| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ritonavir perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ritonavir_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.135864 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.104627 |
| POTEF | POTE ankyrin domain family, member F | 0.0982492 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.088374 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0836186 |
| TPM3 | tropomyosin 3 | 0.0813407 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0664355 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0658409 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.060961 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0598488 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0526931 |
| IL6 | interleukin 6 | 0.0510339 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0506608 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0501866 |
| RPS27A | ribosomal protein S27a | 0.0495183 |
| ENO1 | enolase 1, (alpha) | 0.0493521 |
| PCBP2 | poly(rC) binding protein 2 | 0.0480533 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0480029 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0471993 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0458216 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0450638 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0446267 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0444678 |
| COPA | coatomer protein complex, subunit alpha | 0.0437987 |
| MSN | moesin | 0.0437402 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0407646 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0404621 |
| FMNL2 | formin-like 2 | 0.0398581 |
| FAM107B | family with sequence similarity 107, member B | 0.0398564 |
| FLNB | filamin B, beta | 0.0397955 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0388156 |
| ERBIN | erbb2 interacting protein | 0.0386043 |
| HDGF | hepatoma-derived growth factor | 0.0385285 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0383672 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0378937 |
| UBC | ubiquitin C | 0.0370495 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0365997 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0360576 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0355967 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0352616 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0352568 |
| CDCP1 | CUB domain containing protein 1 | 0.0347807 |
| ITGB5 | integrin, beta 5 | 0.0336311 |
| LAMC2 | laminin, gamma 2 | 0.0329805 |
| BRD2 | bromodomain containing 2 | 0.0329158 |
| PLS3 | plastin 3 | 0.0327956 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0326305 |
| B2M | beta-2-microglobulin | 0.031677 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0305891 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0305473 |
| EGFR | epidermal growth factor receptor | 0.0304292 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0303782 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0300884 |
| GLG1 | golgi glycoprotein 1 | 0.0298956 |
| PYGL | phosphorylase, glycogen, liver | 0.0298928 |
| DIAPH1 | diaphanous-related formin 1 | 0.0297904 |
| ACTN1 | actinin, alpha 1 | 0.0297125 |
| HLA-A | major histocompatibility complex, class I, A | 0.0295505 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0292822 |
| GRAMD1B | GRAM domain containing 1B | 0.0290113 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0289534 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0287939 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0285574 |
| RPL3 | ribosomal protein L3 | 0.0285216 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0285145 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.028324 |
| MCL1 | myeloid cell leukemia 1 | 0.0280454 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0278526 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0276554 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0276521 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0276167 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0275549 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0275405 |
| TJP1 | tight junction protein 1 | 0.027394 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0269654 |
| RANBP9 | RAN binding protein 9 | 0.0264832 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0263027 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0260912 |
| MT1X | metallothionein 1X | 0.0260117 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0258492 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0257703 |
| HLA-B | major histocompatibility complex, class I, B | 0.025727 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0252948 |
| AXL | AXL receptor tyrosine kinase | 0.0252318 |
| RPS2 | ribosomal protein S2 | 0.0248788 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.024506 |
| ANXA5 | annexin A5 | 0.0244262 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.024342 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0239042 |
| RAB18 | RAB18, member RAS oncogene family | 0.0236769 |
| NEBL | nebulette | 0.0234299 |
| RBM25 | RNA binding motif protein 25 | 0.0232837 |
| JMJD1C | jumonji domain containing 1C | 0.0232312 |
| RNF145 | ring finger protein 145 | 0.0232247 |
| CCNL1 | cyclin L1 | 0.023055 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0230213 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0228899 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.022694 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0226625 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0225787 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.211749 |
| VIM | vimentin | -0.182261 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.146049 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.12072 |
| TMSB10 | thymosin beta 10 | -0.103781 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0971481 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0963136 |
| FTL | ferritin, light polypeptide | -0.0854071 |
| TXNRD1 | thioredoxin reductase 1 | -0.0833398 |
| ACTG1 | actin gamma 1 | -0.0763996 |
| IGF2 | insulin-like growth factor 2 | -0.0741891 |
| RPS21 | ribosomal protein S21 | -0.0676498 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0676286 |
| RPL19 | ribosomal protein L19 | -0.0627538 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0591919 |
| DENND4A | DENN/MADD domain containing 4A | -0.0583941 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0556448 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0554864 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0545725 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0497672 |
| HDAC9 | histone deacetylase 9 | -0.046724 |
| BICC1 | BicC family RNA binding protein 1 | -0.0464547 |
| IER3 | immediate early response 3 | -0.0462241 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0446089 |
| KLF6 | Kruppel-like factor 6 | -0.0445839 |
| TMEM123 | transmembrane protein 123 | -0.0440929 |
| SMAD2 | SMAD family member 2 | -0.0418342 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0413875 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0397187 |
| RPS19 | ribosomal protein S19 | -0.0392873 |
| KYNU | kynureninase | -0.0390001 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0389044 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0388952 |
| RPL23 | ribosomal protein L23 | -0.0382346 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0378072 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0375155 |
| SERF2 | small EDRK-rich factor 2 | -0.035296 |
| GNAS | GNAS complex locus | -0.0351363 |
| RPL35A | ribosomal protein L35a | -0.0350432 |
| RPL32 | ribosomal protein L32 | -0.0349097 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0346666 |
| AK1 | adenylate kinase 1 | -0.0342743 |
| RPL8 | ribosomal protein L8 | -0.0342732 |
| FUS | FUS RNA binding protein | -0.034205 |
| RPL7 | ribosomal protein L7 | -0.0329977 |
| RPL4 | ribosomal protein L4 | -0.0328699 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0319434 |
| RPL34 | ribosomal protein L34 | -0.0318257 |
| RPLP1 | ribosomal protein, large, P1 | -0.0317926 |
| PTMA | prothymosin, alpha | -0.0316161 |
| HMGB1 | high mobility group box 1 | -0.0307331 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0306157 |
| RHEB | Ras homolog enriched in brain | -0.0296244 |
| PTK2 | protein tyrosine kinase 2 | -0.0291523 |
| SRGN | serglycin | -0.0289829 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0289119 |
| RPL38 | ribosomal protein L38 | -0.0287724 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0284299 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0280259 |
| CAVIN1 | caveolae associated protein 1 | -0.027866 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.027555 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0275358 |
| CHN1 | chimerin 1 | -0.0274506 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0272673 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0271359 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.02707 |
| ILF2 | interleukin enhancer binding factor 2 | -0.0269877 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0269809 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0265453 |
| RPS24 | ribosomal protein S24 | -0.0264419 |
| S100A10 | S100 calcium binding protein A10 | -0.0264252 |
| USP34 | ubiquitin specific peptidase 34 | -0.0262246 |
| RBM39 | RNA binding motif protein 39 | -0.0259029 |
| TFRC | transferrin receptor | -0.0258332 |
| RPS5 | ribosomal protein S5 | -0.0254939 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.025421 |
| RPS8 | ribosomal protein S8 | -0.0254038 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0252208 |
| RPL11 | ribosomal protein L11 | -0.0248934 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0246994 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0242789 |
| CLTC | clathrin, heavy chain (Hc) | -0.0242164 |
| RPS29 | ribosomal protein S29 | -0.0241752 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0241739 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0240967 |
| CDK12 | cyclin-dependent kinase 12 | -0.0239935 |
| PARK7 | parkinson protein 7 | -0.0237678 |
| RPL6 | ribosomal protein L6 | -0.0237328 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0236915 |
| AHNAK | AHNAK nucleoprotein | -0.0236222 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0235509 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | -0.0232451 |
| RPLP2 | ribosomal protein, large, P2 | -0.022875 |
| NABP1 | nucleic acid binding protein 1 | -0.0227323 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.0225673 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0225549 |
| HMGA1 | high mobility group AT-hook 1 | -0.0225118 |
| IFRD1 | interferon-related developmental regulator 1 | -0.022401 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0223381 |
| NEGR1 | neuronal growth regulator 1 | -0.0223317 |
