| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ritonavir perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ritonavir_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.1716 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.140956 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.118856 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10155 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0755349 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0742865 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0708506 |
| ENO1 | enolase 1, (alpha) | 0.060542 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0583533 |
| VMP1 | vacuole membrane protein 1 | 0.0581159 |
| TPM3 | tropomyosin 3 | 0.0573732 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0516015 |
| PCBP2 | poly(rC) binding protein 2 | 0.0492873 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0456943 |
| GOLGA4 | golgin A4 | 0.0426946 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0421991 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0415098 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0408807 |
| GRAMD1B | GRAM domain containing 1B | 0.0408661 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0393338 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0389303 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0387034 |
| ATP11A | ATPase, class VI, type 11A | 0.0383121 |
| RPL37 | ribosomal protein L37 | 0.0380954 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0374034 |
| TMEM165 | transmembrane protein 165 | 0.0365198 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0350743 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0346969 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0345549 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0337016 |
| PGK1 | phosphoglycerate kinase 1 | 0.0333385 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0328174 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0326961 |
| PRELID2 | PRELI domain containing 2 | 0.0324748 |
| ATXN1 | ataxin 1 | 0.0320884 |
| CANX | calnexin | 0.0314661 |
| YBX1 | Y box binding protein 1 | 0.0304679 |
| GOLGB1 | golgin B1 | 0.0301228 |
| TMEM41B | transmembrane protein 41B | 0.0295989 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0293532 |
| TPM4 | tropomyosin 4 | 0.0292459 |
| COPA | coatomer protein complex, subunit alpha | 0.0290806 |
| FMNL2 | formin-like 2 | 0.0281931 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0274499 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0273474 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0266003 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0264985 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0262751 |
| KMT5B | lysine methyltransferase 5B | 0.025997 |
| SSH2 | slingshot protein phosphatase 2 | 0.0258182 |
| TJP1 | tight junction protein 1 | 0.0253798 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.0253025 |
| OGA | O-GlcNAcase | 0.0252992 |
| ZNF638 | zinc finger protein 638 | 0.0251418 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0250764 |
| LDHA | lactate dehydrogenase A | 0.0246893 |
| RNF145 | ring finger protein 145 | 0.0244918 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0244261 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0239911 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0235831 |
| TBK1 | TANK-binding kinase 1 | 0.0235636 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0234653 |
| NGLY1 | N-glycanase 1 | 0.0234352 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0232118 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0230615 |
| CDCP1 | CUB domain containing protein 1 | 0.0229512 |
| ZNF292 | zinc finger protein 292 | 0.0228989 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0227261 |
| AAK1 | AP2 associated kinase 1 | 0.0221194 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0220186 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0218891 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0216748 |
| NUP58 | nucleoporin 58 | 0.0211356 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0209327 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0207648 |
| CALU | calumenin | 0.0205855 |
| PPP1R21 | protein phosphatase 1, regulatory subunit 21 | 0.0205304 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0205173 |
| SET | SET nuclear proto-oncogene | 0.0201861 |
| TMF1 | TATA element modulatory factor 1 | 0.0201433 |
| RBM25 | RNA binding motif protein 25 | 0.0200224 |
| SMAP1 | small ArfGAP 1 | 0.019982 |
| XPO1 | exportin 1 | 0.019893 |
| PKM | pyruvate kinase, muscle | 0.0198308 |
| ZNF148 | zinc finger protein 148 | 0.0198175 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0197476 |
| RPS29 | ribosomal protein S29 | 0.0196387 |
| SEC24A | SEC24 family member A | 0.0196227 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0196206 |
| RPLP0 | ribosomal protein, large, P0 | 0.0195739 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0195496 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0195443 |
| ITSN2 | intersectin 2 | 0.019454 |
| USP24 | ubiquitin specific peptidase 24 | 0.0194362 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0191749 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0191695 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0191647 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0191208 |
| DSPP | dentin sialophosphoprotein | 0.0190646 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0189545 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.0921898 |
| TMSB10 | thymosin beta 10 | -0.0796142 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0771356 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0739949 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0710758 |
| YBX3 | Y box binding protein 3 | -0.0698158 |
| NABP1 | nucleic acid binding protein 1 | -0.0565092 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0476716 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0455111 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0450567 |
| HMGA2 | high mobility group AT-hook 2 | -0.042539 |
| KLF6 | Kruppel-like factor 6 | -0.0379281 |
| EGR1 | early growth response 1 | -0.0366521 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0365403 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0357437 |
| EGFR | epidermal growth factor receptor | -0.0326425 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.032623 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0320051 |
| TXNRD1 | thioredoxin reductase 1 | -0.0315375 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0307418 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0293093 |
| RPL23 | ribosomal protein L23 | -0.0291213 |
| E2F3 | E2F transcription factor 3 | -0.0275818 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0272027 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0265826 |
| ADAR | adenosine deaminase, RNA-specific | -0.0264118 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0263956 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0262918 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.026222 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0260701 |
| INTS6 | integrator complex subunit 6 | -0.0255403 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0254606 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0252933 |
| CDK12 | cyclin-dependent kinase 12 | -0.0251824 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0250076 |
| AHNAK | AHNAK nucleoprotein | -0.024878 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0243337 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0240882 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0233945 |
| STC1 | stanniocalcin 1 | -0.0233097 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0229058 |
| ST7L | suppression of tumorigenicity 7 like | -0.0227475 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0227214 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0227085 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0224088 |
| RPS21 | ribosomal protein S21 | -0.0223956 |
| RPL12 | ribosomal protein L12 | -0.0221857 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.022172 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0221574 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0218861 |
| AEBP2 | AE binding protein 2 | -0.0218486 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0217765 |
| EXOC4 | exocyst complex component 4 | -0.0205036 |
| SETX | senataxin | -0.0203991 |
| ADIPOR2 | adiponectin receptor 2 | -0.0195322 |
| RIGI | RNA sensor RIG-I | -0.0195248 |
| GNAS | GNAS complex locus | -0.0194716 |
| IER3 | immediate early response 3 | -0.0194211 |
| THADA | thyroid adenoma associated | -0.0191299 |
| FLNA | filamin A, alpha | -0.019092 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0188352 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.0184043 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0183788 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0180513 |
| PFN1 | profilin 1 | -0.0179621 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0177437 |
| SMYD3 | SET and MYND domain containing 3 | -0.0173341 |
| DHFR | dihydrofolate reductase | -0.0171518 |
| RAD51B | RAD51 paralog B | -0.017133 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0170116 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0169125 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -0.0167704 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0167185 |
| CRY1 | cryptochrome circadian clock 1 | -0.016544 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0165391 |
| MYPN | myopalladin | -0.0163231 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0163117 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0162033 |
| PLSCR1 | phospholipid scramblase 1 | -0.01617 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0161514 |
| FBXO11 | F-box protein 11 | -0.0161377 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0160387 |
| TRIM56 | tripartite motif containing 56 | -0.0159966 |
| SMAD3 | SMAD family member 3 | -0.0159086 |
| KNTC1 | kinetochore associated 1 | -0.0158362 |
| OSMR | oncostatin M receptor | -0.0157962 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0156355 |
| PHF3 | PHD finger protein 3 | -0.0156354 |
| GPHN | gephyrin | -0.0156324 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0155514 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | -0.0154748 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0152751 |
| PMP22 | peripheral myelin protein 22 | -0.0152739 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0152103 |
| EHBP1 | EH domain binding protein 1 | -0.0151218 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0151122 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0150716 |
| MOB1A | MOB kinase activator 1A | -0.0149833 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0149712 |
| ZBTB7A | zinc finger and BTB domain containing 7A | -0.0149364 |
