
ZNF7 zinc finger protein 7 1.838
SPATA2 spermatogenesis associated 2 1.836
PYGL phosphorylase, glycogen, liver 1.832
IL1A interleukin 1, alpha 1.829
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.827
ATG7 autophagy related 7 1.824
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.817
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.816
NWD2 NACHT and WD repeat domain containing 2 1.812
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 1.808
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 1.8
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.8
GRID1 glutamate receptor, ionotropic, delta 1 1.799
POTEF POTE ankyrin domain family, member F 1.798
IL33 interleukin 33 1.792
RIGI RNA sensor RIG-I 1.792
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1.774
GSDMB gasdermin B 1.772
TRPM7 transient receptor potential cation channel, subfamily M, member 7 1.767
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.764
MYD88 myeloid differentiation primary response 88 1.756
ULK1 unc-51 like autophagy activating kinase 1 1.754
TICAM1 toll-like receptor adaptor molecule 1 1.751
MEFV Mediterranean fever 1.751
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 1.747
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.747
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.743
CASP5 caspase 5, apoptosis-related cysteine peptidase 1.739
KANK2 KN motif and ankyrin repeat domains 2 1.736
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.736
BID BH3 interacting domain death agonist 1.732
IRF3 interferon regulatory factor 3 1.728
GSDMC gasdermin C 1.723
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.712
TBK1 TANK-binding kinase 1 1.711
JUN jun proto-oncogene 1.709
ACSL4 acyl-CoA synthetase long-chain family member 4 1.708
MAPK8 mitogen-activated protein kinase 8 1.706
PYGB phosphorylase, glycogen; brain 1.701
RTL10 retrotransposon Gag like 10 1.691
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 1.685
PYGM phosphorylase, glycogen, muscle 1.668
HTRA2 HtrA serine peptidase 2 1.667
NINJ1 ninjurin 1 1.666
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.654
CD4 CD4 molecule 1.653
ENDOG endonuclease G 1.652
NAIP NLR family, apoptosis inhibitory protein 1.647
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.646
TGFB1 transforming growth factor, beta 1 1.637
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.628
CLSTN1 calsyntenin 1 1.625
GLUL glutamate-ammonia ligase 1.621
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.621
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.615
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.589
TLR2 toll-like receptor 2 1.589
ZUP1 zinc finger containing ubiquitin peptidase 1 1.585
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.584
CCL2 chemokine (C-C motif) ligand 2 1.584
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 1.582
SAP130 Sin3A-associated protein, 130kDa 1.579
MAVS mitochondrial antiviral signaling protein 1.579
ATG3 autophagy related 3 1.572
PPID peptidylprolyl isomerase D 1.571
TNIP1 TNFAIP3 interacting protein 1 1.57
MFF mitochondrial fission factor 1.566
IDO1 indoleamine 2,3-dioxygenase 1 1.563
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.558
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.558
BIRC7 baculoviral IAP repeat containing 7 1.55
BBC3 BCL2 binding component 3 1.545
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 1.545
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.542
MAP3K5 mitogen-activated protein kinase kinase kinase 5 1.535
TRAF1 TNF receptor-associated factor 1 1.534
STAT1 signal transducer and activator of transcription 1, 91kDa 1.532
TRAF3 TNF receptor-associated factor 3 1.531
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.53
CXCL8 chemokine (C-X-C motif) ligand 8 1.527
ATG12 autophagy related 12 1.527
PXDN peroxidasin 1.499
PXDNL peroxidasin-like 1.495
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.492
NOD2 nucleotide-binding oligomerization domain containing 2 1.487
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 1.487
METAP1 methionyl aminopeptidase 1 1.482
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.48
IDO2 indoleamine 2,3-dioxygenase 2 1.479
CTSS cathepsin S 1.475
CGAS cyclic GMP-AMP synthase 1.474
KEAP1 kelch-like ECH-associated protein 1 1.467
CTSB cathepsin B 1.467
PIDD1 p53-induced death domain protein 1 1.465
PINK1 PTEN induced putative kinase 1 1.463
IL10 interleukin 10 1.463
DNTT DNA nucleotidylexotransferase 1.46
BIRC5 baculoviral IAP repeat containing 5 1.458
IL1R1 interleukin 1 receptor, type I 1.452
IRF1 interferon regulatory factor 1 1.45
BAK1 BCL2-antagonist/killer 1 1.444
CD274 CD274 molecule 1.444
IFIH1 interferon induced with helicase C domain 1 1.441
LPCAT3 lysophosphatidylcholine acyltransferase 3 1.441
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.441
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 1.433
IFNA1 interferon, alpha 1 1.429
NABP1 nucleic acid binding protein 1 1.428
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.426
PJVK pejvakin 1.425
NEK7 NIMA-related kinase 7 1.421
NFE2L2 nuclear factor, erythroid 2-like 2 1.419
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.418
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 1.412
TLR9 toll-like receptor 9 1.41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.41
DSTYK dual serine/threonine and tyrosine protein kinase 1.409
IREB2 iron-responsive element binding protein 2 1.403
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.397
RIPK4 receptor-interacting serine-threonine kinase 4 1.396
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.392
RB1CC1 RB1-inducible coiled-coil 1 1.392
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.389
PLK1 polo-like kinase 1 1.387
ATG13 autophagy related 13 1.382
CALR calreticulin 1.382
SIRT1 sirtuin 1 1.375
EGFR epidermal growth factor receptor 1.374
BOK BCL2-related ovarian killer 1.373
CD40 CD40 molecule, TNF receptor superfamily member 5 1.369
NOD1 nucleotide-binding oligomerization domain containing 1 1.366
NCOA4 nuclear receptor coactivator 4 1.361
MAPK3 mitogen-activated protein kinase 3 1.359
PANX1 pannexin 1 1.359
ATG14 autophagy related 14 1.356
AURKA aurora kinase A 1.347
PELI3 pellino E3 ubiquitin protein ligase family member 3 1.347
GSK3B glycogen synthase kinase 3 beta 1.346
JAK1 Janus kinase 1 1.34
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.339
BCL2L2 BCL2-like 2 1.338
GRAMD4 GRAM domain containing 4 1.337
HMOX1 heme oxygenase 1 1.337
OPTN optineurin 1.334
IL4 interleukin 4 1.334
PTEN phosphatase and tensin homolog 1.327
FBF1 Fas (TNFRSF6) binding factor 1 1.325
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.324
IL17F interleukin 17F 1.322
BIRC6 baculoviral IAP repeat containing 6 1.317
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.316
AXL AXL receptor tyrosine kinase 1.314
IRAK1 interleukin-1 receptor-associated kinase 1 1.314
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.313
FTH1 ferritin, heavy polypeptide 1 1.313
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.297
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 1.296
AGER advanced glycosylation end product-specific receptor 1.295
ATM ATM serine/threonine kinase 1.288
CXCL10 chemokine (C-X-C motif) ligand 10 1.286
ADAM17 ADAM metallopeptidase domain 17 1.286
HSPA4 heat shock 70kDa protein 4 1.281
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.278
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1.277
RIPK2 receptor-interacting serine-threonine kinase 2 1.275
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 1.274
CTSD cathepsin D 1.273
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.271
NOX1 NADPH oxidase 1 1.268
BMF Bcl2 modifying factor 1.268
MAP1S microtubule-associated protein 1S 1.268
TFEB transcription factor EB 1.261
CCL5 chemokine (C-C motif) ligand 5 1.26
PRKN parkin RBR E3 ubiquitin protein ligase 1.258
NLRP6 NLR family, pyrin domain containing 6 1.255
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.249
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.248
ZNF711 zinc finger protein 711 1.246
BCL2A1 BCL2-related protein A1 1.246
ZNF395 zinc finger protein 395 1.246
CUL3 cullin 3 1.244
RUBCN rubicon autophagy regulator 1.244
ELANE elastase, neutrophil expressed 1.241
CLEC7A C-type lectin domain family 7, member A 1.236
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.231
HRK harakiri, BCL2 interacting protein 1.229
UVRAG UV radiation resistance associated 1.229
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.225
AMBRA1 autophagy/beclin-1 regulator 1 1.222
TFRC transferrin receptor 1.219
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.215
PTPRC protein tyrosine phosphatase, receptor type, C 1.214
GABARAPL1 GABA(A) receptor-associated protein like 1 1.213
ERN1 endoplasmic reticulum to nucleus signaling 1 1.21
IL2 interleukin 2 1.206
HSH2D hematopoietic SH2 domain containing 1.201
SMDT1 single-pass membrane protein with aspartate-rich tail 1 1.192
FOXO3 forkhead box O3 1.192
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.188
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.187
CSF1 colony stimulating factor 1 (macrophage) 1.181
IRAK4 interleukin-1 receptor-associated kinase 4 1.18
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 1.179
APP amyloid beta (A4) precursor protein 1.178
MAP1B microtubule-associated protein 1B 1.178
TYRO3 TYRO3 protein tyrosine kinase 1.177
AIF1 allograft inflammatory factor 1 1.177
CXCL2 chemokine (C-X-C motif) ligand 2 1.174
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.174
CARD8 caspase recruitment domain family, member 8 1.173
CXCL5 chemokine (C-X-C motif) ligand 5 1.172
IL13 interleukin 13 1.171
MALT1 MALT1 paracaspase 1.171
ATG4B autophagy related 4B, cysteine peptidase 1.168
GPX3 glutathione peroxidase 3 1.167
GPX6 glutathione peroxidase 6 1.164
GPX8 glutathione peroxidase 8 (putative) 1.162
GPX2 glutathione peroxidase 2 1.159
GPX7 glutathione peroxidase 7 1.159
UBE2N ubiquitin-conjugating enzyme E2N 1.158
MKRN1 makorin ring finger protein 1 1.155
GPX5 glutathione peroxidase 5 1.155
TANK TRAF family member-associated NFKB activator 1.153
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 1.144
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 1.142
EGF epidermal growth factor 1.141
ATG101 autophagy related 101 1.14
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.14
ATF6 activating transcription factor 6 1.139
OTUD7B OTU deubiquitinase 7B 1.137
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.136
BCL10 B-cell CLL/lymphoma 10 1.132
DDIT3 DNA-damage-inducible transcript 3 1.126
NOX4 NADPH oxidase 4 1.125
USP2 ubiquitin specific peptidase 2 1.124
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.124
ATG10 autophagy related 10 1.124
CST7 cystatin F (leukocystatin) 1.12
MPO myeloperoxidase 1.115
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.111
ANXA8L1 annexin A8-like 1 1.107
MAP3K11 mitogen-activated protein kinase kinase kinase 11 1.107
CCND1 cyclin D1 1.107
CYBB cytochrome b-245, beta polypeptide 1.106
MAPK1 mitogen-activated protein kinase 1 1.101
CDKN2A cyclin-dependent kinase inhibitor 2A 1.099
IRF9 interferon regulatory factor 9 1.098
TARDBP TAR DNA binding protein 1.098
BAG4 BCL2-associated athanogene 4 1.087
TXN2 thioredoxin 2 1.086
H2AX H2A.X variant histone 1.086
DAPK1 death-associated protein kinase 1 1.085
MERTK MER proto-oncogene, tyrosine kinase 1.084
TXNIP thioredoxin interacting protein 1.084
SIRT3 sirtuin 3 1.083
CD40LG CD40 ligand 1.082
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.081
ADAR adenosine deaminase, RNA-specific 1.081
MFN2 mitofusin 2 1.081
VDAC1 voltage-dependent anion channel 1 1.081
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 1.08
GLTP glycolipid transfer protein 1.08
FPR1 formyl peptide receptor 1 1.078
IPMK inositol polyphosphate multikinase 1.076
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.075
CCL4 chemokine (C-C motif) ligand 4 1.075
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.074
MMP9 matrix metallopeptidase 9 1.073
JAK2 Janus kinase 2 1.073
NLRP12 NLR family, pyrin domain containing 12 1.072
ICAM1 intercellular adhesion molecule 1 1.072
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 1.067
ULK2 unc-51 like autophagy activating kinase 2 1.062
CDK2 cyclin-dependent kinase 2 1.06
ZP4 zona pellucida glycoprotein 4 1.059
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 1.056
MAPK9 mitogen-activated protein kinase 9 1.055
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.055
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 1.053
CSNK1A1 casein kinase 1, alpha 1 1.051
CCL3 chemokine (C-C motif) ligand 3 1.051
APOE apolipoprotein E 1.049
OTUD1 OTU deubiquitinase 1 1.045
CDK1 cyclin-dependent kinase 1 1.045
SYK spleen tyrosine kinase 1.045
PELI2 pellino E3 ubiquitin protein ligase family member 2 1.044
BIK BCL2-interacting killer (apoptosis-inducing) 1.04
PPP1R3G protein phosphatase 1, regulatory subunit 3G 1.04
MPLKIP M-phase specific PLK1 interacting protein 1.038
USP22 ubiquitin specific peptidase 22 1.037
CDIP1 cell death-inducing p53 target 1 1.037
ALOX15 arachidonate 15-lipoxygenase 1.035
GZMM granzyme M (lymphocyte met-ase 1) 1.035
TLR7 toll-like receptor 7 1.033
STING1 stimulator of interferon response cGAMP interactor 1 1.033
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.032
MFN1 mitofusin 1 1.032
CXCR2 chemokine (C-X-C motif) receptor 2 1.032
CCR2 chemokine (C-C motif) receptor 2 1.031
FTL ferritin, light polypeptide 1.026
FUNDC1 FUN14 domain containing 1 1.024
ERBB2 erb-b2 receptor tyrosine kinase 2 1.021
ATG4D autophagy related 4D, cysteine peptidase 1.02
IFI16 interferon, gamma-inducible protein 16 1.019
ZNHIT3 zinc finger, HIT-type containing 3 1.019
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 1.013
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 1.011
CD47 CD47 molecule 1.01
INS insulin 1.01
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 1.01
TRIM21 tripartite motif containing 21 1.009
DENR density-regulated protein 1.005
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.005
RARG retinoic acid receptor, gamma 1.004
CD86 CD86 molecule 1.001
DNAH8 dynein, axonemal, heavy chain 8 1.001
MAPK14 mitogen-activated protein kinase 14 0.999
LTA lymphotoxin alpha 0.999
IRF7 interferon regulatory factor 7 0.997
CALCOCO2 calcium binding and coiled-coil domain 2 0.993
BAD BCL2-associated agonist of cell death 0.99
CSNK1G1 casein kinase 1, gamma 1 0.99
CD300C CD300c molecule 0.986
CTSG cathepsin G 0.985
LAMP1 lysosomal-associated membrane protein 1 0.984
TRIM11 tripartite motif containing 11 0.98
MAP2K4 mitogen-activated protein kinase kinase 4 0.974
SOD1 superoxide dismutase 1, soluble 0.973
CHEK1 checkpoint kinase 1 0.973
STEAP3 STEAP family member 3, metalloreductase 0.971
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.97
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 0.97
CD68 CD68 molecule 0.969
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.967
LRRK1 leucine-rich repeat kinase 1 0.967
NLRP4 NLR family, pyrin domain containing 4 0.965
FOXP3 forkhead box P3 0.964
PPARG peroxisome proliferator-activated receptor gamma 0.962
IL22 interleukin 22 0.962
STAT2 signal transducer and activator of transcription 2, 113kDa 0.962
CCNB1 cyclin B1 0.954
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.952
NQO1 NAD(P)H dehydrogenase, quinone 1 0.951
PHRF1 PHD and ring finger domains 1 0.95
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.949
PITPNA phosphatidylinositol transfer protein, alpha 0.948
ITPK1 inositol-tetrakisphosphate 1-kinase 0.948
PADI4 peptidyl arginine deiminase, type IV 0.948
HSPB1 heat shock 27kDa protein 1 0.946
KRT18 keratin 18, type I 0.944
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.941
TSC2 tuberous sclerosis 2 0.94
LEF1 lymphoid enhancer-binding factor 1 0.939
MRC1 mannose receptor, C type 1 0.937
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.937
TCHP trichoplein, keratin filament binding 0.935
ANXA1 annexin A1 0.934
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.931
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.931
XDH xanthine dehydrogenase 0.93
N4BP1 NEDD4 binding protein 1 0.929
CHMP2B charged multivesicular body protein 2B 0.928
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.928
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.927
TRIM25 tripartite motif containing 25 0.927
NLRP9 NLR family, pyrin domain containing 9 0.927
CCNA2 cyclin A2 0.926
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 0.925
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B 0.923
CARD9 caspase recruitment domain family, member 9 0.922
TRAT1 T cell receptor associated transmembrane adaptor 1 0.921
HSPB3 heat shock 27kDa protein 3 0.919
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.917
IL5 interleukin 5 0.915
LAMP2 lysosomal-associated membrane protein 2 0.914
FLT3 fms-related tyrosine kinase 3 0.912
IL1RAP interleukin 1 receptor accessory protein 0.912
XBP1 X-box binding protein 1 0.912
BECN2 beclin 2 0.911
LCN2 lipocalin 2 0.908
TREM2 triggering receptor expressed on myeloid cells 2 0.907
CDPF1 cysteine-rich, DPF motif domain containing 1 0.905
LRRK2 leucine-rich repeat kinase 2 0.905
BCL2L10 BCL2-like 10 (apoptosis facilitator) 0.903
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.902
FOXO1 forkhead box O1 0.901
MCU mitochondrial calcium uniporter 0.901
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.899
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.898
COLGALT1 collagen beta(1-O)galactosyltransferase 1 0.896
SIRT2 sirtuin 2 0.896
SCARB1 scavenger receptor class B, member 1 0.893
COPS8 COP9 signalosome subunit 8 0.893
PROM2 prominin 2 0.893
UBE2D1 ubiquitin-conjugating enzyme E2D 1 0.892
DRAM1 DNA-damage regulated autophagy modulator 1 0.891
CAV1 caveolin 1, caveolae protein, 22kDa 0.89
CHEK2 checkpoint kinase 2 0.89
CCL20 chemokine (C-C motif) ligand 20 0.89
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.889
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.887
STX17 syntaxin 17 0.887
CD28 CD28 molecule 0.884
ANKK1 ankyrin repeat and kinase domain containing 1 0.883
RNASE3 ribonuclease, RNase A family, 3 0.883
FN1 fibronectin 1 0.883
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.882
TFAM transcription factor A, mitochondrial 0.881
S100A9 S100 calcium binding protein A9 0.879
E2F1 E2F transcription factor 1 0.877
PDCD1 programmed cell death 1 0.877
STK11 serine/threonine kinase 11 0.877
TXNRD1 thioredoxin reductase 1 0.876
USP8 ubiquitin specific peptidase 8 0.876
CD80 CD80 molecule 0.874
CD44 CD44 molecule (Indian blood group) 0.873
ITCH itchy E3 ubiquitin protein ligase 0.872
HDAC9 histone deacetylase 9 0.868
H3-7 H3.7 histone (putative) 0.866
H3C13 H3 clustered histone 13 0.865
H3-5 H3.5 histone 0.865
H3-4 H3.4 histone, cluster member 0.864
TJP1 tight junction protein 1 0.862
FDX1 ferredoxin 1 0.86
EDAR ectodysplasin A receptor 0.86
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.858
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.858
AGXT alanine-glyoxylate aminotransferase 0.858
H3C7 H3 clustered histone 7 0.857
H3-3B H3.3 histone B 0.856
MAPT microtubule-associated protein tau 0.854
MROH9 maestro heat-like repeat family member 9 0.854
PKM pyruvate kinase, muscle 0.852
IAPP islet amyloid polypeptide 0.852
SOD2 superoxide dismutase 2, mitochondrial 0.851
CALML4 calmodulin-like 4 0.851
CALML6 calmodulin-like 6 0.851
CALML5 calmodulin-like 5 0.85
CALML3 calmodulin-like 3 0.85
PRKCD protein kinase C, delta 0.849
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.848
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.848
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.848
LOX lysyl oxidase 0.847
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.846
PHF20 PHD finger protein 20 0.845
NBR1 neighbor of BRCA1 gene 1 0.844
TIMD4 T-cell immunoglobulin and mucin domain containing 4 0.842
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.842
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.841
LTB lymphotoxin beta (TNF superfamily, member 3) 0.84
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.84
CCNA1 cyclin A1 0.837
IL33R interleukin 33 receptor 0.836
HAVCR2 hepatitis A virus cellular receptor 2 0.836
ATF4 activating transcription factor 4 0.834
CIRBP cold inducible RNA binding protein 0.832
SCAF11 SR-related CTD-associated factor 11 0.831
CDK4 cyclin-dependent kinase 4 0.831
C1D C1D nuclear receptor corepressor 0.828
RNF11 ring finger protein 11 0.827
MPPE1 metallophosphoesterase 1 0.826
CXCR4 chemokine (C-X-C motif) receptor 4 0.826
TSLP thymic stromal lymphopoietin 0.826
OGA O-GlcNAcase 0.825
CREB1 cAMP responsive element binding protein 1 0.825
FOS FBJ murine osteosarcoma viral oncogene homolog 0.824
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 0.822
TMEM275 transmembrane protein 275 0.821
CARD11 caspase recruitment domain family, member 11 0.82
VCAM1 vascular cell adhesion molecule 1 0.82
DPP8 dipeptidyl-peptidase 8 0.819
CASP14 caspase 14, apoptosis-related cysteine peptidase 0.819
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.817
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.815
USP27X ubiquitin specific peptidase 27, X-linked 0.813
IFNGR1 interferon gamma receptor 1 0.812
HSPA8 heat shock 70kDa protein 8 0.811
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.811
TRIM28 tripartite motif containing 28 0.81
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.809
ZNF629 zinc finger protein 629 0.809
ZNF501 zinc finger protein 501 0.808
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.808
ZNF763 zinc finger protein 763 0.808
ZNF44 zinc finger protein 44 0.808
ZNF436 zinc finger protein 436 0.807
SETDB1 SET domain, bifurcated 1 0.807
CCNL2 cyclin L2 0.805
CDC42 cell division cycle 42 0.803
IRAK2 interleukin-1 receptor-associated kinase 2 0.802
CSF3 colony stimulating factor 3 (granulocyte) 0.802
OCLN occludin 0.802
STAT5A signal transducer and activator of transcription 5A 0.801
TMEM230 transmembrane protein 230 0.799
IRF5 interferon regulatory factor 5 0.799
ISG15 ISG15 ubiquitin-like modifier 0.798
STAT5B signal transducer and activator of transcription 5B 0.797
SDCBP2 syndecan binding protein (syntenin) 2 0.795
NANOS2 nanos homolog 2 (Drosophila) 0.795
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.795
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.795
LGALS3 lectin, galactoside-binding, soluble, 3 0.794
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.79
MMP2 matrix metallopeptidase 2 0.79
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.789
ZNF569 zinc finger protein 569 0.783
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.783
OR1K1 olfactory receptor, family 1, subfamily K, member 1 0.782
SCARB2 scavenger receptor class B, member 2 0.781
NFE2 nuclear factor, erythroid 2 0.781
SRXN1 sulfiredoxin 1 0.78
PARL presenilin associated, rhomboid-like 0.779
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.777
CXCL11 chemokine (C-X-C motif) ligand 11 0.777
RPTOR regulatory associated protein of MTOR, complex 1 0.776
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.776
KDR kinase insert domain receptor 0.776
COPS5 COP9 signalosome subunit 5 0.775
MAP2K1 mitogen-activated protein kinase kinase 1 0.774
PMEL premelanosome protein 0.773
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 0.771
PELP1 proline, glutamate and leucine rich protein 1 0.771
RHOA ras homolog family member A 0.771
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.771
ALK anaplastic lymphoma receptor tyrosine kinase 0.769
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.769
CSF1R colony stimulating factor 1 receptor 0.767
HOOK2 hook microtubule-tethering protein 2 0.763
TNIP3 TNFAIP3 interacting protein 3 0.762
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.762
MDM4 MDM4, p53 regulator 0.761
XKR8 XK, Kell blood group complex subunit-related family, member 8 0.759
CD36 CD36 molecule (thrombospondin receptor) 0.758
SNAP29 synaptosomal-associated protein, 29kDa 0.757
BTK Bruton agammaglobulinemia tyrosine kinase 0.756
MFGE8 milk fat globule-EGF factor 8 protein 0.753
PPARA peroxisome proliferator-activated receptor alpha 0.75
PARP2 poly (ADP-ribose) polymerase 2 0.746
MAPK7 mitogen-activated protein kinase 7 0.745
TLR1 toll-like receptor 1 0.744
BATF3 basic leucine zipper transcription factor, ATF-like 3 0.743
USP20 ubiquitin specific peptidase 20 0.742
NKRF NFKB repressing factor 0.741
PCNX4 pecanex 4 0.741
MAPK11 mitogen-activated protein kinase 11 0.74
HSPB2 heat shock 27kDa protein 2 0.74
IFNA13 interferon, alpha 13 0.738
RHEB Ras homolog enriched in brain 0.738
IL1RN interleukin 1 receptor antagonist 0.738
SLC39A7 solute carrier family 39 (zinc transporter), member 7 0.738
IL37 interleukin 37 0.736
FNDC4 fibronectin type III domain containing 4 0.736
SIRT6 sirtuin 6 0.736
RFK riboflavin kinase 0.735
TYK2 tyrosine kinase 2 0.733
PTK2 protein tyrosine kinase 2 0.732
IL3 interleukin 3 0.731
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.731
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.731
TLR5 toll-like receptor 5 0.727
ESR1 estrogen receptor 1 0.727
COG6 component of oligomeric golgi complex 6 0.726
NLRP7 NLR family, pyrin domain containing 7 0.726
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.725
ANKRD13A ankyrin repeat domain 13A 0.725
SMAD2 SMAD family member 2 0.724
SARM1 sterile alpha and TIR motif containing 1 0.724
MED12 mediator complex subunit 12 0.723
IFNA4 interferon, alpha 4 0.723
PSEN1 presenilin 1 0.719
IFNA2 interferon, alpha 2 0.719
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.718
IGF1 insulin-like growth factor 1 (somatomedin C) 0.718
PECAM1 platelet/endothelial cell adhesion molecule 1 0.715
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.715
MAP2K3 mitogen-activated protein kinase kinase 3 0.715
ADAM10 ADAM metallopeptidase domain 10 0.714
PKN2 protein kinase N2 0.713
ACOD1 aconitate decarboxylase 1 0.713
GSR glutathione reductase 0.712
MAP2K5 mitogen-activated protein kinase kinase 5 0.711
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.709
FGF13 fibroblast growth factor 13 0.709
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 0.708
RNF183 ring finger protein 183 0.708
IL15 interleukin 15 0.707
CXCL12 chemokine (C-X-C motif) ligand 12 0.706
EGR1 early growth response 1 0.706
CTSL cathepsin L 0.705
ADA adenosine deaminase 0.705
UBD ubiquitin D 0.704
NPC1 Niemann-Pick disease, type C1 0.703
ELAVL1 ELAV like RNA binding protein 1 0.703
LAG3 lymphocyte-activation gene 3 0.703
PRKCA protein kinase C, alpha 0.702
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.701
CASKIN2 CASK interacting protein 2 0.699
CARD14 caspase recruitment domain family, member 14 0.699
GABARAP GABA(A) receptor-associated protein 0.697
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.695
PHKG2 phosphorylase kinase, gamma 2 (testis) 0.695
SLTM SAFB-like, transcription modulator 0.695
IGF1R insulin-like growth factor 1 receptor 0.693
RPL8 ribosomal protein L8 0.691
ACLY ATP citrate lyase 0.691
BRCA1 breast cancer 1, early onset 0.69
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.69
TIMP1 TIMP metallopeptidase inhibitor 1 0.69
CD19 CD19 molecule 0.689
MPEG1 macrophage expressed 1 0.688
IFNA8 interferon, alpha 8 0.687
CDK7 cyclin-dependent kinase 7 0.685
SKP1 S-phase kinase-associated protein 1 0.685
SMAD3 SMAD family member 3 0.684
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.684
CD34 CD34 molecule 0.683
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.683
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.682
NUBP2 nucleotide binding protein 2 0.68
GFAP glial fibrillary acidic protein 0.68
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.68
ATF3 activating transcription factor 3 0.679
BDNF brain-derived neurotrophic factor 0.679
RARA retinoic acid receptor, alpha 0.679
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.677
BMAL1 basic helix-loop-helix ARNT like 1 0.676
IL9 interleukin 9 0.676
NUPR1 nuclear protein, transcriptional regulator, 1 0.674
IFNA17 interferon, alpha 17 0.674
CH25H cholesterol 25-hydroxylase 0.674
HDAC6 histone deacetylase 6 0.673
MAPK13 mitogen-activated protein kinase 13 0.672
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.67
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.67
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.67
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 0.669
HAGH hydroxyacylglutathione hydrolase 0.667
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.666
SPHK1 sphingosine kinase 1 0.664
DIAPH1 diaphanous-related formin 1 0.663
NLRC5 NLR family, CARD domain containing 5 0.662
MIEF2 mitochondrial elongation factor 2 0.662
TRIM31 tripartite motif containing 31 0.661
TOLLIP toll interacting protein 0.659
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.659
SNAI1 snail family zinc finger 1 0.658
ATG4C autophagy related 4C, cysteine peptidase 0.658
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.656
EFS embryonal Fyn-associated substrate 0.655
IL6R interleukin 6 receptor 0.654
IFNA6 interferon, alpha 6 0.653
CD163 CD163 molecule 0.653
DNASE2 deoxyribonuclease II, lysosomal 0.652
IFNA5 interferon, alpha 5 0.65
RRM1 ribonucleotide reductase M1 0.65
RPE65 retinal pigment epithelium-specific protein 65kDa 0.647
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.647
ADGRB1 adhesion G protein-coupled receptor B1 0.647
HSPA1B heat shock 70kDa protein 1B 0.647
SHPK sedoheptulokinase 0.644
TBCE tubulin folding cofactor E 0.644
ADPRS ADP-ribosylserine hydrolase 0.643
RNF135 ring finger protein 135 0.643
NFS1 NFS1 cysteine desulfurase 0.643
CASP8AP2 caspase 8 associated protein 2 0.642
GNLY granulysin 0.642
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.641
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.641
DAPK2 death-associated protein kinase 2 0.64
CISD1 CDGSH iron sulfur domain 1 0.639
PLBD2 phospholipase B domain containing 2 0.638
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.637
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.636
CLEC9A C-type lectin domain family 9, member A 0.635
CLIP3 CAP-GLY domain containing linker protein 3 0.633
RNF216 ring finger protein 216 0.632
LCK LCK proto-oncogene, Src family tyrosine kinase 0.63
HSF1 heat shock transcription factor 1 0.629
ZCCHC14 zinc finger, CCHC domain containing 14 0.628
ATG2A autophagy related 2A 0.627
EPAS1 endothelial PAS domain protein 1 0.627
NRL neural retina leucine zipper 0.626
MAP2K7 mitogen-activated protein kinase kinase 7 0.626
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 0.626
IRGM immunity-related GTPase family, M 0.625
VMP1 vacuole membrane protein 1 0.624
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.622
MAPK12 mitogen-activated protein kinase 12 0.621
MAP2K2 mitogen-activated protein kinase kinase 2 0.621
JMJD8 jumonji domain containing 8 0.621
IFNA16 interferon, alpha 16 0.621
IFNA10 interferon, alpha 10 0.621
IFNA21 interferon, alpha 21 0.62
COMMD4 COMM domain containing 4 0.62
IFNA7 interferon, alpha 7 0.62
IFNA14 interferon, alpha 14 0.619
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.618
LDLR low density lipoprotein receptor 0.617
GAS6 growth arrest-specific 6 0.617
MACO1 macoilin 1 0.616
IRAK3 interleukin-1 receptor-associated kinase 3 0.615
TIGAR TP53 induced glycolysis regulatory phosphatase 0.614
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.614
SELE selectin E 0.614
DLAT dihydrolipoamide S-acetyltransferase 0.612
TGFBR1 transforming growth factor, beta receptor 1 0.61
ZFP36 ZFP36 ring finger protein 0.61
MIURF mitochondrial elongation factor 1 upstream open reading frame 0.609
LTF lactotransferrin 0.609
TMED7-TICAM2 TMED7-TICAM2 readthrough 0.607
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.607
EPX eosinophil peroxidase 0.606
SIRPA signal-regulatory protein alpha 0.606
SOCS1 suppressor of cytokine signaling 1 0.606
UBE2S ubiquitin-conjugating enzyme E2S 0.605
RNF146 ring finger protein 146 0.604
CAPN1 calpain 1, (mu/I) large subunit 0.604
MX2 MX dynamin-like GTPase 2 0.604
GLS2 glutaminase 2 (liver, mitochondrial) 0.604
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.603
ALOXE3 arachidonate lipoxygenase 3 0.602
BRD4 bromodomain containing 4 0.601
IL32 interleukin 32 0.601
HAVCR1 hepatitis A virus cellular receptor 1 0.601
NANOS3 nanos homolog 3 (Drosophila) 0.6
DAPK3 death-associated protein kinase 3 0.6
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.6
SOS1 son of sevenless homolog 1 (Drosophila) 0.599
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.598
GLB1 galactosidase, beta 1 0.598
MGMT O-6-methylguanine-DNA methyltransferase 0.597
NT5E 5'-nucleotidase, ecto (CD73) 0.596
DPP9 dipeptidyl-peptidase 9 0.596
AASDH aminoadipate-semialdehyde dehydrogenase 0.594
LIPT1 lipoyltransferase 1 0.592
RPP14 ribonuclease P/MRP 14kDa subunit 0.592
CENPV centromere protein V 0.591
LIAS lipoic acid synthetase 0.591
EP300 E1A binding protein p300 0.59
ADIPOQ adiponectin, C1Q and collagen domain containing 0.59
PEA15 phosphoprotein enriched in astrocytes 15 0.589
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.589
C8G complement component 8, gamma polypeptide 0.588
EDN1 endothelin 1 0.587
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.587
CCL22 chemokine (C-C motif) ligand 22 0.586
FUS FUS RNA binding protein 0.585
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.583
PYDC1 PYD (pyrin domain) containing 1 0.583
USP36 ubiquitin specific peptidase 36 0.583
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.581
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.58
CDC25C cell division cycle 25C 0.579
PCNA proliferating cell nuclear antigen 0.579
MARK2 MAP/microtubule affinity-regulating kinase 2 0.577
CTRC chymotrypsin C (caldecrin) 0.577
PHGDH phosphoglycerate dehydrogenase 0.576
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.576
DHODH dihydroorotate dehydrogenase (quinone) 0.575
PGLYRP1 peptidoglycan recognition protein 1 0.574
PDCD1LG2 programmed cell death 1 ligand 2 0.572
CRBN cereblon 0.572
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.572
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.572
ANAPC11 anaphase promoting complex subunit 11 0.572
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.571
CLEC6A C-type lectin domain family 6, member A 0.571
VDAC3 voltage-dependent anion channel 3 0.569
NOTCH1 notch 1 0.567
LEP leptin 0.566
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.565
TUG1 taurine up-regulated 1 (non-protein coding) 0.565
NGFR nerve growth factor receptor 0.564
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.563
NGF nerve growth factor (beta polypeptide) 0.562
IRF8 interferon regulatory factor 8 0.562
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.56
CXCL9 chemokine (C-X-C motif) ligand 9 0.559
USP9X ubiquitin specific peptidase 9, X-linked 0.559
NKAP NFKB activating protein 0.558
GCLM glutamate-cysteine ligase, modifier subunit 0.558
HAMP hepcidin antimicrobial peptide 0.558
MT1G metallothionein 1G 0.557
HDAC1 histone deacetylase 1 0.557
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.556
ACE2 angiotensin I converting enzyme 2 0.556
DAXX death-domain associated protein 0.556
TREM1 triggering receptor expressed on myeloid cells 1 0.555
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.554
MX1 MX dynamin-like GTPase 1 0.554
CYBA cytochrome b-245, alpha polypeptide 0.553
JAK3 Janus kinase 3 0.552
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.552
XAF1 XIAP associated factor 1 0.551
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.551
TRIM24 tripartite motif containing 24 0.55
USP25 ubiquitin specific peptidase 25 0.55
DUOX1 dual oxidase 1 0.549
PPP6C protein phosphatase 6, catalytic subunit 0.549
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.548
RICTOR RPTOR independent companion of MTOR, complex 2 0.547
HRAS Harvey rat sarcoma viral oncogene homolog 0.547
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.547
PLAT plasminogen activator, tissue 0.547
ATP11C ATPase, class VI, type 11C 0.547
FGF18 fibroblast growth factor 18 0.547
DPP4 dipeptidyl-peptidase 4 0.547
ALOX5 arachidonate 5-lipoxygenase 0.545
RABIF RAB interacting factor 0.544
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.544
USP11 ubiquitin specific peptidase 11 0.543
SMAD7 SMAD family member 7 0.542
SMAD4 SMAD family member 4 0.541
SESN2 sestrin 2 0.541
DAND5 DAN domain family member 5, BMP antagonist 0.541
CD69 CD69 molecule 0.541
VDAC2 voltage-dependent anion channel 2 0.54
UXT ubiquitously-expressed, prefoldin-like chaperone 0.539
RDH8 retinol dehydrogenase 8 (all-trans) 0.539
IL24 interleukin 24 0.539
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.538
SDCBP syndecan binding protein (syntenin) 0.538
FGF9 fibroblast growth factor 9 0.537
NLRP2 NLR family, pyrin domain containing 2 0.534
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.532
FGF6 fibroblast growth factor 6 0.532
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.532
DUSP12 dual specificity phosphatase 12 0.532
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.531
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 0.53
FGF20 fibroblast growth factor 20 0.529
UBA1 ubiquitin-like modifier activating enzyme 1 0.529
ARG2 arginase 2 0.528
THBD thrombomodulin 0.528
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 0.528
TBPL2 TATA box binding protein like 2 0.528
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.528
FGF17 fibroblast growth factor 17 0.525
FGF4 fibroblast growth factor 4 0.525
FGFR1 fibroblast growth factor receptor 1 0.524
LDHA lactate dehydrogenase A 0.524
FGF3 fibroblast growth factor 3 0.523
NRBF2 nuclear receptor binding factor 2 0.521
PRSS57 protease, serine, 57 0.521
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.521
OMA1 OMA1 zinc metallopeptidase 0.521
HIPK2 homeodomain interacting protein kinase 2 0.518
CCN2 cellular communication network factor 2 0.517
PEAK3 PEAK family member 3 0.516
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.515
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.515
CD59 CD59 molecule, complement regulatory protein 0.514
BCL3 B-cell CLL/lymphoma 3 0.513
TBP TATA box binding protein 0.511
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.51
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.51
IL18RAP interleukin 18 receptor accessory protein 0.509
FGF22 fibroblast growth factor 22 0.508
FKBP1A FK506 binding protein 1A, 12kDa 0.507
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.507
CDK6 cyclin-dependent kinase 6 0.507
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 0.506
FGF16 fibroblast growth factor 16 0.506
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.505
AURKB aurora kinase B 0.504
SREBF1 sterol regulatory element binding transcription factor 1 0.504
SOCS3 suppressor of cytokine signaling 3 0.502
CD200R1 CD200 receptor 1 0.502
ZDHHC1 zinc finger, DHHC-type containing 1 0.502
EIF5B eukaryotic translation initiation factor 5B 0.502
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.501
PROM1 prominin 1 0.501
FGF7 fibroblast growth factor 7 0.501
PAWR PRKC, apoptosis, WT1, regulator 0.5