Ritonavir_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ritonavir perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ritonavir_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0909019
RIGI RNA sensor RIG-I 0.0809701
STS steroid sulfatase (microsomal), isozyme S 0.0771365
EXT1 exostosin glycosyltransferase 1 0.0727027
GMDS GDP-mannose 4,6-dehydratase 0.0680489
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0678712
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.065549
EPSTI1 epithelial stromal interaction 1 (breast) 0.0628117
INTS6 integrator complex subunit 6 0.0617049
ANXA2 annexin A2 0.0584656
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.058324
RNF213 ring finger protein 213 0.0542554
SP100 SP100 nuclear antigen 0.0502273
SMAD3 SMAD family member 3 0.0483939
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0483034
ETV6 ets variant 6 0.0440917
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0440873
RSAD2 radical S-adenosyl methionine domain containing 2 0.0408256
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0407048
NPSR1 neuropeptide S receptor 1 0.0399774
CATSPERB catsper channel auxiliary subunit beta 0.0395592
TSHZ2 teashirt zinc finger homeobox 2 0.038862
GCLC glutamate-cysteine ligase, catalytic subunit 0.0387426
MSI2 musashi RNA-binding protein 2 0.0380121
VCL vinculin 0.0373095
SQSTM1 sequestosome 1 0.0372623
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0370755
IGFBP3 insulin-like growth factor binding protein 3 0.0367921
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0360478
TOX3 TOX high mobility group box family member 3 0.0358274
ANKRD10 ankyrin repeat domain 10 0.0351442
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0350179
MX2 MX dynamin-like GTPase 2 0.0349167
LAMA4 laminin, alpha 4 0.0335878
AKAP13 A kinase (PRKA) anchor protein 13 0.0333984
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0332502
ARHGAP26 Rho GTPase activating protein 26 0.0330186
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0324667
PLSCR1 phospholipid scramblase 1 0.0323258
ERBIN erbb2 interacting protein 0.0320404
VMP1 vacuole membrane protein 1 0.0318142
TM4SF19 transmembrane 4 L six family member 19 0.031778
LPP LIM domain containing preferred translocation partner in lipoma 0.031699
BAIAP2L1 BAI1-associated protein 2-like 1 0.0316631
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0314831
XAF1 XIAP associated factor 1 0.0312383
MAML2 mastermind-like 2 (Drosophila) 0.0308838
CTBP2 C-terminal binding protein 2 0.0306622
MACC1 metastasis associated in colon cancer 1 0.0304836
MX1 MX dynamin-like GTPase 1 0.0303843
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0302766
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0296786
SAMD9 sterile alpha motif domain containing 9 0.0290253
SPATA13 spermatogenesis associated 13 0.0289034
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0279866
PRSS3 protease, serine, 3 0.0267092
CEMIP cell migration inducing protein, hyaluronan binding 0.0261345
TRIO trio Rho guanine nucleotide exchange factor 0.0260393
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0257613
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0256891
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0254782
TMC5 transmembrane channel-like 5 0.0253057
IGF1R insulin-like growth factor 1 receptor 0.0250684
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0247114
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0246898
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0242348
NCOA7 nuclear receptor coactivator 7 0.0242114
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0241044
PLSCR2 phospholipid scramblase 2 0.0237537
MYH14 myosin, heavy chain 14, non-muscle 0.0237365
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0237131
EFNA5 ephrin-A5 0.0236874
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0236339
APP amyloid beta (A4) precursor protein 0.0236241
ATP10B ATPase, class V, type 10B 0.023373
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0233689
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0232885
ZHX2 zinc fingers and homeoboxes 2 0.0231057
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.022892
ZBTB20 zinc finger and BTB domain containing 20 0.0227617
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0223157
TMEM65 transmembrane protein 65 0.0222267
SLK STE20-like kinase 0.022089
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0218487
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0215414
RABGAP1L RAB GTPase activating protein 1-like 0.0213796
SPAG9 sperm associated antigen 9 0.0213534
RBM47 RNA binding motif protein 47 0.021149
CUX1 cut-like homeobox 1 0.0208313
MUC20 mucin 20, cell surface associated 0.0206809
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0205722
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0203504
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0202704
NT5C2 5'-nucleotidase, cytosolic II 0.020223
TSC22D1 TSC22 domain family, member 1 0.0201689
GTF2IRD1 GTF2I repeat domain containing 1 0.0201016
UBAP2 ubiquitin associated protein 2 0.0199209
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0198037
FHIT fragile histidine triad 0.019751
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0197082

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.182267
B2M beta-2-microglobulin -0.129001
NDRG1 N-myc downstream regulated 1 -0.107515
PDIA3 protein disulfide isomerase family A, member 3 -0.105187
MBNL2 muscleblind-like splicing regulator 2 -0.101501
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0808783
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0790509
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.078614
GOLGB1 golgin B1 -0.076281
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0719665
DSCAM Down syndrome cell adhesion molecule -0.0686547
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0655194
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0652635
BTBD9 BTB (POZ) domain containing 9 -0.0611982
BCLAF1 BCL2-associated transcription factor 1 -0.0602047
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0577441
CCNL1 cyclin L1 -0.0572366
RUNX1 runt-related transcription factor 1 -0.0551545
EIF1 eukaryotic translation initiation factor 1 -0.0533454
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0523958
RPS6 ribosomal protein S6 -0.0517342
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0515626
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0512938
ZMYM2 zinc finger, MYM-type 2 -0.05078
ARGLU1 arginine and glutamate rich 1 -0.050112
PTBP3 polypyrimidine tract binding protein 3 -0.0489535
GOLGA4 golgin A4 -0.0480992
NCKAP5 NCK-associated protein 5 -0.0460166
NRIP1 nuclear receptor interacting protein 1 -0.045702
DIAPH3 diaphanous-related formin 3 -0.0441291
AKAP9 A kinase (PRKA) anchor protein 9 -0.0439796
CLTC clathrin, heavy chain (Hc) -0.0420896
IFNGR1 interferon gamma receptor 1 -0.0417822
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0415723
AHI1 Abelson helper integration site 1 -0.0413569
SBF2 SET binding factor 2 -0.0410321
RHOBTB3 Rho-related BTB domain containing 3 -0.0402913
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0394064
NCOR1 nuclear receptor corepressor 1 -0.0392513
RBM26 RNA binding motif protein 26 -0.0390572
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0386184
PTEN phosphatase and tensin homolog -0.0375382
N4BP2L2 NEDD4 binding protein 2-like 2 -0.037235
SREBF2 sterol regulatory element binding transcription factor 2 -0.0370451
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0368433
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0368216
MEIS2 Meis homeobox 2 -0.0363865
UBC ubiquitin C -0.0360588
RNF43 ring finger protein 43 -0.0359489
NUCB2 nucleobindin 2 -0.0358851
EHF ets homologous factor -0.0354568
MKI67 marker of proliferation Ki-67 -0.0353609
KMT2E lysine (K)-specific methyltransferase 2E -0.0349528
HM13 histocompatibility (minor) 13 -0.0348831
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0347858
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0346947
DSTN destrin (actin depolymerizing factor) -0.0342613
SEC24D SEC24 family member D -0.033893
THOC2 THO complex 2 -0.0338923
IFI27 interferon, alpha-inducible protein 27 -0.033524
BPTF bromodomain PHD finger transcription factor -0.0325752
UFM1 ubiquitin-fold modifier 1 -0.0323852
ZMYND8 zinc finger, MYND-type containing 8 -0.0323112
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0318897
FNDC3A fibronectin type III domain containing 3A -0.0318126
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0310913
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.031026
PKM pyruvate kinase, muscle -0.0301503
CMIP c-Maf inducing protein -0.0300571
TM9SF2 transmembrane 9 superfamily member 2 -0.0300349
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.029789
CALU calumenin -0.0296468
TTC3 tetratricopeptide repeat domain 3 -0.0296104
TMEM51 transmembrane protein 51 -0.0291472
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0286633
IRF1 interferon regulatory factor 1 -0.028618
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0283128
CALR calreticulin -0.0280751
BRD4 bromodomain containing 4 -0.0280287
RPL23 ribosomal protein L23 -0.0279478
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0278722
WDR45B WD repeat domain 45B -0.027646
RNF145 ring finger protein 145 -0.0275647
VEGFA vascular endothelial growth factor A -0.0274912
TRAM1 translocation associated membrane protein 1 -0.0274154
ADAR adenosine deaminase, RNA-specific -0.0273787
RAB1A RAB1A, member RAS oncogene family -0.0272865
TENT2 terminal nucleotidyltransferase 2 -0.027131
RB1CC1 RB1-inducible coiled-coil 1 -0.0267875
ACBD3 acyl-CoA binding domain containing 3 -0.0267669
RBM39 RNA binding motif protein 39 -0.0264243
ATP11B ATPase, class VI, type 11B -0.0262851
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -0.0259568
EPB41 erythrocyte membrane protein band 4.1 -0.0257883
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0257338
FNIP1 folliculin interacting protein 1 -0.0256428
CENPF centromere protein F, 350/400kDa -0.0256302
ESRP1 epithelial splicing regulatory protein 1 -0.0254629
USP3 ubiquitin specific peptidase 3 -0.0254363
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0254307