Ritonavir_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ritonavir perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ritonavir_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.117387
EGFR epidermal growth factor receptor 0.110921
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0848164
THSD4 thrombospondin, type I, domain containing 4 0.0813982
INTS6 integrator complex subunit 6 0.0765895
PDLIM5 PDZ and LIM domain 5 0.0732541
GRAMD1B GRAM domain containing 1B 0.0706866
SLTM SAFB-like, transcription modulator 0.0625988
MCL1 myeloid cell leukemia 1 0.0530716
NABP1 nucleic acid binding protein 1 0.0510471
VMP1 vacuole membrane protein 1 0.0477265
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0473236
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0470001
SAMD4A sterile alpha motif domain containing 4A 0.0469146
PM20D1 peptidase M20 domain containing 1 0.0446953
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0444697
ZNF638 zinc finger protein 638 0.0421939
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0415015
BCAR3 breast cancer anti-estrogen resistance 3 0.0380697
MYOF myoferlin 0.0378181
DOCK5 dedicator of cytokinesis 5 0.0374044
RAD51B RAD51 paralog B 0.0344082
PCBP2 poly(rC) binding protein 2 0.0334572
FNDC3B fibronectin type III domain containing 3B 0.0328456
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0324891
MSN moesin 0.0313677
CCSER1 coiled-coil serine-rich protein 1 0.0307647
TRIP12 thyroid hormone receptor interactor 12 0.0301589
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0300505
ZSWIM6 zinc finger, SWIM-type containing 6 0.0300209
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0295524
CEMIP cell migration inducing protein, hyaluronan binding 0.0289979
DOCK1 dedicator of cytokinesis 1 0.0287627
LPP LIM domain containing preferred translocation partner in lipoma 0.0287512
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0286276
JMJD1C jumonji domain containing 1C 0.0283854
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0282946
TRAPPC9 trafficking protein particle complex 9 0.0281254
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.027466
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0270382
RIMS2 regulating synaptic membrane exocytosis 2 0.0266881
MAML3 mastermind-like 3 (Drosophila) 0.0265684
GPHN gephyrin 0.0258951
SCEL sciellin 0.025694
BMP6 bone morphogenetic protein 6 0.0253749
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0251284
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0248703
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0247012
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0242653
SMOC1 SPARC related modular calcium binding 1 0.0242096
SMYD3 SET and MYND domain containing 3 0.02408
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0235617
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0232294
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0231631
IGFBP5 insulin-like growth factor binding protein 5 0.0225383
IGFBP3 insulin-like growth factor binding protein 3 0.0222484
SKIL SKI-like proto-oncogene 0.0219606
ATP11A ATPase, class VI, type 11A 0.021898
MBNL1 muscleblind-like splicing regulator 1 0.0217851
PTK2 protein tyrosine kinase 2 0.0213226
FAF1 Fas (TNFRSF6) associated factor 1 0.0213095
KMT2E lysine (K)-specific methyltransferase 2E 0.0211925
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0211037
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0210337
RASAL2 RAS protein activator like 2 0.0210109
PACS1 phosphofurin acidic cluster sorting protein 1 0.0209983
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0208343
CMIP c-Maf inducing protein 0.0207566
AKAP13 A kinase (PRKA) anchor protein 13 0.0207068
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0204233
NTN4 netrin 4 0.0203809
PLS3 plastin 3 0.0203581
CCNL1 cyclin L1 0.0202761
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0201901
FOXP1 forkhead box P1 0.0201863
USP34 ubiquitin specific peptidase 34 0.0201606
MAST4 microtubule associated serine/threonine kinase family member 4 0.0198575
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0198155
DTNA dystrobrevin, alpha 0.0197715
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.019672
FNDC3A fibronectin type III domain containing 3A 0.0194774
DST dystonin 0.0194351
HOMER1 homer scaffolding protein 1 0.0189032
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0186972
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0185291
HSPA8 heat shock 70kDa protein 8 0.0180368
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0179822
DNAH14 dynein, axonemal, heavy chain 14 0.0178925
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0178534
BABAM2 BRISC and BRCA1 A complex member 2 0.0172507
DOCK4 dedicator of cytokinesis 4 0.0170392
CAV2 caveolin 2 0.0170295
GSK3B glycogen synthase kinase 3 beta 0.0170144
FBXL17 F-box and leucine-rich repeat protein 17 0.0169894
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0167668
MAP7 microtubule-associated protein 7 0.0167564
CATSPERB catsper channel auxiliary subunit beta 0.0166739
STK24 serine/threonine kinase 24 0.0166666
MIPOL1 mirror-image polydactyly 1 0.0166048
DIAPH1 diaphanous-related formin 1 0.0162817

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.156771
TPT1 tumor protein, translationally-controlled 1 -0.119192
TXNRD1 thioredoxin reductase 1 -0.110352
NAMPT nicotinamide phosphoribosyltransferase -0.0934185
H1-0 H1.0 linker histone -0.0869843
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0869209
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0799978
NDRG1 N-myc downstream regulated 1 -0.0767174
PGK1 phosphoglycerate kinase 1 -0.075929
PTMA prothymosin, alpha -0.0746829
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0728909
FAM13A family with sequence similarity 13, member A -0.068441
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0670797
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0644411
HDLBP high density lipoprotein binding protein -0.0640223
RPS24 ribosomal protein S24 -0.0594572
LAMB3 laminin, beta 3 -0.0592954
KRT18 keratin 18, type I -0.0575123
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0568952
GCLC glutamate-cysteine ligase, catalytic subunit -0.0567325
ZMYND8 zinc finger, MYND-type containing 8 -0.054749
ASPH aspartate beta-hydroxylase -0.0546797
NGLY1 N-glycanase 1 -0.053121
RPS3 ribosomal protein S3 -0.0521476
LAMC2 laminin, gamma 2 -0.0513615
RAB1A RAB1A, member RAS oncogene family -0.0503687
CAMTA1 calmodulin binding transcription activator 1 -0.0500628
LMO7 LIM domain 7 -0.0492433
ANKRD10 ankyrin repeat domain 10 -0.0471939
IFI6 interferon, alpha-inducible protein 6 -0.0471759
LDHA lactate dehydrogenase A -0.0469111
S100A10 S100 calcium binding protein A10 -0.0448819
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0445589
AKR1C1 aldo-keto reductase family 1, member C1 -0.0441143
TMEM165 transmembrane protein 165 -0.042625
ACTG1 actin gamma 1 -0.039897
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0397213
SEPTIN2 septin 2 -0.0396446
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0387583
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0386103
ABLIM1 actin binding LIM protein 1 -0.0385946
RPL35A ribosomal protein L35a -0.0382251
GM2A GM2 ganglioside activator -0.0374391
ANXA2 annexin A2 -0.0370437
PRRC2C proline-rich coiled-coil 2C -0.0368845
S100A6 S100 calcium binding protein A6 -0.0360398
NDE1 nudE neurodevelopment protein 1 -0.0359087
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0356435
KDM3A lysine (K)-specific demethylase 3A -0.0355062
HLA-B major histocompatibility complex, class I, B -0.0352684
CANX calnexin -0.0351068
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0350213
FTL ferritin, light polypeptide -0.0348871
BRWD3 bromodomain and WD repeat domain containing 3 -0.0341686
MARF1 meiosis regulator and mRNA stability factor 1 -0.0340325
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0338677
OGA O-GlcNAcase -0.0338204
MORF4L2 mortality factor 4 like 2 -0.0336365
EGR1 early growth response 1 -0.0334171
RPS12 ribosomal protein S12 -0.0330797
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0328958
TOP1 topoisomerase (DNA) I -0.0326518
WDR45B WD repeat domain 45B -0.0324654
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0322905
CAV1 caveolin 1, caveolae protein, 22kDa -0.0318403
BRWD1 bromodomain and WD repeat domain containing 1 -0.0314664
RPL34 ribosomal protein L34 -0.0314616
HOOK2 hook microtubule-tethering protein 2 -0.0312373
ARRDC3 arrestin domain containing 3 -0.0309902
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0309365
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0308386
ZNF292 zinc finger protein 292 -0.0307271
AGR2 anterior gradient 2 -0.030479
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0303903
SEC31A SEC31 homolog A (S. cerevisiae) -0.0299866
RPS25 ribosomal protein S25 -0.0296508
RPS27A ribosomal protein S27a -0.0295765
S100P S100 calcium binding protein P -0.029415
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0287006
HBP1 HMG-box transcription factor 1 -0.0286824
B2M beta-2-microglobulin -0.0286059
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0284886
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0278539
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0275672
PKM pyruvate kinase, muscle -0.0274238
ENO1 enolase 1, (alpha) -0.027277
LRP1B low density lipoprotein receptor-related protein 1B -0.02708
SEC61G Sec61 gamma subunit -0.0268308
SEC24D SEC24 family member D -0.0267622
RPL37 ribosomal protein L37 -0.0267401
SPAG9 sperm associated antigen 9 -0.0264144
S100A9 S100 calcium binding protein A9 -0.026294
UBE2O ubiquitin-conjugating enzyme E2O -0.0260569
ZC3H11A zinc finger CCCH-type containing 11A -0.0258091
SDC4 syndecan 4 -0.0255417
SQSTM1 sequestosome 1 -0.0255417
UVRAG UV radiation resistance associated -0.0254708
RPL37A ribosomal protein L37a -0.0254005
SPTSSA serine palmitoyltransferase, small subunit A -0.025171
KCMF1 potassium channel modulatory factor 1 -0.0250608